Patient and Health System Related Factors Associated with Non-Adherence to Antihypertensive Medication among Patients at Chuka Referral Hospital, Kenya

Background: Non-adherence to hypertensive medication continues to be-come a contributing factor to hypertensive complications like stroke, heart attacks, kidney disease heart failure. Associated factors to non-adherence are complex, are both internal and external to the patient and are difficult to extrapolate. Reports from Chuka referral hospital records showed that in 2016 there were 140 patients with hypertensive complications from 560 patients who attended the medical clinic that year. Objective: This study sought to explore the patient’s related factors that are associated with non-adherence to hypertension medication. Methods: This is a descriptive study design of (N = 575) people among them doctors, pharmacists, nurses, record officers and hypertension patients. Simple random sampling for patients (n = 81) and census sampling for health care workers was done and data collected using questionnaires and interview schedules between April 4 th -May 30 th 2019. Inferential and descriptive statistics were used for data analysis, aided by SPSS version 25. Results: 64% of the patients stated that they had missed medication. A significant negative correlation (r pb = −0.23, p < 0.05) between age and non-adherence, significant positive correlation with monthly income (r pb = 0.24, p < 0.04), non-significant relationship between non-adherence and marital status (r pb = −0.13, p = 0.25) and patients’ level of education (r pb = −0.06, p = 0.57). The overall model of health system related factors were found to be significant


Introduction
Hypertension, or elevated blood pressure, is the leading risk factor for the development of cardiovascular disease (CVD) the leading cause [1] of death worldwide [2] [3]. Approximately 45 -81 percent of patients worldwide with hypertension (HPT) have poor blood pressure control [4]. An estimated 1.13 billion people worldwide have hypertension, most (two-thirds) living in low-and middle-income countries [5]. Further WHO states that the continent of Africa has the highest hypertension prevalence (46%) for both the male and females [6]. Hypertension prevalence of 28.7% in Kenya was reported [7], a burden to low resource countries like Kenya [8].
One way of managing hypertension (HPT) to an optimal blood pressure control level is by the use of antihypertensive medication. The success of antihypertensive drugs is well recognized and has been measured in terms of reduction of overall relative risk of cardiovascular disease and other hypertensive complications like stroke and as well as lower healthcare costs [9] [10] [11] [12]. Compliance with hypertension drugs is a key factor to avoiding poor controlled hypertension and the possibilities of developing complications linked to hypertension for example renal failure, heart attacks, strokes and eye complications which are dangerous and can lead to sudden death [13] [14]. Non-adherence to hypertensive medication is the major impendent in the fight against hypertensive complications like heart attacks, heart failure, stroke and other complications [15] [16] [17] [18].
The problem of non-adherence to medication is unlikely to end soon [19]. A number of analyses have revealed that in developed countries, non-adherence to long term therapeutics including HPT therapy in the population, has a high prevalence [20].
Only 29% of patients under treatment with antihypertensives drugs had their BP contained in the recommended levels of <140/90 mmHg [21]. Non-adherence to hypertensive medication in many hospitals is characterized by failure to refill the regimen, failing to honor appointments, patients stopping the medication when they felt better or due to the side effects. Earlier studies identified multifactorial patients and health care systems related factors that lead to non-adherence to antihypertensive medication that includes patient's beliefs, income, age, gender and education [20] [22]- [27].
Such demographic investigations are essential, but they have a tendency to limit comprehension of the multifaceted set of influences that in collaboration or on their own effect non-compliance in regards to the termination of taking me- [17].
The development of a sustainable, systematic healthcare system in Kenya is designed to benefit all the country citizens, including prevention of common health issues and disease-related complications, and to ensure public wellbeing is the focus of the healthcare service. The government in Kenya is intent upon creating mechanisms to improve and implement comprehensive health service programmes through the Ministry of Health (MOH), as well as other related health organizations [30].
Accordingly, the MOH has adopted a number of programmes and health policies designed to prevent, detect, evaluate and treat non-communicable diseases, one of which is hypertension [31].
Healthcare system sustenance to patients with hypertension has a substantial role in enhancing adherence to HPT treatment. Support related to patients with hypertension in relation to adherence activities contemplates elements of providing information that is supporting or helpful in regards to the recommended medications. Successful management of hypertension relies on comprehension, endurance of hypertension care, and link with health education. The chief emphasis of provision of information resources or educational support is to benefit patients with hypertension to follow medical instruction on drugs and highlight the significance of performing health examinations and screening periodically [32]. Providing educational sessions or educational material through conduction of educational interventions, provide patients with facts concerning their health condition and treatments which can help to better HPT treatment compliance [33].
Physician communication is a helpful predictor of adherence to medication thus if physician communication is poor can result to non-adherence to medication [34] Good communication between patient and clinicians led to a good patient-client relationship which is a significant predictor increasing adherence to medications [35].
This study was thus expected to identify some of these factors influencing non-adherence to antihypertensive medication at the local level due to the effects of patients and health system.
The research objectives were to describe the association between patients' characteristics and non-adherence to hypertension medication and describe system related factors that are associated with non-adherence to hypertension medication at Chuka Referral Hospital. The research question posed for this study Open Journal of Clinical Diagnostics was, "what are the health system and patient related factors that contribute to antihypertensive medication non-adherence in a sample drawn from hypertensive patients visiting Chuka referral hospital".

