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Dr. Jayadev Raju

Toxicology Research Division

Bureau of Chemical Safety

Food Directorate

Health Canada, Ottawa, Canada

Email: jayadev_raju@hc-sc.gc.ca



1999, PhD, Life Sciences, School of Life Sciences, Jawaharlal Nehru University, India

1994, MS, Life Sciences, School of Life Sciences, Jawaharlal Nehru University, India

1992, BS, Zoology, R.K.M. Vivekananda College, University of Madras, India


Selected Publications:

[1]   Jayadev Raju, Chandni Sondagar, Jennifer Roberts, Syed Aziz, Don Caldwell, Elizabeth Vavasour, Rekha Mehta. Dietary acrylamide does not augment azoxymethane-induced colon aberrant crypt foci formation in male F344 rats. Food and Chemical Toxicology, 49(6): 1373-1380, 2011.

[2]   Qixuan Chen, Eleonara Swist, Jocelyn Beckstead, Judy Green, Fernando Matias, Jennifer Roberts, Cunye Qiao, Jayadev Raju, Stephen P.J. Brooks and Kylie A. Scoggan. Different doses of dietary oligofructosaccharides and wheat bran elicit different gene expression responses in colon epithelia of healthy Fisher 344 rats. Journal of Nutrition, 141(5): 790–797, 2011.

[3]   Agnieszka Bielecki, Jennifer Roberts, Rekha Mehta, Jayadev Raju. Estrogen receptor-mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones. Nutrition and Cancer, 63(1): 139-150, 2011.

[4]   Sonal Varma, Michael Eskin, Ranjana Bird, Brion Dolenko, Jayadev Raju, Omkar B. Ijare, Tedros Bezabeh. The potential of magnetic resonance spectroscopy (1H MRS) to assess the effect of dietary fatty acids on the progression of inflammatory bowel disease in an animal model. Lipids, 45(9): 843-854, 2010.

[5]   Jayadev Raju, Agnieszka Bielecki, Donald Caldwell, Eric Lok, Marnie Taylor, Kamla Kapal, Ivan Curran, Gerard M. Cooke, Ranjana P. Bird and Rekha Mehta. Soy isoflavones modulate azoxymethane-induced colon carcinogenesis exposed pre- and postnatally and inhibit the growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-. Journal of Nutrition, 139: 474-481, 2009.

[6]   Jayadev Raju, Rekha Mehta. Cancer chemopreventive and therapeutic properties of diosgenin, a food saponin. Nutrition and Cancer, 61(1): 27-35, 2009.

[7]   Jayadev Raju. AOM-induced rat aberrant crypt foci: Relevance in studying chemoprevention of colon cancer. World Journal of Gastroenterology, 12(23): 6637-6670, 2008.

[8]   Sonal Varma, Ranjana Bird, Michael Eskin, Brion Dolenko, Jayadev Raju, Tedros Bezabeh. Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model. Journal of Inflammation, 4(1): 24, 2007.

[9]   Jayadev Raju and Ranjana P. Bird. Diosgenin, a naturally occurring furostanol saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Letters, 255: 194–204, 2007.

[10]N.A. Michael Eskin, Jayadev Raju and Ranjana P. Bird. Novel mucilage fraction of Sinapis alba L. (mustard) reduces azoxymethane-induced colonic aberrant crypt foci formation in F344 and Zucker obese rats. Phytomedicine, 14(7-8): 479-485, 2007.

[11]Jayadev Raju and Ranjana P. Bird. Alleviation of liver steatosis accompanied by modulation of plasma and liver TNF-levels by Trigonella foenum graecum (fenugreek) seeds in Zucker obese (fa/fa) rats. Int. J. Obesity, 30(8): 1298-1307, 2006.

[12]Jagan M.R. Patlolla, Jayadev Raju, Malisetty V. Swamy and Chinthalapally V. Rao. β-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21 waf1/cip1 in colon cancer cells. Molecular Cancer Therapeutics, 5(6): 1459-1466, 2006.

[13]Jayadev Raju, Gagan D. Bajaj, Jennifer Chrusch and Ranjana P. Bird. Obese state leads to elevated TGF-and COX isoforms in platelets of Zucker rats. Mol. Cell. Biochem., 284(1-2): 19-24, 2006.

