Anesthesia Considerations in Emergency C-Section and Perioperative Neonatal Resuscitation : A Case Report and Review of Literature

Emergency C-sections are performed for various reasons. This is a case report of emergency C-section performed due to fetal distress. This is a classic case report which emphasizes the importance of managing emergency C-sections according to international standards and acknowledges co-operation of obstetrician and anesthesiologist. We reviewed literature about emergency C-sections and discussed sensitive time intervals, types of anesthesia and neonatal resuscitation.


Introduction
Emergency C-sections are very challenging for both anesthesiologists and obstetricians.They are associated with significant morbidity and mortality for both mother and newborn.This is a case of severe preeclampsia with a category 2 fetal heart rate tracing, which required emergency C-section.In this case report and literature review, we described choice of anesthesia, decision to delivery interval (DDI) and neonatal resuscitation.

Labor and Delivery Unit Course
The patient was admitted for induction of labor with vaginal insertion of Cytotec, and several hours later was noticed to have decelerations to 80 bpm on fetal heart monitoring.These resolved after administration of O 2 and left sided-positioning.
However, subsequent episodes of decelerations were noted to 90 bpm and 70 bpm as shown in Figure 2. The decision was made to take the patient for C-section due to fetal bradycardia and category 2 fetal heart tracing.

Intraoperative Course
C-section was performed under General anesthesia.IV Induction with Propofol 160 mg and Succinylcholine 100 mg and easy intubation with MAC 3 blade and ETT 7.0.Sevoflurane was used as maintenance agent for GA.Neonatology team was consulted and was present during C-section prior to delivery of Newborn.
Newborn delivered with no spontaneous cry, cyanotic and no HR or respirations.The neonatologist began non-invasive ventilation and CPR.Ultimately, intubation was performed, and two doses of epinephrine (0.3 ml and 0.6 ml) were administered.At 11 minutes of life HR noted to be 95 bpm.The baby was transferred to NICU with HR of 120 bpm, SPO 2 90's on 100% O 2 .Decision to delivery interval was 12 min and in room to delivery interval was 7 min.

Post Delivery Neonatal Course
Post-delivery baby was admitted to NICU and was started on hypothermia protocol due to clinical encephalopathy and severe acidosis on cord gas with pH of 6.5.She received IV Ampicillin and Cefepime for three days.Neurology was consulted.VEEG done, which did not reveal any epileptiform activity.Baby was eventually weaned to RA.She stayed a total of 2 weeks in the NICU and intermediate care nursery.Head US revealed an echogenic periventricular area in the left parietal lobe which may represent hypoxic ischemic encephalopathy (HIE).MRI brain with spectroscopy showed T2 hyperintensity in the left parietal periventricular white mater (likely secondary to ischemic insult) and a focus of hypointensity along the left caudothalamic groove (likely sequela of prior hemorrhage).
Baby is having regular follow up clinic visits.Despite her difficult birth baby is developing normally.No deficits noted in the neurological exam.She is feeding, voiding and stooling normally.

