Tuberculosis and COVID-19 Screening at Health Facilities: A Cross-Sectional Survey of Health Care Workers in Nigeria during the COVID-19 Pandemic

Background: The coronavirus disease 2019 (COVID-19) incidence continues to rise in many parts of the world with increasing fatality. At the same time, tuberculosis (TB) has been identified as the leading cause of death amongst all infectious diseases globally. Routine screening of clients visiting health facilities can help to prevent the spread of these diseases. Aim: To assess the relationship between the practice of facility-based routine tuberculosis screening and routine screening for COVID-19. Methodology: Using a Snowball technique, a cross-sectional online survey was carried out during the national lockdown from 5 July to 5 August 2020. The target population for this survey was health care workers from the different health facilities across Nigeria. An online semi-structured questionnaire was used to interview healthcare workers to identify their knowledge, attitudes, and practices (KAP) towards COVID-19 and the practice of routine TB screening. Descriptive analysis, analysis of variance (ANOVA), and Pearson’s Chi-square test was used for statistical comparative analysis. Results: This shows that 53.9% of healthcare workers did not practice routine TB screening while 46.9% did not practice routine COVID-19 screening. Respondents who practiced routine TB screening were found to be more likely to practice routine COVID-19 screening (p < 0.001). Healthcare workers in primary healthcare centers were more likely to carry How to cite this paper: Okoro, C.A., Onyenweaku, E.O., Okwudire, E.G., Kalu, M.K., Kusimo, O.C. and Williams, V. (2021) Tuberculosis and COVID-19 Screening at Health Facilities: A Cross-Sectional Survey of Health Care Workers in Nigeria during the COVID-19 Pandemic. Journal of Tuberculosis Research, 9, 18-30. https://doi.org/10.4236/jtr.2021.91002 Received: February 1, 2021 Accepted: March 27, 2021 Published: March 30, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access


Introduction
World Health Organization (WHO) reported the outbreak of the novel coronavirus disease for the first time on the 31st December 2019 and went on to declare it a pandemic on the 11 th of March, 2020 [1]. The Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) has been demonstrated to cause mild to severe respiratory disease that could be fatal in the elderly and persons with co-morbidities [2]. As of October 12 th , 2020, the weekly updates by WHO showed 37,109,851 persons had been infected globally with 1,070,355 deaths and an estimated case fatality rate of 2.9% globally [1]. The total number of cases reported in Nigeria in the same period was 60,430 with 1115 deaths recorded giving a case fatality rate of 1.8% for the country [3]. The symptoms of the disease include fever, respiratory distress, fatigue, dry cough, and in some cases, loss of smell and taste [1]. A high number of people who get infected with COVID-19 remain asymptomatic [1]. These asymptomatic persons are more likely to be the source of transmission of the disease in the community if they do not follow protocols for the prevention of COVID-19 [1] which has been characterized by high morbidity and mortality rates [4].
Similarly, tuberculosis is also an infectious disease which also primarily causes respiratory distress and is caused by mycobacterial species [5]. About one-third of the world population is infected with latent tuberculosis globally and can be on this latent phase all their lives without developing active TB disease except they become immunocompromised [5]. However, a significant percentage of the infected persons go on to develop active TB disease and have the potential to spread the disease from one person to another [6]. People with HIV or other immunosuppressive conditions are more likely to develop active TB from a latent state compared to those who are immunocompetent [6]. The natural history of TB is such that almost all who develop TB disease will eventually die of the disease if appropriate treatment is not instituted [7]. This contrasts with the natural history of COVID-19 where the majority of the persons who develop the disease recover spontaneously [8]. Health mandating them to hold heads of facilities responsible for implementing this policy [12].
To screen a client for tuberculosis, a healthcare worker is expected to ask a client questions relating to a standardized symptoms checklist that seeks to know whether the client has had a cough of two weeks or more, weight loss, drenching night sweats, loss of appetite and persistent low-grade fever [13] [14].
Any client coughing for 2 weeks or more with or without any of the other symptoms is considered a "presumptive TB case" and is referred for sputum analysis or X-ray [13]. To screen for COVID-19, a health worker is expected to ask questions related to the occurrence of the following symptoms: fever, respiratory distress, fatigue, dry cough, loss of smell, and taste [1]. Symptomatic clients are then referred for testing. Given the above, this study seeks to evaluate the extent of routine facility-based TB screening practiced by Nigerian health workers and whether the practice has any relationship with the practice of routine COVID-19 screening in the facilities following the outbreak of the pandemic.

