Meta-Analysis of Clinical Outcomes of Lumbar Fusion Surgical Interventions for Degenerative Spondylolisthesis

Introduction: Surgical interventions for degenerative spondylolisthesis are varied with comparable claims of success. Fusion based technique is one of the most commonly used surgical interventions in treating this condition. The aim of this meta-analysis is to compare the effectiveness of the Lumbar Interbody Fusion techniques (specifically Posterolateral Interbody approach—PLIF) versus Posterolateral Instrumented Fusion (PLF). The clinical outcomes investigated were: back pain, leg pain, function, Oswestery Disability Index (ODI), Disability Rating Index (DRI), fusion and revision rates if reported. Methods: Combinations of keywords and MeSH terms, where appropriate, were used to search for studies in Medline via Ovid, Embase, Cochrane Library, and Google scholar. The initial search was conducted on 10 August 2016 and updated on 13 June 2017. Eligibility criteria for the studies to be selected for this meta-analysis were: Randomised Controlled Trials (RCTs), cohort and consecutive cases studies that compared at PLIF versus PLF surgical interventions at the lumbar region. Heterogeneity indicators and Forest plot were computed using RevMan 5. Results: Out of the initial hits of 3021, 5 articles were selected as relevant and assessed for risk of bias and then data was extracted and tabulated. These 5 studies reported data from (900 patients’ records, follow up ranges from 6 months to 5 years) undergone one of 2 interventions (PLIF or PLF). The overall effect for ODI and leg pain showed no advantage of any intervention over the other while there was a greater odd ratio of fusion if the operation applied PLIF techniques (Overall Z = 2.86, p = 0.004). Conclusions: There is a need for more high quality clinical trials to compare these two interventions. However, available data indicate that there How to cite this paper: Aneiba, K., Garoushi, S., Elmajee, M., Elsllabi, M. and Tashani, O.A. (2018) Meta-Analysis of Clinical Outcomes of Lumbar Fusion Surgical Interventions for Degenerative Spondylolisthesis. International Journal of Clinical Medicine, 9, 590-599. https://doi.org/10.4236/ijcm.2018.97050 Received: March 15, 2018 Accepted: July 21, 2018 Published: July 24, 2018 Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/


Introduction
Spinal disorders at the lumbar region affect around 11% -15% of the population worldwide [1].Causes of disc problems at the lumbar region include a degenerative process because of ageing, spinal deformities and instability such as spondylolisthesis.Spondylolisthesis is usually defined as a forward displacement of one of the lower lumbar vertebrae over the vertebra beneath it.When this occurred the resulting pressure on the spinal nerves could lead to pain and other symptoms including a loss of mobility and loss of sensory and motor functions along the nerve pathways [1].Surgical

Methods
Combinations of keywords and MeSH terms, where appropriate, were used to search for studies in Medline via Ovid, Embase, Cochrane Library, and Google scholar.The lists of keywords were (lumbar disc/disk or disc/disk disease, discectomy, posterior, posterolateral, transforaminal, anterior, spondylosis, spondylolisthesis) and (vertebr*, lumbar spine, spine) and (pain, disability, quality of life, outcome).The initial search (No time or language limits) was conducted on 10 August 2016 and updated on 13 June 2017.Eligibility criteria for the studies to be selected for this meta-analysis were: Randomised Controlled Trials (RCTs), cohort and consecutive cases studies that compared at PLIF versus PLF surgical interventions at the lumbar region.Initial screening of titles was conducted by one reviewer (SG) and screening of full articles and data extraction International Journal of Clinical Medicine was conducted by two reviewers independently with a third reviewer acting as an arbiter in case a disagreement between the two systematic reviewers on the inclusion of a study arises.The decision process to select the relevant studies was as follows: 1) Title and abstracts from databases were managed by Endnote library.
2) If the study is not an RCT, case-control or cohort study involving human patients then it is excluded.
3) If the study does not include a surgical intervention, then it is excluded.4) If the surgical technique is not a fusion technique, then it is excluded.
Data were extracted by two systematic reviewers and checked by other contributors.The data which extracted from the selected studies included; the study design, grades of the disc disease and the spinal levels affected, number of patients and their age, length of the follow up period after surgery.Data on the fusion rate at the spinal level, outcome score (SF12, SF36), ODI, revision rate, patients' satisfaction and both radiating and back pain on a visual analogue score are also extracted and tabulated.
The risk of bias in the selected articles was assessed using the Cochrane collaborations guidelines.Two reviewers assessed the articles independently and then convened to produce the risk of bias judgment using RevMan 5 software [2].
Any disagreements between the two reviewers were resolved by asking a third reviewer to provide further judgment on the article in question.Heterogeneity indicators were calculated using RevMan 5 and it has been decided if pooling of data on any clinical outcome was required that a fixed effect model should be applied if the heterogeneity indicator I 2 was less than 70% and at least three studies provided suitable data for meta-analysis [3] [4].Publication bias was assessed visually after producing Funnel plots.