Theoretical Framework
This study was grounded on behavior change theory known as theoretical domain framework (TDF) [36]. The TDF was chosen because it incorporates 33 behavior change theories and has related tools to support the application of behavior change interventions. TDF is able to acknowledge and enlighten the progress of the intervention expected [37].
Many adherence interventions to date have not been effective [38]. Intervention that is effective has often involved a level of difficulty that has been too expensive and challenging to apply in practice [38] and thus clarifications and models of medication adherence/non-adherence have changed over the years. Previous studies focused on the part of patient and doctor statement and its outcome on satisfaction of patient, comprehension and forgetfulness as main factors of succeeding adherence to treatment [39]. Though, research in health behavior has reliably proven that the delivery of facts alone is not an actual means to modification of behaviour, and thus studies have now progressed onto models and approaches which concentrate on beliefs of patients' planning abilities and motivation as the main descriptive variables. The models include self-regulatory models and social cognition models which put emphasis on the importance of the opinions that the persons have in regard to their ailment and management as well as their own capability to track the advice and treatment recommended [40].
Growth in behavior change comprises also of participants who records and monitors their behavior [40] and these interventions were found to be more effective and significantly at supporting healthy eating and physical activity more than interventions that the technique was not included [40]. The growth of classification of behavior change techniques lead to new techniques of theorizing the factors which determine or explain person's health associated behaviors and at the center of this new methodology is a psychological model for explanation of human behavior that is wished to include the array of technique that will be included in change [40]. The classifications include Capability, Opportunity and Motivation (COM) B behavior. These classifications were established with quotation to current theories of behavior change. A consensus meeting was held by behavioural theorists in the United State of America which reflected the fundamentals for the enactment of an identified volitional behavior They proposed that classifications were set as a preliminary directive to select interventions that were more effective [40]. Behavior change is crucial to promoting hypertension adherence and improving the health outcomes [36]. For example, behaviors may be those of healthcare providers such as evidence-based practice implementation, of patients, such as adhering to medication or of the general population, such as cessation of smoking and increasing physical activity. In spite of high-level noble work to promote the execution of evidence-based practice by developing field of implementation in science and Clinical Effectiveness Research Agenda Group (CERAG, 2008) [41] Execution remains variable, with various individual and health system factors influencing healthcare providers' behavior. These factors include the accessibility of evidence, relevance to exercise, the distribution of guideline and evidence, motivation of the individual, clarity of roles and practice, the culture of specific healthcare practices and the ability to preserve current changes [42].
Hypertensive medication adherence can be attained through changing health care workers' behavior [43]. If interventions are based on principle of change of behavior, changing is easy but if there are no principles then change of behaviour is hard [44]. Behavior change interventions informed by the theory are more effective than those that are not [45]. TDF is a theoretical framework rather than a theory thus it delivers a theoretical lens through which factors influencing behavior are viewed, these include; the affective, cognitive, social, and environmental effects on behavior.

