Odontogenic Cervico-Facial Cellulitis at the University Hospital of Brazzaville: About 431 Cases

Context and Objective: Cellulitis is potentially serious polymicrobial infections that can be life-threatening for the patient. They are clearly increasing in our service. It is with the aim of determining the hospital frequency of cellulitis of dental origin epidemiological profile, describing the clinical types, the therapeutic modalities and evaluating the results obtained. Subjects and Methods: This is a retrospective descriptive study on the files of 431 hospitalized patients, between January 2010 and December 2018 in the department of stomatology and maxillofacial surgery of the University Hospital of Brazzaville (Congo). The studied parameters: The frequency, the age, the gender, the origin, the consultation average time, the contributing factors, the entrance gate, the seat, the paraclinical assessment, the therapeutic modalities and the evolution. Results: Cervico-facial cellulitis accounted for 32.8% of hospitalizations. The average age was 32.8 ± 1.98 years, ranges from 3 to 93 years. The predominance was male with 241 cases, or 55.9%. 64.73% of patients came from CHUB emergencies. The mandibular seat was dominant with 77.72% of cases. The average consultation time was 6 days. As a contributing factor, we found the consumption of nonsteroidal anti-inflammatory drugs (NSAIDs). Tooth decay was the most common etiology 92.5%. Antibiotic therapy and surgery had a good evolution in 96.8% of cases. The mortality rate was 3.3%. Conclusion: odontogenic cervicofacial cellulitis remains common in daily practice. Patient care should focus on the preventive component integrating patient awareness of oral health.


Introduction
Cellulite is a polymicrobial condition with a predominance of anaerobes and commensal germs of the oral flora [1] [2].
Cervico-facial cellulitis is a complication of dental and periodontal infections, it constitutes a real emergency in daily dental practice [3]. It is of dental origin in 56% to 95% of cases [4] [5] [6]. Tooth decay accounts for more than 90% of cases in Africa [7]. The main causative teeth are the mandibular molars [8]. It is an infection that has an extensive tendency and may be life-threatening because of the progressive speed and severity of the complications. Despite this seriousness, no study has been conducted to determine the incidence of odontogenic cellulitis in the department of stomatology and maxillofacial surgery of the University Hospital of Brazzaville (rep. of Congo). NGOUONI et al. found a prevalence of cellulite of 34% in their series of diffuse cellulites carried out in 2005 [9]. In this perspective, we realized this study which aims to determine the hospital frequency of dental cellulitis, describe the clinical types and evaluate the results obtained.

Subjects and Methods
This is a retrospective descriptive study concerning 431 patient files treated in the department of stomatology and maxillofacial surgery of the University Hospital of Brazzaville (rep. of Congo). Patients were treated for cervicofacial cellulitis of dental origin between January 2010 and December 2018. The files collected included all patients with clinical signs of an acute cervicofacial infection of a dental origin requiring hospitalization and whose records were exploitable. Data were collected from the hospital registry and medical files. The variables studied were frequency, age, gender, origin, location, consulting period, contributing factors, entrance gate, reason for consultation, paraclinical assessment, therapeutic modalities and treatment, evolution. Patients with a non-dental condition were excluded: tumoral, salivary, traumatic, ganglionic and those that did not require hospitalization. Data were processed with MS Excel 2013 software.
The study had the ethical clearance of the institutional ethics committee. The collection of data was done taking into consideration the global rules of ethics relating to the respect of confidentiality and the protection of data specific to patients.

Results
We recorded 431 cases of cervicofacial cellulitis out of a total of 1315 hospitalized in the department during the study period, representing 32.8% of all hospitalizations with a rate of about 45 cases/year. The annual rate of cervicofacial cellulitis cases is reported in Figure 1. The mean age of the patients was 32.8 ± 1.98 years with extremes of 3 and 93 years. The most affected age group is 16 -30 years old. We found a male predominance with 241 cases or 55.9%, the sex ratio was 1.3.
The distribution of cases of cervicofacial cellulitis by age and sex is reported in Figure 2.
Inpatients came from CHUB emergencies in 279 cases (64.73%), 144 cases (33.41%) in the outpatient unit and 8 cases (1.68%) directly from the home. The average consultation time was 6 days, with extremes of 2 and 14 days. As a contributing factor, we recorded the consumption of nonsteroidal anti-inflammatory drugs taken in self-medication in 72.4% of cases ( Figure 3).     All patients received parenteral bi or triple therapy ( Table 2).
112 patients were put on steroids: solu-medrol 80 to 120 mg once a day, for a duration of 3 to 5 days. The main analgesic molecule used was paracetamol.
Surgical drainage was performed on three 312 patients, consisting of a mechanical knife incision with evacuation of pus, debridement of necrotic tissue, and heavy washing with dakin and hydrogen peroxide, with the placement of a drainage slide.
The duration of hospitalization ranged from 2 to 30 days with an average of 12 days.
The evolution was favorable with a high cure rate of 96.7%. The mortality rate was 3.3% in patients who developed severe septicemia.

