Impact of Pregnancy on the Sex Life of Women : State of the Art Liliam

Introduction: Women’s sexual function is a complex ensemble of variables that involve physical, emotional, and psychosocial states. Objective: This review aims to evaluate the evidence about the sexual behavior of women during pregnancy. Methods: Survey of PubMed for the period from 1996 to 2011 for prospective, retrospective and case-control studies, randomized clinical trials, meta-analyses and systematic reviews on the sexual function of women during pregnancy using the terms “sexual function”, “sexual dysfunction”, “sexuality”, “pregnancy”, and “pregnant woman”. Results: Changes occur in the sexual function of women during pregnancy; however, due to the heterogeneity of the studies and the incomparability of samples for lack of pairing for cultural, age, length of relationship and gestational age variables, and other methodological biases, it is not possible to characterize the sexual response of pregnant women. Conclusions: The changes observed are not sufficient to characterize sexual behavior during pregnancy as pathological. It is therefore necessary to standardize the study groups and the instruments for the assessment of sexual function, to determine the presence of distress concomitant with changes in sexual function, and to assess the sexual function of the partner and the impact of changes on the dyadic relationship before and after the gestational period.


Introduction
The last few decades have been marked by particular scientific interest in female sexual behavior [1], especially in situations such as the gestational period, which can course with an increased prevalence of sexual dysfunction [1,2].
The nature of female sexuality is complex and contextual and is correlated with mental health [3] and feelings for the partner [4,5], as well as with other factors that may modify the physical and psychological condition of a woman [2].In general population, 40% to 50% of women may experience some form of sexual dysfunction during their lifetime [6].
During the gestational period, in addition to the presence of a great hormonal impact, emotional changes may occur in life style and self-image, possibly changing the expression of sexuality and sexual behavior [7][8][9].
During the first trimester of pregnancy, progesterone is responsible for the physical and mental changes that may interfere with sexual functioning of the pregnant women.In addition, progesterone increases the sensitivity and excitability of the breasts, and promotes congestion of vulvar and vaginal tissue which may lead to dyspareunia, and provoke increased vaginal flow and involuntary urine loss, conditions that may negatively affect sex life [10].In addition, the hormone induces vasodilation and, in consequence loss of pressure levels can occur, possibly causing fatigue and the emotional changes frequently related to depressive states [10].
Psychological changes, such as emotional lability with a tendency to depression, reduced self-esteem and the feeling of being less attractive [11] are common conditions among pregnant women, which can also interfere with sexual response.This concern with body pattern was demonstrated in a recent study showing that body image is a component of satisfaction and of the feeling of comfort with one's body in front of one's partner [12].
Cultural differences and myths about sexual practice are also other factors that contribute to altering the sexual response during pregnancy [13].The orgasm, for example, courses with an oxytocin peak that stimulates contraction of the uterine fibers [14] which, although not sufficient to induce labor in a pregnancy of habitual risk, may generate discomfort and insecurity for the couple.Several studies have included fear of damage the fetus and of postcoital bleeding as factors associated with reduced sexual frequency [7,[15][16][17][18].These myths typical of each culture may also be responsible for the diverse sexual behavior of pregnant women.
A survey of the literature showed that changes appear to occur in the sexuality of pregnant women, although there is no consensus about this aspect.On this basis, the objective of the present study was to determine the possible modifications of sexual behavior in women during the gestational period.

Methods
The present literature review was based on the survey of the PubMed data base regarding studies on the sex function of women during pregnancy published from January 1966 to December 2011.The search involved prospective, retrospective and case-control studies, randomized clinical studies, meta-analyses, and systematic reviews.To this end, the following terms were used: "sexual function", "sexual dysfunction", "sexuality and pregnancy" and "pregnant woman".The survey was limited to studies conducted on humans and published in English, which used instruments and/or structured questionnaires to determine the sexual function of pregnant women.Studies that performed only qualitative analyses were excluded.A total of 1055 articles were selected.Two investigators selected the studies in an independent manner.After refinement, 24 articles that satisfied the inclusion criteria were left, and are listed in Table 1.
