Pregnant-Postpartum Women with Severe Epigastric Pain and HELLP Syndrome: A Highly Dangerous Combination

OBJECTIVE: HELLP syndrome is a severe preeclampsia spectrum disorder diagnosed when laboratory evidence of hemolysis, liver dysfunction and thrombocytopenia are present. The presence of epigastric pain with laboratory criteria for HELLP syndrome may indicate higher maternal-fetal risk. Thus we explored maternal outcomes in 42 pregnant/postpartum women that had HELLP syndrome by laboratory criteria in addition to sudden severe epigastric pain. METHODS: A database was constructed from the medical files of all patients with medical/hypertensive disorders evaluated by the first author from 1986-2015 for medicolegal purposes. All patient files of women who presented to their physicians with a diagnosis of presumptive HELLP syndrome were examined. RESULTS: Fifty-eight pregnant/postpartum women fulfilled study inclusion criteria; they presented to physicians for evaluation usually in non-tertiary care hospital settings. Clinical presentation and care including lab data and details of pregnancy outcome were evaluated. A correct diagnosis of HELLP syndrome was verified for 42 women (72.4%); others were determined to have AFLP-Acute Fatty Liver of Pregnancy (n = 8) or TTP-aHUS-Thrombotic thrombocytopenic purpura-adult/atypical hemolytic uremic syndrome (n = 8). All 42 HELLP women (100%) in our cohort had severe epigastric pain. Treatment modalities for maternal HELLP syndrome included magnesium sulfate (n = 35, 83%), antihypertensives (n = 17, 40%); corticosteroids (CORT) for HELLP were not utilized. Major maternal morbidity (21 strokes, 9 liver ruptures/hematomas) affected 41 HELLP women (98%); 22 died, 7 were permanently disabled. CONCLUSION: HELLP syndrome patients presenting with sudden, severe epigastric pain in this highly selected cohort experienced very high maternal morbidity and mortality. Laboratory evidence of HELLP syndrome in association with epigastric pain is a How to cite this paper: Martin Jr., J.N. and Tucker, J.M. (2021) Pregnant-Postpartum Women with Severe Epigastric Pain and HELLP Syndrome: A Highly Dangerous Combination. Open Journal of Obstetrics and Gynecology, 11, 1081-1091. https://doi.org/10.4236/ojog.2021.118101 Received: July 22, 2021 Accepted: August 27, 2021 Published: August 30, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/


Introduction
Four decades ago, Dr. Louis Weinstein proposed the acronym "HELLP syndrome" to characterize a special group of pregnant or postpartum patients with a severe preeclampsia-spectrum disorder characterized by laboratory evidence of hemolysis, elevated liver enzymes and moderate to severe thrombocytopenia [1]; epigastric pain was not a criterion then for the diagnosis nor had it become a criterion in the intervening years (ACOG 2013(ACOG , 2020. Over time controversy about HELLP has persisted with regard to diagnostic criteria [2] [3], systems of classification [4] [5] [6], and recommendations for treatment [7] [8] [9] [10]. As a unique and infrequent form of preeclampsia, HELLP presents a diagnostic and therapeutic challenge to clinicians and a challenge also to investigators wanting to undertake large randomized prospective clinical research trials. To date there has not been a large multicenter trial in the United States to rigorously study various proposed treatments for HELLP syndrome patients such as potent glucocorticoids (CORT), especially with stratification of results based upon composite severity of disease expression such as comparing patients with severe epigastric pain to those with milder asymptomatic, "laboratory abnormality only" HELLP syndrome. Almost four decades after the acronym HELLP was formalized, the most recent meta-analysis of worldwide prospective trials comparing potent corticosteroids (CORT) versus matched controls as principal therapy for HELLP was able to aggregate only 22 qualifying studies [11] [12]. These were not separated for analysis according to the presence or absence of severe epigastric pain in the study subjects.
Novel research methodologies such as maternal morbidity/mortality reviews that aggregate statewide and national data of infrequently occurring conditions, or aggregations of medicolegal case analyses that are properly deidentified to protect patient confidentiality, can be used to assess the impact of various therapies on diseases and disorders notwithstanding their inherent risk of selection bias. Both of these approaches to the study of infrequently occurring specific maternal complications or diseases can provide worthwhile information both for clinicians and researchers.
Our purpose in this retrospective investigation was to explore maternal-fetal outcomes in a large previously unreported 1986-2015 cohort of women with presumptive HELLP syndromes that were managed by obstetrician-gynecologists practicing mostly in diverse hospital settings in the United States which thereafter led to litigation related to causation and appropriateness of rendered care. Maternal-perinatal outcomes were assessed with regard to accomplishing timely and safe delivery employing various therapies that have been advocated for women with this disorder.

