COVID-19: Africa’s Challenge and the Need for a Paradigm Shift on the Use of Ventilators

Background: The December 2019 Chinese epidemic of Corona Virus Disease [COVID-19], which erupted in Wuhan, South China, was declared a pandemic, by the World Health Organization [WHO], on 12 th January 2020. The worldwide spread from China was rapid, but Africa was the last port-of-call. Her first diagnosed case was two months after China’s, on 14 th February, 2020 in Egypt. The morbidity and mortality rates have, however, remained lower in Africa than in the developed world, and analysts believe that it was more of a temporary respite, since Africa’s poor health infrastructure will become her eventual albatross. Methodology: Data were collected on COVID-19 and records of the socio-economic capacity of Africa by accessing the relevant previous and current peer-reviewed publications from multiple search engines on internet. The data were, then, collated and comparatively analyzed. Results: The available data revealed that Africa had, mostly, the milder forms of COVID-19, and so, morbidity and mortality were low. Her shrinking elderly population of spread and re-focusing of critical care away from the expensive and un-available ventilators.


Introduction and Overview of COVID-19
. The causative organism was identified and code-named SARS-CoV-2, by WHO [4].

Spread
The spread from China was rapid, all around the world, but Africa was the last port-of-call, recording her first confirmed case in Egypt on 14 th February, followed by Nigeria 25 th February, Morocco 3 rd March and South Africa 5 th March, 2020.

Tissue Concentration of the Virus
When the virus gains entry into the human body, it concentrates mostly in the respiratory system, and saliva. On account of this, any of four secretions are useful in screening for SARS-CoV-2: sputum, throat swab, respiratory tract secretions and saliva [5]. The focus of the treatment of COVID-19 is, logically, on the respiratory tract, where it concentrates.

Interleukin-6 as a Biomarker for Poor Prognosis
In critically ill patients, the inflammatory cytokine, interleukin-6 [Il-6], levels increase significantly, to almost 10 times the normal levels. This high rise is correlated to the detection of RNAaemia. Remarkably, also, all cases of death exhibited high levels of Il-6, suggesting that it as an important biomarker for poor prognosis [6]. Post-mortem Findings Sharif Sultan, recently, reported that, based on the observations from postmortem studies done on deceased COVID-19 patients, there was a consistent International Journal of Clinical Medicine finding of pulmonary thrombosis, which was not typical of Acute Respiratory Distress Syndrome [ARDS]. Also, that the hypoxaemia found in the patients did not respond to PEEP ventilation, but to high oxygen flow [7]. And so, he advised that patients be started early on maximum oxygen flow, until ventilation becomes inevitable.

Molecular Findings, Cytokine Storm and Failure of Haemoglobin
The viral structural protein, was discovered to stick to haeme, displacing oxygen releasing iron-free ion, and leading to toxicity at the pulmonary bed with inflammation of alveolar macrophages. The virus attacks the beta chain of haemoglobin, dissociates haeme and removes the iron converting it to porphyrin, and leading to "failure of blood" to carry oxygen. The underlying pathology, therefore, is not "failure of respiration".
The oxidative iron released from the haemolysed blood cells damages the lungs, leading to an abnormal rise in levels of Il-6 which becomes the hallmark and driving force of the associated Cytokine Storm, that leads to MODS [7]. The final common pathway, therefore, is the metabolic hypoxia from blood organ failure.
The physiological implication of this is that an invasive ventilation will not be of the best benefit, rather, frequent plasmapheresis and transfusions, to replace the compromised haemoglobin and boost the oxygen-carrying capacity, will be more beneficial in ameliorating the Cytokine Storm [7].
This study evaluates the current status of COVID-19 around the world and the challenges facing the resource-poor African nations. It, then, suggests a paradigm shift from mandatory mechanical ventilation to mandatory plasmapheresis and packed cell transfusion in the management of COVID-19.
Data were collected on the available body of knowledge on COVID-19 and socio-economic capacity of African countries, from multiple search engines on internet. The results collected from all the sources were collated and presented in prose, tables and a graph and analyzed.

Methodology
Data were collected on COVID-19 and records of the socio-economic capacity of African countries by accessing the relevant previous and current peer-reviewed publications from multiple search engines on internet. The data were, then, collated and comparatively analyzed.  [10]. China, the source of the coronavirus, had 82,874 confirmed cases, 4633 deaths and 77,642 recoveries [11]. And, there were the 300 International Journal of Clinical Medicine million non-infected pupils worldwide, who were taken off schools and asked to stay at home, until the pandemic came under control.

Statistics on SARS-CoV-2 Infection around the World
The USA topped the world list with 1,095,019 confirmed cases, 1,039,136 recoveries and 63,856 deaths; followed by Spain with 239,639 cases, 137,984 recoveries and 24,543 deaths; Italy 205,463 cases, 75,945 recoveries and 27,967 deaths; UK 171,253 cases and 26,771 deaths; France 167,178 cases, 49,476 recoveries, 24,376 deaths; and Germany 163,009 cases, 123,500 recoveries and 6623 deaths [12]. As the UK and French figures rose rapidly, the German figures rose less rapidly, just as her comparative death rates, as well. Surprisingly, China, with the largest population in the world [1.4 billion], came a distant 11 th , and did not even make the Top-10; see Table 1.