Cross-sectional and cohort studies were included for the evaluation of sexual function and reviews and metaanalyses were considered to compare the data of the present study.

Results
Twenty-four articles were included, 14 of them crosssectional studies, five cohort studies, one a clinical trial, three reviews, and one a meta-analysis.The Female Sexual Function Index (FSFI) was the instrument used in seven studies and was the only one used for of evaluation of sexual function in four of them, whereas it was associated with other instruments in the other three.It is interesting to note the variability of the cut-off points of the FSFI score used by the several authors.A cut-off from 26.55 to 30 was considered to indicate a risk for sexual function.The seven studies that used the FSFI revealed that sexual function declines during the gestational period, with the third trimester presenting the lowest FSFI scores regarding the cut-off points used.Only one study reported greater sexual satisfaction during the gestational period [15,[19][20][21][22][23][24].
Four studies evaluated sexual behavior using a modified version of the Pregnancy and Sexuality Questionnaire (PSQ).In a study with 141 pregnant women, Bartellas et al. [7] detected orgastic dysfunction in 34% of them.Fantasy was referred by 44% of the sample, 97% referred kissing, and 31% masturbation.In 79% of the couple sexual games was part of sexual behavior and caresses of the breast in 87%, and vaginal coitus in 86% of the women interviewed.Fok et al. [17], using a modified version of the PSQ, demonstrated an overall reduction of sexual activity in 93% of pregnant women, especially during the third trimester, although sexual games represented by breasts caresses and kissing were clearly present.A retrospective Brazilian study conducted during the immediate puerperium [25] detected higher PSQ scores for sexual desire during the third trimester among women who took the initiative in sex.
Nine studies used structured questionnaires for the evaluation of sexual function.Sexual desire remained unchanged in 60% of 500 Nigerian women who were in different gestational periods; however, coital frequency was reduced in 64% of them due to nausea and vomiting, fear of abortion, fear of fetal damage, physical limitation, lack of interest, and discomfort [26].Frequency was unchanged in 32% of them, who considered sexual relations to be important for maintaining the marital relationship and harmony.This reason was also reported by 26% of 375 pregnant women studied by Bello et al. [27].In a study of 360 Asian women, Senkumwong et al. [9] detected reduction of sexual desire with the advent of pregnancy.In the cited study, 79.7% of the pregnant women reported fear of sexual practice and of damage to the fetus.In a retrospective evaluation of puerperae performed on the day of hospital discharge, Pauleta et al. [18] observed that the first trimester was the one of highest frequency of sexual relations (44.7%) and that 55% reported a reduction of sexual frequency during the third trimester.Fear of sexual relations was reported by 23.4% of the women and sexual desire was reduced in 32.5% of them.A perception of lower attractiveness was reported by 41.5% and reduced sexual interest of the partner was reported by 24.5%.Sexual satisfaction was unchanged in 48.4% of the women.Eryilmaz et al. [16] evaluated the perception of 238 women regarding their sex life before and during pregnancy.Eighty percent of the pregnant women reported worsening of sexual funcion and 61% felt that sexual relations represented a risk t Desire, excitement, satisfaction and orgasm did not change in the 2 groups (with and without an educational action about sexuality), and there was a reduction of coital frequency in more than 90% of the pregnant women in the 2 groups.
