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< T in ABCB1 and 825T > C in ABCC1\), \(3435C > T in ABCB1 and -15281_-15278CTCT > delete in ABCB11\), and \(825T > C in ABCC1 and -15281_-15278CTCT > delete in ABCB11\) were significantly associated with HCC. The present study suggests that genetic variations of ABC transporters such as ABCB1, ABCB11, and ABCC1 are associated with susceptibility to develop HCC, implying that aberrant hepatic clearance of toxic substances may increase the risk of hepatocarcinogenesis. Further studies of how these polymor-phisms are associated with phenotypic differences are warranted.)/Author(Minoru Fukuda, Yasutsugu Kawahara, Takeshi Hirota, Setsuko Akizuki, Shigeto Shigeto, Hisato Nakajima, Ichiro Ieiri, Akihiro Ohnishi)/CreationDate(D:20100925145451+08'00')>>
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