Effect of Behavioural Therapy on Depression in Adolescents with Sickle Cell Disease

Background: Depression, one of the commonest mental health problems in SCD, has high prevalence rates. While psychological therapies have been found to be beneficial in mild to moderate depression, their use as non-pharmacological methods amongst adolescents in sub-Saharan Africa, particularly Nigeria, is still at its infancy. Objective: To determine the effect of behavioural activation therapy on depression in adolescents living with Sickle Cell Disease attending out-patient clinic at the Lagos State University Teaching Hospital, Lagos, Nigeria. Method: The study was conducted in Lagos State University Teaching Hospital, Lagos, Nigeria, between November 2017 to February 2018 (4 months) among adolescents living with SCD and depression attending out-patient clinic. A randomized control trial (RCT) was conducted among participants assigned to treatment (30) versus control (30) group. A manualized behavioral therapy programme developed was delivered to the treatment group. The data was analysed using the Statistical Package for Social Sciences (SPSS) version 23. Pair T-test was used to compare the two groups across continuous variables, preand post intervention. Analysis of Covariance (ANCOVA) was used to determine treatment effects controlling for baseline scores. Result: After the intervention, the mean depression score reduced from 22.13 ± 3.08 to 13.02 ± 4.56 while Paediatric quality of life score increase from 62.57 ± 17.85 to 67.90 ± 7.99 in the treatment group (BDI, p < 0.001; PedsQL, p = 0.045). However, the preand post-intervention mean depression scores in the control group showed insignificant reduction from 22.23 ± 3.24 to 21.60 ± 2.75 and mean PedsQL from pre-intervention scores of 59.67 ± 12.60 to 56.73 ± 8.94 post intervention (BDI, p = 0.388; PedsQL, p = 0.242). From multivariate analysis (ANCOVA), only the Quality of Life scores ceased to show any significant effect of the intervention. Conclusion: This study further strengthens and supports the extant literature that behavioral therapy alone is efficacious for depressive. How to cite this paper: Taiwo, T., Atilola, O., Ani, C. and Ola, B.A. (2020) Effect of Behavioural Therapy on Depression in Adolescents with Sickle Cell Disease. Open Journal of Psychiatry, 10, 127-140. https://doi.org/10.4236/ojpsych.2020.103013 Received: June 12, 2020 Accepted: July 13, 2020 Published: July 16, 2020 Copyright © 2020 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access