Study Population
The study was conducted at Chuka Referral Hospital in Tharaka Nithi County  Table 1 presents the distribution of population that the study targeted. The study used simple random sampling to select study sample size for hypertensive patients and census taken for health workers that include: doctors, pharmacists, record officers and nurses attached to the medical outpatient clinic because they are too few to sample. The sample size was derived according to Nassiuma [47].
The study population included all hypertensive patients on follow-up at the hospital medical clinics. Patients aged 18 years and above were eligible to participate in this study. Enrolment of study participants was carried out at the beginning of each clinic day. This was done at the registration desk where all patients report for their appointments. The study used simple random sampling to select a subsample of the patients from a population of 560. A list of accessible patients was prepared and then the number to be interviewed was determined from the attendance list. Every client was given a number which was placed in a container and then the number was picked randomly, the patient corresponding to the number picked was included in the sample.

Sample Size
The size of the sample was derived according to Nassiuma [47] whereby a coefficient of variance at most is 30% of the population which is considered adequate for most surveys.

Data Collection and Analysis
A semi structured questionnaire that was reviewed for face and content validity presented by the use of charts, tables and graphs. Binary logistic regression models were used to analyze the association between the patients' related and health related factors allied with medication non-adherence. The Nagelkerke R2 was tested to measure the percentage of difference accounted for by the independent variables [49]. Predicted probabilities of an event occurring were determined by Exp (β). The Wald statistic was used to measure the support of individual predictors or the significance of individual coefficients in the model. A p-value of less than 0.05 was considered statistically significant for this study.

Study Limitations
This study was conducted in government referral Hospitals in Tharaka Nithi County and did not include patients who attended private Hospitals. Therefore results cannot be generalized to all hypertension patients in the county. However, the results have important insights for the same hospitals within the same characteristics. Self-reporting of the questionnaire could introduce recall bias by either over-reporting or under-reporting depending on the patient's behaviour in the recent past. However, the researcher was clarifying the questions when asking participants.

Inclusion Criteria
Hypertensive patients aged 18 years and above and consenting to participate in the study.
Patients on follow-up at the medical outpatient clinic.
Patients on treatment for over 6 months.
All doctors, nurses, pharmacists and record officers working in the hypertensive clinic.

Exclusion Criteria
Patients declining consent for participation and below 18 years.
Very sick patients warranting admission.

Results and Discussion
The overall questionnaire response rate was 50%, (81/161), of the patients who were engaged in the study. In addition, 10 medical staff members participated in the interview, intended to gather information to elaborate the quantitative facts.
The involvement of an expanded spectrum of stakeholder involving patients, nurses, pharmacists, and doctors illuminates the representativeness of the sample and thus, the external validity of the results.

Profile of the Respondents
In an attempt to profile the research participants, the study focused on their age, gender, education level, occupation and marital status. First, the study wanted to know the gender of the participants. The findings are shown in Figure 1. The finding indicates that most of the respondents (68%) were female while 32% were male.
The participants were also asked to give their ages. Figure      frequencies and percentages of respondents based on their occupation. The results suggest that the patients fell under four categories of employment, government employees, private firms employees, self-employed and unemployed. The research study found that over half of the participants (58%) were selfemployed. This suggests that most of the hypertension patients in the county are self-employed either working on their farms or in private business. Surprisingly, less than 10% of the patients were government employees. Figure 6 shows the distribution of participants depending on their levels of monthly income. The income levels were grouped in classes of ksh 10,000. A majority (54.3%) earned less than ksh 10,000 per month.

Association between Respondents Profile and
Non-Adherence to Hypertensive Medication

Gender of the Respondents
Research has shown that gender is one of the most significant factors influencing behavior in health including medication adherence [50]. More studies have shown that women visit care providers to a greater extent than does men, for Open Journal of Clinical Diagnostics  The findings contradict the results of Courtenay [50] who found in their study that anti-hypertensive medication non-adherence is 1.3 times higher in male than in female patients. The research finding also contradicts results from a study conducted on Chinese immigrants in America investigating the association amongst cultural associated factors and socio-demographic associated factors in relation to adherence to hypertension medication which revealed that women had greater adherence than men [53].

