Atypical Trigger Finger : First Manifestation of Gout

Gout is a form of inflammatory arthritis caused by hyperuricemia characterized by painful, hot and swollen joints. However, tophi involving carpal tunnel with concomitant presence of finger movement dysfunction as the first presentation of gout is rare. This suggests the involvement of flexor tendon inside the carpal tunnel. Here, we report a case of infiltration of tophi at the flexor tendon of the hand presented as the first clinical manifestation of gout causing trigger finger like symptoms. Patient underwent surgery to confirm the diagnosis and improve flexor tendon excursion. Our patient’s finger movement improved dramatically after operation.


Introduction
Gout is one the commonest inflammatory arthropathy, affecting more than 8 million Americans [1].The disease characterized by painful joint inflammation, frequently involves first metatarsophalangeal joint [2].Diagnosis is often made clinically and confirmed by identification of monosodium urate crystal in the synovial fluid of the affected joint.Tophi is normally present in long term disease and generally located in elbow, ear pinna and Achilles tendon.Tophi involve the flexor tendons in the hand as the first presentation of gout is uncommon [3].Rarity of this injury leads to scarcity of reports detailing its management and outcome.Due to its rarity, it is often not included in the differential diagnosis of stenosingtenosynovitis.We report a case of tophaceous gout infil-Open Journal of Orthopedics trating flexor tendon at the wrist causing finger movement dysfunction.

Case Report
42 years old gentleman with no known medical illness was presented to the orthopedic out-patient clinic with complaint of inability to extend his left ring finger which progressively is worsen.There is no tingling sensation or numbness at the left hand.He reported no prior episodes of gouty arthritis and not on regular medication.
Clinically, there was a palpable firm to hard mass over the volar aspect of the left wrist.He had flexion contracture at the proximal interphalangeal (PIP) joint of the left ring finger with limited passive movement (Figure 1).All routine laboratory blood investigations were withinnormal range, including serum uric acid (394 umol/L).Ultrasonography of left wrist showed well defined oval-shaped lesion with perilesional hypoechogenicity seen at the medial aspect of the left wrist.The lesion measuring 0.9 cm × 1.8 cm × 1.9 cm, overlying the bone arising from the flexor tendon.There is no significant finding on the x ray of the left wrist.
First, we proceeded with A1 pulley release of the left ring finger.However, the finger still remained in flex position.We then proceeded with extended carpal tunnel release.An extended zigzag incision was made from the left palm to the distal forearm to explore the mass proximal to the flexor retinaculum.We identified a chalky white mass infiltrated the flexor digitorum superficialis of the ring finger with hypertrophy of the flexor tendon (Figure 2).The gouty tophus sits mostly on the proximal of the flexor retinaculum, preventing the flexor tendon from gliding through the flexor retinaculum.Flexor tenosynovectomy and excision of the gouty tophus was performed.
Histopathological examination of intra operative specimen confirmed the diagnosis of gouty tophus.Patient was followed up closely in both orthopaedic and internal medicine clinic for 6 months.To reduce the likelihood of recurrence, patient was started on Allopurinol and advised to limit consumption of purine rich food and avoid alcoholic beverages.After aggressive physiotherapy post operatively, the patient recovered and regained full range of motion of his left ring finger (Figure 3 and Figure 4).

Discussion
Gout is an arthritis cause by excessive uric acid in the blood resulting in deposition of monosodium urate crystal in the joints.Uric acid is a byproduct of purine breakdown.It is excreted by the kidneys.Overproduction of uric acid or reduce excretion of uric acid can lead to gout.The former is the more common cause of hyperuricemia.
Deposition of crystalline uric acid into joints and surrounding tissues leads to formation of tophi.Tophi can erode the bone or cause compression to the surrounding structure.It is commonly found at the external ear, olecranon bursa, Achilles tendon and first metatarsophalangeal joint.Rarely, it is found in atypical places such as tarsal tunnel, second metacarpal and wrist flexor tendon [3].
Only around 0.8% to 2% of gout first presented with wrist symptoms [4].Patients who do not receive any treatment for gout will have 19% -30% chance of developing tophi in the wrist [4].

Conclusion
Most of the cases of gout first are presented as painful joints.Tophi mostly present in those longstanding cases and first presentation of it in patients who is not known to have gout is rare.When tophi cause significant morbidity and surgery is required, its aim is mainly to reduce the mass effect to the underlying structure and improve the gliding of the tendon.Delay in treatment may lead to deformity and impair function of the hands.Combination of surgical and medical treatment can lead to improved clinical outcomes.

Figure 1 .
Figure 1.Initial presentation with flexion deformity of the ring finger.

Figure 3 .
Figure 3. Patient regains full range of motion of left ring finger with ability to fully extend the ring finger.

Figure 4 .
Figure 4. Full recovery of left hand function after operation.
D. C. H. Chieng et al.Sano K et al. and Hyun-Sook Kim et al. both reported a case of atypical triggering at the wrist and severe carpal tunnel syndrome caused by tophaceous gout respectively [6] [9].In their report, patient is known case of gout with present of tophi in other body parts.Hence, the diagnosis is more obvious.Our patient has no previous history of gouty arthritis with normal serum uric acid.Hence, gouty tenosynovitis is at the bottom of our differential diagnosis list.Measurement of serum uric acid level is not the definitive tool in diagnosing gout.Snaith and Coomes et al. found a normal serum uric acid in 17% of acute episodes of gout [10].Detailed history, clinical examination, laboratory investigations and imaging can aid in achieving the diagnosis.