Epidemiological , Clinical and Paraclinical Aspects of Cirrhosis at Borgou Departmental University Hospital Center ( Benin )

Objective: To study the epidemiological, clinical and paraclinical aspects of cirrhosis at Borgou Departmental University hospital Center. Methods: This is a retrospective study for descriptive purpose conducted in the Internal Medicine Department. The study population consists of patients hospitalized in the Internal Medicine Department during the period from 1st January 2009 to 31st December 2016. Results: The frequency of cirrhosis was 1.35%. The sex ratio was 3.76. The average age of patients was 45.22 ± 15.23 years old, with a range from 15 to 82 years. There is a post hepatitis Bcirrhosis predominance in 87.5% of cases, followed by alcoholic cirrhosis in 21.59% of cases. The complications of cirrhosis are dominated by ascites (78.4%) and jaundice (52%). Conclusion: Cirrhosis is a condition that is wide spread. The hepatitis B virusis the main cause of liver cirrhosis followed by alcoholism. Ascites is the most encountered complication. It’s very important now to educate the populations for a behaviour change and to promote vaccination against viral hepatitis.


Introduction
Hepatic cirrhosis is a pathology characterized by the disorganization of liver architecture attributable to hepatocytes destruction since the hepatocellular regeneration remains in form of regeneration nodules with the presence of fibrosis.
Nowadays, it's a public health problem [1].The real world prevalence of hepatic cirrhosis is not well known but can exceed 1% if a liver biopsy and anatomopathological examination are realized for the benefit of the general population.In United State, Cirrhosis prevalence is 0.15% and represents respectively the tenth and the twelfth cause of death in men and in women, killing about 35,000 people every year [2].In Europe, almost 170,000 of death related to cirrhosis are registered per year and represent 1.8% of all causes of death [3].In Africa, the hospital prevalence of cirrhosis is at 7.02% in 2012 in Togo [4] and 2.35% in 2008 in Mali [5].In Cotonou (Benin), Sèhonou et al. have reported 22.6% as prevalence in 2006; Viral hepatitis Band chronic alcoholism are the most frequent reported causes [6].No studies on hepatic cirrhosis have been performed in northern Benin.The present study was initiated to identify the different and the most common cause of hepatic cirrhosis.The results of this study will help prevent liver cirrhosis.The goal of this study is to describe the epidemiological, clinical and paraclinical aspects of cirrhosis in Borgou Departmental University hospital Center.This study has used the data of a retrospective cohort.Neither the names nor others characteristics allowing the patients recognition were collected.The agreement of the National Ethics Committee for Health Research http://www.ethique-sante.org/)according to the recommendations was not requireddue to its retrospective character.

Epidemiological Data
Out of 9260 patients who consulted or have been hospitalized in the Internal Medicine Department, 125 suffered from hepatic cirrhosis or a frequency at 1.35%.
Among the cirrhotic patients, a male predominance has been noticed: 99 men for 26 women.The sex ratio was 3.76.
Figure 1 shows cirrhotic patients distribution by age.The average age of the patients was 45.22 ± 15.23 years, with the extremes 15 and 82 years of age.About 8 out 10 patients were between the ages of 25 and 64 years old.

Ascitic fluid examination
 Ascitic fluid was macroscopically yellow citrine (89.6%), hemorrhagic (8.6%) or cloudy (1.6%). Cytobacteriological examination of the fluid showed a leukocyte count lower than 250/mm 3 in 96.8% of the cases.o The average diameter of the portal vein was 15.87 ± 2.27 mm with 21 mm as maximum.
Table 3 shows the observed signs by the abdominal ultrasonography.  2 shows the etiologies of cirrhosis.The complications of cirrhosis are dominated by ascites (78.4%) and jaundice (52%).Table 4 shows the complications of cirrhosis.

Discussion
The All the patients were seen at a phase of decompensation, the average period for consultation was 4.45 months.In Togo, that has been observed by Bouglouga et al. who reported that 78.1% of patients consulted one year after the progression of the disease [4].
Among the patients history, jaundice and alcoholism account for respectively 36.80% and 29.60% of cases.According to the study of Ouavene et al., 63.5% had jaundice as history and 34% are chronic alcoholics [11].
Most of the patients had a poor general condition with asthenia (83%) and loss of weight (78%).The cirrhotic patients were undernourished.The prevalence of under nutrition during cirrhosis is approximately 50% at all the stages of the disease.That under nutrition is due to the reduction of food intake, a malabsorption and a hypercatabolism.The cirrhotic patient doesn't eat much since he is still anorexic, nauseous, with an altered sense of taste and a feeling of gastric fullness.According to the study of Xie et al., 56.6% of the patients were asthenic and 34.1% were anorexic [15].Hepatomegaly was found in 68.8% of cases, ascites (78.40%) andsplenomegaly (56%), collateral venous circulation (40%) and abdominal pain (56.80%).Hepatomegaly was the main morphological change reported by the authors [4] [6].Aboutsplenomegaly and collateral venous, Bouglouga et al. [4] have respectively reported 13% and 5.2% and Ouavene et al. reported [11] 77.50% and 95.50%.
Hepatic ultrasonography realized showed hepatomegaly in 65.71% of cases.In the series of Ouavene et al. [11], hepatomegaly accounted for only 30% whereas the liver size was normal in 67.5% of cases.