Age of the Respondents
The current study findings revealed that most of the patients (57.6%) were aged over 50 years thus elderly people have been found to be more non-adherent to medication than young people. The study results revealed a negative correlation (r pb = −0.271) between age and non-adherent to medication (Table 2). This implies that young ages relate to high levels of adherence. This can be interpreted to mean that elderly patients were more likely to miss drugs than young people.
The study findings contradict the results of a prior study that investigated the relationship between adherence to medication by the patient and increasing age which put forward that older patients made fewer errors in non-adherence and were more regular in taking their prescribed treatments due to the influence of having more consistent daily schedules [54].

Marital Status of the Respondents
Majority of the participants (69.1%) were found to be married. The point biserial test revealed a negative negligible relationship between non-adherence to medication and marital status (r pb = −0.12, p = 0.25). Involvement of domestic relationship with a spouse did not contribute positively to adherence of antihypertensive. This contradicts a cross-sectional study at Duke University in the United States of America, which explored emotive well-being for a hypertensive individual who was unmarried in respect to their adherence to hypertensive medication which found that being married was related to a higher likelihood of adherence to hypertensive medication [55].  It is perceived that married people should be more adherent than other forms of marital status because of the support from the spouses. A study that examined mediation between marital status and outcomes in individuals with heart failure revealed that unmarried individuals with heart failure had a higher risk of cardiac events than married patients [56].

Education Level of the Respondents
Regarding education, the study found that most of the patients (75.3%) knew how to read and write, this revealed an insignificant (r pb = −0.06, p = 0.57) correlation between patients' education level and adherence to hypertension medication. Most of the respondents had basic education hence capable of following doctor's directions and adhering to hypertension medication. Patients with higher levels of formal education may have a better knowledge of the aim of maintaining their blood pressure, though a different study noted the increase in adherence with increasing educational status which was inconsistent with this study [57], however Arshia and others confirm the results where it was found out that non-adherence was high in the individuals who had more education years [20], thus this calls for collaborative work, not only clinicians but even other health care workers to include nurses clinicians, physicians, pharmacists and nutritionists have a significant part in the monitoring and educating individuals with hypertension. Plain language is advocated instead of technical language or medical jargon to aid in more understanding.

Economic Status of the Respondents
A point biserial test results (Table 2) revealed a positive correlation between the monthly income of the patients and medication non adherence (r pb = 0.241, p = 0.04). This means that an increase in the patients' income by one unit would result in an increase in adherence by 0.241 units. The study finding further revealed that the majority of the participants earned less than 10,000 shillings per month which are in line with a study done in the United States of America which showed that individuals with poor health management and low income were more non-adherent due to the of the struggle they encountered to seek out healthcare services or afford treatment [58] [59]. Thus Low levels of economic status are associated with high levels of non-adherence. Open Journal of Clinical Diagnostics Hypertension treatments are long-term medications that necessitate repeated refilling however one of the obstacles in medication adherence is the cost which obstructs the steadiness of medication for patients with low incomes [22]. The main reason for the present result is that not all prescriptions are obtainable in the hospital and thus patients have problems dealing with the cost of prescriptions. Research has previously indicated that poor treatment adherence which is cost-related may tell the meaning of necessity and offer an explanation for nonadherence to treatment [22]. Hypertension drugs vary in price from expensive to affordable [60] [61].
The role of individual economic status is relative to adherence to prescription as restricted to the capability to purchase the medications. In this study, education level did not matter as most participants had post-secondary education though many were still self-employed. Therefore, it is reasoned that individuals with high earnings are associated with better management of their health. Individuals with poor health management and low income had the struggle to afford drugs or even other services in health care. Low-income status was a problem related to poor adherence as was the case for low-income African Americans in the United States of America ([56] [57], and in individuals in urbanized communities in rural Eastern Uganda [62]. Therefore poor adherence was associated with low monthly earning for patients attending Chuka referral hospital.

