Application of an Advanced Image-Based Virtual Monoenergetic Reconstruction of Dual Source Dual-Energy CT Data at Low keV Increases Image Quality for Esophageal Cancer Patients Imaging

Purpose: To explore the significance of dual-source computed tomography (DECT) virtual monoenergetic reconstructions technology in improving the imaging quality of esophageal cancer patients. Materials and methods: 68 patients with clinically suspected esophageal cancer (all confirmed by pathology) were collected. Routine plain scan was performed with SIEMENS Force dual-energy CT and then dual-phase scans were performed. The venous phase images were respectively subjected to traditional virtual monoenergetic reconstructions (Mono_E) and new generation virtual monoenergetic reconstructions (Mono+). Mono_E 55 keV and Mono+ 55 keV virtual single-energy images were obtained respectively. The signal-to-noise ratio (SNR) of normal esophageal tissue and esophageal cancer lesions, noise and contrast noise ratio (CNR tumor) of normal esophageal tissue and esophageal cancer lesions were compared among 100 kV images, Mono_E images and Mono+ images. At the same time, two imaging physicians read the films and scored the images of each group by using a 5-point scoring method. Results: Mono+ 55 keV images, SNR, SNRtumor, noise and CNRtumor were statistically different from those of 100 kV images and Mono_E images (P < 0.05). And Mono+ 55 keV images also had the highest subjective score, with statistical significance (P < 0.05). The results showed that Mono+ 55 keV images had the best quality. Conclusion: The new generation of virtual monoenergetic reconstructions post-processing (Mono+) could reduce image noise and improve the contrast between esophageal cancer lesions and normal esophaHow to cite this paper: Zhuo, S.Q., Chen, X.L., Yu, J.P., Zhou, J. and Xie, C.M. (2018) Application of an Advanced Image-Based Virtual Monoenergetic Reconstruction of Dual Source Dual-Energy CT Data at Low keV Increases Image Quality for Esophageal Cancer Patients Imaging. Open Journal of Medical Imaging, 8, 81-88. https://doi.org/10.4236/ojmi.2018.83010 Received: August 23, 2018 Accepted: September 23, 2018 Published: September 26, 2018 Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/


Introduction
Esophageal cancer is a common fatal malignant tumor.The Chinese incidence rate of esophageal cancer ranks the fourth in the world [1].Esophageal cancer has hidden onset and late appearing clinical symptoms.As a result, most of the clinical patients have reached the middle and late stage, and their 5-year survival rates after treatment are very low [2].The early diagnosis and treatment of esophageal cancer are of great significance to the surgical resection rate of esophageal cancer lesions and the improvement of survival rate of patients.The purpose of this study is to explore the advantages of dual-source dual-energy CT new-generation virtual single-energy post-processing technology (Mono+) compared with 100 kV mixed-energy images and traditional virtual single-energy post-processing technology (Mono_E) and its significance in improving the imaging quality of esophageal cancer patients.

General Data
68 patients with esophageal cancer from July 2016 to June 2018 were retrospectively collected, including 58 males and 10 females, aged 46 to 78 years old.Their average age was 59.15 ± 7.83 years old.The median age was 59.5 years old, and the average weight was 58.02 ± 6.89 kg.All of them were confirmed by pathological results, including 13 cases of poorly differentiated squamous cell carcinoma, 13 cases of highly differentiated squamous cell carcinoma, 41 cases of moderately differentiated squamous cell carcinoma and 1 case of adenocarcinoma.There was no statistical difference in patients' weights (P < 0.05).Case inclusion criteria: 1) All the patients were initially diagnosed; 2) All patients with pancreatic cancer confirmed by pathological results; 3) The patients were conscious and able to cooperate with the examination.Exclusion criteria: 1) The patients have hepatic and renal insufficiency; 2) The patients have contraindication of iodinated contrast agent; 3) Have serious cardiac dysfunction and other diseases.