Conclusion
Hepatic cirrhosis is a growing pathology.Hepatitis B virus is the main cause of hepatic cirrhosis followed by chronic alcoholism.Vaccination against hepatitis B virus and a decrease in alcoholic consumption are necessary in order to reduce the incidence of hepatic cirrhosis.That vaccination against hepatitis B virus is necessary from childhood especially in our developing countries.

o
is a retrospective study for a descriptive purpose conducted in the Internal Medicine Department.The study population consists of the patients hospitalized in the Internal Medicine Department from 1 St January 2009 to 31 St December 2016.We included only the patients with liver cirrhosis.Diagnostic criteria used for the diagnosis of liver cirrhosis were as follows: -Signs in accordance with cirrhosis in the laboratory analyses: AST/ALT ratio > 1, presence of thrombocytopenia, and prolonged prothrombin time.-Imaging findings (ultrasonography and/or tomography): decrease in the liver size, parenchymal heterogeneity, superficial nodular changes, hypertrophy of the left lobe, splenomegaly and dilatation of portal vein.-Clinical and endoscopic signs suggestive of cirrhosis; splenomegaly, esophageal varices, ascites, hepatic encephalopathy.The study variables are: -Epidemiological Data o Frequency of liver cirrhosis.The diagnosis of cirrhosis is decided based on clinical and paraclinical arguments.Liver biopsy and anatomopathological examination were not done due to the lack of technical capacity means.Age of the patients o The sex -Clinical Data o Functional signs o History o General signs o Physical signs -Paraclinical Data o Liver function tests Open Journal of Internal Medicine o Liver morphology explorations The analysis has been done using the software Epi Data, version 3.1.

Table 2
points out the results of the ascitic fluid examination.Figure 1. Distribution of the 125 cirrhotic patients by age groups.
o The average level of AST (Aspartate Aminotransferase) was 189.13 ± 24.02 UI/L and the one of ALT (Alanine Aminotransferase) was 87.98 ± 17.15 UI/L.The ratio AST/ALT ≥ 1 in 92.1% of cases.

Table 1 .
Physical signs found in 125 cirrhotic patients.

Table 2 .
Results of the ascites fluid examination in 125 cirrhotic patients.The average value of totalbilirubinemia was 77.82 ± 14.6 mg/L and varied from 1 to 498 mg/L.o The level of Gamma Glutamyl Transferase (GGT) varied from 39 to 3024 UI/L with an average level at 413 ± 33 UI/L.

Table 3 .
Results of abdominal ultrasonography in 105 cirrhotic patients.

Table 4 .
[14]uency of cirrhosis in Internal Medicine Department of Borgou Departmental University hospital Center was 1.35%.The prevalence of cirrhosis is extremely variable from one country to another and from one continent to another.In West Africa Sèhonou et al. in 2006 [6] have reported 22.60% as frequency in Internal Medicine Department of National Teaching Hospital in Cotonou; Bouglouga et al. in 2012 [4] have reported a prevalence at 7.02% in Togo.The frequency of cirrhosis at 1.35% in Borgou Departmental University Figure 2. Patient distribution by etiologies of cirrhosis.Complications encountered in 125 cirrhotic patients.hospitalCenterislowerthantheone at 22.60% reported by Sèhonou et al. at National Teaching Hospitalin Cotonou.In reality, the prevalence reported by Sèhonou et al. was the one of hepatitis cirrhosis at the hepatogastroenterology department that usually receives patients suffering from digestive pathologies like chronic hepatopathies.The Internal Medicine Department of Borgou Departmental University hospital Centerreceives patients coming from all the medical specialities.The average age of our patients was 45.22 ± 15.23 years.That was similar to the one reported by many authors notably Sèhonou et al. (49 years of age) and Ouavene et al. (45 years) [6][11].In Turkey, en Greece and Romania, the average age of the cirrhotic patients was higher.Those authors have respectively reported 55.3 years, 56 years and 59 years[12][13][14].That higher average age could be explained by the exposure to the hepatitis B virus (HBV) which was the main cause of cirrhosis in childhood in developing countries like Benin and also the absence of vaccination against that virus.Mother-to-child transmission is a real source of infection.This is augmented by unprotected sex mostly for teenagers.