Severe Hepatic Sinusoidal Obstruction Syndrome during the Induction Chemotherapy of Burkitt ’ s Lymphoma

The Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease (VOD), is a well-known complication of haematopoietic stem cell transplantation, of the treatment of Wilms tumor and rhabdomyosarcoma and maintenance therapy of acute lymphoblastic leukemias. Its occurrence is rare in other cancers of the child. We report the observation of a 7-year-old girl with Burkitt’s lymphoma who developed a severe HSOS during her second induction treatment with dexamethasone, cisplatin, cytosine arabinoside. The evolution was fatal. This observation shows that the diagnosis of HSOS should not be excluded in the absence of the risk factors usually described.


Introduction
The serous hepatosis or Hepatic sinusoidal obstruction syndrome (HSOS) is due to an occlusion of the terminal hepatic venules and hepatic sinusoids.It is characterized clinically by painful hepatomegaly, hyper bilirubinemia and/or jaundice and rapid weight gain in relation to hydro-sodium retention.This frequent complication of transplantation of hematopoietic stem cells is also described during the chemotherapy of nephroblastoma and rhabdomyosarcoma.This syndrome is rare in conventional chemotherapy and in other childhood cancers [1] [2] [3].We report the observation of a 7-year-old girl who developed

Discussion
The hepatic sinusoidal obstruction syndrome is a serious disease that results from alteration of endothelial cells and hepatocellular lesions.It is characterized by clinical and biological signs related to liver damage without other identifiable causes of a liver disease [1].The pathogenesis of VOD is complex.The histological confirmation represents the gold standard of diagnosis [4].However, the risk associated with the invasive nature of liver biopsy, the perfect correlation [2].Its prevalence during transplantation in children varies from 5 to 60% with an average of 25% [5] [6].This variability depends on the conditioning treatment and the type of transplant, as well as on the diagnostic criteria used.The VOD is more frequent in allografts compared to the autografts (13% -20% vs 9-10%) and in packs using total body irradiation, The Busulfan and/or the Cyclophosphamide.The frequency is higher with the Seattle criteria than with those of Baltimore (17.3% vs 9.6%) [4] [5] [6] [7].The main risk factors reported in children in addition to myeloablative conditioning treatments and allogenic grafts are young age, pre-existing liver disease or irradiation, parenteral nutrition [5] [7].The Hepatic sinusoidal obstruction syndrome has also been described during conventional chemotherapy of nephroblastoma and rhabdomyosarcoma.The prevalence varies from 1.2% to 8% for nephroblastoma and from 1.2% to 5.3% for rhabdomyosarcoma.The Actinomycin D is the major etiological factor identified in the case of nephroblastoma; The chemotherapy with VAC treatments (Vincristine, Actinomycin D, Cyclophosphamide) and young childhood (less than 36 months) are the main risk factors for rhabdomyosarcoma [8] [9].This syndrome is also a common complication of the treatment of acute lymphoblastic leukemia using 6-thioguanine [10], whereas only isolated cases have been reported during the induction treatment of leukemia [11] [12].The SOS has been described in series of children with an autograft of hematopoietic stem cells for malignant lymphomas [13], but it is very rare during conventional lymphoma chemotherapy.We report to our knowledge the second fatal case of VOD during the induction of lymphoma.The first case published by Yamamoto and Al is that of an overweight 9-year-old child who presented central nervous system lymphoma treated with Vincristine, Cyclophosphamide, Daunorubicin, L-Asparaginase.The causal agent identified was vincristine, the risk factors for death were severity of VOD and the overweight [3].In our case the drugs re-Open Journal of Blood Diseases ceived were Cytosine Arabinoside high dose, Cisplatin and dexamethasone.Our case emphasizes the appearance of SOS outside the usual framework described.
The anti-cancer drugs may have variable liver toxicity ranging from elevated transaminases to life-threatening hepatic necrosis [14].The hepatic lesions occurring during cancer treatment may result from the combined action of anticancer agents, antibiotics, antiemetics, analgesics or other drugs.The pre-existing medical problems (hepatitis, other infections, nutritional deficiencies and parenteral nutrition) may influence the response of the host to drug toxicity [15].The SOS may result from the use of specific anti-cancer combinations [2].Kotécha et al. described a case in a child with medulloblastoma who received maintenance therapy with vincristine, cisplatin and cyclophosphamide in whom hepatic involvement was attributed to vincristine [16].Bairey  the other products concomitantly received were metoclopramide, allopurinol, dexamethasone and diazepam.The hepatotoxicity of the treatment was related to high doses of Cytosine Arabinoside [17].The VOD in our case was attributed to the combined effect of high doses of Cytosine Arabinoside and other drugs received.Several therapeutic strategies are proposed in addition to supportive care: the high-dose methylprednisolone, the antithrombin III-associated heparin, the N acetylcysteine, the Defibrotide [18].The Defibrotide is an oligonucleotide with a local anti-thrombotic affect, anti-ischemic, anti-inflammatory activity, with no significant side effects.This treatment has been shown to be effective in the management of VOD during transplantation [1] [19].The severity of VOD is a key prognostic factor; the published series report mortality rates ranging from 50 to 85% in severe forms.Three increasing levels of severity are described: the mild form (resolution of symptoms and decrease in bilirubin <34.

Conclusion
We described the observation of a child with Burkitt's lymphoma who developed a fatal SOS during induction chemotherapy.This observation shows that the diagnosis of VOD should not be excluded in the absence of the risk factors usually described.

L
. Couitchere et al.DOI: 10.4236/ojbd.2018.8100211 Open Journal of Blood Diseases a severe VOD during the treatment of Burkitt's lymphoma.

A 7 -
Figure 1.(a) and (b): Massive facial CT: voluminous tumor of the left hemiface with extension to the orbit, maxillary sinus and lysis of the mandible.

Figure 2 .
Figure 2. HE × 400: Monomorphic proliferation of medium-sized lymphoid cells with scanty cytoplasm containing a pale chromatin vesicular nucleus.Presence of macrophages, with tangible body within the cellular layers, giving a starry sky appearance.
between histology and clinical signs of hepatic dysfunction, validated the clinical diagnosis[4] [5].Criteria have been established for the diagnosis of this disease.The Seattle Criteria stipulate that the diagnosis of VOD is made in front of at least two of the signs including a jaundice, a painful hepatomegaly or ascites, and/or an unexplained weight gain occurring within 30 days after transplantation.The Baltimore criteria include an increase in bilirubinaemia of at least 2 mg/dL associated with two or more of the following signs: hepatomegaly, ascites, or weight gain of at least 5% within 21 days after transplantation[1] [4][5].The SOS is a common complication of hematopoietic stem cell transplantation[1] 2 μmol/l (<2 mg/dl) with or without specific treatment), moderate form (presence of clinical signs of progressive disease in ascites or pleurisy but without signs of multivisceral failure) and severe form (multivisceral failure, oxygen requirement, mechanical ventilation and/or renal failure and/or encephalopathy)[16] [19].
et al. reported a case of VOD that occurred during LAM induction with a combination of Idarubicin, Cytosine Arabinoside, and Etoposide.The reintroduction of Cytosine Arabinoside in consolidation did not produce another episode.The VOD was attributed to the combined effect of the toxicity of all drugs received including antibiotics and antifungals [2].Kirtley DW et al. described a fatal case in a patient with relapsing LAM, who received standard doses of cytosine arabinoside, vincristine, 6-thioguanine, daunorubicin, and developed an SOS under Cytosine Arabinoside administered in high doses;