Materials and Methods
Over three decades between 1986 and 2015 the first author was independently retained to critically evaluate for medicolegal defense purposes 161 medicolegal files of patients that experienced medical or hypertensive disorders of pregnancy. After all legal activities involving each case were concluded, all legal documents and communications were shredded and only the de-identified medical record materials were retained in locked cabinets for possible later review, study and/or use in teaching exercises. Among the 161 confidential, privately maintained and HPPA-compliant protected medical record files were 58 women that had a probable diagnosis of presumptive HELLP syndrome at initial presentation; each was reviewed for possible inclusion in this investigation. Subsequently 8 women were determined to have AFLP (acute fatty liver of pregnancy) and 8 others had either TTP (thrombotic thrombocytopenic purpura) or adult/atypical HUS (hemolytic uremic syndrome); the findings with these 16 women have been published previously and are not addressed in the present report [13] [14].
Following detailed file review and data extraction from the remaining 42 study subjects that met HELLP diagnostic criteria, a clinical summary for each woman was prepared including details of presentation, clinical findings, lab results, surgeries, interventions, complications, and maternal-fetal/newborn outcomes.
Careful attention was given to details of the three principal therapeutic interventions proposed for patients with HELLP syndrome: magnesium sulfate by infusion, antihypertensive therapy to minimize severe systolic hypertension, and corticosteroid (CORT) administration either for fetal and/or maternal indication(s) [15]. In some instances there was enough data to accurately determine a time course between onset of some signs/symptoms and later outcomes. Data extraction accuracy was verified by both authors; no other persons had access to these confidential medical records.
Categories of major maternal morbidity included intracranial hemorrhage (ICH), cerebral edema, cerebral venous thrombosis (CVT), eclampsia/eclampsia like convulsion, sustained severe systolic hypertension (SSH), placental abruption, acute pulmonary edema, acute kidney injury (AKI), acute liver rupture/hemorrhage, disseminated intravascular coagulation (DIC), cardiac dysfunction or failure, and indicated blood/plasma/platelet transfusion. Once the initial reviews and data sheets were completed for each study subject, simple descriptive basic statistical analysis was undertaken; the information was reviewed confidentially by the second author to assure accuracy of the recorded findings.

Results
Comprehensive medical information was present for all 42 study subjects. Mean maternal age was 29 years (range 16 -43 years); 62% were nulliparas, 38% were parous. There were 25 White, 11 Black, 1 Asian and 4 Hispanic women. Mean gestational age at delivery was 34 2/7ths weeks (range 23 -40 3/7ths); 21 were ≤34 weeks' gestation at the time of hospital admission. All 42 women in the cohort (100%) experienced epigastric pain usually described as severe and sudden in onset. Laboratory testing obtained immediately after epigastric pain was first reported revealed a mean platelet count of 122,400/ul (range 67,000 -192,000/ul) and a mean AST level of 315 IU/L (range 31 -2771 IU/L). Subsequently the platelet count nadired in the Class 1 HELLP range of ≤50,000/uL in 29 women and in the Class 2 HELLP range of >50,000 -≤100,000/uL for 9 women; classification was indeterminate in four.
As shown in the accompanying Table 1 Consistent with prior reports showing that patients with HELLP syndrome as opposed to those with TTP/aHUS exhibit low LDH to AST calculated ratios, the mean LDH to AST ratio for our cohort was 2.1 to 1 [16] [17].
Magnesium sulfate was utilized for 35 of the 42 HELLP women in the study cohort (83%); in 3 others it was begun after eclamptic convulsion or other complication(s) developed. Antihypertensives were utilized in 17 women (40%; 51% of 33 with severe systolic hypertension or SSH) without achieving effective blood pressure control as assessed against ACOG guidelines in place since 2011 [18]. CORT was not a component of HELLP therapy for any women in our cohort. Open Journal of Obstetrics and Gynecology (24%) and 9 had liver hematoma/ruptures (21%) (see Table 1). Platelet counts obtained immediately preceding detection of a liver rupture/hematoma in the 9 affected women ranged between 167,000/ul and 17,000/ul, always in association with epigastric pain. Two women had shock-induced hypoxic brain and multiple organ injury, one had sepsis and one had uterine rupture. Transfusion was required in 31 of 38 patients (82%) or 31 of 42 (74%) for the entire cohort; chart information was missing to fully assess this factor in four members of the HELLP cohort.
Mode of delivery was cesarean in 31 (74%); 6 of 8 women with postpartum-onset HELLP syndrome delivered vaginally as did 3 women with stillbirths in the antepartum-onset group. There were 7 stillbirths and 1 early neonatal death due to extreme prematurity. Maternal outcome was death for 22 mothers (52%), permanent disability for 7 others (17%), and 13 (31%) survived the HELLP syndrome pregnancy medically intact.

