Late Neonatal Mortality at Teaching Hospital of Brazzaville (Congo)

Background: Neonatal mortality is a major public health problem. Its reduction is one of the targets of the objectives for sustainable development. Objectives: To determine the frequency of late neonatal mortality, to determine the causes of death and to identify the factors associated with late neonatal mortality at Brazzaville University Hospital. Patients and methods: This was a descriptive and analytical study conducted in the neonatal department of the Brazzaville University Hospital from 1 January to 30 June 2018. It concerned all newborns admitted to the service and died between 7th and 28th day of life. The variables studied were epidemiological, clinical and evolutionary. For the study of the factors associated with late mortality, we compared the deceased newborns with those hospitalized in the service whose stay was at least seven days. The materiality threshold was 5%. Results: During the study period, 697 newborns were admitted to the service, 286 (41%) died, 79 (27.6%) on the seventh day or beyond. The median age at admission was one hour. These were male (44.3%) and female (55.7%) newborns. The causes of death were prematurity (50.7%), neonatal infection (36.7%), perinatal asphyxia (6.3%) and others (6.3%). The mean age at death was 13.5 ± 6.4 days (range: 7 and 28 days). Prematurity OR = 3.62 (95% CI: 1.2 10.6) is the factor associated with late mortality. Conclusion: Reducing late neonatal mortality requires the implementation of measures to improve the human and material capacities of the service.

. Southeast Asia and sub-Saharan Africa are the most affected regions of the world [1]. In the Congo, the neonatal mortality rate is 16 per 1000 live births [1]. Neonatal mortality accounts for 44% of the mortality of children under 5 [3].
Neonatal mortality is said to be early when death occurs in the first six days of life and late in the seventh to the twenty-eighth day.
In the vast majority of cases, the occurrence of newborn deaths is reported in the first six days [4] [5] [6] [7]. Late mortality is poorly documented. Worldwide, it accounts for 24.2% of global neonatal mortality [8].
Reducing neonatal mortality to less than 10 per 1000 live births is a target of the goals for sustainable development [3] [4]. It requires that the causes and factors associated with the newborn's death be known, both in the early and late onset [8]. But, whether it is early or late causes death diverge [8] [9]. Also, it seemed useful to us to carry out this study on the late neonatal mortality.
The objective of this study is to determine the frequency of late mortality in the Neonatology Department of the Brazzaville University Hospital, to determine the causes of death and to identify factors associated with late infant mortality

Patients and Methods
This was a descriptive and analytical study conducted in the neonatal department of the CHU Brazzaville from January 1 to June 30, 2018 (6 months). This service is the main one in the city; it welcomes the newborns coming from the maternity of the same CHU and other maternities of the city. The study involved neonates hospitalized in the department during the study period. Those who died between the 7th and the 28th day of civil age were included.
The variables studied were the age, sex, the delivery route, the source, the clinical signs at admission and the causes of death.
Excel and Epi Info 7 software enabled data entry and analysis. For the study of the factors associated with late mortality, we compared the deceased newborns with those hospitalized in the service whose stay was at least seven days. The ANOVA test, the chi-square test, and the Odds Ratio (OR) with a 95% confidence interval were used for univariate analysis to compare means and proportions. All variables that were found to be associated during the univariate analysis were selected for multivariate analysis. We performed a logistic regression to adjust the confounds. The materiality threshold was 5%.
For ethical considerations, we have taken into account the recommendations of the Helsinki Protocol.
The clinical signs at admission are shown in Table 1.
The gestational age was 31.4 +/− 3.8 weeks (range 25 -40 weeks). The premature babies were 66 or 83.5%. The causes of death are reported in Figure 1.
The mean age at death was 13.5 ± 6.4 days (range: 7 and 28 days). Factors associated with late mortality are reported in Table 2 and Table 3.

Discussion
Reducing neonatal mortality by 2030 is a challenge for developing countries, particularly those in sub-Saharan Africa. Achieving this objective requires knowledge of the causes and factors involved in neonatal mortality in a global way but also in its various components. This study specifically devoted to late neonatal mortality in hospitals is part of this approach. However, as this study has as a limitation, the small size of our population because of the short duration of data collection. The Neonatology Department of the University Hospital was the setting for the study. This service is almost the only one in the city, allowing us to extrapolate our results to all health centers in the city.
Kedy Koum in Douala [11], which reports late mortality on all admissions and not on all deaths as we did, at a rate of 16.6%. In Ivory Cost, Mutombo [12] has a late neonatal mortality rate of 7.44%. These disparities in our observations can be justified by the differences in the health systems of our countries and the specificities of the Neonatology units. So, the uniqueness of our service in the city, justifies admitting all newborns in vital distress, explaining the high rate of death.    The classic causes of neonatal mortality as a whole were also pinned on late neonatal mortality in Brazzaville. But prematurity occupies a special place, because of its frequency, 83.5% of our population, its implication 50.7% of the causes of death and the only factor associated with mortality. In the Congo and other developing countries, prematurity is a real public health problem and is a cause and a major factor associated with death in the first 28 days of life [5] [13] [14].
Neonatal infection, reported as the leading cause of late mortality by Oza in 194 countries and Bezzaoucha in Blida (Algeria) [8]  Others ity in Blida due to the high frequency of nosocomial infections [10]. In our series, apart from nosocomial infections, the usual bacterial resistance to antibiotics observed in the department [15] can also explain the no less important role of neonatal infection.
Prematurity is the only associated factor found in multivariate analysis. The significant mortality of the premature infant is due to the susceptibility to infections and immaturity, especially respiratory, but also to the difficulties of breeding in Neonatology units in Africa south of the Sahara, which is poorly equipped [10] [12].

Conclusion
Representing just over a quarter of overall mortality, late neonatal mortality is a concern in the neonatology department of the Brazzaville University Hospital. Prematurity and its complications are a great provider. The reduction of the late mortality requires that the human and material means necessary to the management of the premature infant and to the fight against the nosocomial infections should be implemented.