Rare Antenatal Fetal Malformations of the Anterior Abdominal Wall in Mali: About a Case

Abdominal wall malformations correspond to a wide spectrum of congenital anomalies that are due to a defect in the closure of the anterior abdominal wall and can be fatal. We report the case of laparoschisis associated with a poly malformation syndrome in the same fetus at the reference health center of commune III of the district of Bamako. The objective is to clarify the interest of antenatal ultrasound in the diagnosis and prognosis of these malformations. It was a 19-year-old prim gravid woman received as part of the prenatal check-up. Antenatal ultrasound had allowed the diagnosis of mal-formation of the anterior abdominal wall of the gastroschisis type associated with abnormalities of the neural tube, the urogenital system and the bone skeleton. The antenatal diagnosis of the malformations had motivated the realization of a therapeutic termination of pregnancy at 19 weeks of ame-norrhea and 3 days by triggering and vaginal delivery, allowing the confirmation of the diagnosis of gastroschisis and the poly malformation syndrome which is extremely rare. Antenatal ultrasound remains an ideal means of imaging for monitoring pregnancy and had made it possible to make the prognosis and antenatal diagnosis of multiple malformations in association, and to indicate better therapeutic decision-making.


Introduction
Laparoschisis, also called "gastroschisis", are congenital anomalies characterized by a defect in the closure of the abdominal wall of the fetus, associated with an exteriorization (hernia) of part of its abdominal viscera [1] [2]. There is no membrane surrounding the intestines. These malformations require specialized care at birth and surgery to reintegrate the viscera into the abdomen. But the association with a poly malformation syndrome is extremely rare and constitutes a bad factor [1] [2] [3]. It is estimated between 1.7 and 3.6 out of 10,000 births and the young age of the mother is an important risk factor. The risk of having a child with this malformation is 16 times greater before age 20 than at age 30, there are also environmental factors [2] [3] [4]. According to Public Health France, in the six French registers of congenital anomalies, over the period 2011-2015, omphalocele concerned between 3.8 and 6.1 births out of 10,000 and gastroschisis between 1.7 and 3.6. births per 10,000 [2]. We report a case of laparoschisis associated with a poly malformation syndrome in a fetus, one of the first described in Mali with the aim of clarifying the interest of antenatal ultrasound in the diagnosis and prognosis of fetal malformations.

Observation
It was a young 19-year-old woman received as part of the prenatal consultation, first ultrasound. The patient had no medical and surgical history. The examination was carried out at the radiology department of the reference health center of commune III of the district of Bamako in Mali using a GE (General Electric) type device (General Electric) brand LOGIQ P3 with color Doppler equipped with 3 multi-frequency probes ( convex, endovaginal and barrette) and put into service in 2008. Obstetric ultrasound performed with the convex probe (2)(3)(4)(5) found: a defect in the closing of the anterior abdominal wall with herniation of the viscera floating freely in the liquid amniotic (liver, gallbladder, intestines and stomach) whose neck was 31 mm in diameter. This is associated with moderate dilation of the right lateral ventricle at brain level ( Figure 1).
Discovery also in antenatal ultrasound of other malformative abnormalities of the bony skeleton such as exaggeration of the dorsal kyphosis with lumbar hyperlordosis, of the urogenital apparatus of the type major dilation of the pyelocalicielles cavities of the two kidneys without visualization of the bladder ( Figure 2).
The heart rate was normal estimated at 147 beats/minute; the amniotic fluid was of an acceptable quantity with the presence of linear fibrous tissue related to the amniotic band ( Figure 3). The umbilical Doppler made it possible to find the umbilical vessels at the level of its base of implantation close to the viscera but not in the same plane ( Figure 4).
All three segments of upper limbs and lower limbs were visible. The sex of the fetus was female. Despite the presence of the semiology of gastroschisis described Open Journal of Medical Imaging    above, we also thought we had eliminated a ruptured omphalocele. And the presence of the polymalformative syndrome grouping the anomaly of the brain, the bony skeleton and the urogenital system, a decision to terminate the pregnancy was taken. The interruption was made by induction and vaginal delivery which confirmed with certainty the laparoschisis associated with a poly malformation syndrome and the visibility also of the position anomalies of the right foot and the left hand ( Figure 5).
The evolution was favorable for the mother who is doing well. And the fetus was dead seconds after delivery.

Discussion
Socio-epidemiological characteristics: Laparoschisis is a rare malformative pathology affecting 1.6/10,000 live births in France in 2015 [5] [6]. It is defined as the issue of free viscera in the amniotic fluid by a parietal defect most often right latero-umbilical. It is most often made up of small bowel or colonic loops but can sometimes include the externalization of other organs such as the liver or the stomach [5] [7]. Our case is one of the rare malformative anomalies discovered in our service. Its frequency is increasing and is thought to be linked to the action of a teratogen on the embryonic mesenchyme preventing normal closure of the anterior abdominal wall [1] [8]. Gastroschisis is often isolated and not associated with chromosomal abnormalities and seems to be linked to young maternal age and teratogenic factors [9]. Our patient was really young 19 years old but without environmental factors (no tobacco or cocaine). Exceptionally, other associated malformations have been found, which one of the first in the literature is.
Radiological characteristics: In gastroschisis, ultrasound shows several herniated intestinal loops through a right Para umbilical orifice not covered by a  [5]. The umbilical cord is normally inserted at the left edge of the parietal orifice [10]. In our case, we had great difficulty in highlighting the implantation base of the umbilical cord, which is why the idea of a ruptured omphalocele was discussed and especially the presence of the poly malformation syndrome. The omphalocele is a midline opening of the anterior abdominal wall involving muscle and skin [1] [11]. The herniated organs, intestinal loops and sometimes stomach and liver, are covered by a sac which is continued by the umbilical cord [12]. The loops, stomach and liver floated freely in the amniotic fluid without being covered by a membranous sac in our case. The omphalocele presents on antenatal ultrasound as an anterior midline mass of the abdominal wall with sharp outlines, surrounded by a membrane, containing the intestines and sometimes the stomach and the liver [10].
Certain sonographic aspects allow better definition of the contents of the malformation: the intestine is more hyper echoic than the hepatic parenchyma, the umbilical vein bypasses the herniated viscera when it is only a question of intestines and remains median through the parietal opening to the top of the omphalic sac, when the liver is herniated due to its intrahepatic course [12].

Conclusion
Laparoschisis or gastroschisis associated with other malformations are rare. It can be confused with ruptured omphalocele. Antenatal ultrasound had made it possible to make a precise diagnosis by eliminating the ruptured omphalocele. It had made it possible to indicate a therapeutic decision-making by termination of pregnancy by triggering and thus allowing the confirmation of the diagnosis of certainty of gastroschisis and poly malformation syndrome. Antenatal ultrasound is still the best imaging examination for diagnostic, prognostic and therapeutic management during pregnancy.

Informed Consent
The patient and her husband gave their informed consent for the scientific publication.