Lumbar Spondylolisthesis in Rheumatological Practice in Lome (Togo): Frequency and Semiological Profile

Objectives: To determine the frequency, the clinical and radiological features of lumbar spondylolisthesis in a rheumatological practice in Lomé. Patients and methods: This was a cross-sectional study conducted in the rheumatology department of the Sylvanus Olympio Teaching Hospital in Lomé between January 1997 and December 2019. Medical records of patients with symptomatic spondylolisthesis with radiographic confirmation were reviewed. The Meyerding classification system was used for grading. Results: Of the 350 patients contacted, 118 consented to participate in the study, making a response rate of 33.71%. Of the 118, 104 (88.1%) were females. 109 (92.4%) presented with radicular pain and 9 (7.6%) presented low back pain. The mean age of the patients was 54.24 ± 11.19 years. The average duration of the pain was 4.56 ± 1.32 years. The spondylolisthesis level most involved was the L4 L5 (92/118), followed by L5 S1 (23/118). 106 (89.8%) patients had anterolisthesis only, seven (5.9%) combination anterolisthesis and retrolisthesis. The spondylolisthesis was associated with spondylosis in 110 (93.2%) patients. Spondylosis was found at level L4 L5 in 38.98% patients, followed by L5 S1 (24.58%), L3 L4 (18.64%). Grade I slip was found in 108 (91.53%) patients and Grade II slips 10 (8.47%). Isthmic lysis was found in 40 (33.9%) patients and it was located at L4 in 30 (75.0%). Conclusion: Lumbar spondylolisthesis appears to be expected in Lomé patients with nonspecific back pain and mainly affects females. How to cite this paper: Tagbor, C.K., KoffiTessio, V.E.S., Houzou, P., Fianyo, E., Kakpovi, K., Amegan-Aho, K.H., Oniankitan, S., Atake, A.-E., Adjenou, V., Oniankitan, O. and Mijiyawa, M. (2022) Lumbar Spondylolisthesis in Rheumatological Practice in Lome (Togo): Frequency and Semiological Profile. Open Journal of Rheumatology and Autoimmune Diseases, 12, 21-28. https://doi.org/10.4236/ojra.2022.121003 Received: October 17, 2021 Accepted: January 3, 2022 Published: January 6, 2022 Copyright © 2022 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access


Introduction
Spondylolisthesis is the slippage of one vertebral body, with its pedicles, transverse and superior articular processes with respect to the adjacent vertebral body [1]. It may remain asymptomatic and only diagnosed accidentally, but often, it causes excruciating low back pain by fatigue and sciatica [1]. Sometimes, there may be lumbosacral radiculopathy syndrome and spinal stenosis in long term [1]. Conventional radiography is the first-line investigative approach in diagnosing degenerated discopathy since it is easy to do, cost less, and provides valuable information [2]. Spondylolisthesis is common, affecting 3% to 5% of the world population [2]. Degenerative lumbar spondylolisthesis is a common cause of low back pain, affecting about 11.5% of the United States population [3]. The prevalence is 6% in France, with the black population being affected the most [4]. There are limited published studies on spondylolisthesis in Africa despite the importance of the pathology. In Togo, spondylolisthesis is a risk factor for lumbar spinal stenosis in 3.2% of the cases [5]. This study was undertaken to add to the limited published local data on lumbar spondylolisthesis. The primary purpose of this study was to determine the frequency, the clinical and radiographic features of lumbar spondylolisthesis in Togolese patients.

Patients and Methods
A cross-sectional study conducted on the medical records of patients with symptomatic spondylolisthesis with radiographic confirmation diagnosed between January 1997 and December 2019 in the Rheumatology department of the Sylvanus Olympio Teaching Hospital and at the Clinic Autel d'Elie, in Lome, Togo. All out-patients and in-patients at admission in the rheumatology department who suffered from non-specific low back pain and had performed x-ray showing spondylolisthesis during the study period were included. All patients suffering from non-specific low back pain without radiography; and patients with radiography and who were unable to perform the new digital radiography at Clinic Autel d'Elie were excluded. The medical records were reviewed for patients' clinic identification and telephone numbers, demographics, date of symptom onset, date of initial presentation, pain characteristics, and physical examination findings, and radiography features (forms, types, grades, and presence of isthmic lysis and discopathy).
Firstly, a total of 450 patients with non-specific low back with or without spondylolisthesis on plain x-ray were selected. Of the 450 patients only patients, only 350 patients had available telephone contact and were called to participate in the study. Secondly (fundraisings), project work requests for financial support were duly drafted and sent to the various state companies in the country. Of the 350 patients contacted by telephone, only 118 (33.71%) were finally studied. The 118 patients were asked to undergo digital radiography within three months in the Clinic Autel d'Elie a private clinic specialized in medical imaging and located 14 miles from the Sylvanus Olympio Teaching Hospital. The same radiologist reviewed all images to ensure uniformity in interpretation. The study covered all expenses. The Meyerding classification system was used for grading [6] [7]. The data was collected using Epi info7.0, and statistical analysis was performed using STATA/IC 11.0. This research was approved by the ethics committee affiliated to the teaching hospitals and the Director of the Sylvanus Olympio teaching hospital. Patients' verbal consent was required before the publication.