Impact on Africa
In Africa, by the end of April, 52 out of her 54 countries were already infected, with 39,713 confirmed cases, 13,070 recoveries, and 1,638 deaths. Out of these, South Africa was the worst hit with 5647 confirmed cases, followed by Egypt with 5537 cases and Morocco 4423 cases.
But, Algeria with 4006 cases, 1779 recoveries and 450 deaths, had the worst outcome amongst the African nations. Ghana was 5 th with 2074, cases; Nigeria was 6 th with 1932 cases, and Cameroon 7 th with 1832 cases; see Table 2 [13].

Discussion
Africa appeared lucky with her much lower incidence and mortality rates than the rest of the world; and the worst hit African country was South Africa with 5647 cases, though Algeria had the highest mortality rate, followed by Egypt; see Table 2.
The Infamous "Bleak Situation" in Our Continent Being that massive resources are required for the diagnosis and treatment of patients, protection of the care givers and community, as well as research, with a hope to developing a cure, or, vaccine, Africa's capacity to cope with this pandemic appears to be, unarguably, sub-optimal. Observers believed that the African situation was like a ticking time-bomb, and that, it was just a matter of time before the pandemic will overrun the continent. A few disagree on account of some observed factors.

Immunity by Default?
At the outbreak of the pandemic, there appeared to be in Africa: 1) a lytic hot climate, adverse to the survival of SARS-CoV-2, which showed a predilection to the cold regions; 2) a viral strain, Type B mostly, which was less toxigenic; 3) the factor of low population of elderly persons, due to her lower life expectancy, from poverty and disease.
Perhaps, these 3 variables explained the lower morbidity and mortality rates in Africa; but, may well be confounding factors, only.
Capacity for the Care of the Severely Ill Cases in Africa In Africa [population 1.2 billion], the total number of COVID-19 cases was 39,713 confirmed cases, which was 3.63% the figure for USA [population 331 million] [20] [21] [22]. Yet, it is noteworthy that in Africa, the volume and quality of essential expertise, equipment and infrastructure, for the intensive care of critically ill persons, are grossly inadequate. Kenya

African Initiatives
Learning from the experiences of their forebears in the COVID-19 pandemic in USA, Asia and Europe, many African states adopted some indigenous measures to contain COVID-19 [24]. Madagascar produced an organic drink from the antimalarial, artemisia, which was reported to reduce the mortality from COVID-19 [25]. Senegal, with UK government and Bill and Melinda Gates Foundation, adapted the screening kit originally used for Dengue Fever to a International Journal of Clinical Medicine cheap $1 COVID-19 quick diagnostic kit [26]. The Senegalese researchers, also, designed an affordable ventilator, costing $60 each, as against $16,000 for each imported unit in the country which had only 50 ventilators for her 16million population [27].

Abuja Declaration on Health Budgets of African Nations
At the April 2001 Abuja Declaration, African Heads of Government under the auspices of the WHO, agreed to allot, at least, 15% of total annual budgets to health [28]. After the first decade following that Declaration, only one African country met that target, and 11 actually reduced their budgets. Nigeria's health budget range, very embarrassingly, averaged at 4% -6% since the Abuja Declaration [29].

WHO Recommendations on Healthcare Personnel and Equipment
The WHO recommends 1 doctor to 1000 persons; 1 nurse to 1 patient in ICU [1 nurse to 2 or 3 acutely ill but stable patients]; and 1 nurse to 500 persons; see Table 3 and Figure 1 Table 5.
And so, what are the options available to Africa?
By April 2020, Senegalese researchers had begun the production of very cheap ventilators at $60 per unit [cc: $16,000/imported unit], and, if these can be mass-produced, Africa will improve on her current ventilator/100,000 persons ratios, to a good extent [27]. But those may be reserved for just the critical cases.
Sultan had in his report clearly enunciated the pathological basis for the respiratory difficulties and Il-6 Cytokine Storm in COVID-19, and gone ahead to proffer the solution of plasmapheresis and packed cell transfusion, with maximum oxygen flow, as more effective than PEEP ventilation [7].
At the average cost of $40 per unit of blood and $400 for 10units in the African countries, it appears that multiple transfusions will even be 400 times   In the long term, nevertheless, the more impacting factors like poverty, malnutrition, corruption and endemic diseases, which pre-dated COVID-19, along with the poor healthcare infrastructure, have to be resolutely addressed by all African nations, as a priority.

Conclusions
With COVID-19, Africa is going to face harder times ahead, because of the protracted negligence of the health infrastructure of her countries over the decades; and so, despite the initial low morbidity and mortality rates, there is a possibility that these figures may rise astronomically.
Developing countries need to adopt home-grown indigenous hygienic and health promotional measures to successfully fight COVID-19.
If, however, the lockdown remains imperative, appropriate measures should be taken to avert both food and economic crises, by ensuring that food supply lines and essential businesses are sustained.
Africa should immediately explore the prospects of plasmapheresis and packed cell transfusion as a cheaper and more efficient treatment protocol for critically International Journal of Clinical Medicine ill COVID-19 patients. The absolute dependence on mechanical ventilators, which are both expensive and in short supply, should be reserved for the critical cases.

Disclosures
I have nothing to disclose; I have no commitment whether financial, intellectual or philanthropic to any of the references or institutions or companies cited and I have no form of payment or gratification to any individual or group, whatsoever.