for the fetus.The main reasons for the decline were fatigue and exhaustion and reduced desire.The time of the relationship, as well as schooling and parity, showed a significant negative correlation with the change in sexual behavior.Kamis et al. [13] studied 190 pregnant women during different gestational periods and non-pregnant women who had had at least one gestation, aged 17 to 49 years, and detected an increase in sexual desire in 37.4% of them.Forty-eight percent reported improved sexual satisfaction during the second trimester and 43.7% believed that sexual relations can affect gestation [13].Uwapusitanon and Choobun [13] prospectively evaluated 149 pregnant women using a structured questionnaire and observed that desire, excitement, frequency, orgasm and satisfaction decreased significantly throughout pregnancy [13].Dejudicibus & McCabe [28] studied 104 primigravidae aged 22 -40 years and detected reduction of sexual desire, frequency and satisfaction.Depression was a predictor of reduced sexual desire and satisfaction and a better mood was associated with better rates of sexual satisfaction.According to Gokyildiz and Beji [29], the frequency and time of intercourse and sexual satisfaction decrease with increasing gestational age.In this group, 33% of the pregnant women studied in the in the third trimester reported signs of marital dissatisfaction of the partner.

Discussion
The present review demonstrates that the most recent studies are in contrast to the first literature reports regarding the expression of sexuality and the quality of female sexual function during the gestational period.According to the work of Masters and Jonhson [30], sexual behavior of pregnant women remains unchanged during the first trimester of gestation, with improved sexual function occurring during the second trimester.
A survey of the literature revealed a wide methodological variety regarding the topic since the instruments were not always validated and most studies lacked control of important variables such as culture, age, relational aspects, and partner's sexual function, among others that may interfere with the results.Such problems may prevent studies to establish the real impact of pregnancy on women sexual functioning as well as couple's sexual functioning [31].Even so, the data show symmetry favoring a modification not only of the sexual response, but also of the sexual behavior of pregnant women that may be related to biopsychic changes commonly occurring during this period.
An abrupt change occurs in the hormonal profile of pregnant women, with an increase of prolactin levels, which acts negatively on sexual desire [14,32].On the other hand the increase in circulating estrogen and androgen [33], which is known to modulate sexual response also occur.Additionaly, the change of sexual behavior during pregnancy seems to be also influenced by the time of relationship of the couple, as well as culture aspects, age, physical changes and discomfort related to this period [7], and by the fear of fetal damage [16].
According to Johnson's study [18], changes in sexual function during pregnancy do not only affect couple's individually.Instead it may also have a negative influence on partner [34], by reducing his sexual interest and therefore affecting the interaction of the couple.This condition worsens according to the quality of the relationship, whereby marital adjustment and stability, commitment and communication between partners favor a good sexual relationship [12].In 2003, Bancroft et al. [5] reported that the main predictor of sexual problems is not linked to the physiology of the sexual response cycle, but rather to the emotional and marital satisfaction.
Age seems to be an important predictor of changes of sexual function among pregnant women, being more evident among adult women [15,22,29].Indeed, according to Basson [35], age is one of the factors involved in sexual dysfunction.However, this is still a controversial topic since a study conducted in Turkey demonstrated that age does not change sexual behavior [16].This disagree-ment, however, may express the cultural difference involved in sexual behavior in different countries.Within this context, a Nigerian study demonstrated that coital frequency did not change in 32% of pregnant women and increased in 4%, the main reason being the belief that this behavior maintains marital harmony [26].This result was reproduced in another Nigerian study which also detected an increased sexual desire [27].Also regarding cultural aspects, Chinese women did not show changes in sexual desire [17] and women that had negative body image before pregnancy improved their self-perception with the progression of gestational age [20].Previous studies had already reported that body image is a predictor of sexual satisfaction in women [12] and that sexual dysfunction is associated with a negative body image [24], with appearance being an important component of the human sexual experience [36].
