Dr. Maja Diana Neely

Vanderbilt Kennedy Center for Research on Human Development

Email: diana.neely@Vanderbilt.Edu

Qualifications

1990 Ph.D, Brown University, Molecular Biology, Cell Biology and Biochemistry

Publications (selected)

1. Neely, M.D. and K. Boekelheide (1988) Sertoli cell processes have axoplasmic features: an ordered microtubule distribution and an abundant high molecular weight microtubule-associated protein (cytoplasmic dynein). J. Cell. Biol. 107: 1767-1776.
2. Neely, M.D., H.P. Erickson, and K. Boekelheide (1990) HMW-2, the Sertoli cell cytoplasmic dynein from rat testis, is a dimer composed of nearly identical subunits. J. Biol. Chem. 265 (15): 8691-8698.
3. Boekelheide, K., Eveleth, J., Neely, M.D., and T.M. Sioussat, T.M (1991) Microtubule assembly is altered following covalent modification by the n-hexane metabolite 2,5-hexanedione. Adv. Exp. Med. Biol. 283: 433-442.
4. Neely, M.D. (1993) Role of substrate and calcium in neurite retraction of leech neurons following depolarization. J. Neurosci. 13: 1292-1301.
5. Masuda-Nakagawa, L.M., A. Walz, D. Brodbeck, M.D. Neely, S. Grumbacher-Reinert (1994) Substrate-dependent interactions of leech microglial cells and neurons in culture. J. Neurobiol. 25: 83-91.
6. Neely, M.D. and M. Gesemann (1994) Disruption of microfilaments in growth cones following depolarization and calcium influx. J. Neurosci. 14: 7511-7520.
7. Neely M.D. and E. Macaluso (1997) Motile areas of leech neurites are rich in microfilaments and two actin-binding proteins: gelsolin and profilin. Proc. R. Soc. Lond. Biol. Sci. 264: 1701-1706.
8. Montine, K.S., E. Reich, M.D. Neely, K.R. Sidell, S.J. Olson, W.R. Markesbery and T. J. Montine (1998) Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype. J. Neuropath. Exp. Neurol. 57: 415-25.
9. Neely M.D., K.R. Sidell, D.G. Graham and T.J. Montine (1999) The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin. J. Neurochem. 72: 2323-2333.
10. Bassett, C.N. , M.D. Neely, K.R. Sidell, W.R. Markesbery, L.L. Swift and T.J. Montine (1999) Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer’s disease and are neurotoxic when oxidized ex vivo. Lipids. 34: 1273-1280.
11. Neely, M.D., L.L. Swift and T.J. Montine (2000) Human, but not bovine, oxidized CSF lipoproteins disrupt neuronal microtubules. Lipids 35: 1249-1257.
12. Neely, M.D., L. Zimmerman, M.J. Picklo, J.J. Ou, C.R. Morales, K.S. Montine, V. Amarnath and T.J. Montine (2000) Congeners of N-acetyl-L-cysteine but not aminoguanidine act as neuroprotectants from the lipid peroxidation product 4-hydroxy-2-nonenal. Free Radic. Biol. Med. 29: 1028-1036.
13. Neely, M.D., V. Amarnath, C. Weitlauf and T.J. Montine (2002) Synthesis and cellular effects of an intracellularly activated analogue of 4-hydroxynonenal. Chem. Res. Toxicol. 15: 40-47.
14. Swift, L.L., Zhu, M.-Y., Kakkad, B., Jovanovska, A., Neely, M.D., Valyi-Nagy, K., Roberts, R.L., Ong, D.E. and W.G. Jerome (2003) Subcellular localization of microsomal triglyceride transfer protein. J. Lipid. Res. 44: 1841-1849.
15. Shie, F.S.*, Neely, M.D.*, Maezawa, I., Wu, H., Olson, S.J., Jürgens, G. Montine, K.S. and T.J. Montine (2004) Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion. Am. J. Pathol. 164: 1173-1181. (* contributed equally to the work)
16. Neely, M.D., Boutte, A., Milatovic, D. and T.J. Montine (2005) Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction. Brain. Res. 1037: 90-98.
17. Boutte, A.M., Neely, M.D., Bird, T.M., Montine, K.S. and T.J. Montine (2005) Diminshed taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer’s disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment. J. Alzheimers. Dis. 8: 1-6
18. Mathur, B.N., Neely, M.D., Dyllick-Brenzinger, M., Tandon, A, and A.Y. Deutch (2007) Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration. Brain. Res. 1168: 83-89
19. Neely, M.D., Schmidt, D.E. and A.Y. Deutch (2007) Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons. Neuroscience. 149: 457-464
20. Neely, M.D., Robert, E.M., Baucum, A.J., Colbran, R.J., Muly, E.C. and A.Y. Deutch. (2009) Forebrain localization of MEF2: Regionally-specific cytoplasmic expression of MEF2A. Brain. Res. 1274: 55-65
21. Nayyar, T., Bubser, M., Ferguson, M., Neely, MD., Goodwin, J.S., Montine, T.J., Deutch, A.Y., and T.A. Ansah (2009) Cortical serotonin and denervation in parkinsonism: Preferential loss of the beaded serotonin innervation. Eur. J. Neurosci. 30: 207-216
22. Neely, M.D., Stanwood, D.G. and A.Y. Deutch. (2009) Combination of diOlistic labeling with retrograde tract tracing and immunohistochemistry. J. Neurosci. Methods. 184: 332-336
23. Garcia, B., Neely, M.D. and A.Y. Deutch (2010) Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Cerebral. Cortex. 20: 2423-2432
24. Neely, M.D., Litt, M.J., Tidball, A.M., Li, G.G., Aboud, A.A., Hopkins, C.R., Chamberlin, R., Hong, C.C., Ess, K.C., and A.B. Bowman (2012) DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 expression during neural induction. ACS Chem. Neurosci. 3: 482-491 PMCID: PMC3400384