Study on the Relationship between Nursing Staffing and Nosocomial Infection in Very Low Birth Weight Infants

Background: At present, there is no domestic research on the relationship between nurse staffing and hospital infection in very low birth weight infants. In this paper, we will explore the relationship between nurses of very low birth weight (VLBW) infants in neonatal intensive care unit (NICU) and nosocomial infections. Methods: The clinical data of 280 very low birth weight infants born in our hospital from January 2010 to January 2020 were collected, and the chi-square test and multiple logistic regression analysis were used to study the nursing staff of each very low birth weight infant who was admitted to the NICU The relationship between the number of infections and hospital infections. Results: On average, each nurse needs to care for 4.3 very low birth weight infants (lowest to highest: 2.50 8.42). In the univariate analysis, the higher the incidence of urinary tract infection (P < 0.05), the multivariate logistic regression analysis of neonatal nosocomial infection showed that nurse staffing was significantly related to the incidence of urinary tract infection (OR = 1.78; 95% confidence interval, 1.17 2.35, P < 0.05). However, there was no significant correlation between nurse staffing and bloodstream infection (OR = 0.91; 95% confidence interval, 0.74 1.06, P > 0.05) or Ventilator associated pneumonia (VAP) infection (OR = 1.17; 95% confidence interval, 0.94 1.47, P > 0.05). Conclusion: Our research shows that in the neonatal intensive care unit, the reasonable deployment of nursing staff is an important factor in preventing urinary tract infections in very low birth weight infants. It is important for improving the survival rate of very low birth weight infants and reducing the occurrence of sequelae.


Introduction
Very low birth weight infants (VLBW) refer to premature infants whose birth weight is less than 1500 g [1]. Very low birth weight infants usually have a gestational age of less than 30 weeks, and their organs are extremely immature and have a high risk of nosocomial infection. The newborn with the highest mortality and disability rate, and the incidence of very low birth weight infants is 1.25% [2] [3] [4] [5]. With the continuous advancement of neonatal medical technology and perinatal medicine, the rescue success rate of very low birth weight infants has greatly increased, but the quality of life is not optimistic. Research data at home and abroad shows that survival of very low birth weight infants have different degrees of cerebral palsy. Cognitive impairment, audiovisual impairment, etc., bring heavy economic and spiritual burdens to society and families, and the quality of care plays a very important role in the mortality and disability rate of very low birth weight infants in the neonatal intensive care unit (NICU) Effect [6] [7] [8], studies have reported that in 67 intensive care units in the United States, the shortage of nursing staff is closely related to the incidence of nosocomial infections in ultra-low birth weight infants, and the infection rate is significantly increased [9]. This study analyzes the clinical data of 280 very low birth weight infants born in our hospital to study neonatal intensive care. The relationship between nurses for very low birth weight (VLBW) infants in the ward (NICU) and nosocomial infections to improve the success rate of treatment for very low birth weight infants.

General Information
Collect the clinical data of 280 extremely low birth weight infants born in Foshan women and children's hospital from January 2010 to January 2020. These clinical data include the sex, birth weight, gestational age, diagnosis and clinical related operations of the children. The configuration of nurse staff is defined as the number of newborns nursed by each nurse. The nurses in this study only include registered nurses. The nursing time required by the child is calculated by multiplying the number of hospitalization days of all hospitalized children in a year by 24. The full-time nursing staff in our hospital need to work an average of 40 hours a week, but the actual time for newborn care accounts for about 85% of the total weekly working time, excluding full-time work such as vacation, sick leave, education and management tasks time. Therefore, by multiplying the number of nurses by 40 hours per week, and then multiplying by the result 0.85, the time spent in neonatal care can be obtained. This study was approved by the Medical Ethics Committee of Foshan women and children's hospital.