Discussion
Cellulitis was the first reason of hospitalization in our department, with a hospital prevalence of 32.8% and an annual rate of about 45 cases, compared with results of Rouadi 43 cases [10]. In 2012, Assouan et al. reported an annual incidence of 57.7 cases [11]. This digit did not reflect the actual number of cellulitis cases, as many where treated as outpatients, others were referred to O. R. L. department or refused to be hospitalized for lack of funds. The high incidence of odontogenic cellulitis in our context was mainly due to neglect of oral health and declining socioeconomic level.
The average age in our series was 32.8 ± 1.98 years, while HOUNKPE [12] reported 18 years old. In other African studies, this age ranges were 28 to 31 years [10] [13]. In France, it was about 51 years [14]. These different studies show that cellulitis can affect patients of any age.
A male predominance was found in our study, which was almost unanimous of the authors [ [22]. In fact, NSAIDs mask the signs of inflammation and lower immunity, leading to an increase in infection [11].
Among the comorbidities associated, diabetes accounted for only 49 cases or 11.4% of our series, contrary to the results mentioned by Diallo et al., who describe in their cohort the dramatic evolution of cervico-facial cellulitis on this field debilitated with high mortality [16].
The entrance gate is the starting point for the dissemination of the germ. Dental involvement is found in 100% of the patients in our series, Keita and Bengondo, found the same entrance gate in the proportions of 90% and 76% respectively [5] [6]. Tooth decay is the most common cause, particularly in Africa where it can be found in more than 90% of cases [6] [15] [16] [18]. The carious pathology is often neglected, hence the high rate in the occurrence of cervico-facial cellulitis. Contrary to our results, in France, Mateo et al. noted a prevalence of pharyngeal involvement in 50% of cases, followed by dental involvement in 20% of cases [19].
The mandibular molars are the most incriminated in the appearance of cellulitis and our results are comparable with the literature [6] [7]. The susceptibility of the mandibular molars to caries and the ease of diffusion of the infection into the cellulo-fatty tissues of the perimandibular regions explain the frequency of cellulitis at the lower floor of the face.
The low frequency of maxillary point cellulitis is due to the depth of the vestibule and its lack of cellulo-fatty tissue, mainly to the palate where the adhering fibro mucosa limits the proliferation of the infection and only leads to periosteum abscess [23].
The patients consulted when a painful cervicofacial inflammatory tumefaction appeared with an aesthetic prejudice. It was also the reason for consultation most frequently found in the literature [14] [18]. Usually, we found the association to a trismus and an odynophagia. Often General signs were also present: fever, chills and sweating [18].
The majority of patients in our series consulted between the 4th and the 14th day of evolution, which justifies the high rate of suppurated cellulitis found with 74% of cases. They usually consulted late after failure of self-medication or traditional therapy.
The germs involved are variable; it is most often saprophytic germs of the oral cavity. The predominance of anaerobic germs is unanimous [17] [24]. Despite the formal indication of the literature data, we were able to perform only 12% or 2.8% of bacteriological samples because of the problems of indigence of most of our patients.
Panoramic dental radiography is essential for odontogenic cellulitis. Chest x-rays can be used to diagnose complications, especially if there is a spread of infection to the mediastinum. Computed tomography is a considerable diagnostic, topographical and prognostic contribution and allows an adequate therapeutic choice but it's very high-cost limits access to this examination [17] [20]. In our series, all patients underwent a panoramic dental x-ray or maxillary parade.
Our therapeutic approach is based on antibiotic therapy associated with elimination of etiology. The absence of bacteriology has forced us to adopt a probabilistic attitude for most patients in our series. The medical treatment consisted of a combination therapy consisting of amoxicillin-metronidazole, amoxicillin-clavulanic acid-metronidazole or amoxicillin-clavulanic acid-ciprofloxacinmetronidazole, based on data from the literature [11] [16] [24]. This therapeutic choice is based on the fact that all cellulites are polymicrobial. The synergy of these associations is recognized as active on streptococci and anaerobes, very often incriminated in the presence of areas of necrosis and fetidity encountered intraoperatively [25]. Short-term corticosteroid therapy lasting 3 to 5 days was instituted to reduce obstructive edema in 78% of cases. The influence of corticosteroids on morbidity or the risk of mediastinal extension has been suspected, but never demonstrated [21].
The surgical treatment consisted of draining the suppurated collections and debridement of all necrotic tissues under local or general anesthesia, with local care and multi-day dressings, as well as the management of the entrance point as in the literature [5] [12] [16] [22]. We found that in patients treated with general anesthesia with good drainage, symptom improvement was achieved within 48 to 72 hours. Patients treated under local anesthesia the amendment was much slower due to insufficient drainage, which forced us to do the dressings multiple times and for consequences the increase in the length of stay and hospital costs.
The average duration of hospitalization was 12 days, with extremes of 3 and 30 days.
The evolution was favorable, with a high cure rate of 96.7%. The various published series find a mortality rate in the order of 7% to 40% [5] [16] [25]. In our series, the mortality rate was 3.3% in patients with severe septicemia charts.

Conclusion
Odontogenic cervicofacial cellulitis is a potentially serious and increasing infection in our department. Most of these patients are young, healthy and with a generally good dental condition. Mainly of dental origin, they are aggravated by taking anti-inflammatory drugs and inadequate initial management. The management of these infections is expensive and the socio-professional and economic repercussions are heavy hence the interest of an effective and targeted prevention, through oral prevention measures, proper management of carious pathology and knowledge of possible complications. Hospital mortality can be reduced with the condition of early diagnosis and immediate management.