Introduction
Sickle cell diseases (SCD) constitute a global health problem [1] with high burden of disease worldwide. The heamoglobinopathy is a public health problem with approximately 300,000 affected infants born worldwide every year [2]. However, it is particularly common amongst those from sub-Saharan Africa, Mediterranean countries and Saudi Arabia, with more than half of global cases in Africa [1].
In the year 2010, Nigeria, Congo and Democratic Republic of Congo accounted for 57% of new born with SCD. The projection for the year 2050 revealed that Nigeria's contribution to incidence would increase from 30% to 35%, which translates to 91,000 annual births in 2010 to approximately 140,800 by 2050 [3].
The currently high and the projected increased burden are thought to be due to inadequate screening and genetic counseling services [4]. Furthermore, the level of care for patients with SCD is still sub optimal in the country [4] making the consequences more serious. Poor treatment options and affordability of the sub-optimal treatment also contributes to the chronicity of the disorder. Like other chronic disorders, SCDs are often associated with physical and psychosocial problems either due to organic dysfunctions or a reaction to the disorder [5]. Several psychosocial correlates have been identified to occur with sickle cell diseases such as depression, anxiety and low self-esteem [6]. Depression has been identified as one of the commonest mental-health problems in SCD, with prevalence rates as high as 27% -46% reported [7]. Persons with SCD have also been reported to be at greater risk of depression compared with the general population [8]. Several factors have been identified with episodes of depression in sickle cell disease which includes pain, and other psychosocial correlates. The onset of depression, either in SCD or the general population, is often during adolescence or runs a chronic recurrent course [9].
Non pharmacological therapies such as psychological therapies have been found to be beneficial in treatment of depression especially when the degree of severity is mild or moderate. In fact, psychological therapies are considered first line in management of depression in the adolescent age group [10]. These psychological therapies include behavioral therapy and cognitive-behavioral therapy.
Despite the success of psychological therapies in adolescent depression, very few studies have used and demonstrated how effective the use of psychological therapies are among adolescents in sub-Saharan Africa [11] [12]. The limited use of psychological therapies in sub-Saharan Africa is multifactorial. Aside the constrained public mental-health resources and limited number and training of practitioners; users have had to discontinue psychological therapies for reason of the logistic and financial constraints of attending multiple sessions [13]. The use of been advocated for such regions like sub-Saharan Africa [13]. It is thought that such will be more user-friendly and easier to scale. Behavioral Activation Therapy (BAT) is a form of Psychological therapy which is less complex, shorter, and invariably cheaper than other forms of therapies. It has been found to be of benefit in depressive symptoms among adolescents in sub-Saharan African population [13]. Behavioral Activation Therapy provides a potential opportunity to address the high burden of depression in SCD clinics in resource constrained settings such as Nigeria. This is because BAT may provide a cheap, short, and easy to deliver alternatives to other therapies such as cognitive-behavioral therapy in countries like Nigeria with a high burden of SCD and limited resources to respond to the mental-health impact of the disease. The fact that BAT is less complex and easily administered also means that it can be easily up scaled to be delivered by non-specialist health workers, if found effective. This study, therefore, aimed to determine the effect of Behavioral Activation Therapy on depression among adolescents with sickle cell disease in a tertiary SCD clinic in Lagos, Nigeria.

Setting
The study was conducted at the paediatric SCD clinic of the Lagos State University Teaching Hospital, Ikeja, Lagos (LASUTH) between November 2017 to February 2018 (4 months). This clinic attends to adolescents aged 12 -17 years with SCD.

Participants
The participants were a sample of consenting adolescents (12 -17 years) with SCD who had mild to moderate depression.We excluded those with severe depression on anti-depressant medications. The participants were divided into two groups, the treatment group and wait list (control) group. The minimum participants included in the intervention study was calculated using the formula from Wade, 1999 [14], a mean effect size of 0.80 was hypothesised. For an unpaired t-test to detect this difference with a power 0.80 and a desired significance of 0.05, a minimum of 25 participants would be needed in each group.  minutes to be administered and has been used in Nigeria [19].

Instruments
All questionnaire and instruments were administered by the author and two other trained interviewers. The participants were all informed about the aims and objectives of the research, both verbal and written consent were properly obtained in the out-patient clinic during follow-ups. Following this, participants who had been confirmed by MINI-Kid depression had BDI-II administered for severity and those who had severe depression scores (BDI-II > 29) were offered support.

The Intervention
A manualized behavioural therapy programme developed by the authors was delivered. The programme consists of 5 structured weekly sessions each lasting 45 -60 minutes. The sessions were delivered in groups of 2 -5 participants. The first session focused on psycho-education on causes, symptoms and treatment of depression. The link between cognitions, emotions and behaviour was explained and participants were taught a simple cognitive technique to generate and use positive self-talk. The latter technique includes religious-based coping self-talk, which is commonly used in the local population (e.g. counting your blessings). Also, local metaphors and analogies such as "however dark the night might be, a sunrise will eventually come" was used to promote hope. The second session explained the rationale for behavioural activation. Participants were taught to identify pleasurable activities and avoidant activities as well as how to monitor their mood. In the third session, more pleasurable activities were identified and participants were encouraged to have a list of pleasurable activities to carry out daily. The fourth session focused on relaxation techniques and participants were taught muscle ting advices were given to guardians. Following this, Behavioral Activation Therapy was administered over a 5-week period. However, results of intervention for the wait-list (control) group are not included in this study.

Procedure
As shown in Figure 1, the study design was multi staged.

