Effect of Therapeutic Group Education on Adherence and Blood Pressure Control among Uncontrolled Hypertensive Patients in Sub Saharan Africa

Background: Hypertension is the leading cardiovascular risk factor worldwide, with the greatest burden in low-income settings. Blood pressure (BP) control is usually low resulting in high rates of uncontrolled patients and complications. Low awareness resulting in poor therapeutic adherence represents an important factor for insufficient blood pressure control in developing countries. Methods: This was a three months non-randomized control trial at the cardiology clinic of the Yaoundé Central Hospital. We included adults with essential and uncontrolled hypertension. The intervention consisted of group educative sessions every week focusing on knowledge of hypertension risk factors, complications, treatment, comorbidities, home self-monitoring of BP. Home blood pressure figures, drug compliance, and knowledge regarding hypertension were evaluated before and after. Results: 17 participants (8 women) with a mean age 56.2 ± 8.1 years. During intervention, mean SBP decreased by 30 mmHg while mean DBP drooped by 11 mmHg using home BP measures. Knowledge regarding hypertension, adherence and drug compliance increased by 36.5%, 88.2% and 81.4% respectively. Conclusion: Therapeutic group education resulted in a significant improvement in BP control amongst uncontrolled hypertensive patients in sub Saharan Africa. How to cite this paper: Nganou-Gnindjio, C.N., Domning, H.G.K., Mfeukeu-Kuate, L., Hamadou, B., Kamdem, F., Bediang, G., Tankeu, A.T., Menanga, A.P. and Kingue, S. (2018) Effect of Therapeutic Group Education on Adherence and Blood Pressure Control among Uncontrolled Hypertensive Patients in Sub Saharan Africa. World Journal of Cardiovascular Diseases, 8, 183-195. https://doi.org/10.4236/wjcd.2018.83018 Received: January 30, 2018 Accepted: March 24, 2018 Published: March 27, 2018 Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/


Introduction
High blood pressure is a major public health threat affecting nearly 40% (about one billion) of adults worldwide [1].It is by far the leading cardiovascular risk factor responsible for 7% of the years lost life and 9.4 million deaths [2].In 2010, hypertension was responsible for more than 500,000 deaths, 10 million years of life lost and alone accounted for about 7.3% of total health care expenditures [3] [4] [5].More than 80% of the global burden of high blood pressure weighs on low-and middle-income countries [6].Africa presents the highest prevalence of hypertension, where 46% of adults over 25 years of age are affected by the disease amongst which 66% of patients are unaware of their condition and 82% are untreated [1] [5].Moreover, despite increasing efforts and the multiple treatment modalities available today, the proportion of uncontrolled hypertensive individuals have increased from 605 million in 1980 to 978 million in 2008 [3].This situation is even worst in Africa where about 93% of treated patients do not reach the targets [1] [5].This has been attributing to a low adherence and lack of compliance of patients to pharmacological and non-pharmacological treatment in our context [7].Therefore, improving treatment adherence and patient compliance could increase hypertension control and reduce the total burden of this condition.This has been suggested by some studies which showed that raising adherence to therapeutic recommendations is associated with better BP control [8].The aim of this study was to investigate the effect of therapeutic group education on adherence and blood pressure control in uncontrolled hypertensive patients in Cameroon, sub Saharan Africa.

Ethical Considerations
This study was carried out in accordance with the Declaration of Helsinki, and was approved bythe Institutional Research Ethical Committee of Université des Montagnes (N˚2017/o28/UdM/PR/CIE), and by the institutional review board of the Yaoundé Central Hospital of Cameroon.This project was also approved by the regional ethic committee of the central region of Cameroon Identifier (No.: 0551/CRERSHC/2016).All participants provided written informed consent.

Participants
We included adults with essential, uncontrolled hypertension (systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg) according to international guidelines (JNC8 and WHO 2010) [1] [9], on any stable antihypertensive therapy for at least 3 months, non-observant to therapeutic measures who consent to participate.Patients with chronic pathology other than high blood pressure (diabetes, gout, heart failure, renal insufficiency, dementia, asthma, Parkinson's disease, epilepsy, cancer, and chronic obstructive pulmonary disease) as well as pregnant and/or breastfeeding women were not included.Exclusion criteria consisted of individuals presenting acute complications of high blood pressure such as stroke, MI or elevated BP over 180/110 mm Hg during the study.Patients whose antihypertensive treatment was changed or modified during the study and those attending less than 10 therapeutic education sessions out of the 12 were also excluded.

