Prof. Arun Seth
Sunnybrook Health
Sciences Centre, Cananda
E-mail: arun.seth@utoronto.ca
Qualifications
1981 PhD,
Molecular Biology, University of New Brunswick, Canada
1975 MS,
Organic Chemistry, Meerut University, India
Publications (Selected)
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Seth, A and Jay E: A
study of the efficiency and problem of sulfonation of several condensing
reagents and their mechanisms for the chemical synthesis of deoxyoligoribonucleotides.
Nucleic Acids Res. 8:5445-5459, 1980.
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Jay, E, Seth, A and
Jay, G.: Specific binding of a chemically-synthesized ribosome recognition
site-prospect for molecular cloning and expression of eukaryotic genes. J Biol.
Chem. 255:3809-3812, 1980.
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Jay, G., Khoury, G,
Seth, A. and Jay, E.: Construction of a general vector for efficient expression
of mammalian proteins in bacteria: Use of a synthetic ribosome binding site.
Proc. Natl. Acad Sci.USA 78:5543-5548, 1981.
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Young, TS, Modrich,
P, Seth, A, Jay, E and Kim, SH : Preliminary X-ray diffraction studies of EcoRI
restriction endo-nuclease-DNA complex. J. Mol. Biol. 145:607-610, 1981.
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Jay, E, Seth, A,
Rommens, J, Sood, A and Jay, G: Gene expression Chemical synthesis of E. coli
ribosome binding sites and their use in directing the expression of mammalian
proteins in bacteria. Nucleic Acids Res. 10:6319-6329, 1982.
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Seth, A: A new
method for linker ligation. Gene Anal. Techn 1:99 – 103, 1984
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Seth, A and Vande
Woude, GF: High-level expression of v-mos protein of Moloney murine sarcoma
virus in E. coli. In Whelan, W.J. and Schultz, J. (Eds): Advances in Gene
Technology: Human Genetic Disorders. Cambridge, Cambridge University Press,
p.240.
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Lautenberger, SA,
Seth, A, Jorcyk, C and Papas, TS: Useful modification of the Escherichia coli
expression plasmid pJL6. Gene Anal. Techn. 1:63-69, 1984.
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Seth, A: Linker
ligation. Trends Genet. 1:195, 1985.
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Seth, A and Vande
Woude, GF: Nucleotide sequences and the biochemical activities of the HT1MSV
mos gene. J Virol. 56:144-152, 1985.
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Seth, A, Lapis, P,
Vande Woude, GF and Papas, TS: High-level expression vectors to synthesize
infused proteins in Escherichia coli. Gene 42:49-57, 1986
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Blair, DG,
Oskarsson, MK, Seth, A., Dunn, KJ, Dean, M, Zwig, M, Tainsky, MA and Vande
Woude, GF: Analysis of the transforming potential of the human homology of mos.
Cell 46:785-794, 1986.
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Ascione, R, Sacchi,
N, Watson, DK, Fisher, RJ, Fujiwara, S, Seth, A.,and Papas, TS: Oncogenes:
Molecular probes for clinical application in malignant diseases: Gene Anal.
Techn 3:25-39, 1986.
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Seth, A., Priel, E
and Vande Woude, GF: Nucleoside triphosphate-dependent nucleic acid-binding
properties of mos protein. Proc. Natl. Acad. Sci. USA 84:3560-3564, 1987.
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Li, C_C H, Shah, DV,
Seth, A and Gilden, RV: Identification of the human papillomavirus-6b L1 open
reading frame protein in condylomas and corresponding antibodies in human sera.
J Virol. 61:2684-2690, 1987.
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Samuel KP, Seth, A,
Konopka, A, Lautenberger, JA and Papas, TS: The 3’-ORF protein of
human immunodeficiency virus shows structural homology with the phosphorylation
domain of human interleukin-2 receptor and the ATP-binding site of the protein
kinase family. FEBS Letters 218:81-86, 1987.
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Gonzatti-Haces, M,
Seth, A, Park, M, Copeland, T, Croszlan, S and Vande Woude, GF:
Characterization of the tpr-met oncogene p65 and the met proto-oncogene cell
surface p140 tyrosine kinase. Proc. Natl. Acad. Sci., USA 85:21-25, 1988.
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Fujiwara, S, Fisher,
RJ, Seth, A, Bhat, NK and Papas, TS: Characterization and localization of the
products of the human homologs of the v-ets oncogene. Oncogene 2:99-103, 1988.
