Dr. Ho-Yin Edwin Chan

The Chinese University of Hong Kong (China)

Associate Professor

Email: hyechan@cuhk.edu.hk

Qualifications

1999 Ph.D., University of Cambridge, Genetics

1995 B.Sc., University of Hong Kong, Biochemistry

Publications

1. Chai, K.H., McLoughlin, D.M., Chan, T.F., Chan, H.Y.E., and Lau, K.F. (2012)  Genomic organization and promoter cloning of the  gene APBA1. DNAahuman X11 & Cell Biol. 31, 651-659.
2. Hao, C.Y., Chai, K.H., McLoughlin, D.M., Chan, H.Y.E. and Lau, K.F. (2012) Promoter  gene APBA2. bcharacterization and genomic organization of the human X11 NeuroReport 23, 146-151.
3. Chow, W.N., Luk, H.W., Chan, H.Y.E. and Lau, K.F. (2012) Degradation of mutant huntingtin via ubiquitin-proteasome system is modulated by FE65. Biochem. J. 443, 681-689.
4. Tsoi, H., Lau, C.K., Lau, K.F. and Chan, H.Y.E.* (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Hum. Mol. Genet. 20, 3787-3797.
5. Chan, W.M., Tsoi, H., Wu, C.C., Wong, C.H., Cheng, T.C., Li, H.Y., Lau, K.F., Shaw, P.C., Perrimon, N. and Chan, H.Y.E.* (2011) Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Hum. Mol. Genet. 20, 1738-1750.
6. Hao, C.Y., Perkinton, M.S., Chan, W.W., Chan, H.Y.E., Miller, C.C.J. and Lau, K.F. (2011) GULP1 is a novel APP interacting protein that alters APP processing. Biochem. J. 436, 631-639.
7. Lu, J.H., Tan, J.Q., Durairajan, S.S., Liu, L.F., Zhang, Z.H., Ma, L., Shen, H.M., Chan, H.Y.E.*, and Li, M.* (2011) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy (in press).
8. Lee, F.K.M., Wong, A.K.Y., Lee, Y.W., Wan, O.W., Chan, H.Y.E.*, and Chung, K.K.K.* (2009) The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease. J. Neurochem. 110, 208-219.
9. Protective role of Engrailed in a Drosophila model of Huntington’s disease. Hum. Mol. Genet. 17, 3601-3616.
10. Lau, K.F., Chan, W.M., Perkinton, M.S., Chang, R.C.C., Chan, H.Y.E., McLoughlin, D.M., and Miller, C.C.J. (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor.
11. Wong, S.L.A., Chan, W.M. and Chan, H.Y.E.* (2008) SDS-insoluble oligomers are involved in polygluta9.Mugat, B., Parmentier, M.L., Bonneaud, N., Chan, H.Y.E., and Maschat, F. (2008) mine degeneration. FASEB J. 22, 3348-3357.
12. Chau, K.W.K., Chan, W.Y., Shaw, P.C., and Chan, H.Y.E.* (2006) Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila. Biochem. Biophys. Res. Comm. 346, 150-159.
13. Chan, H.Y.E. et al. (2002) Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Hum. Mol. Genet. 11, 2895-2904.
14. Auluck, P.K., Chan, H.Y.E. et al. (2002) Chaperone suppression of -synuclein toxicity in a Drosophila model for Parkinson’s disease. Science 295, 865-868.
15. Chan, H.Y.E. et al. (2000) Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy, and modulation of protein solubility in Drosophila. Hum. Mol. Genet. 9, 2811-2820.
16. Warrick, J.M., Chan, H.Y.E. et al. (1999) Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat. Genet. 23, 425-428.

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