Data Analysis
The data was analysed using the Statistical Package for Social Sciences (SPSS)

Ethical Considerations
All participants were informed about the aims and objectives of the study, and then verbal and written consent were properly obtained. Following parental con-

Socio-Demographic and Clinical Characteristics Description of Study Participants
A total of 230 adolescents respondents living with SCD were screened for the presence of Major Depressive Episode (MDE) using MINI kid. Out the people screened, 30 adolescents were selected into treatment group and 30 adolescent were selected into control group. Socio-demographics of respondents are presented in Table 1 and Table 2 below. The two groups were similar in their socio-demographic and clinical characteristics except for the marital status of their parents and the number of crisis they have had. As shown in Table 1, parents of participants in the control group were more likely to be married (χ 2 = 6.667, df = 1, p = 0.010) while Table 2 shows that participants in the treatment group were more likely to have had crises (χ 2 = 12.839, df = 2, p = 0.003). These outcomes further confirmed age and sex matching in treatment and control group.

Between-Group Differences of Baseline Scores on Measured Outcomes
As shown in Table 3 there were no statistically significant differences in clinical characteristics between the two groups (treatment and control) in both depressive symptom scores and quality of life scores (t = −0.122, df = 58, p = 0.903 and t = 0.727, df = 58, 0.470 respectively).

Within-Group Differences of Pre-and Post-Outcome Measured Scores
Within-group analysis showed that there was a reduction at post intervention in the two groups on both BDI and PedsQL score measures (as shown in Table 4).
Only the treatment group, however, showed statistically significant differences in the mean pre-and post-intervention BDI scores, (t = 7.895, df = 29, p < 0.001).
There was, however, no statistically significant difference in the quality of life scores in the treatment group even though scores were comparatively higher post intervention. The control group did not show any statistical difference within the group following assessment after 5 weeks on both BDI and PedsQL measures.

Between-Group Mean Differences in Pre-and Post-Intervention Scores
Post intervention mean differences on measured outcome variables between treatment and control group are presented in Table 5. There were statistically significant differences on all measured variable scores; BDI and PedsQL between the two groups (BDI treatment = −8.93, BDI control = −0.63; t = 6.18, df = 58, p < 0.001), (PedsQL treatment = 5.33, PedsQl control = −2.93; t = −2.05, df = 58, p < 0.0045). Hence, null hypothesis rejected for both depression scores and health related quality of life.

Test of Treatment Effects
One way Analysis of Covariance (ANCOVA) was used to determine the effect of intervention on depressive symptoms (BDI scores) and quality of life (PedsQL). Age, gender, class, religion, ethnicity, family types were not included in these ANCOVAs as these variables did not differ significantly between the groups.

Test of Effects between Participants Effects on BDI and PedsQL
The effects of the intervention on BDI scores are shown in Table 6. The first model used post intervention BDI scores as the dependent variable while the study group was used as the independent variable (fixed factor). The pre-intervention BDI scores were included in the analysis as a covariate while the number of time crisis and marital status were controlled as they were significantly different between the intervention and control group. There was a significant treatment effect of the intervention on depressive symptoms measured by BDI {F (1.47) = 13.03, p = 0.001}. The intervention explained 21.7% of the variance in the postintervention BDI scores. The intervention had a large effect size (Cohen's d) of 2.1 using the calculation Cohen's d = (X 1 − X 2 )/s (where X 1 is the mean post intervention BDI score of the treatment group; X 2 is the mean post intervention BDI score of the control group, and "s" is the pooled standard deviation of the two groups). Similar to the first model, in the second model, post intervention PedsQL was used as the dependent variable, the treatment group was entered as a fixed factor being the independent variable. The pre-intervention PedsQL scores were included in the analysis as covariate while number of crisis and marital status were also controlled for as there were significant differences between the intervention and control groups. There was no significant treatment effect of the intervention on quality of life as measured by PedsQL {F (1.47) = 0.35, p = 0.557} (Table 7).