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Samuel, KP, Seth, A,
Zweig, M and Papas, TS: Characterization of eight human immunodeficient virus
envelope polypeptides produced in E. coli. Gene 64:121-134, 1988.
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Wang, LC, Gao, C,
Vaso, WC, Seth, A, and Chen, K: The role of v-mos in transformation,
oncogenicity and metastatic potential of mink lung cells. Oncogene 3:267-273,
1988.
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Psallidopoulos, M,
Seth, A, Dubois, G and Papas, TS: Expression of the first exon open reading
frame of human myc in E. coli as a fusion protein with v-mos oncogene product.
Gene Anal. Techn. 6:47-56, 1989.
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Seth, A, Watson, DK,
Fujiwara, S, Showalter, SD and Papas, TS: Expression of human and viral ets
genes in E. coli productions of human ets-2 specific monoclonal antibodies.
Oncogene Res. 5:61-66, 1989.
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Seth, A, Watson, DK,
Blair, DG and Papas, TS: C-ets-2 proto-oncogene has mitogenic and oncogenic
activity. Proc. Natl. Acad. Sci, USA 86:7833-7837, 1989.
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Seth, A, Thompson,
D, Chen, SM and Papas, TS: An improved vector for the expression of proteins in
all three translational reading frames. Gene Anal. Techn. 6:97-100, 1989.
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Koizumi, S, Fisher,
R J, Fujiwara, S, Jorcyk, C, Bhat, N, Seth, A and Papas, T
S.: Isoforms of the human ets-1 protein: Generation by alternative
splicing and differential phosphorylation. Oncogene 5:675-681, 1990
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Samuel, K P,
Ascione, R, Kottaridis, S D, Seth, A, Lautenberger, J A, Zuber, M, Strouboulis,
J and Papas, T S: Expression of animal and human retroviral gene
products in Escherichia coli with the _PL promoter pJL6 vector system. Gene
Anal. Techn. Appl. 7:178-208, 1990.
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Chen, ZQ, Burdett,
LA, Seth, A, Lautenberger, J A and Papas, TS: Requirement of ets-2 expression
for Xenopus oocyte maturation. Science 250:1416-1418, 1990.
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Papas, TS, Watson, D
K, Sacchi, N, Fujiwara, S, Seth, A, Fisher, RJ, Bhat, NK, Mavrothalassitis, G,
Koizumi, S, Jorcyk, CL, Schweinfest, CW, Kottaridis, SD and Ascione,
R: ETS family of genes in leukemia and Down syndrome. Am.
J. Med. Genet. (Suppl.) 7:251-261, 1990.
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Seth, A. and Papas,
TS: The c-ets-1 protooncogene has oncogenic activity and is positively
autoregulated. Oncogene 5:1761-1768, 1990.
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Papas, TS, Blair,
DG, Watson, DK, Yuan, CC, Ruscetti, SK, Fujiwara, S, Seth, AK, Fisher, RJ,
Bhat, N.K, Mavrothalassitis, G, Koizumi, S, Jorcyk, CL, Schweinfest, CW. and
Ascione, R.: The ETS family of genes: Structural analysis, gene products, and
involvement in neoplasia and other pathologies. Prog. Clin. Biol.
Res. 360:137-168, 1990.
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Seth, A, Ascione, R,
Fisher, RJ, Mavrothalassitis, GJ, Bhat, NK and Papas, TS: The ets gene family. Cell
Growth Differ. 3:327-334, 1992.
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Watson, DK, Smyth,
FE, Thompson, DM, Chen, J, Testa, JR, Papas, TS and Seth, A.: The ERGB gene:
isolation and characterization of a new member of the family of human ETS
transcription factors. Cell Growth Differ. 3:705-713, 1992.
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Ascione, R.,
Thompson, DM, Thomas, R., Panayiotakis, A, Ramsay, R, Tymms, M., Kola, I and
Seth, A.: Influence of nucleotides flanking the -GGAA- core sequence on ETS1
and ETS2 DNA-binding activity and the mechanism of ETS1 autoregulation. Int. J.
Oncol. 1:631-637, 1992.
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Topol, LZ, Tatosyan,
AG, Ascione, R, Thompson, DM, Blair, DG, Kola, I and Seth, A: c-ets-1
protooncogene expression alters the growth properties of immortalized rat
fibroblasts. Cancer Lett. 67(1):71-78, 1992.
