Acute Mesenteric Ischemia : A Challenging Diagnostic Disease — Four Cases Reports and Literature Review ( AMI )

Acute Mesenteric Ischemia (A.M.I.) is a potentially life-threatening condition syndrome due to inadequate or completely absent blood supply through superior or inferior mesenteric artery. The etiologies are various. Early diagnosis is essential to improve the clinical outcome. Despite advances in knowledge of pathophysiology, laboratory diagnosis and imaging techniques, acute intestinal ischemia is still associated with mortality rates.


Introduction
Laboratory evaluation revealed high leukocytosis with a white blood cell (WBC) count of 30 per mm 3 .Arterial Blood Gases (ABG) demonstrated metabolic acidosis.Computed tomography angiography (CTA) reveled a superior mesenteric artery completely occlused after aorta origin, dilatated ileum and abdominal fluid (Figure 1).The patient was immediately started intravenous (IV) fluids of 2 l in 6 hours, Foley and jugular cathether vein canulation to support main arterial pressure and urine output.The patient was transferred to surgical services.
A xifo-pubic incision laparotomy was made.A totally ischemic small and partially large intestine was found.We made only a laparostomy for a second look.
The patient died the day after.

2) Clinical scenario
A 74 years old woman was referred to our hospital because of sudden onset of continuous to severe abdominal pain.The pain was associated with nausea and passage of dark, loose stools.His medical history was significant for permanent was commenced.A nasogastric tube was inserted to relieve distension.The patient was transferred to surgical services.After laparotomy, we found totally hypoperfused jejunum and ileum without necrosis.For this reason a laparostomy was made.24 hours later, we performed a second-look surgery but we found a totally necrotic intestine.
3) Clinical scenario A 63 years old man was admitted in our Emergency Room for acute abdominal pain associate with fever, vomiting, diarrhea and hypotension.His medical history reveled diabetes mellitus type II, hypertension, a history of Hairy Cell Leukemia with splenomegaly and cytopenia and endoprosthesis for thoracic aneurism.Physical examination demonstrated Temperature 37.5˚C, blood pressure 98/60 mmHg with mild orthostatic hypotension.Normal bowel sounds were noted in the abdomen, which was moderately tender in the right lower quadrant with focal rebound tenderness.The rectal exam was normal, with a stool sample negative for occult blood.Pelvic exam was unremarkable.WBC count was 24,300 per mm 3 .Serum chemistries and arterial blood gases (ABG) were remarkable for a mild anion gap metabolic acidosis.Abdomen TC scan with artery phases was performed, revealing S.M.A. occluded at aorta origin, small bowel dilatation, pneumomatosi, peritoneal fluid (Figure 3(a) & Figure 3(b)).After resuscitation with crystalloid through jugular vein catheterization, we explored the abdomen.We found a 30 cm necrotic ileum and hypoperfusion wall in the other part of small intestine.We performed a 30 cm of small bowel resection and superior mesenteric artery longitudinal arteriotomy, Fogarty exploration with

Anatomic Reasons for Intestinal Ischemia
Anatomy is crucial for the understanding of the pathophysiology, clinical presentation of intestinal ischemia.The splanchnic circulation is characterized by linking the 3 major vessels together [2].The major connections are: the junction  of the superior and inferior pancreaticoduodenal arteries (linking the celiac axis and the superior mesenteric artery SMA), the marginal artery of Drummond and the Riolan's arch, between the middle colic and the left colic arteries (linking the superior mesenteric artery with the inferior mesenteric artery, IMA) and the collateralization between the inferior mesenteric artery and systemic circulation which occurs in the rectum (superior and middle rectal vessels) (Figure 5) [3].

Etiology
Based on its etiology, acute mesenteric ischemia can be caused by various type of  Other symptoms are nausea in 44%, vomiting in 35%, diarrhea in 35%, heart rate > 100 in 33%, "blood per rectum" and mucorrea in 16%, constipation in 7% [5].

2) Diagnosis
Laboratory studies are nonspecific.The most common laboratory abnormalities are hemoconcentration, leukocytosis, and metabolic acidosis, with high anion gap and lactate concentrations [6].High levels of serum amylase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase are frequently observed at presentation, but none is sufficiently sensitive or specific to be diagnostic In these four cases we found an altered Blood Test Count with WBC ranging from 10 to major 20 mmc in 90% of cases associated of increased lactic acidosis with arterial blood gases evidences metabolic acidosis but only in the advanced disease.In one cases a part of altered WBC the laboratory studies were normal.Normal laboratory values do not exclude this diagnosis and do not justify delaying angiography when clinical suspicion exists.MDCT (multidetector CT) scan angiography is first line diagnostic images to discover acute intestinal ischemia with sensitivity 83%, specificity 93%, positive predictive value (at prevalence of 62%) 93%, negative predictive value (at prevalence of 62%) 61%.Findings on CT scan include: Mesenteric edema, Bowel dilatation, Bowel wall thickening, Intramural gas, Mesenteric stranding, portal vein gas, abdominal fluid [7].Angiography is a diagnostic and therapeutic method and it is considered the gold standard for the diagnosis of acute mesenteric ischemia associated with MDCT scan [8].Its sensitivities in five of six studies have ranged between 90% and 100%; specificity was reported in two of these studies to be 100%.Although it has serious risks, angiography provides the possibility of direct infusion of vasodilators in the setting of non-occlusive ischemia [9].