Discussion
Almost four decades after the first report of the acronym "HELLP Syndrome" to facilitate identification and improved treatment of mothers suffering this potentially morbid or mortal complication of pregnancy, debate continues regarding optimal therapy for these women. A substantial number of women with "laboratory evidence only" of HELLP syndrome do not develop epigastric pain; they usually recover spontaneously following delivery/uterine evacuation and the provision of excellent medical (prevention of sustained severe systolic hypertension) and obstetric (timed delivery, magnesium sulfate, FLM steroids for preterm pregnancy) care. Most published patient series do not specify if epigastric pain were present or absent nor is data analyzed according to the presence or absence of this important reflector of disease severity. Because for many decades in the United States it has been taught that the presence of epigastric pain suggests the presence of HELLP syndrome until proven otherwise, the physicians caring for many of these study subjects obtained HELLP laboratory studies. Based on the very high major maternal morbidity and maternal mortality experienced by the 42 women with HELLP syndrome in this cohort, all of whom presented with severe epigastric pain, it seems likely that the presence of this significant symptom identifies a subset of HELLP patients who are at much greater risk of morbidity and mortality compared to asymptomatic HELLP patients.
We emphasize that 100% of our HELLP cohort experienced sudden, severe epigastric pain consistent with an acute attack on maternal hepatic structure/function. This was uniformly followed by rapidly deteriorating laboratory indices reflecting HELLP syndrome progression usually to merit classification as class 1 HELLP disease. Importantly, not all patients evidenced full criteria for HELLP syndrome at the time of epigastric pain onset but it always followed soon thereafter. Unless epigastric pain historically was present for longer than 4 hours prior to admission in our patient cohort, the initial platelet level obtained was usually not yet below 100,000/uL although AST was ≥70 IU/L. Therefore the finding of a platelet count > 100,000/uL in a patient with very recent onset of epigastric pain and signs and symptoms consistent with a diagnosis of preeclampsia should not confuse the clinician into ruling out the probable diagnosis of HELLP syndrome. Importantly the finding of an AST level ≥ 70 IU/L was reliably present in all patients of this cohort even if the platelet count had not yet descended below 100,000/ul.
Liver hemorrhage and rupture can occur before platelets decrease below the 100,000/ul threshold early in the development of HELLP Syndrome, consistent with the finding that some of our patient cohort with severe epigastric pain initially had platelets counts briefly above 100,000/ul. [19] Specifically, platelet counts obtained immediately preceding detection of a liver rupture/hematoma in the 9 women of our HELLP cohort with this complication were recorded at 167,000/ul, 109,000/ul, 80,000/ul, 78,000/ul, 51,000/ul, 49,000/ul, 24,000/ul, 20,000/ul and 17,000/uL always in association with epigastric pain. Thus platelet count per se does not help in determining likelihood of detectable liver bleeding or frank hepatic rupture nor does the sudden development of severe epigastric pain guarantee the presence or subsequent development of macroscopic hepatic hemorrhage or rupture. The potential use of routine hepatic ultrasound examination of patients with epigastric pain/HELLP syndrome probably deserves more study and physician consideration since it might facilitate liver integrity and injury evaluation in these mothers [20].
In our cohort of very ill HELLP patients with epigastric pain, it appears that intravenous magnesium sulfate alone was insufficiently effective monotherapy. There were no maternal deaths, no liver ruptures and no strokes. Moreover, two recent meta-analyses of CORT versus placebo [11] [12] found 1) significant improvement in HELLP laboratory markers, 2) less indicated blood transfusion and 3) shorter length of intensive care for CORT-treated HELLP patients.
Since mean blood pressure was also significantly reduced in the almost 800 CORT-treated patients compared to matched controls in the two recent meta-analyses [11] [12], it is possible that routine CORT use in our 42 HELLP cohort also might have reduced hypertension severity and stroke occurrence. The high incidence of stroke, liver injury, acute pulmonary edema and placental abruption likely is interrelated with uncontrolled SSH as well as the absence of CORT therapy in our HELLP cohort. The reported significant reduction in maternal blood pressure in CORT-treated mothers [11], especially severe elevations in blood pressure, likely is integral to risk reduction for stroke in HELLP patients treated with these medications [21] [25] [26].

Summary
In summary, HELLP Syndrome is an obstetric emergency which poses a significant threat to safe motherhood [5]. The findings summarized in the present report provide compelling evidence of the danger posed for pregnant and postpartum women by HELLP syndrome especially when manifested by severe epigastric pain. HELLP syndrome associated with sudden, severe epigastric pain appears to identify patients at very high risk to develop severe maternal morbidity and mortality [4]. Less than 100% utilization of magnesium sulfate and inadequate/ineffective antihypertensive therapy to control SSH are factors contributory to the very high maternal mortality and major maternal morbidity experienced by the 42 women in our cohort, likely aggravated by the absence of CORT therapy. Because significant liver pathology can be demonstrated very early in the development of HELLP syndrome soon after the beginning of severe epigastric pain, early initiation of CORT therapy likely is important before clinically evident brain, liver or other pathology develops [19] [26]. Prospective randomized clinical trials of various therapies including the early initiation of CORT for patients with HELLP syndrome, which do not distinguish between those with or without epigastric pain, may fail to identify benefit attributable to CORT. For the future it will be important to separate these two patient groups in order to improve our research and our practice.

Confirmed
Each author has confirmed compliance with the journal's requirements for authorship. The authors received no financial support for this undertaking. Neither has any potential conflict of interest. The first author prepared the original manuscript which the second author critiqued. This information has not been presented to a professional meeting nor is it under consideration for publication elsewhere.