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Panayiotakis, A,
Hodge, DR, Robinson, L, Watson, DK and Seth, A: Sequence-specific binding of
the ETS1 protein to the HIV-2 LTR enhancer. J. Viral Diseases 1:53-60,
1993.
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Seth, A, Mariano, J,
Metcalf, R, Li, H, Panayiotakis, A, Kottaridis, SD, Papaevangelou, ME and
Papas, TS: Relative paucity of p53 gene mutations in male breast carcinomas. Int.
J. Oncol. 2:739-744, 1993.
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Seth, A, Robinson,
L, Thompson, DM, Watson, DK and Papas, TS: Transactivation of GATA-1 promoter
with ETS1, ETS2 and ERGB/Hu-FLI-1 proteins: Stabilization of the ETS1 protein
binding on GATA-1 promoter sequences by monoclonal
antibody. Oncogene 8:1783-1790, 1993.
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Kola, I, Brookes, S,
Green, T, Garber, R, Tymms, M, Papas, TS and Seth, A: The Ets-1 transcription
factor is widely expressed during murine embryo development and is associated
with mesodermal cells involved in morphogenetic processes including organ
formation, cell migration and tissue-modeling. Proc. Natl. Acad.
Sci. USA 90:7588-7592, 1993.
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Seth, A, Hodge, DR,
Thompson, DM, Robinson, L, Panayiotakis, A, Watson, DK and Papas, TS: ETS
family proteins activate transcription from HIV-1 long terminal
repeat. AIDS Res. Hum. Retroviruses 9:1017-1023, 1993.
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Seth, A, Robinson,
L, Panayiotakis, A, Thompson, DM, Hodge, DR, Zhang, XK Watson, DK, Ozato, K and
Papas, TS: The EndoA enhancer contains multiple ETS binding site repeats and is
regulated by ETS proteins. Oncogene 9:469-477, 1994.
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Li, H, Hodge, DR,
Pei, GK and Seth, A: Isolation and sequence analysis of the human syntaxin-encoding
gene. Gene 143:303-304, 1994.
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Seth, A, Palli, D,
Mariano, JM, Metcalf, R, Bianchi, S, Kottaridis, SD and Papas, TS: p53 gene
mutations in women with breast cancer and a previous history of benign breast
disease. Eur. J. Cancer 30A:808-812, 1994.
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Salesiotis, A.N,
Wang, CK, Wang, CD, Burger, A, Li, H and Seth, A: Identification of novel genes
from stomach cancer cell lines by differential display. Cancer Letters 91, 1995, 47-54.
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Thomas, RS, Tymms,
M.J, Seth, A, Shannon, MF and Kola, I: ETS1 transactivates the human
granulocyte-macrophage colony-stimulating factor promoter in PMA/ionomycin
stimulated T cells. Oncogene,11:2135-2143, 1995.
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Sumarsono, S, Tymms,
M, Corrick, C, Wilson, T, Kola, R, Papas, TS, Seth, A and Kola, I: Down’s
syndrome-like skeletal abnormalities in Ets2 transgenic mice. Nature
379:534-537, 1996.
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Hodge, DR, Robinson,
L, Watson, D, Lautenburger, J, Zhang, XK and Seth, A, Interaction of ETS and
ERGB/FLI proteins with DNA is modulated by spacing between multiple binding
sites as well as phosphorylation. Oncogene 12:11-18, 1996.
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Burger, AM, Li, H,
Panayiotakis, A, Salesiotis, AN and Seth, A. Identification of
differentially expressed genes in breast cancer. International Journal of
Oncology 8:395-400, 1996.
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Venanzoni, MC,
Robinson, LR, Hodge, DR, Kola, I and Seth., A ETS1 and ETS2 in p53
regulation: spatial separation of ETS binding sites (EBS) modulate protein: DNA
interaction. Oncogene 12:1199-1204, 1996.
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Bhat, N, Fischinger,
P, Seth, A., Papas, TS: Pleiotropic Functions of ETS-1. Int. J. Oncology
8:841-846, 1996.
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Watson DK, Robinson
L, Hodge DR, Kola I, Papas TS, and Seth A.: FLI1 and EWS-FLI1 function as
ternary complex factors and ELK1 and SAP1a function as ternary and quaternary
complex factors on the Egr1 promoter serum response elements. Oncogene 14:
213-221, 1997.