Methodology
The study employed quantitative methodology and data was collected by means

Study Population
The population for the cross-sectional study consisted of 426 respondents (all healthcare workers) from 29 states in Nigeria.

Sample Size
Using a confidence interval of 5% and a confidence level of 95%, the sample size for the survey was calculated using the formula: where N = sample size, Z = value corresponding to a given confidence level (1.96 at 95% level), p = percentage of primary indicator taken as 0.5 and c = standard error taken as 0.05 at 5% confidence interval.
The calculated sample size was 384 with a 10% adjustment for non-response getting it to 422. A total of 426 responses from 29 states were analyzed for the survey.

Sampling Procedure
This study is a cross-sectional survey conducted in Nigeria using a snowball sampling approach. The online questionnaire link was sent to prospective respondents by the investigators via emails, WhatsApp, and other social media handles. Prospective respondents were encouraged to share the survey with their contacts and other online platforms. Thus, the link was forwarded to other people apart from the first respondents.
The online survey was conducted during the latter phase of the COVID-19 pandemic (between June and August 2020) when the lockdown was eased by the Nigerian government to allow interstate movement and some restricted gatherings with strict observance of COVID-19 protocols. The online survey was selected for this study since a population-based survey was not feasible under the current social restrictions due to COVID-19.
The study population included only individuals with access to the internet.
Respondents who understood the English language and were 18 years old and above, were recruited for the study. Respondents were healthcare workers such as doctors, nurses, pharmacists, laboratory scientists, community health workers, and records staff pooled from 29 states in Nigeria. Being an online study using a Snowball sampling method, the survey allowed respondents from many states in Nigeria to participate. Participation in this survey was anonymous, consensual, and voluntary.

Questionnaire Design and Administration
A semi-structured questionnaire was designed and converted to the online version using Google forms. The survey instrument used in this study was designed according to the guidelines recommended for the awareness and prevention of and tuberculosis, particularly considering the study population. The finalized questionnaire was pretested on 10 participants and these were excluded from the study.
The finalized questionnaire contained questions assessing socio-demographics, knowledge, attitudes, perceptions, and practices of the respondents regarding the coronavirus pandemic and screening for TB. A sample of this questionnaire is attached as supplementary material.

Informed Consent and Data Privacy
Respondents were asked to carefully read and understand the content summary before proceeding to the questionnaire. Informed consent was obtained for all participants. Participants' responses were anonymous and confidential according to Google's privacy policy (https://policies.google.com/privacy?hl=en). Participants were not permitted to provide their names or contact information. Additionally, participants were able to end study participation and leave the questionnaire at any stage before the submission process; if doing so, their responses would not be saved. Responses were saved only by clicking on the provided "submit" button. By completing the survey, participants acknowledged their voluntary consent to participate in this anonymous study.

Ethical Clearance
Ethical clearance was obtained for the survey from the Research Ethics Committee of the University of Calabar, Calabar, Nigeria.

Data Analysis
Descriptive statistics such as frequencies, percentages, and charts, were used to define the proportion of responses for each question and the total distribution in the total score of each questionnaire. All statistical analyses were performed us-    Table 2). The study widely covered healthcare workers