Employment Status of the Respondents
The results of employment and association to ant hypertensive medication non-  nonadherence, and this is discussed in the coming subsections. Table 3 reveals the categorized reasons, frequencies and percentages of patients with hypertension who are non-adherent to medication. A significant majority (55.7%) of respondents cited lack of funds as the major reason for non-adherence, 24.6% cited lack of time, 16.4% stated that they forgot, and 3.3% thought they had healed. An investigation on the level of non-adherence with medication indicated that a majority of the hypertensive patients at Chuka Hospital were not adherent to hypertension medication. The results revealed that 64% of the patients with hypertension had missed medication due to lack of funds, forgetfulness, lack of time, forgetfulness and others thought they had healed. Open Journal of Clinical Diagnostics  In the present study, forgetfulness is a contributor to hypertensives non-adherence. This is due to the fact that the highest category was elderly patients. Elderly patients are known to forget to take their medicine, alter the schedule of the doses or overuse the drugs. This is consistent with the results from Ghana where patients reported forgetfulness as the main reason for non-adherence [64].

Non-Adherence to Hypertension Medication
Forgetting to take drugs is a common problem in older people and especially when older people have several drugs to take.
Participants raised up the issue of lack of refill to antihypertensive treatment which is consistent with a previous study that revealed that lack of knowledge on effects of non-adherence, negative attitude to drugs, lack of time for refills and lack of family member support and cooperation on management contributes to non-adherence [65]. This calls for a focus on behavioral and social support as-   The respondents (60.5%) further stated that most of the drugs prescribed by the doctors were unavailable in the hospital pharmacy hence making the patients source them from external chemists at exorbitant prices.
A study on relationship between adherence to antihypertensive medication regimen and out-of-pocket cost showed that medication non-adherence was more likely for those who paid higher out of pocket [66]. This is consistent with the study results as only 48.1% had a medical scheme and the majority of respondents revealed that non-adherence was due to inability to pay prescribed medicine, tests and lack of funds to enable access to the health facility. Patients with a high pill burden and those without family support were found to be non-adherence to antihypertensive medication. 30.9% of the respondents had no family support. Treatment partners and family support improves patient with chronic conditions [67]. Family support is the most accessible source of support system, therefore hypertension condition, which is a chronic condition, requires family support in its management and thus the study emphasizes the necessity of ensuring family support at the commencement and continuation of ant hypertensive therapy.

Experience of the Medical Staff
The study also sought to determine the duties and experiences of the medical staff that were sampled to participate in the study. As shown in Table 4  detection of the cause of secondary hypertension as well as dealing with complications that arise as the disease advances. The study found that a majority (60%) had served in the clinic for a period of over 5 years. Meaning they had adequate experience in management of hypertension and providing adequate advice to the patients. Hypertension directs attention to itself not only due to its prevalence but also due to the fact that it is asymptomatic, has diverse drugs and treatment procedures, requires long-time drug therapy, and demands to be followed up by the medical staff [68].

