A Syndrome of Vitamin D3 Deficiency/Fibromyalgia/Hyperparathyroidism Mimicking Rheumatoid Arthritis, a Clinical Prospective Study

Objectives: Rheumatoid arthritis is sometimes misdiagnosed for other diseases, like psoriatic arthritis, erosive OA, viral arthritis, reactive arthritis, IBD arthritis, Lyme’s disease, and palindromic rheumatism. Secondary hyperparathyroidism was not included in the differential diagnosis of RA, though it sometimes presents with joint pains and tenderness, and even arthritis. Fibromyalgia is a psychosomatic disorder characterized by chronic widespread pain and tender areas. Mimicry of some manifestations of these diseases sometimes results in misdiagnosis as RA. Methods: Two hundred patients previously diagnosed as RA from outpatient clinics in Al-Azhar Faculty of Medicine, attended as not responding to medical treatment of RA. All patients were subjected to a re-evaluation of disease activity including HAQ, and DAS 28, CDAI, and SDAI. Also, we measured serum vitamin D3, PTH, total and ionized Calcium, Phosphorus, Uric acid, ACPA, and other routine lab. All patients were exposed to various radiological imaging modalities. Results: Cases not responding to RA treatment were reevaluated and were found to have a syndrome of fibromyalgia associated with vitamin D3 deficiency and secondary hyperparathyroidism. Conclusions: Fibromyalgia/Hyperparathyroidism syndrome is an underdiagnosed disease, which results from chronic vitamin D3 deficiency. SHPT can cause bone erosions, which are mostly shaggy in appearance and distributed in the radiocarpal, radioulnar, metacarpophalangeal and distal interphalangeal joints, in contrast to that which predominate proximal IP joints of rheumatoid arthritis. Radiology of FM/HPT syndrome patients revealed a sign of spur-like excrescences in terminal finger tufts unilaterally or bilaterally, which we think is pathognomonic. How to cite this paper: Elbeialy, A., Bauomi, A., Elnaggar, B. and Elzomor, H. (2021) A Syndrome of Vitamin D3 Deficiency/Fibromyalgia/Hyperparathyroidism Mimicking Rheumatoid Arthritis, a Clinical Prospective Study. Open Journal of Rheumatology and Autoimmune Diseases, 11, 79-88. https://doi.org/10.4236/ojra.2021.112010 Received: April 21, 2021 Accepted: May 24, 2021 Published: May 27, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/


Introduction
Secondary hyperparathyroidism (SHPT) is the medical condition of excessive secretion of parathyroid hormone (PTH) by the parathyroid glands in response to hypocalcemia, with resultant hyperplasia of these glands. Chronic kidney failure is the most common cause of SHPT due to failure of kidneys to not convert enough vitamin D2 to its active form D3, and hence to not adequately excrete phosphate. When this happens, insoluble calcium phosphate forms in the body and removes calcium from the circulation. Both processes lead to hypocalcemia and hence SHPT [1]. SHPT can also result from malabsorption (chronic pancreatitis, small bowel disease, malabsorption-dependent bariatric surgery) in that the fat-soluble vitamin D cannot get reabsorbed. This leads to hypocalcemia and a subsequent increase in parathyroid hormone secretion in an attempt to increase the serum calcium levels. A few other causes can stem from inadequate dietary intake of calcium, a vitamin D deficiency, or steatorrhea [2].
HPT is usually associated with muscle cramps and bone pain, perioral tingling or paresthesia in fingers or toes, positive Chvostek and Trousseau signs. Arthritis simulating rheumatoid arthritis as the presenting feature of HPT was reported in literatures only rarely [3].
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects joints. It typically results in warm, swollen, and painful joints. Most commonly, wrists and hands are involved, with the same joints typically involved bilaterally. It was known that RF is not specific for RA and could be found in other diseases such as Epstein-Barr virus or Parvovirus infections and in 5% to 10% of healthy persons, especially the elderly [4] [5]. Anti-CCP antibodies are produced locally at sites of inflammation, not only in the synovium of RA, but also in other non-RA diseases. Therefore, anti-CCP positivity may be expected in a proportion of patients with non-RA diseases as well [6].
As we know, one of the causes of SHPT is vitamin D3 deficiency which was found to be widespread in Middle East whilst the area is rich in sun rays and consequently UV exposure. One of the most probable causes of vitamin D deficiency in Middle East area is pollution with heavy metals, like cadmium and lead [7] [8]. The mitochondria of proximal convoluted tubule cells of the kidney are the site of production of circulating 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], and parathyroid hormone (PTH) markedly stimulates 1,25(OH)2D3 production, while 1,25(OH)2D3 suppresses production of PTH itself [9].
Cadmium preferentially selects to settle in kidneys. Renal cadmium deposition induces injury resulted from accumulation of cadmium-metallothionein (CdMT) in the proximal convoluted tubules. CdMT-induced nephrotoxicity might be due, at least in part, to its preferential uptake of CdMT into the S1 and S2 segments of the proximal tubules, which is responsible for converting 25(OH)D3 to 1,25(OH)2D3 [10]. Vitamin D3 deficiency and HPT are established to be associated with Fibromyalgia syndrome [11] [12]. Hyperparathyroidism is known to be associated with multiple articular manifestations including gout, pseudogout, juxtaarticular erosions, tenosynovitis, periarthritis, and pericapsular calcification [13].