Outcome
Our primary outcome was the difference in adherence scores before and after intervention.Secondary outcome measures were: improvement in blood pressure and the improvement of knowledge concerning BP and its treatment as well as pre-and post-intervention physical activity levels.

Sample Size
The sample size was calculated using Whitley's formula: N = 2 Cp, power/d 2   where N = sample size, Cp, power = constant defined by the values of p (threshold of significance) chosen available in the statistical tables [10].For a value of α = 0.05 and a power of 95%, cp, power = 13.D = expected difference/standard deviation.We hypothesized a variation of the adherence score of about 25% compared to that obtained before our intervention.Given that the mean score obtained in the study for the validation of the 8-item Morisky questionnaire was 6.96 with a standard deviation of 1.25 [11].The minimum sample size was therefore estimated at 14 patients.

Data Collection and Procedure
After recruitment of eligible patients, we carried out an initial evaluation based on socio-demographic, anthropometric parameters, clinical and home blood pressure figures, history of hypertension, drug compliance, and knowledge concerning hypertension and other cardiovascular risk factors, level of physical activity, quality of food and stress in the working environment.These data served as baseline characteristics.
Then, the working materials were given to each patient namely; electronic home blood pressure devices, pedometers, educative materials and follow-up cards.Under the supervision of a cardiologist and a dietician, we carried out group patient education that consisted of lessons focusing on knowledge of risk factors World Journal of Cardiovascular Diseases for hypertension, complications, treatment, comorbidities, home self-monitoring of BP, quality of food, drug adherence, alcohol consumption, tobacco and stress.These lessons were carried out in the form of standard lecture followed by group discussion and quizzes with answers.The follow-up was done using regular phone calls and daily text messages that were sent to remind each patient of their medication, blood pressure monitoring, dietary measures and subsequent appointments.The patient recorded on follow-up cards home blood pressure figures, names, dose and number of medications taken per day and hours, pedometer data during physical activity, alcohol consumption, and cigarette smoking.In addition, follow-up was carried out once a week at the hospital.During the re-evaluation sessions, patients exchanged personal experiences with their illnesses, difficulties encountered in daily compliance with the recommendations given during therapeutic education, and with the help of the cardiologist and dietician we discussed to find solutions adapted to their needs.
Re-evaluation was done three months after the beginning of intervention and focused on characteristics measured at baselines especially medication adherence, level of knowledge, quality of feeding and level of satisfaction with education received during the study.Therapeutic education was defined as a continuous, integrated, patient-centered process, including organized awareness, information, learning and psychosocial support activities related to disease, prescribed treatment, care and hospitalization while concordance between a person's behavior and a caregiver's recommendations was considered as therapeutic compliance.For all participants, we measured height to the nearest 0.5 cm, and weight in light clothing to the nearest 0.1 kg, and calculated the body mass index (BMI) using Quetelet's index.
Therapeutic drug adherence was evaluated using the Morisky 8-items questionnaire [12], assessment of high blood pressure related knowledge was done with the Hypertension Knowledge Level Scale, while the quality of the diet was evaluated with the food evaluation questionnaire [13] [14], and the Karasek questionnaire (validated French version) was used to estimate the level of stress in professional environment [15].Home BP were measured using an automated sphygmomanometer (Omron RS1, Omron Corporation, Tokyo, Japan).An armband was placed around the wrist with the arm slightly folded at the level of the elbow and resting on a table such that the cuff and the wrist is at the level of the heart.Measurements were performed on both hands by the participants after at least five minutes of rest, in a quiet place, and in the sitting position.Participants were not to move or talk during the measurement.The measures were repeated on the hand presenting the highest values of BP, and the mean of the two measurements on this arm was considered and reported on the card.This was repeated twice a day (morning and evening) during three successive days of every week.
Energy expenditure related to physical activity was determined using a pedometer (Incutex).Before the beginning of physical exercise, the device was placed on the hip of each patient and was switched off at the end of the exercise.The World Journal of Cardiovascular Diseases patient was asked to report the type and duration of physical activity as well as data shown by the pedometer (number of steps, of kilocalories, and the distance).Assuming the recommendations of WHO, the following principles were applied: it was estimated that the caloric expenditure of a moderately active person was four times higher, and that of a person very active eight times higher than the caloric expenditure of a person sitting without moving.To calculate the total energy expenditure of a person using the data from the questionnaire, 2 METs (Metabolic Equivalent Task) were allocated to time spent in light-intensity physical activities, 4 METs to time spent on moderately intense physical activities and 8 METs time spent in intense physical activity.Total physical activity in MET-minutes/week = sum of MET-minutes corresponding to each situation [16].