Challenge Facing the Medical Staffs
The study further investigated on challenges facing the medical staff at the clinic and four main challenges emerged as shown in Table 6. The challenges are; 40% stated that stock-outs of essential medicine for hypertensive patients, 10% felt that they had too many patients to handle, 10% cited low knowledge levels of patients on hypertension and 40% mentioned ignorance of patients. They pointed out that some individuals take half dosages or even stay without taking drugs for some time.
Findings of the study on stocks outs of antihypertensive medicines collaborate evidence from Tanzania where the review of availability of hypertensive drugs in year 2012-2013 pointed out stock-outs [70]. Access to essential medicines still Open Journal of Clinical Diagnostics Stock-outs of hypertensive drugs disproportionately influence low-income patients as most often they cannot afford to travel looking for more affordable therapy due to high cost of transportation, for example. Low-income patients may most probably be unlikely to send supporters to buy the drugs in other markets due to lack of extra finances for transport cost and for purchase of drugs, hence the result to purchase of drugs at the nearby private-owned drugstore, which is the most costly alternative since it may be the only drug store in Chuka town.
Some others forgot the drug that is out of stock and thus is left managing the condition with only the available prescribed regimen. Patients also explained that hypertension drugs were more affordable and at times issued out for free at the county health facilities.
Low knowledge or unawareness of hypertension and the asymptomatic nature of hypertension is the primary patient-related barrier [71]. The study findings are consistent with the results which revealed low knowledge on hypertension.
Correct knowledge on elevated BP, its treatment and management creates understanding and prevents confusion. A study from Gaza and Pakistan revealed that individual who was knowledgeable about their disease and treatment had improved compliance to treatment compared to those who were less informed of their condition [72].
Though in contrary to the findings, studies from developed world showed no relationship between compliance and knowledge [73] [74].
In a study done in Western Kenya on barriers and facilitators to nurse management of HPT, nurses reported that there were inadequate training and excessive workload. They expressed concern on increased workload in the circumstance of present obligations and fear of further obligation associated with HPT management [71]. The result of this study reviewed that health care providers had too many patients to handle. Health care providers play a key role in the Ignorance of patients on adherence to treatment was a predictive factor to patients attending the institution. The observed results on ignorance were also reported by Isezuo and Opera as being responsible for non-adherence in a study done in India on medication adherence rating of patients with hypertension [75]. Kaboru in his study on adherence to hypertensive treatment revealed that adherence was low in African countries and this was due to ignorance of severity and low knowledge of the treatment of hypertension [76]. The reasons for this challenge could be due to providing patients with non-comprehensive information or they may be having insufficient knowledge about the illness and the se-

Reasons for Non-Adherence According to Medical Staffs
Health providers were asked what makes their patients miss drugs. According to the practitioners, the patient missed drugs because of ignorance (40%), polypharmacy (10%), denial (10%), lack of transport (10%), unaffordability of laboratory investigations and drugs (20%), and intolerance to the side effect of the hypertension drugs (10%).
Cost of medication and laboratory investigation are some of the explanations why individuals do not adhere to hypertensive drugs, this is consistent with a study done in Western Kenya on barriers and facilitators to nurse management in HPT which revealed that hypertensive medications were un-affordable [71].
Long standing conditions care management went further than the aggregate expenses of lifelong treatments; these include expenses related to laboratory testing, consultation, and transportation [71]. 54% of participant in this study earned less than ksh. 10,000 per month and when a point biserial test was done it revealed positive correlation between monthly income and non-adherence to medication. Given the reality of low economic status in the form of monthly income and patients purchasing their own drugs out of their pocket was a barrier to the achievement of adherence.
Health providers reported that side effect is a contributing factor to non-ad-Open Journal of Clinical Diagnostics herence. The consequence of use of drug to patient makes them get afraid due to thinking that they may do more harm than good [77]. Unintended side effects felt by others or individually and fear concerning potential side effect impacts the behavior of adherence. When patients are mandated to select between side effects and control of asymptomatic ailment some patients may deliberately nonadhere [77]. Patients probably assessed the risk of the unintended side effect than by evaluating the circumstance [78]. Three-quarter of hypertensive patients in a study stated clinician/physician did not discuss the possible side effects that they were likely to experience [79].
Polypharmacy which is simultaneous use of multiple medications was a concern to some health care providers the results finding were consistent with a study by Palterson and others who found out that patient with chronic medical conditions are most susceptible to polypharmacy due to others taking more medication for their other medical disorders [80]. The use of numerous medicines is related to an increased risk of adverse effects which may even raise the danger of unwanted drug interaction for example a patient with angiotensin converting enzyme inhibitor which is antihypertensive drug and is also given potassium sup- Medical staffs revealed that lack of transport by patients was also a factor that influenced non-adherence. The longer distance was an obstacle to non-adherence to providers' advice particularly when it was accompanied by poor terrain and poverty. Medical staff continued to say that patients who came from far were more likely to be non-adherent as compared to patients who came from nearby.
The study finding is consistent with a study in India which revealed that patient who took a long time for reviews were the poor and those who came from far [81].

