Biography

Dr. Shile Huang

Department of Biochemistry and Molecular Biology
Louisiana State University Health Sciences Center, USA
Associate Professor


Email:shuan1@lsuhsc.edu


Qualifications


1994- 1997 Ph.D., Institute of Zoology, University of Salzburg, Austria

1984- 1987 M.S., Nanjing Agricultural, University, Nanjing, China

1980- 1984 B.S., Anhui Agricultural University, China


Publications

  1. Luo Y, Liu L, Rogers D, Su W, Zhou H, Chen W, Shen T, Alexander JS,Huang S*(2011) Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating VEGFR-3 protein expression.Cell Mol Life Sci.(submitted)
  2. Lee YJ, Burlet E, Wang S, Xu B,Huang S, Galiano FJ, Witt SN. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochem Biophys Res Commun. 2011 Sep 16. [Epub ahead of print]
  3. Chen S, Xu Y, Xu B, Guo M, Zhang Z, Liu L, Ma H, Chen Z, Luo Y,Huang S*, Chen L*. CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal apoptosis.J Neurochem.2011 Sep 20. [Epub ahead of print]. PMID: 21933187
  4. Luo Y, Chen W, Zhou H, Liu L, Shen T, Alexander JS, Zheng S, Lu Y,Huang S*(2011) Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways.Cancer Prev Res. 2011 Aug 31. [Epub ahead of print]. PMID: 21881029
  5. Chen L, Zheng SZ, Sun ZG, Wang AY, Huang CH, Punchard NA,Huang SL, Gao X, Lu Y (2011). Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity.Cancer Chemother Pharmacol.68:17-27. PMID: 20820782; PMCID: PMC3032829
  6. Xu B, Chen S, Luo Y, Chen Z, Liu L, Zhou H, Chen W, Shen T, Han X, Chen L*,Huang S*(2011) Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network.PLoS One6: e19052. PMID:21544200
  7. Luo Y, Zhou H, Liu L, Shen T, Chen W, Xu B, Han X, Alexander JS, Alam A,Huang S* (2011) The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway.Oncogene.30:2098-2107. PMID: 21217783; PMCID: PMC3088775
  8. Chen L, Xu B, Liu L, Luo Y, Zhou H, Chen W, Shen T, Han X, Kontos CD,Huang S*(2011) Cadmium induction of reactive oxygen species activates mTOR pathway, leading to neuronal cell death.Free Radic Biol Med.50:624-632. PMID: 21195169; PMCID: PMC3032035
  9. Liu L, Luo Y, Chen L, Shen T, Xu B, Chen W, Zhou H, Han X,Huang S* (2010) Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.J Biol Chem. 285:38362-38373. PMID: 20937815; PMCID: PMC2992269
  10. 10.Zhou H, Shen T, Luo Y, Liu L, Chen W, Xu B, Han X, Rivera CA,Huang S* (2010) The antitumor activity of the fungicide ciclopirox.Int J Cancer127:2467-2477. PMID: 20225320; PMCID: PMC2888914
  11. Chen W, Luo Y, Liu L, Zhou H, Xu B, Han X, Shen T, Liu Z, Lu Y,Huang S* (2010) Cryptotanshinone inhibits cancer cell proliferation by suppressing mTOR-mediated cyclin D1 expression and Rb phosphorylation.Cancer Prev Res.3:1015-1025. PMID: 20628002; PMCID: PMC2917475
  12. Liu L, Chen L, Luo Y, Chen W, Zhou H, Xu B, Han X, Shen T,Huang S* (2010) Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway.PLoS One5:e10578. PMID: 20485667; PMCID: PMC2868031
  13. Chen L, Xu B, Liu L, Luo Y, Yin J, Zhou H, Chen W, Shen T, Han X,Huang S* (2010) Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells.Lab Invest.90:762-773. PMID: 20142804; PMCID: PMC2861733
  14. Chen L, Liu L, Yin J, Luo Y,Huang S* (2009) Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway.Int J Biochem Cell Biol.41:1284-1295. PMID: 19038359
  15. Beevers CS, Chen L, Liu L, Luo Y, Webster NJG,Huang S* (2009) Curcumin disrupts the mammalian target of rapamycin-raptor complex.Cancer Res.69:1000-1008. PMID: 19176385
  16. Kim HI, Huang H, Cheepala S,Huang S, Chung J (2008) Curcumin inhibition of integrin (α6β4) dependent cancer cell motility.Cancer Prev Res.1:385-391. PMID: 19138983
  17. Chen L, Liu L,Huang S* (2008) Cadmium activates MAPK pathway via induction of reactive oxygen species and inhibition of protein phosphatase 2A and 5.Free Radic Biol Med.45:1035-1044. PMID: 18703135
  18. Liu L, Chen L, Chung J,Huang S* (2008) Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins.Oncogene27:4998-5010. PMID: 18504440; PMCID: PMC2562907
  19. Chen L, Liu L, Luo Y,Huang S*(2008) MAPK and mTOR pathways are involved in cadmium- induced neuronal apoptosis.J Neurochem.105:251-261. PMID: 18021293
  20. Zhan J, Easton JB,Huang S, Mishra A, Xiao L, Lacy ER, Kriwacki R, and Houghton PJ (2007) Negative regulation of ASK1 by p21Cip1 involves a small domain that includes serine 98 that is phosphorylated by ASK1 in vivo.Mol Cell Biol.27:3530-3541. PMID: 17325029; PMCID: PMC1899956
  21. Liu L, Li F, Cardelli, JA, Martin KA, Blenis J,Huang S*(2006) Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways.Oncogene.25:7029-7040. PMID: 16715128
  22. Beevers CS, Li F, Liu L,Huang S*(2006) Curcumin inhibits the mammalian target of rapamycin- mediated signaling pathways in cancer cells.Int J Cancer119:757-764. PMID: 16550606
  23. Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ (2004) Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.J Biol Chem.279:36490-36496. PMID: 15218033
  24. Huang S, Shu L, Dilling MB, Easton J, Harwood FC, Ichijo H, Houghton PJ (2003) Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21Cip1.Mol Cell. 11:1491-1501. PMID: 12820963
  25. Thimmaiah KN, Easton J,Huang S, Veverka KV, Germain GS, Harwood FC, Houghton PJ (2003) Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3′-kinase-Akt signaling pathways.Cancer Res. 63: 364-374. PMID: 12543789
  26. Huang S, Liu L, Hosoi H, Dilling MB, Shikata T, Houghton PJ (2001) p53/p21CIP1 cooperate in enforcing rapamycin-induced G1 arrest and determine the cellular response to rapamycin.Cancer Res. 61:3373-3381. PMID: 11309295
  27. Kerschbaum HH,Huang S, Xie M, Hermann A (2000) NADPH-diaphorase activity and nitric oxide synthase activity in the kidney of the clawed frog, Xenopus laevis.Cell Tissue Res. 301:405-411. PMID: 10994786

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Last Updated: December 9, 2011.

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