Focus on Cancer Pain at Home: A Prospective Study of Quality of Life and Its Influencing Factors on Patients

Background and Aims: The treatment of patients with advanced cancer pain is mainly concentrated in the outpatient department, and most of the time in their family, these patients are easy to be ignored, To study the quality of life and its influencing factors of cancer pain patients at home is of great significance to improve the quality of life of patients. Meanwhile, it provides theoretical and practical basis for medical personnel to develop and imple-ment individualized comprehensive intervention programs. Patients and Methods: According to the inclusion and exclusion criteria, 200 patients with cancer pain at home are selected to treat, and their quality of life conditions are observed before treatment, 1 week after treatment and 1 month after treatment, and their influencing factors are analyzed. Results: The patients’ scores of body function, emotional function, cognitive function and social function exist significant difference before and after treatment (p < 0.01), the scores of role function and the overall evaluation scores before and after treatment, two stages after treatment exist significant difference (p < 0.01), the symptoms scores of fatigue, pain, diarrhea, nausea and vomiting are significant differences before and after treatment (p < 0.05). One week after treatment, tumor staging and metastasis have impact on overall health evaluation, role function, cognitive function and emotional function (p < 0.05). The location of metastasis and the type of pain affect the role function and emotional function respectively (p < 0.05). One month after treatment, age, metastasis, metastasis site and pain type have influence on cognitive function, emotional function, overall health evaluation and role function respectively (p < 0.05). The overall health status, body function, role function, emotional function, cognitive function and social function of the patients are lower than those of the Norwegian norm (p < 0.001). The symptoms of pain, appetite, constipation, nausea and vomiting are higher than those of the Norwegian norm before and after treatment (p < 0.001). There was a significant positive correlation between quality of life and total score of social support (p < 0.01). Objective support and subjective support were positively correlated with quality of life (p < 0.01). Conclusion: Cognitive inter-ventions should be individualized. The effectiveness of cancer treatment and the control of cancer recurrence and metastasis have influence on the quality of life of patients with cancer pain at home. Although the patients’ function indexes have been improved after treatment, there exist differences in the improvement after treatment. The symptoms of nausea, vomiting, pain and appetite should be intervened promptly. The management of symptoms such as dyspnea, fatigue, constipation should be focused persistently. Objective support and subjective support were the influencing factors of patients’ quality of life, the construction of social support system should be strengthened, we should help them to overcome negative emotions, return to normal family and social roles, seek help in a positive manner and use support to improve the quality of life.


Introduction
The International Association for the Study of Pain (IASP) revised the definition of pain in 2016, which is a painful experience associated with tissue injury or potential tissue damage in terms of feeling, emotion, cognition and social dimensions [1]. Cancer pain is the most common symptom in cancer patients, especially in patients with advanced cancer. It is also the most painful and frightening symptom [2] [3], which can have different degrees of influence on the physical (including body sensation and function), psycho-psychological and social aspects of the patient, thus these factors affected the quality of life of the patients. Internationally, pain has been listed as the fifth vital sign [4]. In China, there were 1.8 million new cancer patients in 2000, and the incidence of cancer pain was about 40% -65%, including 15% -30% in the early stage, 40% -55% in the middle stage, and 50% -75% in the late stage. Quarter of the patients did not Journal of Cancer Therapy receive any pain relief treatment, among which 20% were moderate to severe [5].
For patients with advanced cancer at home, pain treatment may be the only way that they are likely to receive and benefit from because of limited treatment options. The purpose of this treatment is to relieve symptoms and improve patients' quality of life. The ideal cancer pain treatment should be: 1) continuous and effective elimination of cancer pain; 2) limit the adverse reactions of drugs; 3) cancer pain and treatment of the psychological burden and the social, family caused by the impact to the minimum; 4) improve the quality of life, extend the survival time. Therefore, the significance of cancer pain treatment goes far beyond pain relief itself, it can improve patients' quality of life, work ability, enjoy entertainment and enable them to perform normal functions in family and society [6]. In this study, the patients with moderate and severe advanced cancer pain treated normally at home were selected as the research objects and the follow-up investigation was carried out in different stages; we analyzed the therapeutic effective factors of the quality of life with the patients in order to provide the basis for the home intervention programme and improve the therapeutic effect and the quality of life.