Discussion
Behavioral therapy was introduced to adolescents with SCD who had depressive symptoms on the basis of its efficacy in studies of depressed adolescents who do not have SCD. Following intervention, adolescents with SCD (with mild to moderate depression) in the treatment group showed significant improvements in their depressive symptoms (lower BDI score) compared to control group after 5 weeks, a finding consistent with previous studies with adolescents and adults Open Journal of Psychiatry [20] [21] [22]. In other words, the findings showed that adolescents who received behavioral activation intervention had statistically significant reduction in depressive symptoms compared with the waitlist control group. Symptomatic relief of depressive symptoms suggests evidence of efficacy of the intervention in this cohort. In addition, the short-term nature of the treatment used in this study, marks an important difference between it and other psychotherapy intervention studies for adolescents in Africa. Therefore, the main outcomes of this work support the extant literature that BAT is an efficacious therapy for depressive symptoms among adolescents with depression and now extended to those with SCD and depression. Furthermore, this research indicates that the use of behavioral activation strategies alone may be sufficient to lead to behavioral and cognitive changes that significantly reduce depressive symptoms among adolescents who live with SCD. These conclusions are derived on the basis of between-group differences, which showed that though both treatment and waitlist groups started out at comparable mean levels of depressive symptoms, BAT reduces depressive symptoms in treatment group.
Having reviewed the findings from this work, the clinical effectiveness of BAT in the significant reduction of depressive symptoms among adolescents with SCD is further strengthened.
This present study yielded a large effect size of 2.1 in five sessions which can be attributed to the intervention. This is comparable and indeed higher than the mean effect size of 0.87 (95% Confidence Interval 0.6 -1.15) reported in a metaanalysis of studies which compared the effect of a behavioral activation group to a control group [23].
This study, by demonstrating the efficacy of BAT in adolescents with SCD who have depressive symptoms, is therefore in support of the use of BAT alone for adolescents with SCD who have depression. In other words, the findings show that in and of itself, BAT could be an effective treatment for depressive symptoms in adolescents with SCD and therefore support these theoretical underpinnings and challenges what cognitive therapists could have said previously about the mechanisms of action in CBT for depression in adolescents in general and particularly among those with SCD. More so, BAT is less complex than other forms of therapies; easier to understand compared with cognitive strategies [20] and can be as effective as cognitive interventions for depression [23] especially for young people [24]. A significant Nigerian study has reported the benefit of BAT for depressive symptoms among adolescents in Nigeria [13]. This line of reasoning supports the usefulness of BAT particularly in resource poor countries like Nigeria and helps explain why BAT may stand alone as an efficacious treatment intervention for depression among adolescents who live with SCD. An important negative finding of the present study is the observation that though quality of life was statistically significant in post-intervention bivariate analysis; it ceased to be so after the ANCOVA. Unfortunately, though an important measure of wellness, recent review of randomized control trials which have assessed the impact of BAT on adolescent depression showed that quality of life measures has not been included as outcome measure in most trials [19]. As such, it is difficult to put this particular finding of the present study in context. However, the disappearance of the apparent positive effect of BAT on QoL after multi-variate analysis may be an example of Type II error due to the small sample size. There is need for more research, especially highly powered studies with larger sample sizes, to further explore the impact of BAT on QoL of adolescents beyond symptom reduction. This is because QoL measures are not only useful in tracking treatment outcomes; they also provide reliable information about the impact of specific treatments on well-being and functioning [25].
In conclusion this study aimed to determine the effect of behavioral activation therapy (BAT) in adolescents with SCD and mild to moderate depression using a randomized controlled trial. The results showed that BAT resulted in significant improvements in self-reported rating of depressive symptoms (effect size 2.1) and depression literacy suggesting efficacy of BAT in alleviating depressive symptoms in this cohort, however the QoL scores initially appeared to have had a positive change but ceased to be so after controlling for possible confounders. In the background of knowledge of scarcity of psychological therapies in Sub-Saharan Africa, and BAT relatively being cheap and easy to administer, this intervention could be a turnaround as concerns delivery of psychological therapies in Sub-Saharan Africa.