Measures to Adopt to Curb Non-Adherence
When asked to state the measures that can be adopted to improve adherence to medication, the majority of the medical staff (70%) felt that providing counsel-  [31]. Health care providers felt that the equipment would help them in risk screening assessments and management of hypertensive patients.
Other (10%) felt that the nurses should use mobile phones for making followups. Usage of mobile phones has extended among the communities [85]. Mobile phones are said to be the fastest adopted technology in high and low-income countries [84]. A new approach of model of managing health through phones is on increase. Quick adoption of smartphone technology generates an interesting and promising platform to overcome non-adherence to medication by offering healthy lifestyle education, providing drug intake reminders and keeping records of biometric measurements [84]. This strategy once adopted will overcome medication non-adherence by providing drug intake reminders and clinic follow-ups.

Health System Related Factors and Non-Adherence to Medication
The objective was to determine health system factors associated with non-adherence to hypertension medication in patients followed at Chuka referral hospital.   Null Hypothesis H 01 : which stated that there is no statistically significant association between health systems associated factors and non-adherence to antihypertensive medication among patients followed at Chuka referral hospital. Using the level of significance as 5% and 1 degree of freedom in chi-square table the critical value of chi-square statistics is 3.84 and the calculated/test chi-square is χ 2 = 6.34, p = 0.012) which is greater than critical value proves that is statistically significant association between health system associated factors and nonadherence and hence null hypothesis is rejected.
Prove from the result findings is that health related factors contributed towards non-adherence to hypertensive medication. Health systems factors play a crucial role in the promotion of adherence. A good link between patient and health care provider which comprises reinforcement and encouragement from the health worker has a positive influence on compliance to drugs. Study findings from Ethiopia at university of Gondor hospital indicated a positive relationship between nonperfect adherence to medication and poor physician-patient relationship [85]. The results indicated that health education precisely on hypertension treatment including the use of drugs with fewer side-effects, and probe of potential side-effects the individual may have resulted in adherence improvement.
In low-income countries provision of drugs in health facilities are scarce and thus the majority of patients end up buying from their out of pocket. A recent study revealed that availability of drugs prescribed during hypertension clinic and the cost were predictors of health seeking behavior [8]. Approaches for refining access to drugs, for instance, reliable supply, sustainable financing and subsidized prices have a significant effect on patient adherence and mainly in low-income segments of the population [86]. Hence focus on improving the efficiency of health system functions like financing delivery of care and appropriate medication management can create a significant influence to promoting the adherence rates of hypertensive patients.

Conclusions
Non-adherence to hypertension medication is a major problem at Chuka level five hospital. The majority of the individuals diagnosed with hypertension have been missing medication. Most of the drugs prescribed by the doctors were un-Open Journal of Clinical Diagnostics available in the hospital pharmacy hence making the patients source them from external chemists at exorbitant prices. To practitioners, non-adherence to hypertension medication resulted from stock out and ignorance on the part of the patients. The absence of hypertensive drugs influences poorer patients due to a lack of funds to access cheaper drugs and high charges of transport. Low-income patients may also be unlikely to send supporters to purchase the drugs in towns or markets.
It is clear that individuals with low-income levels and elderly patients are more likely not to comply with HPT drugs than young and those with high monthly income. Education level did correlate with non-adherence to hypertensive medication. However, many of the patients knew how to read and write, hence capable of following doctor's directions and adhering to hypertension medication. Despite the high levels of non-adherence, the care providers were readily available to attend to them, explained to them the importance of B.P control, took them through the schedule of medication and gave health educational materials on hypertension to some.
The study identified three strategies that can be adopted to minimize if not eradicate non-adherence. First, effective counselling should be adopted to change the behavior of the patients. This would entail providing facts on side effects and contraindications, enhancing health status with medication adherence, providing facts on side effects and contraindications, and supporting healthy behaviors.
Secondly, the availability of more hypertension medication equipment would also help to reverse the situation and lastly facilitating the practitioners to make adequate, regular and sustained follow-ups. Health system related factors; quality of health services, physician patient relationship, stock out, health education and availability of medicine factors were revealed to be important predictors of hypertension medication non-adherence. However, no individual factor in the health system was a significant predictor of non-adherent to hypertension medication.