Hospital Infection
We choose to statistically analyze three types of nosocomial infections, namely blood infections, urinary tract infections and rotavirus infections. Because these three types of nosocomial infections are the most common infections in neonatology and are very sensitive to assessing the quality of NICU care, the nosocomial infections in this study refer to blood infections, urinary tract infections and rotas as the main diagnoses secondary to hospitalization. One of the viral infections, and therefore, very low birth weight infants who have been hospitalized for at least 3 days.

Clinical Characteristics of Very Low Birth Weight Infants
According to domestic and foreign literature reports, the following clinical characteristics are selected as the most variables: birth weight, gestational age at birth, gender, insurance type, year of admission, multiple births, birth defects, mechanical ventilation, surfactant injection, central venous catheterization, stomach Number of parenteral nutrition, operations and second diagnosis. Birth defects include major birth defects stipulated in our country, and surgery refers to an operation that takes 1 hour or more under general anesthesia. The number of second diagnoses refers to the number of diagnoses for each newborn except the first (main) diagnosis.

Data Analysis
Review the validity of the research data. Use SPSS 26.0 software to implement double entry and establish a database, statistical analysis and processing of data, in order to analyze the relationship between nurse staffing and nosocomial infection, multiple linear regression analysis was used, and chi-square test was used for measurement data, P < 0.05 The difference is statistically significant.

Result
This study found that about two-thirds of preterm infants had a birth weight of 1000 to 1499 g and a gestational age of 28 to 36 weeks. About 20% of very low birth weight infants have congenital defects. All very low birth weight infants were ventilated with a ventilator and injected with alveolar surfactants, the proportions of which were about 80% and 65%, respectively, as shown in Table 1.
The average number of very low birth weight infants nursed by each nurse was 4.30 (lowest to highest: 2.50 -8.42). The incidence of urinary tract infection and rotavirus infection increased significantly as the number of children nursed by each nurse increased, and the difference was statistically significant (P < 0.05). The incidence of blood infection increased with the increase in the number of patients nursed by each nurse. The increase in the number of children does not increase significantly, see Table 2.
The results of multiple logistic regression analysis for neonatal hospital infections showed that nurse staffing was significantly related to the incidence of urinary tract infections (OR = 1.78; 95% confidence interval, 1.17 -2.35). However, there is no significant correlation between nurse staffing and bloodstream infection (OR = 0.91; 95% confidence interval, 0.74 -1.06) or rotavirus infection (OR = 1.17; 95% confidence interval, 0.94 -1.47). See Table 3.

Discussion
Nosocomial infection is the most important and fatal complication of very low birth weight infants. Children with NICU are susceptible to nosocomial infections [10] [11]. In recent years, the treatment and prognosis of infants with birth   In a study of 108 neonatal intensive care units in Germany, it was found that reduced nurse staffing will increase the risk of central venous catheter-related bloodstream infections in very low birth weight infants. Rotavirus is a common nosocomial viral infection in newborns, which can cause diarrhea and even death in newborns. The study did not find that rotavirus infection in very low birth weight infants was related to nurse staffing. Therefore, in the next step, we will further study the related factors of rotavirus. At present, our research only confirms that clinical nursing staff is related to the incidence of urinary tract infections in very low birth weight infants, but whether it is related to other nosocomial infections. Clearly, such as ventilator-associated pneumonia, postoperative wound infection, etc. Therefore, we need further research to determine whether other nosocomial infections are related to nursing staff. In addition, we recommend the prevention and control of nosocomial infections in newborns. In addition to providing appropriate nursing staff, we should also strengthen the assessment of the quality of NICU care and continuous hospital-sensing training. At present, there is no domestic research on the relationship between nurse staffing and nosocomial infection in very low birth weight infants. The results of this study provide evidence for the clinical nursing staffing on the incidence of urinary tract infection in very low birth weight infants. It is recommended that the neonatal intensive care unit should actively modify the nurse staffing policy, which will help reduce the incidence of nosocomial infections, increase the survival rate of very low birth weight infants, reduce hospitalization complications, and promote the healthy growth of very low birth weight infants.