Dr. Azizul Haque
Department of Microbiol/Immunol
Medical University of South Carolina, USA
Associate Professor
Email:haque@musc.edu
Qualifications
1993-1997 Ph.D., Microbiol. & Immunol, Saga Medical School, Japan
1990-1992 M.Sc., Microbiology, Dhaka University, Bangladesh
1984-1990 B.Sc., Biology, Dhaka University, Bangladesh
Publications
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Haque MA, Hawes JW, Blum JS (2001) Cysteinylation of an MHC Class II Ligand: importance endocytosis and reductive processing in T cell recognition.J Immunol166:4543-4551 (PMID 11254711).
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Li P, Haque MA,Blum JS (2002) Role of disulfide bonds in regulating antigen processing and epitope selection.J Immunol169:2444-2450 (PMID 12193713).
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Haque MA,Li P, Jackson SK, Zarour HM, Hawes JW, Phan UT, Maric M, Cresswell P, Blum JS (2001) Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes.J Exp Med195:1267-1277 (PMID 12021307).
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Haque MA,Mizobuchi T, Yashufuku K, Fujisawa T, Brutkiewicz R, Zheng Y, Woods K, Smith GN, Cummings OW, Heidler KM, Blum JS, Wilkes DS (2002) Evidence for immune responses to a self-antigen in lung transplantation: Role of type v collagen-specific T cells in the pathogenesis of lung allograft rejection.J Immunol169:1542-1549 (PMID 12133982).
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Mizobuchi T, Yasufuku K, Zheng Y,Haque MA, Heidler KM, Woods K, Smith GN, Cummings OW, Fujisawa T, Blum JS,Wilkes DS (2003) Differential expression of Smad7 and TCR V- transcripts identify the CD4-CD45ROhiregulatory T cells that mediate type V collagen-induced tolerance to lung allografts.J Immunol171:1140-1147 (PMID 12874199).
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O'Donnell PW,Haque A, Klemsz MJ, Kaplan MH, Blum JS (2004)Induction of the antigen processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells is STAT1-dependent but CIITA-independent.J Immunol(Cutting Edge)173:731-735 (PMID 15240658).
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Haque A, Blum JS (2005) New insights in antigen processing and epitope selection: development of novel immunotherapeutic strategies for cancer, autoimmunity and infectious diseases. (Review).J Biol Regul Homeost Agents19:93-104 (PMID 16602623).
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Srinivasan M, Debao L, Rajaraman E, Brand D,Haque A, Blum JS (2005) CD80 binding polyproline helical peptide inhibits T cell activation.J Biol Chem280:10149-55 (PMID 15598660).
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Yoshida S,Haque A, Mizobuchi T, Iwata T, Chiyo M, Webb T, Baldridge LA, Heidler KM, Cummings OW, Fujisawa T, Blum JS,Brand DD, Wilkes DS (2006)Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants.Am J Transplant6:724-35 (PMID 16539629).
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Haque A, Das A, Hajiaghamohseni LM, Younger A, Banik NL, Ray SK (2007) Induction of apoptosis and immune response by all-trans retinoic acid plus interferon-gamma in human glioblastoma T98G and U87MG cells.Cancer Immunol Immunother56:615-25 (PMID 16947022).
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Imam SA, Guyton ML,Haque A, Vandenbark A, Tyor WR, Ray SK, Banik NL (2007) Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients.J Neuroimmunol190:139-45 (PMID 17765980).
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Haque A, Banik NL, Ray SK (2007) Emerging role of combination of all-transretinoic acid and interferon-gamma as chemoimmunotherapy in the management of human glioblastoma. (Review)Neurochem Res32:2203-9 (PMID 17676389).
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Younger AR,Amria S,Jeffrey WA,Mahdy A, Goldstein OG,Norris JS,Haque A(2008) HLA class II antigen presentation by human prostate cancer cells.Prostate Cancer Prostatic Dis.11:334-41(PMID 17938645).
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Haque A, Hajiaghamohseni LM, Li P, Toomy K, Blum JS (2007) Invariant chain modulates HLA class II protein recycling and peptide presentation in nonprofessional antigen presenting cells.Cell Immunol249:20-9 (PMID 18067883).
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Amria S, Cameron CA, Stuart RK,Haque A(2008) Defects in HLA class II antigen presentation in B-cell lymphomas.Leuk. Lymphoma49:353-5 (PMID 18231926).
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Haque A, Banik NL, Ray SK (2008)New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer’s disease: cathepsin inhibitors as potential therapeutics. (Review)Curr Drug Targets.7:270-277.
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Goldstein OG, Hajiaghamohseni LM, Amria S, Sundaram K, Sakamuri V. Reddy SV,Haque A(2008) Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma.Cancer Immunol and Immunother.57:1461-1470 (PMID 18343923).
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Amria S, Hajiaghamohseni LM, Harbeson C, Zhao D, Goldstein O, Blum JS,Haque A(2008) HLA-DM negatively regulates HLA-DR4-restricted collagen pathogenic peptide presentation and T-cell recognition.Eur J Immunol.38:1961-1970 (PMID: 18506881).
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Norton DL,Haque A(2009) Insights into the role of GILT in HLA class II antigen processing and presentation by melanoma.J Oncololy2009:142959.
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Doonan BP,Haque A(2010)HLA class II antigen presentation in prostate cancer cells: a novel approach to prostate tumor immunotherapy.Open Cancer Immunology Journal,3:1-7.
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God JM,Haque A(2010) Burkitt lymphoma: pathogenesis and immune evasion.J Oncololy,2010: 516047.
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Johnson BM, Doonan BP, Radwan FF,Haque A(2010) Ganoderic acid DM: an alternative agent for the treatment of advanced prostate cancer.Open Prostate Journal3:78-85.
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Haque A,Banik NL, Ray SK (2011).Molecular alterations in glioblastoma: potential targets for immunotherapy.Prog Mol Biol Transl Sci.98:187-234.
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Smith AW, Doonan BP,Haque A,Banik NL (2011)Regulation of Th1/Th17 cytokines and IDO by inhibition of calpain in PBMCs from MS patients.J Neuroimmunology. 232(1-2):179-85
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Hathaway JD andHaque A(2011)Insights into the role of PAX-3 in the development of melanocyte and melanoma.Open Cancer Journal4:1-6.
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Zhao D, Amria S, Hossain A, Sundaram K, Komlosi, Nagarkatti M,Haque A(2011) Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1.Cell Immunol271(2):392-400.
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Radwan F, Lixia Z, Hossain A, Doonan BP, God J,Haque A(2011) Mechanisms regulating enhanced HLA class II-mediated CD4+ T cell recognition of human B-cell lymphoma by resveratrol,Leuk Lymphoma(In press)
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Hossain A, God JM, Radwan FF, Amria S, Zhao D, Bethard JR,Haque A(2011) HLA class II defects in Burkitt lymphoma: bryostatin-1-induced 17 kDa protein restores CD4+ T cell recognition.Clinical and Developmental Immunology(In press)
Profile Details
Last Updated: December 9, 2011.
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