Discussion
Emergency C-section is defined as C-section required because of immediate threat to life of woman or fetus.Urgent is defined as C-section required because of maternal or fetal compromise which is not immediately life-threatening.
Scheduled is defined as needing early delivery but no maternal or fetal compro-Open Journal of Obstetrics and Gynecology mise.Elective is defined as C-section performed at a time to suit the woman and maternity team [1].DDI of 30 minutes is widely used as an audit standard for emergency C-section.DDI can be optimized with a properly organized, well trained, and cooperative multidisciplinary team.In one institution, which implemented a protocol for extremely urgent C-sections, managed to achieve a mean DDI of 7 minutes with 100% deliveries made within 17 minutes [2].There is a lack of firm evidence supporting better outcomes with DDI ≤ 30 minutes, when compared with one that is greater than 30 minutes [3].For Grade 1 cases, the National Institute for Health and Clinical Excellence (NICE) clinical guidelines advise pursuing the shortest-possible DDI in order to maximize maternal and fetal outcomes [4] [5].For grade 2 cases, studies have shown poorer neonatal outcomes when DDI is greater than 75 min.
As it can be administered rapidly, GA is almost always recommended in emergency situations with the hope of improving neonatal survival without hypoxic-ischemic brain injury [6].However, careful assessment of every patient-most importantly, of the patient's airway must be carried out before choosing a method of anesthesia.A predicted difficult airway as in pregnant patients is sometimes considered a contra-indication to rapid sequence induction of general anesthesia, even in an urgent case such as a category-1 caesarean section for fetal distress.A. J. Krom et al. have used decision analysis to quantify the time taken to establish anesthesia, and probability of failure, of three possible anesthetic methods, based on a systematic review of the literature.They considered rapid sequence induction of general anesthesia with video laryngoscopy, awake fiberoptic intubation and rapid spinal anesthesia.Their results show a shorter mean (95% CI) time to induction of 100 (87 -114) s using rapid sequence induction compared with 9 (7 -11) min for awake fiberoptic intubation (p < 0.0001) and 6.3 (5.4 -7.2) min for spinal anesthesia (p < 0.0001).They calculated the risk of ultimate failed airway control after rapid sequence induction to be 21 (0 -53) per 100,000 cases, and postulate that some mothers may accept such a risk in order to reduce potential fetal harm from an extended time interval until delivery.Although rapid sequence induction may not be the anesthetic technique of choice for all cases in the circumstance of a category-1 caesarean section for fetal distress with a predicted difficult airway, they suggest that it is an acceptable option [7].
In the UK, a case series of 25 patients has described the use of spinal anesthesia in grade 1 C-sections.It is reported that anesthesia can be administered safely in suitable parturient in 6 -8 min with "rapid sequence spinal anesthesia", which consists of a "no touch technique" of donning gloves, the omission of spinal opioids with an increase of the dose of hyperbaric Bupivacaine 0.5% (up to 3 ml), and a limitation in the number of attempts [8].Therefore, rapid sequence spinal anesthesia is a reasonable alternative to general anesthesia for urgent cesarean section cases [9].
Further literature review revealed, we should consider the need for an emer- to clinic with nausea, increased leg swelling, elevated blood pressure (BP) 160/88 in clinic, which did not resolve with labetalol 10mg IV and then resolved with IV hydralazine 5mg IV to 145/78.Cerclage was removed anticipating delivery without complications.Cervix 1/50/-3 after cerclage removal.Fetal heart Tracing category 2 with baseline 140 bpm, minimal variability, accelerations, recurrent deceleration that are a combination of late and variable decelerations as shown in Figure 1.Abnormal labs: Protein > 500 on UA.Normal complete blood count (CBC), basic metabolic panel, Liver function tests and PT/PTT.Normal Ultra sonogram.Patient admitted to severe pre-eclampsia unit started on magnesium for seizure prophylaxis and IV Hydralazine for elevated BP.Plan made to start induction of labor, continue to monitor BPs and fetal heart Tracing with intrauterine resuscitation and if unchanged will go for cesarean delivery.Penicillin prophylaxis for GBS unknown.

Figure 1 .
Figure 1.Fetal heart Tracing category 2, Baseline FHR140 bpm with minimal variability, accelerations, recurrent deceleration that are a combination of late and variable decelerations.

Figure 2 .
Figure 2. Category 2 Fetal heart rate tracing with temporary decelerations to 80 bpm with subsequent episodes of decelerations to 90 bpm and 70 bpm and bradycardia.

Table 1 [
15] [16] [17] [18].If adequate chest compressions have failed to increase the HR > 60 bpm, then it is reasonable to use adrenaline despite the lack of human neonatal data.If Adrenaline is indicated, a dose of 0.01 -0.03 mg/kg should be administered intravenously.If there is no IV access, 0.05 -0.1 mg/kg P. Nadavaluru et al.DOI: 10.4236/ojog.2018.89083807 Open Journal of Obstetrics and Gynecology of Adrenaline can be administered via the tracheal route (Algorithm 1, Algorithm 2 and Table 1) [19].Algorithm 1.Initial newborn evaluation.