Patients and Methods
This study included 200 female patients attended outpatient clinics of Al-Azhar University Faculty of medicine Hospitals, who had a previous diagnosis of RA and not responding to classic treatment including DMARDs, and had been allocated for biological therapy (Table 1).

Inclusion and Exclusion Criteria
All patients were diagnosed according to old and new criteria for classification of RA [14] [15], with exclusion of other mimicking diseases like psoriatic arthritis, erosive OA, viral arthritis, reactive arthritis, IBD arthritis, Lyme's disease, and palindromic rheumatism.
Patients were reevaluated using old and new criteria for classification of RA. [14] [15]. We applied activity indices DAS 28, CDAI, and SDAI, [16] besides lab tests of RF, ACPA, ESR, CRP, LFT, RFT, serum vitamin D3, PTH, total and ionized calcium, phosphorus, and SUA. In addition, all patients did plain X-ray (Toshiba Digital Radiography System, DIGIX U) for hands, knees, and lumbar regions. When recommended, they were exposed to MRI (Philips1.5 tesla), and CT (Multi-Slice spiral CT Aston). High-resolution peripheral quantitative computed tomography (HR-pQCT) imaging allowed for highly reliable assessment of erosion in patients with rheumatoid arthritis (RA). As we noticed presence of fatigue and cognitive disorders in many patients, for that we applied old and new criteria for classification of fibromyalgia syndrome to all patients [17] [18].

Results
We reevaluated 70 seronegative and 130 seropositive RA patients. Eighty patients (Group 1) were fulfilling both old and new criteria of fibromyalgia syndrome, and not fulfilling any RA criteria, 65 of them were seronegative and 15   On the other hand, X-rays of SHPT (Group 1) hands showed subperiosteal and subchondral resorption of mainly thumbs, subchondral osteopenia of proximal and middle phalanges, mild subperiosteal resorption along the radial aspect of the middle phalanx and mild tuft erosions, besides changes in the carpus closely resembling those of rheumatoid arthritis, of ulnar styloid resorption, radiocarpal and scapho-trapezoid joint arthritis. Of special interest, the presence of tuft spurs-like excrescences mimicking that of (spade phalanx sign) of acromegaly, but without any other criteria of acromegaly ( Figure 1). Plain X ray of knees showed chondrocalcinosis, intracortical resorption, and osteopenia ( Figure   2). Lumbar spine shows mild sclerotic bands of the Superior and inferior end plates mimicking rugger jersey sign, as well as osteopenia and brown tumors.
Incidence of X-ray findings of subperiosteal resorption, osteolysis of distal phalanges, brown tumors in lumbar spine, rugger jersey appearance of vertebral column, calcaneal spurs, chondrocalcinosis, and tuft spur-like excrescences were described (Table 5).   Patients who reevaluated as having Fibromyalgia/SHPT syndrome stopped RA treatment, and were allocated to fibromyalgia regimen of SSRI, muscle relaxants, and vitamin D3 supplementation 5000 -10,000 iu/day, in addition to sulphasalazine 1 -2 gm/day to which their inflamed joints responded significantly.