Inspection Methods
All study examinations were performed on the same third-generation dual-source Open Journal of Medical Imaging CT scanner (SOMATOM Force, Siemens Healthcare, Forchheim, Germany); the U.S. MEDRAD Stellant CT special high pressure syringe was used.The contrast agent was 350 mg/ml nonionic iodine-containing contrast agent.The dosage was 1.5 ml/kg body weight and the bolus injection rate was 3 ml/s.20 ml saline was injected at the same speed to test the patency of blood vessels before bolus injection of contrast agent, and 20 ml saline was injected after bolus injection of contrast agent.All cases underwent conventional plain scan, arterial and venous dual energy scan.In the arterial phase, the contrast bolus intelligent tracking technique was used.The tracking point was set at the central part of the descending aorta at the bifurcation level of the trachea.The ROI area was about 1 mm 2 and the trigger threshold was 100 HU.The arterial phase scan was started 7 seconds after the enhancement of the region of interest reached the threshold.The scanning range is from the first rib to the bottom of the lung, and the scanning time is about 3 seconds.The portal phase scan was triggered 28 seconds after the arterial phase was completed.During venous phase, double energy scanning was used to start the A and B bulb tubes.Scanning parameters: CARE Dose4D tube voltage and tube current intelligent modulation technology was used.The reference tube voltage/tube current of the A and B bulb tubes were: 100 kV/ref250 mAs and Sn150 kV/ref125 mAs.The bulb tube rotation time, 0.5 second, pitch 0.9; collimation: 2 × 192 × 0.6 mm; thickness slice: 1 mm.

Image Reconstructions
The three groups of images A, B, and M obtained by intravenous dual energy scanning respectively represent 100 kV images, Sn150 kV images, and linear fusion images of the first two.Workstations that transmit images A and B are post-processed by using the "dual energy" function module in Syngo.viasoftware.Two groups of images were selected for post-processing by traditional Mono_E and new generation of single energy Mono+ respectively to obtain two groups of virtual single-energy images including Mono_E 55 keV and Mono+ 55 keV.

Image Analysis and Measurement
Subjective evaluation: Syngo.viasoftware was used for film reading in Siemens workstation.2 senior imaging diagnostic physicians used double blind method respectively gave subjective evaluation for the above 3 groups of images.In case of disagreement, joint review and consultation would be performed to reach agreement.The window width was 400 HU and the window level was 50 HU.
The structure of the evaluation included normal esophageal and tumor tissue display and overall image.Imaging quality evaluation criteria included: image noise, resolution, contrast, sharpness, artifacts, and the display of the edge of the lesion contour and the lesions.5-point evaluation method was adopted: 1 point: the image quality is very poor and cannot be used for evaluation at all (the image noise is very high; the artifact is extremely significant; the spatial or contrast res-Open Journal of Medical Imaging olution is completely distorted, and the edge definition is very poor); 2 points: the image quality is poor, and can basically be used for evaluation (image noise is high; the artifact is obvious; spatial or contrast resolution is distorted, and edge definition is poor); 3 points: the image quality is general and can be tolerated, but is affected by appropriate amount of noise, artifacts and image distortion; 4 points: the image quality is good.The noise, artifact and image distortion does not affect the clinical diagnosis; 5 points: the image quality is very good.
There is low noise, good contrast, no artifact and no image distortion, which completely meets the clinical diagnostic requirements.
Objective evaluation: Syngo.viasoftware "MM Basic Comparison" was used to read the function module.At the same time, the above three groups of simulated mono-functional images and 100 Kv images were opened.The background noise of the images and the CT values and standard deviation of normal esophageal tissue and tumor tissue were measured.Measurement position: three groups of images were selected at the same level.ROI was placed in the air in front of the images, normal esophageal tissue and tumor parenchyma respectively.The ROI was about 0.3 to 1 mm 3 .Each part was measured 3 times and the average value was taken 3 times.The signal-to-noise ratio (SNR) of normal esophagus and tumor and the contrast noise ratio CNR tumor of tumor were calculated.The calculation formula was: SNR = ROI/SD, CNR tumor = (ROI eso − ROI tumor )/Sd air .

