Incidence and Predictors of Dysphagia Following Anterior Cervical Discectomy and Fusion : Prospective Observational Study

The incidence of dysphagia following anterior cervical discectomy and fusion (ACDF) reported in the literature varies due to differences in measures and time intervals applied, ranging from nearly 3/4 at 2 weeks to 13% at 12 months. The most commonly used dysphagia scales remain subjective, nonvalidated, and do not capture functional impact. Various risk factors have been identified, though few consistently reproduced and none studied in an Australasian context. The aims of this study were to use objective and validated measures, assess both traditional and novel risk factors, and determine the impact of dysphagia on dietary status, length of stay and complications. METHODS: Twenty-nine adults undergoing ACDF for degenerative pathologies were enrolled between March and November 2015 in an Australian institution. Bazaz dysphagia scale, Dysphagia short questionnaire, 3-ounce swallow test and dietary status were assessed preoperatively, and 2 days and 6 weeks postoperatively. Descriptive statistics were used to characterise the study sample and logistic regression modelling performed on risk factors. RESULTS: Dysphagia incidence ranged from 85% on day-2 Dysphagia short questionnaire to zero on 6-week 3-ounce swallow. All measures increased at 2 days and fell by 6 weeks. Failing day-2 3-ounce swallow was the only measure associated with modifications in solids (P = 0.06), showing significant linear correlation (P = 0.02). Respiratory comorbidity increased risk of failing day-2 3-ounce swallow by more than 32-fold (OR: 32.4; 95% CI: 1.8 587.7; P = 0.019) and scoring moderate or severe on Bazaz by almost 10-times (OR: 9.3; 95% CI: 0.9 95.95; P = 0.061). Psychiatric history also increased risk of failing day-2 3-ounce swallow by more than 10-fold (OR: 10.9; 95% CI: 1 123.7; P = 0.054). Failing 3-ounce swallow increased length of stay (5 versus 7 days; How to cite this paper: Li, Y., Hitos, K. Mon, S.-T., Knight, N. and Vrodos, N. (2018) Incidence and Predictors of Dysphagia Following Anterior Cervical Discectomy and Fusion: Prospective Observational Study. Open Journal of Modern Neurosurgery, 8, 132-141. https://doi.org/10.4236/ojmn.2018.81011 Received: December 30, 2017 Accepted: January 27, 2018 Published: January 30, 2018 Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access


Introduction 1.Incidence
Anterior cervical discectomy and fusion (ACDF) is one of the most commonly performed operations on the spine.While complication rates are relatively low, ACDF can be associated with specific risks, including dysphagia, leading to aspiration risk, dietary modification, and even nasogastric feeds or gastrostomy in the severest of cases.Furthermore, postoperative dysphagia has been associated with increased length of stay (LOS), readmission rate, in-hospital costs and mortality [1].Dysphagia incidence reported in the literature varies widely due to differences in measurement tools used and time intervals applied, with rates of up to 71% at 2 weeks [2], gradually decreasing but persistent in up to 13% at 12 months [3].While potentially posing the highest aspiration risk and thus providing an opportunity for early intervention, the incidence and severity of immediate postoperative dysphagia (within the first few days) remain unclear.

Measurement Tools
The most commonly used scale in the literature, the Bazaz dysphagia score [3], is subjective, remains non-validated and does not capture functional impact.On the other hand, validated questionnaires such as the quality of life in swallowing disorders survey (SWAL-QOL) [4] and the MD Anderson dysphagia inventory [5] are complex and serve mainly as research tools.While fibreoptic endoscopy and videofluoroscopy are considered the gold standards, they are invasive, expensive and labour-intensive.The Dysphagia short questionnaire is a short 5-category survey that has recently been validated in a group of patients undergoing anterior cervical surgery [6], while the 3-ounce swallow test is a simple, objective bedside tool that has been validated against fibreoptic endoscopy in a cohort of 3000 patients with varying pathologies, with a sensitivity of over 96% for predicting aspiration status [7].Neither of these tools has been used specifically in the postoperative ACDF setting.and smoking [8].Comorbid factors include psychiatric history, endocrinopathy [9] and preoperative neck pain, however, the role of more common comorbidities such as cardiovascular and respiratory disease remain unclear.Surgical factors include high-level, multilevel and revision surgery, operative duration, implant profile (plate vs. zero-profile), fusion (vs.arthroplasty) [10], overcorrection of kyphosis [11], and use of bone morphogenetic protein.However, the relative indications for zero-profile systems and arthroplasty remain unresolved.