4) Treatment
In the setting of suspected acute mesenteric ischemia, aggressive hemodynamic monitoring along with active resuscitation represents the first therapy.It should also include parenteral broad spectrum antibiotics to prevent bacterial translocation generated by ischemia associated with analgesia therapy.If there are no contraindications to anticoagulation, therapeutic intravenous heparin sodium should be administrated.The treatment of mesenteric ischemia depends on the causes and can be medical or surgical.In non-occlusive mesenteric ischemia, where there is no blockage of the arteries supplying the bowel, the treatment is medical.Thrombolytic medical treatment and vascular interventional radiological techniques have a growing role.When angiography is used to establish the diagnosis, the angiographic catheter should be left in the SMA for infusions of papaverine or other vasodilators.If the ischemia has progressed to the point that the affected intestinal segments are gangrenous, a bowel resection Algorithm 1. Managment for the diagnosis and treatment of patients at risk of acute mesenteric ischemia (by "Acute Mesenteric Ischemia A Clinical Review" W. Andrew Oldenburg). of those segments is called for [10].Surgical revascularisation remains the treatment of choice for mesenteric ischaemia using longitudinal arteriotomy to perform embolectomy using a Fogarty catheter or distal bypass graft anastomosis.
In most of cases multiple re-laparotomies are needed to obtain that news dead segments are removed after first operation and a second-look or even a third-look operation allows assessing segments that are borderline and that may be savable after revascularization [11].

5) Prognosis
Acute Mesenteric Ischemia (A.M.I.) is a potentially life-threatening condition syndrome.Prognosis is very poor and account for a mortality range from 50% to 90% for A.M.A.E, A.M.A.T and N.O.M.I and account of 30% for M.V.T. [12].

Discussion
Despite advances in knowledge of pathophysiology, laboratory diagnosis and imaging techniques, acute intestinal ischemia is still associated with mortality rates of more than 80%.Atrial fibrillation, myocardial disease or vascular disease and advanced age are the most common etiology.Differentiation between viable and nonviable, necrotic bowel tissue is done by exploratory laparotomy.A second-look laparotomy (after 24 -48 hours) is recommended, even after successful primary intervention, because the intraoperative assessment of bowel viability [13].Early diagnosis is the only best change but acute intestinal ischemia still remains a challenging diagnostic disease [14].An algorithm management for the diagnosis and treatment of patients at risk of acute mesenteric ischemia is necessary to following the right steps (Algorithm 1) [15].
Mesenteric Ischemia (A.M.I.) is a potentially life-threatening condition syndrome due to inadequate or completely absent blood supply through superior or inferior mesenteric artery, resulting in hypoperfusion and eventual ischemia/gangrene of the bowel.There are five types of A.M.I. subdivided for anatomic vessels or etiologies: Non occlusive Mesenteric Ischemia (N.O.M.I.) (20% -30%), Acute Mesenteric Arterial Embolism (A.M.A.E.) (50%), Acute Mesenteric Arterial Thrombosis (A.M.A.T) (15% -25%) and Mesenteric Venous Thrombosis (M.V.T.) (5%).The fifth type is only 3% and is a clinical entity that occurs as a consequence of mechanical scenarios such as strangulation, intussusception, volvulus, tumor or trauma.A.M.I. accounting for 0.1% of hospital admissions.In large part because of the association with atherosclerosis.AMI is commonly considered a disease of the older population, with the typical age of onset being older than 60 years.The symptoms are non-specific so the diagnosis DOI: 10.4236/ami.2018.8400660 Advances in Molecular Imaging is very difficult .The radiologic image of choice is angio-TC-Scan.Treatment options include a range of options such as a few invasive management as percutaneous angioplasty plus stenting or thrombolytic therapy until surgical exploration [1].

2. We Demonstrate Four Clinical Scenarios to Underline the Difficult Way to Join a Diagnosis and Treatment
beats/minute; and temperature superior of 38˚C.Oxygen saturation was 85% on room air.The abdominal examination revealed a distended abdomen that was severely tender to palpation, with rigidity, guarding, and rebound tenderness.