Results
Out of the initial hits of 3021 hits 46 articles were deemed relevant (Figure 1).Forty-one full length articles were excluded with reasons such as; being a discussion article or report on experiments on cadavers or examination of learning curve of surgeons.Five articles were assessed for risk of bias (Table 1) and then data was extracted and tabulated.These 5 studies reported data from (900 patients' records, follow up ranges from 6 months to 5 years) undergone one of the 2 interventions (see Table 2 for full characteristics of the studies).Patients were matched for sex and age.All studies lacked description of randomisation process and quality of articles ranged from intermediate to poor.Five studies have not reported pain outcomes or Oswestry Disability Index (ODI) scores.Those reported ODI or pain outcomes found no significant differences between the compared interventions.There were no significant differences.

Studies' Conclusion
Authors of 3 out of the five studies included agreed that overall PLIF resulted in International Journal of Clinical Medicine  similar clinical results as PLF [5] [6] [7] but better fusion rate and better maintenance of reduction is more likely to be obtained post PLIF [5] despite the fact that PLIF could lead to more complications [6].Farrokhi et al. 2012  concluded that PLF provides better clinical outcomes and more improvement in the lower back pain compared to PLIF despite the low fusion rate of PLF [8].Musluman et al. 2011 suggested that PLIF provided more solid mechanical construct compared to PLF [9].But PLF exhibited better clinical outcomes at an earlier stage, including improvements in quality of life pain relief and functional ability.
There is also an agreement between all the studies that additional studies with a larger sample size should be performed to better understand the clinical and

Meta-Analysis Findings
It was very difficult to judge if there was publication bias because of the low number of studies in different outcomes.It was possible to pool data in three outcomes Oswestery Disability Index (ODI) (Figure 2), leg pain (Figure 3) and fusion rate (Figure 4).See Appendix 1 for full calculations and data.The overall   effect for ODI and leg pain showed no advantage of any intervention over the other while there was a greater odd ratio of fusion if the operation applied PLIF techniques (Overall Z = 2.86, p = 0.004).

Complications
Overall there were slightly more complications post PLIF operations.There is some evidence that PLIF procedure resulted in more bleeding and is more invasive [6] and the leak of cerebrospinal fluid was 14% more in post PLIF than post PLF with a slightly greater risk of infection and slightly greater probability of permanent motor impairment in post PLIF patients [8].Blood Loss (ml) 360 ± 30 vs 350 ± 25, Operation time (Hours) 2.6 ± 0.3 vs 2.1 ± 0.2, Hospital stay (Days) 4.7 ± 2.2 vs 4.8 ± 1.7, incision length (cm) 8.6 ± 1.7 vs 8.1 ± 1.5.