Risk Factors
Preoperative tracheal traction exercises have been identified as potentially protective, while there is conflicting evidence regarding reducing endotracheal cuff pressure following retractor placement [12] [13].There are reports of successful dysphagia treatment by removing anterior cervical osteophytes, but not in the setting of ACDF [14].Evidence for an association with postoperative soft tissue swelling is similarly conflicting [15], though analyses have only been performed with plain radiographs.There is randomised trial evidence that systemic and local steroids reduce postoperative dysphagia [16] [17], although concerns regarding non-union remain.
The objectives of our study were to assess the incidence, severity and natural history of postoperative dysphagia in a prospective Australasian patient cohort using validated measurement tools, determine its impact on dietary modification, length of stay and complication rate, and identify risk factors and potential targets for intervention.

Patient Selection
This was a prospective study.All patients undergoing ACDF for degenerative cervical spine disease between March and November 2015 were enrolled.Patients undergoing corpectomy, revision surgery or surgery for traumatic, infectious or malignant pathologies were excluded, as were patients who reported significant preoperative dysphagia.Baseline characteristics including age, gender, smoking status, BMI and specific comorbidities were recorded.Operative details including mode of presentation (emergency versus elective, myelopathy versus radiculopathy), surgical level(s), implant used and duration of surgery were assessed.Postoperatively, hospital LOS and specific complications were also recorded.

Surgical Details
All patients at our institution underwent a right-sided approach, with the use of self-retaining retractors and distraction pins, and cage-plate system (Atlantis plate, thickness 2.

Dysphagia Measurement
The Bazaz dysphagia score, Dysphagia short questionnaire, and standardised Australian food texture and fluid viscosity scales, and the 3-ounce swallow test were administered at pre-admissions clinic, on inpatient postoperative day-2, and at 6-week follow-up.The Bazaz dysphagia score [3] categorises severity into none, mild, moderate and severe based on relative frequencies of difficulty swallowing solids and liquids.The Dysphagia short questionnaire [6] scores a patient out of 18 based on their a) ability to swallow, b) incorrect swallow, c) lump feeling, d) involuntary weight loss, and e) pneumonia.The 3-ounce swallow test [7] has the patient drink 3-ounces of water from a cup in sequential swallows without stopping.Failure is defined as inability to complete the task, or if coughing, choking or wet hoarse voice occurs during or within one minute of task completion.Standardised Australian food texture (normal, soft, minced and puree) and fluid viscosity scales (normal, mildly thick, moderately thick and extremely thick) [18] were used to assess dietary modification.Plate apposition against the vertebral body was assessed on the postoperative sagittal CT and the maximum distance between the posterior margin of the plate and the ventral vertebral surface measured in mm.
The study protocol was approved by the institutional ethics committee.All subjects gave informed consent to participation.

Statistical Analysis
Descriptive statistics were used to characterise the study sample for demographic details, comorbidities, dysphagia incidence and severity, as well as operative and postoperative details.For all data normality of distribution was evaluated using the Kolmogorov-Smirnov test with Lilliefors significance correction.Continuous data is presented as median and interquartile range (IQR, range from the 25 th to the 75 th percentile).Comparisons were made using the Mann Whitney U test for continuous data and the chi-square or Fisher's exact tests for proportions.A multiple regression model with backward stepwise (likelihood ratio) variable selection was used for dysphagia risk.Where possible odds ratios (OR) and 95% confidence intervals (CI) are presented.All analyses were performed using IBM SPSS version 22.0 (SPSS Inc., Chicago, IL, USA).All tests were two tailed and statistically significant differences were considered at the P < 0.05 level.

Patient Sample
Twenty-nine consecutive patients planned for ACDF were enrolled.Three pa-tients were excluded; two underwent non-ACDF procedures following review of their clinical status and imaging (one cervical laminectomy and lateral mass fusion, the other cervical arthroplasty), the third failed to complete the questionnaires, leaving 26 patients available for day-2 analysis.A further 5 patients were excluded from 6-week evaluation; 4 returned interstate or rurally and were lost to follow-up, the fifth was followed up privately, leaving 21 patients available for 6-week analysis.

Dysphagia Incidence and Severity (Figure 1 and Figure 2)
On day-2, dysphagia incidence ranged from as low as 31% on modified solids or liquids to 85% on Dysphagia short questionnaire.At 6 weeks, dysphagia ranged from zero on 3-ounce swallow test to 67% on Dysphagia short questionnaire.
Similarly, day-2 dysphagia severity ranged from 8% on pureed diet to 31% scoring severe on Bazaz, falling at 6 weeks to zero on pureed diet while 38% remained moderately dysphagic on Bazaz.Trends in Bazaz dysphagia scores were closely mirrored by Dysphagia short questionnaire, while dietary status was mirrored by 3-ounce swallow.There was a linear trend towards increasing number of patients on modified solid diets with increasing day-2 Bazaz severity (r = 0.95, P = 0.017) and Dysphagia short questionnaire score (r = 0.29, P = 0.049) only when the solid diet categories were combined.There was no correlation between the different measures and solid modification at 6 weeks or liquid modification at any time interval.Only 8% of patients were on a modified liquid (day-2).

