Dr. Wanli W. Smith

University of Maryland School of Pharmacy

Assistant Professor

Email: wsmith@rx.umaryland.edu

Qualifications

1998 Ph.D., Beijing Institute of Pharmacology, Biochemistry and Molecular Biology

1995 M.S., Xi’an Medical University, Pharmacology

1991 B.S., Xi’an Medical University, Medical Science (equivalent MD in USA) Clinical Medicine

Publications (selected)

1. J Liu, T Li, D Yang, TH. Moran, and WW. Smith*. Synphilin-1 alters metabolic homeostasis: a novel Drosophila model for obesity. Int J. Obesity. 2012; In press
2. D Yang, T Li, Z Liu, N Arbez, J Yan, TH. Moran, CA. Ross and WW. Smith*. LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin. Neurobiol Dis. 2012; 47(3): 385-92
3. Y Zhan, Y Zhang, C Liu, J Zhang, WW Smith, N Wang, Y Chen, L Zheng, and L He. A novel taspine derivative, HMQ1611inhibits breast cancer cell growth via ERK and EGFR signaling pathways. America association of cancer research. Cancer Prev Res (Phila). 2012 Jun;5(6): 864-73
4. X. Li, K. LK. Tamashiro, Z. Liu, NT Bello, X. Wang, S. Aja, S.Bi, E.E. Ladenheim, C A. Ross,, TH. Moran, and WW. Smith*. A novel obesity model: Synphilin-1 induced hyperphagia and obesity in mice. Int. J. Obesity. 2011; doi: 10.1038/ijo; In press
5. G. Zhu, J. Yan, WW. Smith, TH. Moran, S. Bi. Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis. Physiology & Behavior. 2012; 105: 234-411
6. Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, WW Smith#, Dawson VL. Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in C. elegans and Drosophila Parkinson's disease models. Hum. Mol. Genet. 2011; 20: 3933
7. Liu Z, Yu Y, Li X, Ross CA, WW Smith*. Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism. Pharmacol Res. 2011; 63(5): 439-44
8. Jiang M, Porat-Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, Li Q, Gillardon F, Hengerer B, Berlinicke C, WW Smith, Zack DJ, Poirier MA, Ross CA, Duan W. Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism. J. Neurochem. 2010; 114: 419-29
9. WW. Smith#, Z. Liu, Y. Liang, N. Masuda, DA. Swing, A. Jenkins, NG. Copeland,  C. Troncoso, M Pletnikov, T M. Dawson, L J. Martin, TH. Moran, MK. Lee, DR. Borchelt, and CA. Ross. Synphilin-1 attenuates neuronal degeneration in the A53T α-synuclein transgenic mouse model. Hum Mol Genet. 2010, 19: 2087-98
10. X. Li, Z. Liu, K. Tamashiro, B Shi, DD. Rudnicki, CA. Ross, TH. Moran, and WW. Smith*. Synphilin-1 exhibits trophic and protective effects against Rotenone toxicity. Neuroscience. 2010, 165(2): 455-62
11. Liang Y, Jiang H, Ratovitski T, Jie C, Nakamura M, Hirschhorn RR, Wang X, WW Smith, Hai T, Poirier MA, Ross CA. ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line. Brain Res. 2009, 25; 1286: 221-9.
12. HS Ko, B Rachel, WW. Smith, Z Liu, J Shin, Y Lee, CA Ross, L Petrucelli, VL Dawson and TM Dawson. CHIP Regulates Leucine-Rich Repeat Kinase-2 (LRRK2) Ubiquitination, Degradation and Toxicity. Proc Natl Acad Sci U S A. 2009, 106: 2897-902
13. Z. Liu, X. Wang, Y. Yu, X. Li, T. Wang, H. Jiang, Q. Ren, Y. Jiao, A. Sawa, T. Moran, C. A. Ross, C. Montell and WW. Smith*. A Drosophila model for LRRK2-linked Parkinsonism. Proc Natl Acad Sci U S A. 2008, 105(7): 2693-8.
14. H. Jiang, Y. Wu, M. Nakamura, Y. Liang, Y. Tanaka, S. Holmes, V. L. Dawson, T. M. Dawson, C. A. Ross and WW. Smith*. Parkinson’s disease genetic mutations increase cell susceptibility to stress: mutant -synuclein enhances H2O2-and Sin-1-induced cell death. Neurobiology of Aging, 2007, 28(11): 1709-17
15. S. Gao, K. P Kinzig, S. Aja, KA. Scott, W. Keung, S. Kelly, K. Strynadka, S. Chohnan, WW. Smith, K. Tamashiro, EE Ladenheim, GV Ronnett, Y. Tu, MJ. Birnbaum, GD Lopaschuk and TH Moran. Leptin Activates Hypothalamic Acetyl-CoA Carboxylase to Inhibit Food Intake. Proc Natl Acad Sci U S A. 2007 104(44): 17358-63.
16. H. Jiang, MA. Poirier, Y. Liang, Z. Pei, CE. Weiskittel, WW. Smith, DB. DeFranco, CA. Ross. Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin. Neurobiology of Disease, 2006; 23(3): 543-51
17. WW. Smith#, Z. Pei, H. Jiang, VL. Dawson, TM. Dawson, CA. Ross. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nature Neuroscience, 2006, 9(10): 1231-3
18. WW. Smith*, DD. Norton, M. Gorospe, H. Jiang, NJ. Holbrook, S. Nemoto, T. Finkel, JW. Kusiak. Phosphorylation of p66Shc and forkhead proteins mediates Ab toxicity. J Cell Biol. 2005, 25; 169(2): 331-9.
19. WW. Smith, R.L. Margolis, X. Li, JC. Troncoso, MK. Lee, VL.Dawson, TM. Dawson, T. Iwatsubo, and CA. Ross. Aalpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. J. Neurosci. 2005 8; 25(23): 5544-52
20. KL. Lim, Katherine C.M. Chew, Jeanne M.M. Tan, C. Wang, Kenny K.K. Chung, Y. Zhang, Y. Tanaka, WW Smith, S. Engelender, CA. Ross, VL. Dawson, TM. Dawson. Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation. J. Neurosci. 2005, 23; 25(8): 2002-9.
21. WW. Smith, H. Jiang, Z. Pei, Y. Tanaka, H. Morita, A. Sawa, VL. Dawson, TM. Dawson and CA. Ross. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha synuclein-induced toxicity. Hum Mol Genet. 2005, 14(24): 3801-11
22. AB. West, DJ. Moore, A. Bugayenko, S. Biskup, WW. Smith CA. Ross, VL. Dawson, TM. Dawson. Parkinson’s disease associated mutation in Leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A. 2005, 102(46): 16842-7.
23. WW. Smith, Z. Pei, H. Jiang, DJ. Moore, Y Liang, AB. West, VL. Dawson, TM. Dawson, and CA. Ross. LRRK2: Interaction with parkin and mutation-induced neuronal degeneration. Proc Natl Acad Sci U S A. 2005, 102(51): 18676-81.

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