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Westermarck, J,
Seth, A, Kahari, V-M: Differential regulation of collagenase-1 (MMP-1) gene
expression by members of ETS gene family. Oncogene 14:2651-2660, 1997.
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Thomas, Rs, Tymms,
M.J, McKinlay, LH, shannon, MF, Seth, A, Kola I: ETS1, NF B and AP1
synergistically transactivate the human GM-CSF promoter. Oncogene 14:2845-2856,
1997.
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Robinson, L., Papas,
T. S., I. Kola, and Seth A. The ETS target genes: Isolation of novel Ets
responsive genes by whole genome PCR and differential display of mRNAs
expressed in Ets1 and Ets2 transformed cells. Proc. Natl. Acad. Sci. USA 94:7170-7175, 1997.
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Tymms MJ, Ng AYN,
Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M,
Papas T, Debouck C, Kola I: A novel epithelial-expressed ETS gene, ELF3: human
and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2
and expression in tissues and cancer. Oncogene 15:2449-2462, 1997
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Burger, AM, Zhang,
X, and Seth, A,: Detection of Novel Genes that are Up- (Di12) or Down-regulated
(T1A12) with Disease Progression in Breast Cancer. European J. of Cancer
Prevention 7 (suppl 1), S29-S35, 1998.
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Burger A, Zhang X-K,
Li H, Ostrowski JL, Beatty B, Venanzoni M, Papas T, Seth A., : Down-regulation
of T1A12, a novel insulin-like growth factor binding protein related gene, is
associated with disease progression in breast carcinomas. Oncogene May 14;
16(19):2459-2467, 1998.
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Burger A, Li H.
Zhang X-K, Pienkowska M, Venanzoni M, Vournakis J, Papas TS. and Seth A:.
Breast cancer genome anatomy: Correlation of morphological changes in breast
carcinomas with expression of the novel gene product Di12. Oncogene 16:327-333,
1998.
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Pienkowska M, Seth
A.: Frequency of Squirrel monkey retroviral sequences in interferon samples.
Journal of Hepatology 28:396-403, 1998.
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Richter, S and Seth,
A: One step direct detection of recurrent mutations in breast cancer
susceptibility gene, BRCA1 by ASO PCR. International Journal of Oncology
12:1263-1267, 1998.
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Kulkarni GV, Lee WK,
Seth A, and McCulloch CAG : The role of mitochondrial membrane potential. in
Con A-induced apoptosis in fibroblasts. Experimental Cell Research 245:170-178,
1998.
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Zhou, J, Ng, AYN,
Tymms JM, Jermiin, LS, Seth, A, Thomas RS, Kola I : A novel transcription
factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human
chromosome 11p36.31, a region subject to LOH and rearrangement in human
carcinoma cell lines. Oncogene 17:2719-32 1998.
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McKinlay, LH, Tymms,
MJ, Thomas, RS, Seth, A, Hasthorpe, S, Hertzog, PJ, Kola, I : The role of Ets-1
in Mast cell granulocyte-macrophage colony-stimulating factor expression and
activation. Journal of Immunology 161:4098-105 1998.
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DeGeorges A, Wang F,
Frierson HF Jr, Seth A, Chung, LWK, Sikes RA : Human prostate cancer expresses
the low affinity insulin-like growth factor binding protein IGFBP-rP1. Cancer
Research 59:2787-2790, 1999.
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Seth A, Giunta, S,
Franceschi C, Kola I, Venanzoni MC : Regulation of the human stress
response gene GADD153 expression: role of ETS1 and FLI-1 gene products. Cell
Death & Differentiation 6:902-907, 1999.
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Beatty, BG, Qi, S,
Pienkowska, M, Scherer, SW, Herbrick, J, Scheidl, T, Zhang, ZM, Kola, I and
Seth, A: Phospholipase A2 activating protein (PLA2P) an ETS2 target
gene, may have a tumor suppressor role. Genomics 62(3):529-32, 1999.
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Seth A, Lee BK, Qi
S, and Vary CPH.: Coordinate Expression of Novel Genes During Osteoblast
Differentiation, Journal of Bone and Mineral Research: 15(9):1683-96, 2000.
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DeGeorges A, Wang F,
Frierson HF Jr, Seth A, Sikes RA. Distribution of IGFBP-rP1/mac25 in normal
human tissues. Journal of Histochemistry and Cytochemistry 48(6):747-54, 2000.