Predictors of Postoperative Dysphagia
Respiratory comorbidity increased the risk of failing day-

Interaction between Dysphagia, Hospital LOS and Complications
Failing day-2 3-ounce swallow test was the only dysphagia measure associated with increased length of stay (5 versus 7 days; P = 0.013), as did suffering a postoperative complication (4.5 versus 7.5 days; P = 0.006).Cardiovascular comorbidity (40 versus 13%; P = 0.041) and emergency presentation (67 versus 17%; P = 0.017) were associated with increased complication rate, however, the four different dysphagia measures were not.

Incidence, Severity and Impact
Our study findings confirm that the incidence and severity of dysphagia following ACDF depends on the measurement tool used and time interval applied.
Knowledge of the incidence, severity and natural history of postoperative dysphagia in an Australasian cohort of patients allows clinicians to better educate, counsel and reassure patients of their expected swallowing outcomes, including in the immediate postoperative period.In our study, dysphagia rate peaked at 85% on day-2 Dysphagia short questionnaire, with 31% scoring severe on Bazaz dysphagia scale.Both incidence and severity fell over time, often to near baseline by 6 weeks.We demonstrated that while reports of dysphagia are common, particularly in the immediate postoperative period, this for the most part did not translate into dietary modification.We showed that not only is the novel 3-ounce swallow test a feasible bedside tool, it is also the tool most predictive of dietary modification and increased length of stay following ACDF.The 3-ounce swallow test could therefore potentially stratify at-risk patients, obviate the need for more invasive tests such as videofluoroscopy and fibreoptic endoscopy, and significantly impact discharge planning.

Predictors of Dysphagia
In this prospective study, the most powerful predictor of postoperative dysphagia was respiratory comorbidity, followed by psychiatric history.While psychiatric history has previously been shown to be a risk factor for dysphagia [19], this is the first time that respiratory disease has been specifically assessed.Respiratory and swallowing difficulties often coexist in the general population [20], and it is plausible that surgery may unmask an underlying predisposition to dysphagia in patients with respiratory disease.The presence of respiratory and psychiatric history may therefore identify a group of at-risk patients that may benefit from

Limitations
The maim limitation to our study was the small sample size.This may partly explain why no significant correlations were demonstrated between traditional risk factors such as high-level and multilevel surgery and postoperative dysphagia.
Furthermore, our study was performed in a single institution with relatively short follow-up, although most instances of dysphagia had resolved during follow-up.Despite these shortcomings, we were able to demonstrate statistically significant results in a prospective Australasian cohort of patients, adding to the existing dysphagia literature.

Conclusion
Dysphagia incidence and severity are highest during the immediate postoperative period, improves in the majority of cases by 6 weeks, and varies according to the measure used, with the 3-ounce swallow test most predictive of dietary modification and length of stay, independent of postoperative complication.Respiratory comorbidity posed the most significant dysphagia risk, followed by psychiatric history.The presence of either of these comorbidities, particularly if associated with failing the 3-ounce swallow test while an inpatient, may identify an at-risk group of patients who require early intervention and close follow-up.

Figure 1 .
Figure 1.Incidence of dysphagia based on the 4 different measurement tools, expressed as percentage of total patients.

Figure 2 .
Figure 2. Rates of different Bazaz dysphagia severities, expressed as percentage of total patients.

Y.
Li et al.DOI: 10.4236/ojmn.2018.81011139 Open Journal of Modern Neurosurgerypreoperative and early postoperative speech pathology and dietician intervention.A patient's respiratory or psychiatric condition should therefore be optimised prior to ACDF.The presence of inadequately controlled respiratory or psychiatric disease may influence the choice of surgical approach.Furthermore, the lack of an association between plate apposition and postoperative dysphagia, and indirectly the excision of anterior osteophytes, suggests that the pathophysiology of dysphagia extends beyond purely anatomical considerations.
Multiple demographic, comorbid and surgical risk factors have been identifiedY.Li et al.
DOI: 10.4236/ojmn.2018.81011134 Open Journal of Modern Neurosurgery in the literature, though most derived from retrospective studies, few consistently reproduced, and none studied in an Australasian context.Demographic risk factors include increasing age, female gender, high body-mass index (BMI), 95% CI: 1.0 -123.7;p = 0.054).Demographic factors such as age, gender, BMI and smoking status did not correlate with dysphagia risk, nor did cardiovascular disease or diabetes.Surgical factors such as mode of presentation, high-level or multilevel surgery, operative time and plate apposition were also not associated with dysphagia risk.