Intradialytic Hypertension and Associated Factors in Chronic Hemodialysis at the National Hemodidiadiasis Center in Donka, Guinea

Introduction: Dialytic high blood pressure (DHBP), although often ignored, is now recognized as a recurring and persistent phenomenon in a subgroup of hemodialysized patients. Its occurrence is associated with an increased risk of hospitalization and death. The objective of the study was to determine the prevalence of intradialytic hypertension and the factors associated with it. Methods: Study was cross-sectional, monocentric, descriptive and analytical over a three-month period from April 22 to July 22, 2019. Included were all patients 18 years of age or older, chronic hemodialysis for at least three months, with intra-dialytic high blood pressure. The blood pressure machine used for the majority of patients was an electronic “OMRON” blood pressure monitor. Epidemiological, clinical, para clinical and dialysis parameters were studied. The data were collected, captured and analyzed using IBM SPSS Statistics Version 20 software. The factors associated with intradialytic high blood pressure were searched using a univariate logistic regression model. The significance threshold for all statistical tests has been set at 5%. Results: Of our 131 patients, 53 had intradialytic hypertension, a frequency of 40.5%. The time of (DHBP) occurrence was more frequent were: Age range (40 - 50 years), Duration on dialysis (<6 months). Vascular nephropathy, hypoalbuminemia, Pre-dialytic Blood Pressure ≥ 140/90 mmHg. BP post dialysis ≥ 165, Dry weight ≥ 70 Kg, Number of antihypertensive agents ≥ Ultrafiltration rate ≥ 550 ml/h. Conclusion: This study, the first of its kind in Guinea, was able to determine the frequency of intradialytic hypertension and the factors associated with it.


Introduction
High blood pressure, a common problem in chronic hemodialysis patients and high blood pressure variability, is a risk factor for high mortality [1]. Usually, in most chronic hemodialysis patients, blood pressure decreases during the hemodilysis session due to ultrafiltration (UF). However, in some patients, it increases and remains elevated during and after the dialysis session [2]. The definition of dialytic hypertension remains unclear and depends on the subjectivity of the authors who are interested in it. Most defined it as an increase in Systolic Blood Pressure (SBP) −10 mm Hg between pre-dialysis measurement and after dialysis [3]. The frequency of intradialytic hypertension varies according to the definition used [4]. Many reviews report a prevalence between 13.2% and 33.9% [5].
In the United States, in 2018, Assimon MM. et al., in a study of the frequency of intradialytic hypertension, reported 5% -20% of hemodialysis treatments [6].
In Italy, Losito A. et al. in 2016, reported a prevalence of 23.1%. In Morocco in 2015 and in South Africa in 2016, the prevalence rates reported were respectively 29.17% and 28.4% [7].
Observational studies have shown that older age, lower dry weight, lower serum levels of creatinine and albumin, and the use of more antihypertensive drugs are associated with the occurrence of HID [8] [9] [10]. Our attention was drawn to the finding that, normotendus patients prior to dialysis and those controlled on pre-dialysis, developed intradialytic hypertension in per or post dialysis. The objective of the study was to determine the prevalence of intradialytic hypertension and the factors associated with it.

Patients and Methods
This was a cross-sectional, monocentric, descriptive and analytical study over a period of three (3) months from April 22 to July 22, 2019. It involved 131 chronic hemodialysis patients. All patients aged 18 years or older, chronic hemodialysis, have been included for at least three (3) months, with intra-dialytic high blood pressure. Patients were not included, patients: Having refused to participate in the study; Chronic hemodialysis not residing in Guinea, passing to the center; Acute kidney failure heshemodialysed. Open Journal of Nephrology Data collection was manual on a data collection sheet. All epidemiological, clinical, para-clinical, and management data were collected on patient records and hemodialysis notebooks, supplemented by patient interrogation. For each patient, blood pressure was measured at: -H0: Before plugging; -H1: At  The significance threshold for all statistical tests has been set at 5%. A P value of less than 0.05 was considered significant.

