Research Progress of Related Laboratory Testing Indexes before and after Mother-Infant Blocking in HIV/AIDS Pregnant Women

More than 90% of HIV-positive children come from mother-to-child transmission, so mother-to-child interdiction is the main measure to prevent AIDS in children. Relevant data show that the incidence of mother-to-child transmission of HIV usually fluctuates between 15% and 50% without intervention. Standardized and effective comprehensive intervention can reduce the transmission rate of mother to child to less than 1%. At present, it is believed that mother-to-child transmission of AIDS can be blocked by comprehensive intervention, and its mechanism has been clearly studied. Combined with highly effective antiviral treatment, safe labor and artificial feeding, the mother to child transmission rate can be reduced to less than 1%. However, due to the effect of drugs on mother-to-child transmission of AIDS may lead to some changes in the main biochemical indicators of mother-to-child, there is no systematic analysis of the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women before and after ma-ternal-to-child transmission. In this study, the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women minimize the probability of fetal transmission, which will make good economic and social benefits.

Guangxi was the high incidence area of AIDS in China, with the infection rate ranking third only after Yunnan Province and Xinjiang Uygur Autonomous Re-  [6]. In recent years, good results have been achieved in mother-to-child interdiction, but mother-to-child transmission still exists, and the interdiction of mother-to-child transmission among pregnant women with HIV/AIDS cannot be relaxed [4] [5] [6]. Therefore, the research group designs relevant topics according to the actual situation, and makes a literature review as follows.

Pattern of HIV/AIDS Maternal-Neonatal Transmission
There are three main ways of mother-to-child transmission of HIV, namely intrauterine infection, intrapartum infection during childbirth, and postpartum breast infection. According to the mode of mother-to-child transmission, the measures to prevent mother-to-child transmission of HIV are voluntary counseling and testing of pregnant women, to recognize HIV infected people timely.
And viral drugs can be used to intervene HIV in positive pregnant women.
Moreover, cesarean section, artificial feeding and other measures can put into use to effectively reduce the risk of mother-to-child transmission of HIV. It is not difficult to know that mother to child transmission is one of the three ways to spread AIDS [7]- [12]. More than 90% of HIV-positive children occur through mother-to-child transmission. Accordingly mother-to-child interdiction is the main measure to prevent AIDS in children. Studies have shown that without any intervention, the incidence of mother-to-child transmission of AIDS is 15% to 50%. By standardized and effective comprehensive intervention, the incidence of mother to child transmission decreased to less than 1%. At present, it is believed that prevention of mother-to-child transmission of HIV can effectively prevent mother-to-child transmission, and the study of its blocking mechanism has also been made clear. Studies have also shown that combination of highly active antiretroviral therapy, obstructive safe delivery and postnatal artificial feeding can reduce the incidence of mother-to-child transmission to less than 1% [12] [13] [14] [15]. Therefore, it is entirely possible for pregnant women with HIV infection to have babies without HIV infection. At present, in most parts of China, maternal-infant interdiction work has been carried out for HIV-positive pregnant women, and some encouraging results have achieved. However, due to various objective conditions, the work of mother-to-child interdiction of HIVpositive pregnant women is still difficult to carry out. It is gratifying that the Guangxi AIDS Clinical Treatment Center (Nanning) is at the forefront of the country in the work of mother-to-child interdiction of HIV-positive pregnant women. In Guangxi, pregnant women account for a certain proportion of people infected with HIV/AIDS. As pregnant women infected with HIV/AIDS, in a sense, they have the right to give birth to the next generation, and they also have the obligation to make this society harmonious, that is, to give birth to a healthy next generation. How to make rights and obligations do not conflict, which requires AIDS prevention workers pay more attention to the prevention work. In a word, the main responsibility for all kinds of medical workers at all levels is to conduct AIDS propaganda and carried on education. As the medical staff of Guangxi AIDS clinical treatment center, they feel that there is a long way to go, especially in how to stop the mother-to-child transmission of HIV/AIDS infection of pregnant women in the technical tackle, with more profound social significance.

Progress in HIV RNA Laboratory Testing
Since the early 1990s, quantitative detection of HIV viral load has been recog-

Progress in Counting of HIV/AIDS T Lymphocyte Subsets
The determination of T lymphocyte subsets is an important index for the detection of cellular immune function, and is of great significance for the auxiliary diagnosis of some diseases, such as autoimmune diseases, immunodeficiency

Progress in Detection of HIV/AIDS Biochemical Indicators
Some research suggests that after HIV infection, the body's immune function gradually declines and loses, leading to the occurrence of various immunodeficiency syndrome. In this field, a large number of studies at home and abroad have been done to understand the pathogenesis of HIV infection. However, there has not been much research on the changes of biochemical substances in the blood caused by the destruction of target cells after the HIV virus invades the human body, but it has aroused great attention [26] [27] [28]. In recent years, some domestic scholars have made a preliminary analysis of serum biochemical indicators of HIV-infected drug users, and achieved certain results. Studies of SAMUEL K. A. show that HAART can significantly prolong the survival rate and improve the quality of life in HIV-infected patients [29]. However, long-term use of HAART can produce side effects, which may lead to abnormal blood biochemical indicators, and may even endanger life. The study assessed HAART-related blood cell parameters, blood biochemical abnormalities and virological responses in HIV/AIDS infected patients. Blood indices were tested in 200 HIV-positive patients before and after HAART according to clinical laboratory conditions. It was found that HAART had a significant effect on viral load, hematology and biochemical parameters. In particular, the effects of blood cells, liver function and renal function are more significant. In order to understand the changes of microbial, biochemical and hematological indicators before and after antiretroviral therapy (ART) in AIDS patients, Obimba, K. C. [30] and other scholars as a parameter for the diagnosis and prognosis of opportunistic infections in AIDS patients. The research team selected HIV-positive patients as the study subjects. The experiment was designed as a single-factor completely randomized design (CRD), with 20 healthy people as the control group and 50 HIV-positive patients as the experimental group. All patients were tested for HIV viral load (VL), CD4 + T lymphocyte count, serum albumi. N (A), serum aspartate aminotransferase (AST), serum total bilirubin, serum total cholesterol (c), serum triglyceride (T), hemoglobin (Hb) test, blood type and genotype test (HIV positive patients), etc. The results showed that the difference between HIV positive group and healthy control group was statistically significant (P < 0.05). These indicators can be used as effective criteria for the diagnosis and prognosis of HIV infection. Therefore, the detection of HIV/AIDS patients with immunological, hematological and biochemical indicators, in the treatment of AIDS and evaluation of therapeutic effect is of great significance.

Summary and Prospect
To sum up, the relevant literature has not designed the changes of biochemical indicators before and after maternal-fetal blockade. The dynamic analysis of viral load, T lymphocyte subsets and major biochemical indicators before and after maternal-fetal blockade in pregnant women with HIV/AIDS make it helpful to observe the basic physical fitness and disease development of pregnant women with HIV/AIDS. It can also establish a complete set of laboratory indicators to understand the body status of pregnant women at various stages, so as to minimize the probability of fetal transmission, and has good economic and social benefits.