Results
Comparison of functional Indexes in QOL-C30 scale before and after treatment are in Table 1, The scores of somatic function, emotional function and cognitive function are significantly different before and after treatment (p < 0.01), but there is no significant difference between the two stages after treatment (p > 0.05). There are significant differences in role function and overall evaluation score before and after treatment (p < 0.01), There is significant difference in social function score before and after treatment (p < 0.01), but there is no significant difference between the two stages after treatment.
Comparison of symptom factors of QOL-C30 scale before and after treatment are in Table 2, The scores of fatigue, pain and diarrhea are significantly different before and after treatment (p < 0.01), and the scores of nausea and vomiting are significantly different before and after treatment (p < 0.01). There is a significant difference in appetite loss score between one month after treatment and one week after treatment, before treatment (p < 0.01). There is significant difference in constipation symptom score one month after treatment and one month Note:* On behalf of 1 week after treatment compared with pre-treatment, p < 0.01; **On behalf of 1 month after treatment compared with pre-treatment, p < 0.01; ▴On behalf of1 weeks after treatment, compared with 1 months, p < 0.01. week after treatment and before treatment, one month after treatment (p > 0.05).
There is no significant difference in dyspnea score before and after treatment (p > 0.05).
Analysis of characteristic data and quality of Life and functional Indexes of patients before and after treatment are demonstrated in (Tables 3-5): There is only significant difference in cognitive function between sex before treatment (p < 0.05). One week after treatment, tumor staging and metastasis have impacts on overall health evaluation, role function, cognitive function and emotional function (p < 0.05). The location of metastasis has an effect on the role function (p < 0.05), and the type of pain has an effect on the emotional function (p < 0.05).
One month after treatment, the age, location of metastasis and type of pain has significant impacts on cognitive function, emotional function, general health evaluation and role function (p < 0.05).
Scores of General quality of Life, functional Indexes and symptom factors before and after treatment are in Table 6, before and after treatment, the overall health status, body function, role function, emotional function, cognitive function and social function of the patients are lower than the Norwegian norm (p < 0.001). Before treatment, all symptoms except dyspnea and diarrhea are higher than the Norwegian norm (p < 0.001). One week after treatment, all symptoms except dyspnea, insomnia, fatigue and diarrhea are higher than the Norwegian norm, and diarrhea symptoms were lower than the Norwegian norm (p < 0.001).
One month after treatment, all symptoms except dyspnea, fatigue, and other symptoms are higher than the Norwegian norm (p < 0.001).
Correlation between social support and quality of life of patients are shown in Table 7 and Table 8, the total score of social support was 40.15 ± 13.01, the score of objective support was 9.47 ± 4.15, the score of subjective support was 26.27 ± 6.48, and the utilization of support was 6.53 ± 2.79. There was a significant positive correlation between quality of life and total score of social support (r = 0.70, P < 0.01). Objective support and subjective support were positively correlated with quality of life (p < 0.01), while utilization of social support was not correlated with quality of life (p > 0.05). Objective support was correlated with physical function, emotional function and social function, support utilization was correlated with physical function, social function and cognitive function, and the total score of subjective support and social support was correlated with five functional indexes.

Discussion
Pain is one of the most common clinical symptoms in cancer patients. Cancer pain affects the patient's quality of life in many aspects, such as physiology, psychology, society and spirit, which leads to the decline of the patient's overall quality of life [7]. The treatment of patients with advanced cancer pain was mainly concentrated in outpatient clinics, and most of the time in the family and        Pain is a total pain, physical, social, mental, economic, and cognitive factors that may be the cause of other symptoms [8]. In this study, we find that gender factors influence cognitive function before treatment, stage of tumor after treatment, metastasis and age factors, which indicates that cognitive function. This indicates that there are differences in cognitive function before and after treatment, and there are differences in age in addition to the disease itself after treatment. Therefore, attention should be paid to gender and age factors in the implementation of cognitive intervention. In a pain management study by Erol O and other experts, it was suggested that educational intervention should be provided for patients with advanced cancer pain, but the knowledge and skills of pain assessment should be improved [9]. view has been reported in domestic and foreign documents [12].
It was found that the social support of cancer pain patients was higher than that of normal people, which indicated that cancer pain patients received more social support, objective support and subjective support were the influencing factors of patients' quality of life, but the degree of support utilization had no significant effect on patients' quality of life, and patients lacked the willingness to make active use of social support. We should guide patients to seek and make effective use of social support and improve the utilization of social support so as to improve the quality of life of patients. The objective support of the patients is not related to cognitive function, which suggests that we should strengthen the cognitive education of the patients and correct the cognitive error. Cancer pain is not a sign that there is no cure for the disease and we should promote the early intervention. There is no correlation between patient support utilization and emotional function and role function, which suggests that we should pay attention to emotional and role management of patients. Because of long-term pain, patients may have fear, anxiety, despair and lack of role function, we should help them to overcome negative emotions, return to normal family and social roles, seek help in a positive manner, use support to consolidate the therapeutic effect and improve the quality of life.

Conclusion
The influence of quality of life of patients with advanced cancer pain is multidimensional, complex and interactive. In view of this group, it is particularly important to fully understand the many factors that affect the quality of life of patients. How to maintain good therapeutic effect, reduce the adverse reactions caused by treatment, take intervention measures timely for influencing factors, and improve the quality of life of cancer pain patients at home are worthy subjects of our long-term study.

Funding
This paper was funded by the project of Health Research of cadres in Jiangsu Province (Code: BJ17030).