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Vary C, Li V, Raouf
A, Kitching R, Kola I, Franceschi C, Venanzoni M, and Seth A: Involvement
of Ets1 and Ets2 transcription factors and their targets in osteoblast function,
Experimental Cell Research 257:213-222, 2000.
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Raouf, A, Watson DK,
Kola I, and Seth, A: Ets1 protooncogene is regulated by retinoic acid:
Characterization of a Functional Retinoic Acid Response Element in Ets1
Promoter. Oncogene, 19:1969-74, 2000.
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Kahn HJ, Yang LY,
Blondal J, Lickley L, Holloway C, McCready DR, Seth A, Hanna W, Marks A:
Detection of circulating cancer cells in breast cancer patients: an optimized
method using CK19 mRNA. Breast Cancer Research and Treatment, 60:143-151, 2000.
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Raouf A. and Seth,
A: Ets transcription factors and targets in osteogenesis. Oncogene, 19:
6455-63, 2000.
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Wang J, Lukse
E, Seth A, McCulloch CA: Use of conditionally immortalized mouse cardiac
fibroblasts to examine the effect of mechanical stretch on alpha-smooth muscle
actin. Tissue Cell 33(1):86-96. 2000.
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Wang, J, Seth, A,
McCulloch, CA: Force regulates muscle actin in cardiac fibroblasts. Am J Physiol
Heart Circ Physiol 279 (6):H2776-85. 2000
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Landberg, G,
Ostlund, H, Nielsen, NH, Emdin, S, Burger, AM and Seth, A,
: Downregulation of the potential suppressor gene IGFBP-rP1 in human
breast cancer is associated with inactivation of the retinoblastoma protein,
cyclin E overexpression, and increased proliferation in estrogen receptor
negative tumors. Oncogene 20:3497-3505 2001.
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Seth,
A, Catzavelos, C, Vary, C, Ascione, R: Ets transcription
factors and targets and in tumor invasion, angiogenesis and bone metastasis.
Emerging Therapeutic Targets 5:87-108, 2001.
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Kitching, R, Qi, S,
Li, V, Vary, CPH, Seth, A: Coordinate gene regulation patterns during
osteoblast maturation in vitro. Journal of Bone and Mineral Metabolism 20:269-280,
2002.
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Hanna, WM, Kahn, HJ,
Pienkowska, M, Blondal, J, Seth, A: Marks, A. Defining a Test
For HER2/neu Evaluation in Breast Cancer in the Diagnostic Setting. Modern
Pathology 14:677-685, 2001.
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Raouf, A
and Seth, A:. Discovery of osteoblast associated genes Using cDNA
Microarrays. Bone 30:463-471, 2002.
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Raouf, A, Ganss, B,
McMahon, C, Vary, C, Roughley, PJ and Seth, A: Lumican is a Major Proteoglycan
Component of the Bone Matrix. Matrix Biology 21:361-367, 2002.
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Wang, J, Su, M, Fan,
J, Seth, A, McCulloch, CA: Transcriptional Regulation of a Contractile Gene by
Mechanical Forces Applied through Integins in Osteoblasts. J Biol Chem 277(25):22889-95,
2002.
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Venanzoni, MC,
Giunta, S, Muraro, GB, Storari, L, Crescini, C, Mazzucchelli, R, Montironi, R
and Seth, A: Apolipoprotein E (Apo-E) over-expression correlates with Gleason
Score in undifferentiated and hormone resistant prostate cancers. International
Journal of Oncology 22:779-786, 2003.
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Kitching, R, Li, H,
Wong, MJ, Kanaganayakam, S, Beatty, B, Kahn, H and Seth, A: Characterization of
a novel human breast cancer associated gene (BCA3) encoding an alternatively
spliced praline rich protein. Biochemica Biophysica Acta 1625 (1):116-121,
2003.
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Wolvetang, EJ,
Wilson, TJ, Sani, E, Busciglio, J, Hatzistavrou, T, Seth, A, Hertzog, PJ, Kola,
I: ETS2 overexpression in transgenic models and in Down syndrome predisposes to
apoptosis via the p53 pathway. Hum Mol Genet 12 (3):247-55, 2003.
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Burger, AM, Grugel,
R, Landberg, G, Kitching, R and Seth, A: The Breast Cancer Associated Gene Dil2
has Oncogenic Activity. Anticancer Research 23 (3A):2027-2033, 2003.