Statistical Analysis
The measurement data of each group was expressed as mean standard deviation.SPSS 20 software was adopted for analysis.Comparison of the counting data was performed by X 2 test.Comparison of the measurement data was performed by t test, with P < 0.05 indicating statistically significant difference.Kappa consistency analysis was used for the image scoring of the two radiologists.Kappa ≥ 0.75 indicated good consistency; 0.40 ≤ Kappa < 0.75 indicated relatively good consistency; Kappa < 0.40 indicated poor consistency.

Results
The signal-to-noise ratio (SNR) of normal esophagus and tumor, contrast noise ratio (CNR tumor) of tumor, noise air measurement data and statistical results of the three groups of images are shown in Table 1.And subjective scoring results of image quality were shown in Table 2.

Results Analysis
The results of objective evaluation in Table 1 showed that there were significant differences in normal esophageal signal-to-noise ratio (SNRESO), tumor tissue signal-to-noise ratio (SNRtumor), background noise (NOISEair) and tumor tissue contrast noise ratio (CNRtumor) of 3 Group between either two groups of the three groups (P < 0.05).Among them Mono_E 55 keV image had the lowest SNReso, SNRtumor and CNRtumor, and the highest NOISEair.Mono+ 55 keV

Discussion
With the wide application of dual-energy CT and continuous technological innovation, different post-processing and analysis algorithms have been continuously developed.Virtual monoenergetic reconstruction is one of the important post-processing applications of dual-energy CT.It is generated by virtually calculating the CT value of the substance under each single energy through high and low dual-energy CT scanning [3].The third generation of dual-source dual-energy CT (German Siemens SOMATOM Force CT) can calculate single-energy images of any energy level ranging from 40 keV to 190 keV.Because substances with high atomic number such as iodine contrast agent have strong ability to absorb low energy x-ray photons, in low energy single-energy spectrum images, tissues such as blood vessels and lesions enhanced by contrast agent have better contrast than those under ordinary single-energy CT scanning, which can be used to optimize the display of lesions.However, since the lower the energy is, the lower the penetration ability of x-ray photons is and the higher the noise is.In addition, the signal-to-noise ratio of the images will also be lower, and even affect the diagnosis.Therefore, the traditional virtual smonoenergetic reconstructions technology (Mono_E) has not overcome the noise of low energy single-energy image, which affects its wider application.
Mono+, the new generation of virtual smonoenergetic reconstructions technology of dual-source dual-energy CT, overcomes the shortcomings of tradi- It was shown that Mono_E 55 keV images were significantly higher than that of 100 kV images, but the image noise and the air noise were also significantly elevated, which led to the decrease of imaging quality; the CT value of the esophageal tumor location in E55 keV images was significantly higher than that of 100 kV images, but the noise was not found to be different.The air noise was decreased and the subjective imaging quality was improved.
important clinical significance for preoperative evaluation and treatment of esophageal cancer.

Figure 1 .
Figure 1.(a) to (c) were images of 100 Kv, Mono_E 55 keV and Mono+e 55 keV respectively.It was shown that Mono_E 55 keV images were significantly higher than that of 100 kV images, but the image noise and the air noise were also significantly elevated, which led to the decrease of imaging quality; the CT value of the esophageal tumor location in E55 keV images was significantly higher than that of 100 kV images, but the noise was not found to be different.The air noise was decreased and the subjective imaging quality was improved.

Table 1 .
S. Q. Zhuo et al. 3 Statistical results of three groups of image measurement data (x ± s).

Table 2 .
3 Subjective scoring results of imaging quality of three groups ( x ± s).