Synthesis and Characterization of 2 , 2 ’-Bipyridyl-5 , 5 ’-Dialdehyde Schiff Bases from O , S , N and F-Containing Amines

Design and synthesis of organic chelating agents containing nitrogen and sulfur as donor atoms and their metal complexes is an interesting field of research for their different types of activities. The bi-dentate N,N chelating agent such as 2,2-Bipyridal has been playing a vital role in synthetic and medicinal chemistry. 2,2-Bipyridal has been used to prepare many mixed-ligand complexes. Different ligand complexes prepared from 2,2-Bipyridyl are used in different areas such as molecular catalysis, solar energy conversion, calorimetric analysis, herbicides, molecular recognition, self-assembly, antineoplastic agents, and nucleic acid probes. Another important property of these types of compounds is the triplet state photosensitizing character of bipyridyl nucleus, which is shown in metal complexes. It is also found that compounds containing O,S,N atoms have received considerable attention because of their pharmacological studies like anticancer, antibacterial, and antitumour activities. Therefore, it has been decided to synthesize Schiff bases derived from 2,2’bipyridyl-5,5’-dicarbaldehyde compounds with O,S,N and F-containing amines and study their antibacterial properties. Several new Schiff bases have been synthesized and fully characterized by spectral data. This paper presents the synthesis and characterization of newly designed Schiff bases.


Introduction
Design and synthesis of organic chelating agents containing nitrogen and sulfur as donor atoms and their metal complexes is an interesting field of research for their different types of activities.In this case, bi-dentate N,N chelating agent such as 2,2'-bipyridyl has played a vital role in building many mixed-ligand complexes for their desired predictable co-ordination behavior and their electrochemical and photophysical properties [1]- [3].The 2,2'-bipyridyl and ligands derived from it also extensively used in different areas, such as molecular scaffolding, supramolecular assemblies, catalysis, biochemistry, electrochemistry, ring-opening metathesis polymerization and biochemistry [4]- [8], biologically photoredox reactions [9], synthetic, medicinal chemistry, biotechnology [10] and solar cell [11] [12].It has been observed that Schiff bases formed by condensation of S-alkyl/aryl esters of dithio-carbazaic acid with heterocyclic aldehydes and ketones contain both nitrogen and sulfur that are eligible to form stable complexes with a wide variety of metal ions, some of which have found to show interesting properties [13]- [15].In view of the importance of Schiff base derived from 2,2'-bipyridyl-5,5'dicarbaldehyde and O,S,N and F-containing amines in different fields, we report here synthesis and characterization of several new Schiff bases from 2,2'-bipyridyl-5,5'-dialdehyde and some sulfur, nitrogen and fluorine containing amines.

General Method and Procedures
HPLC grade solvents were used in all the reactions.The conventional method of synthesis of the Schiff bases involves refluxing the reaction mixture containing the dialdehydes and amines for 1 hour followed by filtration of the solid products using suction filtration.In all the reactions, 2 -3 drops of conc.sulfuric acid were used.The solid product that had formed was filtered off using suction filtration.All the NMR data were recorded on a 400 MHz Varian NMR Spectrometer.Mass Spectra were obtained on a Varian LC-MS with ESI.

Synthesis of Schiff Base 4 with S-Methyldithiocarbazate (SMDTC) (Scheme 2)
SMDTC was prepared following a literature procedure [18].3 equivalent of SMDTC was added to a solution of one equivalent of 2,2'-bipyridine-5,5'dicarboxaldehyde in 25 ml of methanol containing 2 -3 drops of conc.sulfuric acid.The solution was refluxed for 1 hour and then allowed to cool to room temperature.The solid product formed was filtered off and washed with methanol and dried under vacuum.The isolated yield of the product 4 was 75%.IR, ν (cm

Synthesis of Schiff Base 7 with Thiocarbazate (Scheme 5)
3 equivalent of thiocarbazate was added to a solution of 1 equivalent of 2,2'-bipyridine-5,5'dicarboxaldehyde in 30 ml of methanol.The solution was refluxed for 1 hour and then allowed to cool to room temperature.The solid product formed was filtered off and washed with methanol and dried under vacuum.IR, ν (cm 5,5'dicarboxaldehyde in 25 ml of methanol containing 2 -3 drops of con.sulfuric acid.The solution was refluxed for 1 hour and then allowed to cool to room temperature.The solid product formed was filtered off and washed with methanol and dried under vacuum (Y = 60%).IR, ν (cm

Conclusion
Eight new Schiff bases of 2,2'-bipyridyl-5,5'dialdehyde with O,S,N and F containing amines have been successfully synthesized.Conc.sulfuric addition has been found to significantly enhance the yields of the products.In some cases, sulfuric acid was not added to avoid salt formation with nitrogen and amine group.However, it was observed that the yield increased significantly when the reaction was carried out under mild aicidic conditions.This is due to the fact that protonation of the carbonyl group (C=O) enhances the nucleophilic attack -NH 2 group of the amine.
Synthesis of Schiff base 7 with thiocarbazate.