Discussion
We found many patients with bilateral wrists and hands arthritis who had a constellation of vitamin D3 deficiency, elevated parathyroid hormone, and fibromyalgia. They were misdiagnosed as either seronegative or seropositive rheumatoid arthritis, which resulted in nonresponse to treatment and permanent discomfort. A study by Helliwell showed arthritis in 11% of HPT patients, including two cases of erosive arthritis [19]. HPT presenting as arthritis had been described in few case reports [19] [20] [21] [22] [23]. Meanwhile, HPT can occasionally co-exist with inflammatory arthritis like rheumatoid arthritis [24].
Radiographical features were helpful to differentiate both, in addition to clinical and biochemical features. Other than HPT causes osteoporosis and pathological fractures,it can cause bone erosions, which are mostly shaggy in appearance and distributed in the radiocarpal, radioulnar, metacarpophalangeal and distal interphalangeal joints, in contrast to that which predominate proximal interphalangeal joints of rheumatoid arthritis [25]. HPT is a disease of increased bone resorption and bone formation. Subsequently, plain radiographic findings may include resorption and sclerosis of numerous sites in the skeletal system [26]. Historically, osteitis fibrosa cystica was used to describe the advanced skeletal disease in primary hyperparathyroidism. Bone findings were characterized by the osteoclastic resorption of bone, osteoblastic bone formation, and fibrous replacement of marrow, with radiographic findings of subperiosteal resorption,  [27].
Nowadays, the most common radiologic finding in HPT is osteopenia, which may be generalized or asymmetric. Fine trabeculations are initially lost, with resultant coarse and thickened trabeculae. The disease may progress with further destruction that results in a ground-glass appearance in the trabeculae [27].
Other methods for the quantification of bone density, such as QCT scanning and DXA, are more sensitive in the evaluation of osteopenia [27]. Additional findings include bone resorption, which may occur at many different anatomic sites. Bone resorption may be classified as subperiosteal, intracortical, trabecular, endosteal, subchondral, subligamentous, or subtendinous. Subperiosteal bone resorption is an early and virtually pathognomonic sign of HPT, which is marked by marginal erosions with adjacent resorption of bone and sclerosis. An unusual lacelike appearance may be seen beneath the periosteum with an occasional spiculated external cortex. The underlying resorptive process may progress to complete cortical disappearance [27]. Although subperiosteal bone resorption can affect many sites, the most common site in HPT is the middle phalanges of the index and middle fingers, primarily on the radial aspect [27].
Of special interest, the presence of tuft spurs-like excrescences mimicking that of spade phalanx sign of acromegaly [28], but without any other criteria of acromegaly. A sole literature reported this sign in an unexplained case report, [29].
Due to lack of typical clinical features, hyperparathyroidism is often undiagnosed or misdiagnosed, especially in unspecialized centers. Hence, rheumatologists should have a high degree of suspicion for differential diagnosis at the beginning and during follow-ups especially when the initial diagnosis is doubtful, or the treatment is not effective.

Conclusion
We have characterized a syndrome of VitaminD3 deficiency/Fibromyalgia/ Hyperparathyroidism mimicking Rheumatoid Arthritis. It is characterized by longstanding vitamin D3 deficiency, associated with hyperparathyroidism and fibromyalgia, predominantly negative Anti CCP, while RF may be low positive. Radiologically is characterized by the presence of finger tuft acro-osteolysis with spur like excrescences which is pathognomonic, besides other features of hyperparathyroidism including subperiosteal and subchondral resorption of mainly thumbs, subchondral osteopenia of proximal and middle phalanges, mild subperiosteal resorption along the radial aspect of the middle phalanx and mild tuft erosions, besides changes in the carpus closely resembling those of rheumatoid arthritis, of ulnar styloid resorption, radiocarpal and scapho-trapezoid joint arthritis. This syndrome responds well to treatment of fibromyalgia regimen of SSRI, muscle relaxants, and vitamin D3 supplementation 5000 -10,000 iu/day, in addition to sulphasalazine 1 -2 gm/day to which their inflamed joints responded significantly.