According to most authors, sexual function worsens throughout pregnancy [15,19,20,23,24], with desire being the most affected phase of the sexual response [7-9, 16,17,21,26,27].A perceived tendency toward improvement of the sexual pattern occurs during the second trimester.This aspect was observed in a Brazilian study and seems to be possibly associated with the improvement of the symptoms occurring in the first trimester [22].In fact, stratification of the studies reveals that the first trimester is characterized by reduced coital frequency explained by nausea, vomiting and fear of bleeding [13,16,26,27,37].According to Kitzinger [38], the recovery of sexual function during the second trimester is due to the reduction of physical discomfort and of the fear of fetal damage experienced at the beginning of pregnancy, as well as to the increased vaginal flow which may result in greater facility in reaching orgasm [38].These data were reproduced in other studies which demonstrated a recovery of the sexual pattern in the second trimester [13,20,22,34,39].This is also explained by the fact that this is the gestational period associated to the best emotional condition due to the greater stability of pregnancy [22].Nevertheless, two studies reported that sexual satisfaction is greater during the third trimester justified by the perception of greater attractiveness of the pregnant woman during this period [13,17].However, the authors included women who were pregnant at the time of interview or had been pregnant before, and assessed women sexual functioning by using a non-validated questionnaire.Such methodological bias was also detected in other studies reviewed in the present work.
It is worth to point out that methodological limitations and biases existing in the literature may characterize the sexual changes of gestation as dysfunctions instead of considering the possibility that this behavior may simply express the appropriate and physiological changes that occur in most women [34].Although pregnancy causes changes in the female sexual behavior, it is not clear whether this represents sexual dysfunction.It is important to emphasize that a diagnosis of sexual dysfunction is based on the presence of suffering of the individual with respect to his/her sexual complaint [40].Two studies demonstrated the absence of suffering with the reduction of sexual desire [15] and satisfaction with emotional closeness [23] despite the mean FSFI score at risk for sexual dysfunction.Indeed, for many couples the birth of the child is a time of joy that renders them more susceptible to greater emotional proximity [28].For some women, marital satisfaction has a positive influence on sexual desire, with those showing better rates of sexual satisfaction having a lower decline of desire and a higher coital frequency during pregnancy [28].
An important result observed is that the literature lacks evidence about the impact of pregnancy on the sexual function of the partner.In the present review, only two studies evaluated this aspect, demonstrating that 40% of the men present reduced desire and sexual satisfaction [17] and 26.1% avoid sexual activity during the gestational period [16] for fear or due to the reduced attractiveness of the woman.
In view of the above considerations, it is clear that controlled studies are needed to assess the true impact of pregnancy on the sexual behavior of pregnant women.In order to contextualize sexual behavior during pregnancy it is mainly necessary to evaluate dyadic relationship.There are frequent reports of the importance of this aspect both regarding the safety of the practice during a pregnancy of habitual risk and regarding the preparation of couples about the changes expected during this period in order to promote marital health and well-being.Nevertheless, the lack of professional counseling to pregnant women about their sexual life has been extensively reported [7,39,41].Health professional may avoid tell women about this subject possible due to lack of knowledge about sexuality.According to Kingsberg et al. [42], both the lack of time and the formality involved in approaching this subject can impair a full assessment of sexual health.It is known that a considerable number of women would like to discuss sexuality with their doctors, but 68% of them do not express this wish for fear of causing embarrassment to the professional [43].However, a study evaluated the impact of educational intervention for pregnant women and did not detect a difference between the study and control groups.The limitation of that study was that the educational action occurred only once and only for a period of 20 minutes [37].
Thus, the difficulty of the professionals involved in prenatal care in approaching sexual function [17] frustrates the expectations of the women and fails to consider the excellent opportunity of promoting sexual health during this important period of life.
In conclusion, changes in female sex function occur during the gestational period.However, due to the heterogeneity of the studies and the impossibility of comparing samples because of lack of pairing in terms of culture aspects, age range, time of relationship and gestational age, in addition to other methodological biases, it is not possible to characterize the sexual response of pregnant women.The changes observed are not sufficient to characterize the sexual behavior during pregnancy as pathological.Thus, it is necessary to standardize and instruments for the assessment of sex function, to determine the presence of distress concomitant with changes in sex function, to assess the partner's sexual function and the impact of the changes on the dyadic relationship before and after the gestational period.