Statistical Analysis
Data were analyzed using IBM SPSS Statistics for Windows, version 20.0.(Armonk, NY: IBM Corp).Results were presented as counts with percentage and means ± SD and median (interquartile range) where adpated.The chi-squared test was used to test association between qualitative variables.The non-parametric Wilcoxon-test was used to compare data before and after intervention that was not normally distributed and the parametric paired t-test to compare data between normally distributed variables respectively between study groups.A two-tailed p value <0.05 was considered statistically significant.

Participants' Characteristics
Out of the 50 eligible patients, 20 refused to participate and 30 patients started the intervention.At the end, a total of 17 participants (09 women) completed the study after thirteen patients dropped out during the follow-up and one was excluded due to an acute complication of high blood pressure (Figure 1).The mean age of participants was 56.2 ± 8.1 years.Most of the participants were in the 60 -65 years' age group.The average duration of hypertension was 11.2 ± 9 years.At baseline, the mean office systolic and diastolic blood pressure were 168 ± 26 mm Hg and 97 ± 11 mm Hg, respectively.Stroke was the most common complication (4/17), dual therapy the most commonly used therapeutic regimen (9/17), and occupational stress was reported by 1 out of 8 patients who were active participants.

Therapeutic Adherence before and after Intervention
After therapeutic education, the level of compliance increased from low-to-high for most participants-an improvement of 88.2%.On the other hand, the compliance score increased by 3.51 points/8-an improvement of 81.4% (Table 1).

Home Blood Pressure Values Control before and after
This intervention was carried out in uncontrolled hypertensive patients with BP World Journal of Cardiovascular Diseases

Knowledge of Participants Concerning High BP before and after Intervention
Knowledge of participants on BP and related complications increased by 5.77 points/22-an improvement of 36.5% (Table 1).

Physical Activity before and after Intervention
Similarly, the intervention results in a significant improvement in energy expenditure related to physical activity, with an increase of 625.41 MET, giving an improvement of 185.2% (Table 1).The level of physical activity rated as poor at the beginning of the intervention passed to moderate at the end of the intervention (Figure 3).

Alcohol Consumption and Quality of Diet before and after Intervention
Concerning the consumption of alcohol: it decreased by 0.98 glasses/week-a reduction of 64.5%.The quality of the diet classified as medium before intervention passed to very good for 52.9% of the participants at the end.The mean score increased by 6.94 points/43, a statistically significant variation of 60.19% (Table 1).

Assessment of Patient Satisfaction
At the end of intervention, all patients were satisfied by the lessons learned and acknowledged that lectures were adapted to their comprehension.