Knowledge of COVID-19
The studied population appeared to have a good knowledge of COVID-19 and its mode of transmission (see Figure 1). From the results, most of the respondents (97.7%) correctly identified COVID-19 as being caused by a virus with about 96.2% of respondents correctly stating that COVID-19 was transmitted through contact with infected droplets. About a third (33.8%) of respondents thought it to be airborne, 5.9% thought it was transmitted through contaminated food, while 4.3% stated it was sexually transmitted albeit, wrongly. Doctors were more likely to choose air as the mode of transmission and this was found to be statistically significant (p = 0.008). No significant relationship was found between occupation and choosing droplets, sexual intercourse, faeco-oral, contaminated foods, close contact, contaminated surfaces, or dirty hands as modes of transmission of COVID-19 (p > 0.05). Greater than four-fifths (86%) of all respondents identified handwashing, use of sanitisers, facemasks, social distancing, and restriction of mass gatherings as effective measures for preventing the spread of COVID-19. A good proportion of the respondents identified cough (40.6%), loss of appetite (21.7%), respiratory distress (15.1%), and fever (8.1%) as the commonest symptoms of COVID-19. Also, the majority of the respondents (84.2%) identified nasopharyngeal swab as the sample used in testing for COVID-19, while 8.8% and 7.1% wrongly identified blood and sputum samples respectively, as the test sample. Most of the respondents (89.7%) admitted to knowing where to refer patients with symptoms suggestive of COVID-19 with 2.8% stating they did not know. No significant  relationship was found between occupation, type of facility or facility level, and knowledge of where to refer patients for COVID-19 testing (p > 0.05). Respondents' detailed knowledge of Tuberculosis was not assessed during the survey.

Screening for Tuberculosis and COVID-19
More than half (54.7%) of respondents stated that routine TB screening was not done for clients in their facilities while 46.9% similarly stated routine screening of clients for COVID-19 was not done. About 26.5% and 35.7% of respondents stated that they carried out the routine screening of clients for TB and COVID-19 in their facilities, respectively. Very few (3.8%) of the respondents stated they did not know if routine TB screening was carried out in their facility (see Figure 1 & Figure 2). Among the respondents who agreed they conducted routine TB screening in their facilities, 61.1% of them stated they conduct COVID-19 screening at the same time, while 45.4% of those who stated they conducted routine screening for COVID-19 agreed they also conducted routine TB screening for clients at the same time (see Figure 3). This was found to be statistically significant (p < 0.001).
A strong correlation was found between occupation, facility level and type of facility, and the practice of routine screening for both TB and COVID-19.   27.5% respectively admitted to carrying out routine TB screening in their facilities (p < 0.001).

Discussion
The respondents showed a good knowledge of COVID-19 and a high level of use of preventive measures against it. On the contrary, a poor attitude towards the disease and to work was adopted by most of the respondents during the pandemic. Studies in Pakistan [17] and Vietnam [18] reported similar findings of a high level of knowledge among HCW. This agrees with our findings in Nigeria.
This could be due to the wide publicity on COVID-19 globally with tailored information for different population groups' especially healthcare workers. A study by Bhagavathula et al. [19], however, reported a low level of knowledge of The observed low level of routine screening for tuberculosis among health workers generally may be related to a lack of knowledge of the effectiveness of early diagnosis and treatment in limiting the spread of the disease [20]. It may also be because of the attitude of the health workers who believe TB screening should be left to the designated officers at the TB treatment units in their facilities. The inadequate screening for COVID-19 could be attributed to the unavailability of proximal testing equipment and centres as is currently seen in the country. For these two diseases, the fear of being stigmatized, even at the facility level, may prompt clients to decline providing answers to questions related to the diseases thereby making screening difficult for health workers [21].
Most of the respondents who regularly conducted routine TB screening before the outbreak of the pandemic also showed a higher tendency to routinely screen for COVID-19 as reflected in the results. This will most likely be attributed to the fact that the healthcare workers were already primed to routinely screen for the presence of signs and symptoms of common infectious diseases.

Limitation
This study was limited to an online survey because of the COVID-19 lockdowns which made it impossible for the researchers to move to certain rural/semi-urban settings to include participants from such areas. As a result, the study reflects responses from a socio-economic class of health care workers who can access internet facilities and had smartphones/laptops. Also, the validity of answers, which is a general problem of online surveys, may be difficult to ascertain. In our analysis, we did not conduct advanced statistical analysis such as a multilevel analysis to ascertain if working at a certain level of a health facility or state had any effect on our findings. But this was compensated for by the different com-

Conflicts of Interest
The authors declare no competing interests exist.