Results
Of our 131 patients, 53 had DHBP, representing a frequency of 40.5%. The time of DHBP occurrence was more frequent at the 3rd and 2nd hour, 94.34 and 86.79%, respectively. The average age of patients with DHBP was 45.51 years with extremes ranging from 19 -70 years. The standard deviation was 15.83. Patients whose age was between [29 -40] and [51 -62] years were the most represented 19 cases (35.8%) respectively. and 13 cases (24.5%). The average hemodialysis duration was 23.51 months with extremes ranging from 3 to 156 months. The mode was 11 months and the median was 16 months. Patients with seniority between [12 -24] months and those who had been on dialysis for at least 24 months were the most likely to be 22 cases (41.5%) respectively. and 15 cases (28.3%). Open Journal of Nephrology Kidney disease was vascular in 41.5% of cases, followed by glomerular nephropathy with 30.2%. Diabetic kidney disease was found in 8 patients or 15.1%, tubulo-interstitial nephropathy and indeterminate kidney disease were present in 3 patients each, or 5.7%. Finally, only one patient had hereditary kidney disease, or 1.9%. The average SBP before dialysis was 148 mm Hg with extremes ranging from 104 to 182 mmHg. The standard deviation was 16 Table 2 shows the main risk factors associated with intra-dialytic hypertension. Fifty-three of 131 patients had intra-dialytic hypertension.