Discussion
This study was designed to evaluate the effect of a three months' program of therapeutic group education on therapeutic adherence and blood pressure control in uncontrolled hypertensive patients in sub Saharan Africa.We found that group patient education resulted in great increase of patient's knowledge, therapeutic adherence and physical activity levels resulting in a marked reduction of Therapeutic education carried out during the study contributed to improve patient's knowledge regarding the disease, its complications and the importance of management measures currently prescribed.We obtained a significant difference between the pre-and post-intervention knowledge scores on the Hypertension Knowledge-Level Scale (HK-LS).This significant improvement of knowledge regarding the disease is of great importance considering the low level of knowledge exhibited by most of the participants at baseline and the low awareness on hypertension.Akoko et al., reported in their study published in 2015 only 14% of good knowledge amongst hypertensive patients in Cameroon [17].The consequence of this situation in our context is the patient's difficulties to accept the necessity of lifelong treatment in the absence of obvious symptoms and the cost of certain drugs resulting to low adherence of patients and non-compliance.A factor that could explain this lack of knowledge is low literacy concerning chronic diseases such as high blood pressure and treatment modalities in a context where acute conditions and communicable diseases are still considered as the major health threats by most individuals and even policy makers.Therefore, integrating the concept of chronic conditions despite the absence of symptoms leading to an increase risk of life-threatening complications is a challenge for most patients.This requires an important therapeutic education by physician in daily practice for a better understanding of the condition by patients.However, the limited human resources in sub Saharan Africa, with the resultant high patients-to-physician ratio results in shorter consultation times, which can be insufficient to explain and discuss all the aspects of therapeutic education with patients [18].This stresses the high needs in therapeutic educa- Therapeutic adherence evaluated using the Morisky questionnaire was also low for most participants at baseline with the main reason of non-adherence to drugs medication being oblivion in more than three quarters of patients (82%).
Our intervention resulted in a significant improvement in the mean adherence score of 81.4% after three months of intervention.Similarly, Bosworth et al.In the United States in 2008 achieved a significant improvement in adherence using education and phone calls [19].However, improvement was more important in our study certainly due to the addition of daily text messages and phone calls to the therapeutic education sessions.By increasing awareness of patients on the importance of their drug therapy, the intervention significantly improved adherence.This is consistent with findings of Ikama et al. in Congo in 2013 who found that call reminders was associated with better medication adherence [20].
Given the fact that therapeutic adherence is worse in limited resources settings [21], interventions such as phone reminders by calls or text messages that have been proven effective in communicable diseases such as HIV and tuberculosis could be cost effective, and should be adopted by non-communicable diseases clinics in order to improve therapeutic adherence of patients [22] [23] [24].
Our study also evaluated the difference in physical activity levels before and after intervention using pedometers.We found a significant increase in energy expenditure in 100% of our population study which is by far superior to findings of previous interventions conducted over a much longer period in developed countries [25] [26].This is in agreement with previous findings which showed that short term interventions like ours usually results in greater effect than long term interventions.This marked improvement can also be attributed to the fact that at baseline, most of patients ignored the place and importance of physical activity on blood pressure control in our study.Therefore, increase in patient's knowledge has been associated with increase in physical activity in all participants.
Improvement in therapeutic adherence and physical activity level resulted in a marked reduction of home blood pressure figures in our study population.Systolic blood pressure decreased by 30 mmHg while diastolic blood pressure decreased by 11 mmHg.Our findings are twice to six times greater than those of Cappucio et al., in 2005 in Ghana, who did not achieve 5 mmHg of BP reduction on each component in a randomized clinical trial [27].This could be due to the fact that we used home BP measures to evaluate BP control in our study while others studies used office BP measures.However, this improvement in BP control remained greater than the effect of any anti-hypertensive treatment currently used.Considering the cost of pharmacological treatment in our context [28], and the absence of health insurance, these findings stresses the importance of therapeutic education for uncontrolled hypertensive individuals in sub Saharan World Journal of Cardiovascular Diseases Africa.Physicians should make every effort to improve therapeutic education when facing uncontrolled hypertensive patients before adjunction of another pharmacological treatment to the currently used regimen.Also, given the outstanding results of such interventions, it should be considered by cardiovascular clinics in sub Saharan Africa as an effective method to reduce the burden of cardiovascular diseases.
The present study has some limitations that need to be highlighted.Despite the fact that the sample size was calculated in order to detect any existing effect, the small sample size of our study could be an impediment for the generalization of these results.Another limitation of this study was the absence of a control group that could allow a better quantification of the real effect of our intervention.Also, the short duration of the study could be a limitation since most studies using such interventions usually found greater improvements during the first weeks of the study, but these results tend to be reduced with time.Therefore, the important effects found in our study should serve as base for the design of randomized controlled trials using therapeutic education as the main intervention, with a larger sample size, and longer follow-up to generalize our results to the entire population.
This study revealed that therapeutic group education of uncontrolled hypertensive patients in sub-Sahara Africa improved adherence to therapeutic measures such as drug compliance and physical activity resulting in a marked reduction of BP, and a great amelioration of BP control without adjunction of any additional molecule.

Figure 2 .
Figure 2. Evolutive profile of Systolic and Diastolic Blood pressures over time (T in weeks).

Figure 3 .
Figure 3. Evolutive profile of energy expenditure related to physical activity over time (T in weeks).

Table 1 .
Comparisons of medians (interquartile range) before and after.
controlled and reached the target figures for their BP control.On the other hand, diastolic BP varied from 90 mmHg to 79 mmHg decreasing by 11 mmHg (Figure2).