General Characteristics of the Population Studied
Of the 118 patients studied, 104 were females (88.14%) and 14 males (11.86%). The sex ratio was 0.13. The mean age of the patients at the time of digital radiography was 54.24 ± 11.19 years (range: 27 and 76 years). The mean age of the patient at the onset of pain was 49.13 ± 12.38 years.

Clinical Characteristics of the Studied Population
Radicular pain was the most typical symptom (109/118 patients) ( Table 1). The

Radiographic Characteristics of the Study Population
One hundred six patients (89.83%) presented with antero-listhesis ( Table 2)

Discussion
In this study, we described the clinical and radiological semiology features of lumbar spondylolisthesis in 118 Togolese patients. Similar studies are scanty in Sub-Saharan Africa. In this study, there was a female predominance (sex ratio 0.13), and the mean age of the patients was 54.24 years. The main symptom was radicular pain (92.4%), and the average duration of the pain was 4.56 years. Spondylolisthesis predominated at the L4 -L5 level (77.97%). Most patients (89.83%) presented with antero-listhesis, and 110 (91.53%) patients had Grade I slip. The isthmic lysis was seen in 40 patients (33.9%). One hundred and ten patients (93.2%) had spondylosis on digital radiography. This study was limited to patients seen in the department of rheumatology of the Sylvanus Olympio teaching hospital; and who underwent radiography. This study population does not represent all patients seen in other rheumatology departments in Togo, nor patients who may be found with spondylolisthesis accidentally on radiography. Moreover, the response rate of 33.71% was low making the findings of this study not generalizable to the entire population of patients with spondylosis in Togo.

General Characteristics of the Population
A female predominance was noted in this study with a sex ratio (male/female) of 0.13. This sex ratio is similar to that found in Congo [8], in Cameroun [9], in South Korea [10] but is in contrast with the findings of Xao Xu et al. [11] and Michaud P. [12] that showed a male predominance. The mean age of the patients of 54.24 years in this study approximates those in the studies carried out in Cameroun [9], in Gabon [13], in China [11] [14] and is in keeping with international literature in which degenerative spondylolisthesis occurs only after the age of 40 years [6] [15]. Contrary to degenerative spondylolisthesis, patients with lumbar and sacral dysplastic anomalies present at a relatively younger age with spondylolisthesis as reported in Niger [16] and in China [17]. In these cases, there is an associated development of the lumbar lordosis in the standing position, causing the patient to find an equilibrium which at term leads to isthmic lysis and possibly to spondylolisthesis [15] [18] [19] [20].

Clinical Semiology
In our study, the main symptom at presentation was radicular pain which was found in 92.4% of patients. This is similar to the report by Sanoussi et al. [16] in Niger. Radicular pain is related to isthmic lysis due to the formation of lateral recess stenosis or Gill fragments [21]. In the absence of isthmic lysis, radicular pain is explained by the appearance of a narrowing of the spine [22]. The average duration of the pain in our study was 4.56 years, similar to the studies conducted in China [17] and Niger [16]. The average walking distance observed in the patients of our study was 395.29 meters. This is comparable to reports from Greece [20] and Niger [16].

Radiographic Semiology
Spondylolisthesis was located at the level of L4 -L5 in 77.97% of patients in our study, and this is in keeping with findings from a similar study conducted in China [14] and in Europe [23]. These results reinforce the data from the literature on the site of spondylolisthesis [6]. In comparison, another study in China [16] found a high frequency of L5 -S1 spondylolisthesis in 59.09% of patients.
Spondylolisthesis was grade I in 91.53% of patients in our study, much higher than the 50% reported in a study conducted in Niger [16]. These results are different from the studies of Michaud [12]; and the studies of Zhang W et al. [17], and Gelalis ID et al. [20]. These contrasts could be explained by the fact these studies were carried out in the surgical departments where only patients with C. K. Tagbor et al.
high grades spondylosis were assessed for surgical intervention. The isthmic lysis was notified in 33.9% of the patients of our study. Degenerative spondylolisthesis is found 93.22% patients. These results are close to those of the studies carried out in Seoul [10].

Conclusion
This study shows that spondylolisthesis is a common pathology in rheumatological practice in Lomé and is most often responsible of radicular pain. Its clinical features were noted in the fifties years and affected most females. Spondylolisthesis is mainly located in the L4 -L5 stage with a predominance of Grade I. The isthmic lysis, commonly found at the fourth lumbar vertebra is rare with spondylolisthesis.