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Seth, A, Kitching,
R, Landberg, G, Xu, J, Zubovits, J and Burger, AM: Gene Expression Profiling of
Ductal Carcinomas In Situ and Invasive Breast Tumors
Anticancer Research 23 (3A):2043-2051, 2003.
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Subramaniam, V, Li,
H, Wong, M, Kitching, R, Attisano, L. Wrana, J, Zubovits, J, Burger, A and
Seth, A: The RING-H2 Protein RNF 11 is Overexpressed in Breast Cancer and is a
Target of Smurf2 Ligase. British Journal of Cancer 89:1538-44, 2003.
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Kitching, R, Wong,
MJ, Wong, DK, Burger, AM, Landberg, G, Gish, G and Seth, A: The RING-H2 protein
RNF11 is differentially expressed in breast tumours and interacts with
HECT-type E3 Ligases. Biochimica Boiphysica Acta 1639:104-112, 2003.
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Millson A, Suli A,
Hartung L, Kunitake S, Bennett A, Nordberg MC, Hanna W, Wittwer CT, Seth
A., and Lyon E. Comparison of two quantitative polymerase chain reaction
methods for detecting HER2/neu amplification. Journal of Molecular Diagnostics,
3:184-90, 2003
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Wang J, Chen
H, Seth A, McCulloch, CA:. Mechanical force regulation of myofibroblast
differentiation in cardiac fibroblasts. Am J Physiol Heart Circ Physiol.
285(5): H1871-81, Nov. 2003
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Li, H and Seth, A:.
An RNF11:Smurf2 complex mediates ubiquitination of the AMSH protein. Oncogene
23 (10):1801-1808, 2004.
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Connor, M, and Seth,
A: RNF11: A central role for the ring finger protein RNF11 in ubiquitin
mediated proteolysis via interactions with E2s and E3s. Oncogene Reviews “Ubiquitination
and Cancer”, 23 (11):2089-2095, 2004.
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Burger, AM
and Seth, AK:. The Ubiquitin Mediated Protein Degradation
Pathway in Cancer: Therapeutic Implications. Eur J Cancer 40 (15):2217-2229,
2004.
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Overall CM, Tam EM,
Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente XS, López-Otín C,
and Seth A:. Protease Degradomics: Mass Spectrometry Discovery of Protease
Substrates and the CLIP-CHIP: A Dedicated Oligonucleotide Microarray of all
Human Proteases and Inhibitors. Biological Chemistry 385(6):493-504, 2004.
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Kahai, S, Vary, CPH,
Gao, Y and Seth, A: Collagen, type V, alpha 1 (COL5A1) is Regulated
by TGF-in Osteoblasts. Matrix Biol, 23(7):445-455. 2004.
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Li, V, Raouf, A,
Kitching, R and Seth, A: Ets2 Transcription Factor Inhibits
Mineralization and Affects Target Gene Expression During Osteoblast Maturation.
In Vivo: International Journal of Experimental and Clinical Pathophysiology and
Drug Research, 18 (5):517-24, 2004.
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Tanaka, H, Terada,
Y, Kobayashi, T, Okado, T, Inoshita, S, Kuwahara, M, Seth, A, Sato, Y. Sasaki,
S: Expression and Function of Ets-1 during experimental acute renal failure in rats.
J Am Soc Nephrol 15 (12):3083-92, 2004.
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Landberg, G,
Nilsson. K, Jirstrom, K, Ryden, L, Kitching, R, Burger, AM and Seth, A: Cyclin
I is expressed in human breast cancer and closely associated with VEGF and KDR
expression. Breast Cancer Res Treat 89(3):313-6, 2005.
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Wang, J, Laschinger,
C, Zhao, XH, Mak, B, Seth, A, McCulloch, CA: Mechanical force activates
eIF-2alpha phospho-kinases in fibroblast. Biochem Biophys Res Commun. 330 (1):123-30,
2005.
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Wang J, Fan J,
Laschinger C, Arora PD, Kapus A, Seth A, McCulloch CA. Smooth muscle
actin determines mechanical force-induced p38 activation. J Biol Chem. 280 (8):7273-84,
2005.
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Gao, Y, Ganss, BW,
Wang, H, Kitching, RE and Seth, A: The RING finger protein RNF 11 is
expressed in bone cells during osteogenensis and is regulated by Ets1. Exp Cell
Res 304 (1):127-35, 2005.