Application of Serum Ferritin Combined with Blood Routine Testing in the Screening of Obstetrics and Gynecology Diseases

Objective: To understand the application of serum ferritin combined with blood routine testing in the screening of obstetrics and gynecology diseases in this region. Methods: From January 1, 2017, to October 28, 2020, all obstetric pregnant women, inpatient maternal, gynecological outpatient, and gynecological inpatients in our hospital’s outpatient and inpatient clinics were collected for serum ferritin determination and blood routine related index detection and analysis Changes in results. The application value of serum special protein in gynecological and obstetrical disease screening was put forward. Results: A total of 15,656 cases of obstetrics and gynecology patients were collected, of which 15,300 were pregnant women. Comparing maternity checkups with hospitalized puerpera, the difference of all indexes except RBC was statistically significant (P < 0.05); Comparison of various indicators between gynecological outpatient clinics and gynecological hospitalizations, maternity checkups and gynecological outpatient clinics, inpatient maternal and gynecological hospitalizations, etc.; there was no statistically significant difference in all indicators (P > 0.05). Comparison of hospitalized puerpera and gynecological hospitalization, the difference of other indexes except for MCV, MCH was statistically period of time after delivery, and recovery requires a certain process, which is relatively low; The ferritin in the body slowly recovered and the ferritin con-centration increased. This process is a process of physiological change and does not involve related diseases, but from this result, we are also required to strengthen nutrition for pregnant women in order to give birth to healthier babies. The ferritin test of gynecological patients is mainly a screening of related diseases, and the results of this time did not screen out serious diseases.


Introduction
Ferritin is a soluble tissue protein that stores iron in the body. The serum of normal people contains a small amount of ferritin, but different detection methods have different normal values. Generally, the average value is about 80 -130 ug/L (80 -130 ng/ml for men and 35 -55 ug/L (35 -55 ng/ml) for women [1] [2] [3] [4] [5]. The positive rate of liver cancer patients reported was as high as 90% in China. A type of iron-storing protein widely found in animals and plants. It is most abundant in the liver and spleen of mammals. Its outer diameter is about 12 -14 nm, and the cavity diameter is about 6 nm. The outer shell (that is, apoferritin) is composed of 24 subunits, each subunit contains about 163 amino acid residues, and each molecule can bind up to 4500 Iron atoms. The molecular weight is about 450kd. Iron-bound ferritin is "soluble" in water, and the concentration of plasma ferritin is directly proportional to the iron stored in the body [6] [7] [8] [9] [10]. There are many nutrients in the human body, such as calcium, iron, zinc, selenium, etc., which are important substances for maintaining health. There is also a kind of ferritin that is also very important to human health, especially the iron protein in pregnant women. The ferritin value in the body of women after pregnancy is relatively higher than usual, which is caused by the need for ferritin in the growth and development of the baby. Under normal conditions, the iron protein value in pregnant women should be kept between 35 ug/L and 55 ug/L. As long as the actual iron protein value of pregnant women is within this range, pregnant women do not have to worry, proving that the body is not iron deficient. Maintain a normal diet [11] [12] [13] [14] [15].
The purpose of testing the ferritin content in the blood is to check whether the pregnant woman is anaemic. If the iron protein value in the pregnant woman is lower than the reference value, it proves that the iron stored in the pregnant woman is consumed, which leads to the phenomenon of iron deficiency anemia.
At this time, it is necessary to take some drugs in time to supplement the iron element to avoid affecting the health of the fetus. For pregnant women with low levels of ferritin in their bodies, iron supplementation is an urgent matter; The pregnant women not only take some iron supplements but also need dietary

Research Methods
Select obstetric outpatients, inpatient maternal, gynecological inpatients and gy-Advances in Reproductive Sciences necological outpatients as the research objects, and register the relevant information of the patients, such as specimen collection date, name, gender, age, department, test specimen number, etc., and all the subjects were collected venous blood on an empty stomach for blood routine and serum ferritin detection. Serum ferritin samples should be centrifuged in time after the blood is drawn and the test should be completed within 6 hours. If it cannot be tested in time, it must be stored at −40˚C. After collecting a certain amount of specimens, they are uniformly reconstituted and tested; routine blood testing needs to be completed within 2 hours, and those that cannot be tested in time should be stored in a refrigerator at 2˚C -8˚C, and testing should be completed within 24 hours.
Then collect the test results, compare the differences of related indicators in each group, and put forward relevant conclusions.

Statistical Analysis
The SPSS 24.0 software was used to perform statistical analysis on the obtained data. Age, blood routine indicators, and serum iron are all expressed in measurement units (X average ± s), and the results are compared using t-test; count data uses chi-square χ 2 test and P < 0.05 is considered statistically significant.

Results
Among

Discussion
After pregnancy, due to the growth and development of the fetus, women's demand for iron will increase. If the iron intake is insufficient, the serum ferritin value will decrease, leading to symptoms such as anemia, dizziness, and fatigue.  [32]. Pregnant women with low ferritin: In the late pregnancy, with the rapid growth and development of the fetus in the uterus, the nutrients obtained from the mother will also greatly increase. Pregnant women in the late pregnancy have low ferritin, which is generally considered to be iron de- Advances in Reproductive Sciences the expectant mother may be hypoxic and dehydrated; In severe cases, anemia may occur. Anemia in pregnant women is a common symptom, so at this time they are responsible for the health of two people. The blood volume of expectant mothers will increase than before pregnancy. In addition, at this time, the baby needs to take nutrients from the mother when growing up, so mild anemia can be adjusted with diet, but severe anemia must be treated in time, which can easi-

Conclusion
During the maternity examination of pregnant women, ferritin is consumed too much, blood volume increases, and blood routine-related items are reduced during the maternity examination. The consumption is greater for a period of time after delivery, and recovery requires a certain process, which is relatively low. After the newborn is born, the ferritin recovered slowly and the concentration of ferritin increased. This process is a physiological process and does not involve related diseases, but from this result, we are also required to strengthen nutrition for pregnant women in order to give birth to healthier and healthy babies. The ferritin test of gynecological patients is mainly a screening of related diseases. The results of this time did not screen out serious diseases related to ferritin changes.

Limitations of Research
This research mainly studies the region serum ferritin in combination with related parameters of routine blood test in the application of obstetrics and gynecology disease screening, although the sample size is more, but is given priority to with prenatal women, other maternal hospitalization, outpatient service of department of gynaecology, hospital of department of gynaecology such as sample size is less, do not represent all of the patients, so there are some limitations.
The solution can be to increase the sample size of inpatient puerpera, outpatient department of gynecology and inpatient department of gynecology, so that the data statistics can be balanced to reflect the correlation between the groups.