Discussion
Findings from the 5 articles selected and analysed in this review suggested that fusion rate is slightly better post PLIF despite the likelihood of higher complications with this intervention.In the four studies that reported fusion rates, three studies reported a fusion rate post PLIF to be at least 16% more efficient than post PLF.This finding is in agreement with the meta-analysis outcome of Ye et al. 2013, who found that PLF generally produced less fusion rates than PLIF [10].
Clinically the fusion rate post lumbar surgery for spondylolisthesis is the main International Journal of Clinical Medicine goal of the intervention as it usually linked to the favourite clinical outcomes [11].However, as far as other clinical outcomes are concerned the two interventions are comparable to each other.While the selected studies did not discussed reasons behind a choice of one intervention over the other it is clear that surgeon preference and experience and anatomical consideration determine what type of surgery is performed.
Despite the significant difference between PLIF and PLF in the fusion rate the pain outcomes, whether it was leg or back pain, was similar after the surgery in the two groups of patients.This was also the findings of [10] and [12].This is unexpected in the case of back pain as a better fusion rate should have an impact on the persistence of this type of pain.Differences between the follow-up in the selected studies only partially could explain why there was no differences between PLIF and PLF in visual analogue scale of back pain after surgery.However, the similarity of the pain ratings between the two interventions can be explained by the fact that the two surgeries achieve satisfactory spinal nerve root decompression.Our findings should be cautiously interpreted because the studies selected for this meta-analysis lacked description of randomisation process and not all outcomes were reported.While it is accepted that blinding surgeons is impossible the studies failed to blind patients.Other limitation of this meta-analysis is the differences between studies in the follow-up period.

Conclusion
There is a need for more high quality clinical trials to compare these two inter- interventions for degenerative spondylolisthesis are varied with comparable claims of success.Fusion based technique is one of the most commonly used surgical interventions in treating this condition.There are two major approaches for the fusion techniques namely Interbody fusion (specifically Posterolateral Interbody approach-PLIF) and Posterolateral Instrumented Fusion (PLF).In interbody fusions there are three common techniques; Posterior lumbar, Transforaminalor Anterior.However, clinical outcomes of these interventions are inconsistently reported in trials that compare the effectiveness of these interventions.The aim of this meta-analysis is to compare the effectiveness of the Lumbar Interbody Fusion techniques versus Posterolateral Instrumented Fusion (PLF).The clinical outcomes investigated are: back pain, leg pain, function, Oswestery Disability Index (ODI), Disability Rating Index (DRI), fusion and revision rates if reported.

Figure 1 .
Figure 1.PRISMA flow chart showing results of the selection process.

Figure 2 .
Figure 2. plot of comparison of ODI post-surgery.

Figure 3 .
Figure 3. Forest plot of comparison between visual analogue scale (0 to 10) post operations of leg pain.

Figure 4 .
Figure 4. Forest plot of comparison between the odd ratio of fusion rate outcome in the two interventions.There is a greater odd ratio of fusion if the PLIF technique was applied (Overall Z = 2.86, p = 0.004).

Table 1 .
Risk of bias summary: review authors' judgements about each risk of bias item for included studies.Red circle = high risk of bias, Green circle = low risk of bias, Yellow circle = unclear risk of bias.

Table 2 .
Summary of characteristics of studies included and the reported clinical outcomes.

Data Used to Produce Effect Size and Forest Plot
ventions.However, available data indicate that there are comparable results in the main clinical outcomes with PLIF providing superior fusion rate which does not seem to affect post-operative pain ratings.International Journal of Clinical Medicine Appendix 1:

Table ( a
).Data used to produce Forest plot output in RevMan 5 to compare ODI post-surgery.

Table ( b
).Data used to produce Forest plot output in RevMan 5 to compare between visual analogue scale (0 to 10) post operations of leg pain.

Table ( c
).Data used to produce Forest plot output in RevMan 5 to compare log odd ratio of Fusion Rate outcome.There is a greater odd ratio of fusion if the PLIF techniques were applied.(Overall Z = 2.86, p = 0.004).