Discussion
Of our 131 patients, 53 had Dialytic High Blood Pressure (DHBP), representing a frequency of 40.5%. The time of DHBP occurrence was more frequent at the 3rd and 2nd hour, 94.34 and 86.79%, respectively ( Table 1).
The frequency of DHBP in our series was 40.5%. This frequency is close to that found in a study conducted in Cameroon [5] which reported a frequency of 48.3%, in Nigeria 45.3%, and in the Philippines 37% [11], but far higher than that found in the United States in 2018 with 5% -20% of treatments hemodialysis [6]; Italy in 2016 with 23.1% [12]; South Africa 28.4% [13]. In Senegal, it was 22.6% [7]. In our study, the average age of patients was 45.51 years ( Table 2).  This result is different from those found by other authors; 50.69 -13.89 years [5] and 38.0 -5.9 [13], but much lower than that found in Greece 70.2 -14.3 years [14]. We found a statistically significant link (p-0.044) between age and the occurrence of DHBP. Our result corroborates that reported by Patrice and Collar. Cameroon, which had found age as a factor associated with the occurrence of DHBP. Which would be at odds with those found by Okpa and Col. Nigeria [15], Labarcon and Bad-ang in the Philippines [11], and Van Buren and Col. Texas who had not found a statistically significant link. This finding could be explained in our series by the youngness of the Guinean population, but also by the shorter life expectancy of our population, which is 60.62 [16] years. Among patients with DHBP, men were the most represented 66.0% (n-35) versus 33.9% (n-18) of women, or a sex ratio of 1.9 in favour of men (Text). This result is consistent with those found by Labarcon and Bad-ang in the Philippines [11] in 2015, Sebastian and Col. in South Africa in 2016 [13] and Okpa and Col. Nigeria in 2019 [15] who reported male predominance with a sex ratio of 1.1; 1.2 and 1.2 respectively. Our results are identical to those reported by Moustapha and collar. Senegal [7] and Van Buren and Col. United States [17] who had found a sex ratio of 2 respectively. We did not find a statistically significant link between the occurrence of HID and gender (p-0.820). The average hemodialysis duration in DHBP patients was 23.51 months −25.04. Four patients (7.5%) had done less than 6 months on dialysis in Group I versus 17 (21.8%) Group II. We found a statistically significant link (p-0.029). Our result is in line with that of Patrice and collar. who had also found dialysis duration as a factor associated with DHBP [5]. However, a duration of dialysis-30 months was considered a statistically associated factor (p-0.001). Our result is at odds with those of Van Buren and Col1et Shamir and col. [18] who had not found an association (p-0.9 and p-0.17 respectively). The most observed kidney disease was vascular kidney disease with 41.5% (n-22) of cases. We found a statistically signifi-cant link (p-0.009). Our results are consistent with those found by Moustapha and collar. [7], Okpa and cervix who had also found a predominance of vascular kidney disease respectively 52.4% and 38.7%. However, they did not find a statistically significant association with the occurrence of DHBP. This finding arouses the interest of the hypothesis of the role of endothelial cell dysfunction in the genesis of DHBP [19]. An hourly Ultrafiltration (UF) rate of 550 ml/h was observed in 26.4% of cases (n-14) and was statistically significant (p-0.045) ( Table 2). Our result corroborates that of Patrice and collar. Who had found UF flow as a factor associated with DHBP. However, the flow of UF was 800 ml/h [5]. Our result is contrary to those reported by Sebastian and Collar. [13], Labarcon and Bad-ang, [11] as well as Van Buren and Col. [17] who did not find a correlation. This could be explained by the fact that a high flow of UF significantly reduces volemia and lowers BP [5]. In our study, patients in the DHBP group had a lower average inter dialytic weight gain (1.32 -0.82 vs. 1.55 -0.88) than those in group II without noticing a statistically significant difference (p-0.668) ( Table 2). This result corroborates those of Moustapha and col. Senegal [7] and Van Buren and Col. in 2016 [10], which had not also found a correlation. Our result is contrary to that found by Shamir and collar. United States, which had found a statistically significant correlation (p-0.001) [18]. The average pre-dialytic SBP of DHBP patients was 148 mm Hg-17. The average pre-dialytic DBP was 88 mm Hg-12. Pre-dialysis BP-140/90 mm Hg was rated in 34.0% (n−18) of patients in Group I versus 44 patients, or 56.4% in Group II. We found a statistically significant link (p-0.012). Our results are similar to those found by Patrice and collar. [6] and Moustapha and collar [7], who had found a systolic-diastolic Arterial Hypertension as a factor associated with a value p-0.001 and p-0.004 respectively.
The average dry weight was 57.91 -9.63 kg in Group I compared to 62.57 kg -14.93 in Group II. 6 DHBP patients were rated as a dry weight of 70 kg, or 11.76% compared to 21 patients (26.92%) Group II. We found a statistically significant correlation (p-0.030). Our results are similar with those of Patrice and collar. [5] Who had found dry weight as a factor associated with DHBP. However, the dry weight was 67 kg (p-0.001). Our results are at odds with those of Eftimovska and Col. [6] and Van Buren and collar. [17] Who had not found an association (p-0.521 and p-0.2 respectively). She was informed in 17 cases (32.1%). The average was 32.9 g/l compared to 36.7 g/dL in Group II. More than half (70.6%) DHBP patients had hypo albuminemia versus 40% in Group II. We found a statistically significant link (p-0.036). Our results are consistent with those reported in the literature and with those of Moustapha and collar. [7], and Labarcon and Bad-ang [8], who had found hypo albuminemia peripheral vascular resistance [8]; on the other hand, because these patients are more prone to malnutrition and generally drink more fluids. Fifty (94.3%) DHBP patients were on antihypertensive therapy. Of these, 48 (96%) used at least one dual therapy. We found a statistically significant link (p-0.006). Our results corroborate Open Journal of Nephrology those of Patrice and col. [5] who had also found an association with the use of a number of antihypertensive drugs-2 (p. 0.001). This could be explained by the fact that patients with a large number of antihypertensive drugs are most often those with high hemodynamic instability. Following a one-varied logistic regression model, the factors that increased the risk of DHBP occurring were: A post-dialysis PP 65 mm Hg; Vascular kidney disease; Hypo albuminemia; and the use of a number of antihypertensives. Factors associated with lower risk were: the 40 -50 age group; A flow of UF-550 ml/h; dialysis duration-6 months; A pre-dialysis BP-140/90 mm Hg; and a dry weight of 70 kg (Table 3).

Conclusion
This study, the first of its kind in Guinea, was able to determine the frequency of intradialytic hypertension and the factors associated with it. An upcoming study would be interested in managing these predictors of intradialytic hypertension.