Dr. Veysel Kayser
Department of Chemical Engineering

Massachusetts Institute of Technology, USA

Research Scientist

Email: vkayser@mit.edu

Qualifications

2004 Ph.D., University of Leeds, UK

1998 B.Sc., Hacettepe University, Turkey

Publications (Selected)

1. Kayser V, Chennamsetty N, Voynov V, Helk B, Forrer K, and Trout BL. A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding. Biotechnol J, 7(1): 127-32 2012.
2. Kayser V, Chennamsetty N, Voynov V, Helk B, and Trout BL. Stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding. mAbs, 3(4): 408-411 2011.
3. Kayser V, Chennamsetty N, Voynov V, Helk B, Forrer K, and Trout BL. Evaluation of a non-Arrhenius Model for Therapeutic Monoclonal Antibody Aggregation. J Pharm Sci, 100(7): 2526-42 2011.
4. Kayser V, Voynov V, Chennamsetty N, Helk B, and Trout BL. Glycosylation influences stability and aggregation of therapeutic monoclonal antibodies. Biotec J, 6(1): 38-44 2011.
5. Kayser V, Chennamsetty N, Voynov V, Helk B, and Trout BL. Tryptophan-Tryptophan energy transfer and classification of tryptophan residues in proteins: Therapeutic monoclonal antibody as a model. J Fluorescence, 21(1): 275-288 2011.
6. Chennamsetty N, Voynov V, Kayser V, Helk B, and Trout BL. Prediction of protein binding regions. Proteins: Struct Funct Bioinf 79(3): 888-897 2011.
7. Chennamsetty N, Voynov V, Kayser V, Helk B, and Trout BL. The prediction of aggregation prone regions of therapeutic proteins. J Phys Chem B, 114(19): 6614-6624 2010.
8. Voynov V, Trout B. L, Chennamsetty N, Kayser V, Helk B, and Wallny, H-J. Design and application of antibody cysteine variants. Bioconj Chem, 21(2): 385-392 2010.
9. Voynov V, Chennamsetty N, Kayser V, Helk B, Forrer K, Zhang H, Fritsch C, Heine H, and Trout BL. Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation, Plos One, 4(12): e8425 2010.
10. Voynov V, Chennamsetty N, Kayser V, Helk B, and Trout B. L. Predictive tools for stabilization of therapeutic proteins. mAbs, 1, 1-3 2009.
11. Chennamsetty N, Voynov V, Kayser V, Helk B, and Trout BL. Design of therapeutic proteins with enhanced stability. Proc Nat Acad Sci, 106, 11937-11942. Research highlight: "Unstuck by design", Nature, 460: 155 2009.
12. Chennamsetty N, Helk B, Voynov V, Kayser V, and Trout BL. Aggregation-prone motifs in human immunoglobulin G. J Mol Biol, 391, 404-413 2009.
13. Bartlett S, Beddard GS, Jackson RM, Kayser V, Kilner C, Leach A, Nelson A, Oledzki PR, Parker P, Reid G. D, and Warriner S. L. Comparison of the ATP binding sites of protein kinases using conformationally diverse bisindolylmaleimides. J Am Chem Soc, 127, 11699-11708 2005.
14. Kayser V, Turton D. A, Aggeli A, Beevers, A, Reid GD, and Beddard GS. Energy migration in novel pH-Triggered self-assembled beta-sheet ribbons. J Am Chem Soc, 126, 336-343 2004.
15. Reid GD, Whittaker DJ, Day MA, Turton DA, Kayser V, Kelly JM, and Beddard GS. Femtosecond electron-transfer reactions in mono- and polynucleotides and in DNA. J Am Chem Soc, 124, 5518-5527 2002.