[14]Jayadev Raju, Malisetty V. Swamy, Indranie Cooma, Jagan M.R. Patlolla, Vernon E. Steele, Bandaru S. Reddy and Chinthalapally V. Rao. Low doses of -carotene and lutein inhibits AOM-induced rat colonic ACF formation but augments ACF incidence at higher doses. Int. J. Cancer, 113(5): 798-802, 2005.

[15]Jayadev Raju, Jagan M.R. Patlolla, Malisetty V. Swamy and Chinthalapally V. Rao. Diosgenin, a steroid saponin of Trigonella foenum graecum (fenugreek) inhibit sazoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiology Biomarkers and Prevention, 13(8): 1392-1398, 2004.

[16]Gacheri A. Kiunga, Jayadev Raju, Natasa Sabljic, Carolyn K. Good, Gagan Bajaj and Ranjana P. Bird. Elevated expression of insulin receptor is a phenotype common to colonic tumors of azoxymethane-injected F344 rats irrespective of dietary lipid interventions. Cancer Letters, 211: 145-153, 2004.

[17]Jagan M.R. Patlolla, Malisetty V. Swamy, Jayadev Raju and Chinthalapally V. Rao. Overexpression of caveolin-1 in experimental colon carcinogenesis and human colon cancer cell lines. Oncology Reports, 11(5): 957-964, 2004.

[18]Jayadev Raju and Ranjana P. Bird. Energy restriction reduces the number of advanced ACF and attenuates the expression of colonic TGF- and COX in Zucker obese (fa/fa) rats. Cancer Research, 63: 6595-6601, 2003.

[19]Jayadev Raju, Brendan McCarthy, and Ranjana P. Bird. Steady state levels of transforming growth factor-1 and -2 mRNA and protein expression are elevated in colonic tumors in vivo irrespective of dietary lipids intervention. Int. J. Cancer, 100(6): 635-641, 2002.

[20]Jayadev Raju and Ranjana P. Bird. Dietary lipids modulate transforming growth factors and cycloxygenases in the platelet lysates of Male F344 Rats. Mol. Cell. Biochem. 231(1/2): 139-146, 2002.

[21]Jayadev Raju, Dhananjay Gupta, Araga R. Rao, Pramod K. Yadava and Najma Z. Baquer. Trigonella foenum graecum (fenugreek) seed powder improves glucose and lipid metabolism in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol. Cell. Biochem. 224(1/2): 45-51, 2001.

[22]Jay Adams, Jayadev Raju, Nasreen Khalil and Ranjana P. Bird. Evidence for the involvement of dietary lipids in modulation of transforming growth factor 1 in the platelets of male Sprague-Dawley rats. Mol. Cell. Biochem. 211(1/2): 145-152, 2000.

[23]Dhananjay Gupta, Jayadev Raju, R. Jaya Prakash and Najma Z. Baquer. Changes in the lipid profiles, lipogenic and related enzymes in the livers of experimental diabetic rats: Effects of insulin and vanadate. Diab. Res. Clin. Pract. 46, 1-7, 1999.

[24]Salimuddin, Kailash C. Upadhyaya, Jayadev Raju and Najma Z. Baquer. Modulation of mRNA levels of liver type arginase by insulin and vanadate in experimental diabetes. Ind. J. Biochem. Biophys. 36,125-128, 1999.

[25]Dhananjay Gupta, Jayadev Raju and Najma Z. Baquer. Modulation of some gluconeogenic activities in diabetic rat liver and kidney: Effect of antidiabetic compounds. Ind. J. Exp. Biol. 37,196-199, 1999.

[26]Jayadev Raju, Dhananjay Gupta, A. Ramesha Rao and Najma Z. Baquer. Effect of antidiabetic compounds on glyoxalase I activity in experimental diabetic rat liver. Ind. J. Exp. Biol. 37,193-195, 1999.

[27]Najma Z. Baquer, Dhananjay Gupta and Jayadev Raju. Regulation of metabolic pathways in liver and kidney during experimental diabetes: effect of antidiabetic compounds. Ind. J. Clin. Biochem. 13(2), 63-80, 1998.