Biography

Dr. Wang Bing

Department of Orthopaedic Surgery and Neurology

University of Pittsburgh School of Medicine, USA

Assistant Professor


Email: bingwang@pitt.edu


Qualifications

1998 Ph.D., Chinese Academy of Sciences

1986 M.D., Huazhong University of Science and Technology


Publications(selected)

  1. Christian Isaac, Adam Wright, Arvydas Usas, Hongshuai Li, Ying Tang, Xiadong Mu, Qing Dong, Nam Vo, James Kang, Bing Wang, and Johnny Huard. Dystrophin and Utrophin “Double Knockout” Dystrophic Mice Exhibit a Spectrum of Degenerative Musculoskeletal Abnormalities. Journal of Orthopaedic Research. 2013; 31: 343-349.
  2. Sarah A. Beckman, William CW Chen, Ying Tang, Jonathan Proto, Logan Mlakar, Bing Wang, Johnny Huard. The beneficial effect of mechanical stimulation on the regenerative potential of MDSCs is lost by inhibiting VEGF. Arteriosclerosis, Thrombosis, and Vascular Biology. 2013, (Ahead of Print).
  3. Xiaodong Mu, Arvydas Usas, Ying Tang, Aiping Lu, Bing Wang, Kurt Weiss, and Johnny Huard. RhoA mediates defective stem cell function and heterotopic ossification in dystrophic muscle of mice. The FASEB Journal • Research Communication. 2013 (Ahead of Print).
  4. Gao X, Usas A, Lu A, Tang Y, Wang B, Chen C, Li H, Tebbets JC, Cummins JH, Huard J. BMP2 is superior to BMP4 for promoting human muscle derived-stem cell mediated bone regeneration in a critical size calvarial defect model. Cell Transplant. 2012 Nov 1.
  5. Qing Yang, Ying Tang, Kara Imbrogno, Aiping Lu, Jonathan D. Proto, Anmin Chen, Fengjin Guo, Freddie H. Fu, Johnny Huard, Bing Wang. AAV-based shRNA silencing of NF-κB ameliorates muscle pathologies in mdx mice. Gene Therapy, 2012, 19(12): 1196-204.
  6. Aiping Lu, Jonathan D Proto, Lulin Guo, Ying Tang, Mitra Lavasani, Jeremy S Tilstra, Laura J Niedernhofer, Bing Wang, Denis C Guttridge, Paul D Robbins and Johnny Huard. NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells. Mol Ther. 2012; 20(3): 661-8.
  7. Dawn E Bowles, Scott WJ McPhee, Chengwen Li, Steven J Gray, Jade J Samulski, Angelique S Camp, Juan Li, Bing Wang, Paul E Monahan, Joseph E Rabinowitz, Joshua C Grieger, Lakshmanan Govindasamy, Mavis Agbandje-McKenna, Xiao Xiao and R Jude Samulski Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector.Mol Ther. 2012; 20(2): 443-55.
  8. Xiang G, Yang Q, Wang B, Sekiya N, Mu X, Tang Y, Chen CW, Okada M, Cummins J, Gharaibeh B, Huard J. Lentivirus Mediated Wnt11 Gene Transfer Enhances Differentiation of Skeletal Muscle-derived Stem Cells. Molecular Therapy, 2011, 19(4): 790-796.
  9. Liqiao Zhou, Tong Zhu, Xiaojing Ye, Lin Yang, Bing Wang, Xiaoyan Liang, Lina Lu, Yeou-Ping Tsao, Show-Li Chen, Juan Li, and Xiao Xiao. Long-term protection against HPV E7-positive tumor by a single vaccination of AAV vectors encoding a fusion protein of inactivated E7 of HPV 16/18 and heat shock protein 70. Human Gene Therapy. 2010, 21: 109-119.
  10. Ying Tang, Daniel P. Reay, Melessa N. Salay, Michael Y. Mi, Paula R. Clemens, Denis C. Guttridge, Paul D. Robbins, Johnny Huard, Bing Wang. Inhibition of the IKK/NF-κB Pathway by AAV Gene Transfer Improves Muscle Regeneration in Oldermdx Mice. Gene Therapy, 2010, 17 (12), 1476-1483.
  11. Koppanati BM, Li J, Reay DP, Wang B, Daood M, Zheng H, Xiao X, Watchko JF, Clemens PR. Improvement of the mdx mouse dystrophic phenotype by systemic in utero AAV8 delivery of a minidystrophin gene. Gene Therapy. Gene Therapy, 2010, 17 (11), 1355-1362.
  12. Kornegay JN, Li J, Bogan JR, Bogan DJ, Chen C, Zheng H, Wang B, Qiao C, Howard JF Jr, Xiao X. Widespread Muscle Expression of an AAV9 Human Mini-dystrophin Vector After Intravenous Injection in Neonatal Dystrophin-deficient Dogs.Molecular Therapy. 2010, 18(8): 1501‐1508.
  13. Bing Wang, Juan Li, Freddie H. Fu, and Xiao Xiao. Systemic human minidystrophin gene transfer improves functions and life-span of dystrophin and dystrophin/utrophin deficient mice. Journal of Orthopaedic Research, 2009, 27: 4, 421-426.
  14. Michael Y. Mi, Ying Tang, Melessa N. Salay, Guangheng Li, Johnny Huard, Freddie H. Fu, Christopher Niyibizi, Bing Wang.AAV based ex vivo gene therapy in rabbit adipose-derived mesenchymal stem/progenitor cells for osteogenesis. The Open Stem Cell Journal, 2009, 1, 69-75.
  15. Bing Wang, Juan Li, Chunping Qiao, Chunlian Chen, Peiqi Hu, Xiaodong Zhu, Liqiao Zhou, Janet Bogan, Joseph Kornegay & Xiao Xiao. A canine mini-dystrophin is functional and therapeutic in mdx mice. Gene Therapy, 2008, 15 (15), 1099-1106.
  16. Bing Wang, Juan Li, Freddie H. Fu, Chunlian Chen, Xiaodong Zhu, Liqiao Zhou, Xiancheng Jiang, and Xiao Xiao.Construction and analysis of compact muscle-specific promoters for AAV Vectors. Gene Therapy, 2008, 15 (22), 1489-1499.
  17. A. Draviam, Bing Wang, Juan Li, Xiao Xiao & Simon C Watkins. Mini-dystrophin efficiently incorporates into the dystrophin protein complex in living cells. Journal of Muscle research and cell motility, 2006, 27(1): 53-67.
  18. Romesh A. Draviam, Bing Wang, Stuart Shand, Xiao Xiao & Simon C. Watkins. Alpha-sarcoglycan is recycled from the plasma membrane in the absence of sarcoglycan complex assembly. Traffic, 2006, 7(7): 793-810.
  19. Zhong Wang, Tong Zhu, Chunping Qiao, Liqiao Zhou, Bing Wang, Jiang Zhang, Chunlian Chen, Juan Li, Xiao Xiao. Adeno-associated Virus Serotype 8 Efficiently Delivers Genes to Muscle and Heart. Nat Biotechnol. 2005, 23(3): 321-328.
  20. Bing Wang, Juan Li, Xiao Xiao. Adeno-associated Virus Vector Carrying Human Minidystrophin Genes Effectively Ameliorates Muscular Dystrophy in mdx Mouse Model. Proc. Natl. Acad. Sci. USA., 2000, 97(25): 13714-13719.
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