Prof. Chi-Hin Cho

The Chinese University of Hong Kong, China

Email: chcho@cuhk.edu.hk

Qualifications

1975-1978 Ph.D., Department of Pharmacology, The University of Hong Kong, China

1973-1975 M. Sc., Department of Pharmacology, University of Wisconsin, USA

1968-1972 B. Pharm., School of Pharmacy, National Defense Medical Center, Taiwan

Publications (Selected)

1. Chow, J.Y.C., Ma, L. & Cho, C.H. (1997).  The potentiating action of cigarette smoke on ethanol-induced gastric mucosal damage in rats. Gastroenterology 113, 1188-1197.
2. Guo, X., Wang, W.P., Ko, J.K.S. & Cho, C.H. (1999). Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on experimental inflammatory bowel disease in rats. Gastroenterology, 117: 884-892.
3. Ma, L, Wang, W.P., Chow, J.Y.C., Lam, S.K. & Cho, C.H. (2000). The role of polyamine in gastric mucus synthesis inhibited by cigarette smoke or its extracts. Gut 47, 170-177.
4. Wang, W.P., Guo, X., Koo, M.W.L., Wong, B.C.Y. Lam, S.K., Ye, Y.N. & Cho, C.H. (2001). Protective effect of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats. Am. J. Physiol.  Gastrointest. Liver Physiol. 281, G586-G594.
5. Wong, B.C.Y. Wang, W.P., So, W.H.L., Shin, V.Y., Wong, W.M., Fung, F.M., Liu, E.S.L., Hui, W.M., Lam, S.K. & Cho, C.H. (2001). Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. Aliment. Pharmacol. Therap. 15, 1459-1465.
6. Liu, E.S.L., Ye, Y.N., Shin, V.Y., Yuen, S.T. Leung, S.Y., Wong, B.C.Y. & Cho, C.H. (2003). Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice. Carcinogenesis 24, 1407-1413.
7. Ye, Y.N., Liu, E.S.L., Shin, V.Y., Wu, W.K.K. & Cho, C.H. (2004). The modulating role of NF-kB in the action of  a7 nAChR and cross-talk between 5-LOX and COX-2 in colon cancer cell growth induced by 4-(N-methyl-N-nitrosamin0)-1-(3-pyridyl)-1-butanone from cigarette smoke.  J. Pharmacol. Exp. Therap. 311, 123-130.
8. Shin, V.Y., Wu, W.K.K., Ye, Y.N., So, W.H.L., Koo, M.W.L., Liu, E.S.L., Luo, J.C. & Cho, C.H. (2004). Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2.  Carcinogenesis 25, 2487-2495. 
9. Luo, J.C., Shin V.Y., Yang, Y.W., Wu, W.K.K., Ye, Y.N., So, W.H.L., Chang, F.Y. and Cho, C.H. (2005). Tumor necrosis-a stimulates gastric epithelial cell proliferation. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G32-G38.
10. Ye, Y.N., Wu, W.K.K., Shin, V.Y., Bruce, I.C., Wong, B.C.Y. & Cho, C.H. (2005). Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis 26, 827-834.
11. Wu, W.K.K., Wong, H.P.S., Luo, S.W., Chan, K., Huang, F.Y., Hui, M.K.C., Lam, E.K.Y., Shin, V.Y., Ye, Y.N., Yang, Y.H. & Cho, C.H. (2005). 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via b-adrencoceptors. Cancer Res. 65, 5272-5277.
12. Shin, V.Y., Koo, M.W.L., Wu, W.K.K., Wong, H. P.S., Lam, E.K.Y., Tai, E. K.K., Chu, K.M. & Cho, C.H. (2005).  Nicotine Induces Cyclooxygenase-2 and Vascular Endothelial Growth Factor Receptor-2 in Association with Tumor-Associated Invasion and Angiogenesis in Gastric Mol. Cancer Res.  3, 607-615.
13. Wu, W.K.K., Li, G.R., Wong, H.P.S., Hui, M.K.C., Tai, E.K.K., Lam, E.K.Y., Shin, V.Y., Ye, Y.N., Li, P., Yang, Y.H., Luo, J.C. & Cho, C.H. (2006). Involvement of K_v1.1 and Na_v1.5 in proliferation of gastric epithelial cells. J. Cell. Physiol.  207, 437-444.
14. Yang, Y.H., Wu, W.K.K., Tai, E. K.K., Wong, H. P.S., Lam, E.K.Y., Shin, V.Y. & Cho, C.H. (2006). The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats. J. Pharmacol. Exp. Therap. 318, 547-554.
15. Shin, V.Y., Wu, W.K.K., Koo, Chu, K,M., M.W.L, Wong, H.P.S., Lam, E. K.Y., Tai, E.K.K. & Cho, C.H. (2007). Functional role of b-adrenergic receptor in the mitogenic action of nicotine on gastric cancer cells. Tox. Sci. 96, 21-29.
16. Wong, H.P.S., Yu, L., Lam, E.K.Y., Tai, E.K.K., Wu, W.K.K. & Cho, C.H. (2007). Nicotine promotes colon cancer growth via a7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway. Tox. Appl. Pharmacol. 221, 261-267.
17. Wu, W.K.K., Sung J.J.Y., Yu, L. & Cho, C.H. (2008). Bone morphogenetic protein signaling is required for the anti-mitogenic effect of proteasome inhibitor MG-132 on colon cancer cells. Br. J.  Pharmacol.154, 632-638.
18. Liu, X., Wu, W.K.K., Sung J.J.Y., Yu, L., Li, Z.J. Zhang S.T. & Cho, C.H. (2008). Epidermal growth factor stimulates esophageal cancer cell growth via transactivation of β-adrenoceptor. J. Pharmacol. Exp. Therap. 326, 69-75.
19. Yu, L., Wu, W.K.K., Wong, H.P.S., Tai, E.K.K., Li, Z.J., Li, H.T., Wu Y.C. & Cho, C.H. (2008). EP2 receptor-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E₂ in esophageal squamous-cell carcinoma. J. Pharmacol. Exp. Therap. 327: 258-267.
20. Yu, L., Wu, W.K.K., Li, Z.J., Liu Q.C., Li, H.T., Wu, Y.C. & Cho, C.H. (2009). Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and SC236 via inhibiting P-glycoprotein activity. Mol. Pharmacol. 75, 1364-1373 (accepted, top ten articles viewed by readers in March 2009).
21. Yu, L., Wu, W.K.K., Li, Z.J., Li, H.T., Wu, Y.C. & Cho, C.H. (2009). Prostaglandin E₂ promotes cell prooliferation via protein kinase C / extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. Int. J. Cancer, 125, 2540-2546.
22. Wu, W.K.K., Sung, J.J.Y., To, K.F., Yu, L., Chu, K.M., Yu, J. & Cho, C.H. (2010).  The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells. J. Cell. Physiol.  223, 178-186.
23. Wu, W.K.K., C.H. Cho (co-correspondence author) , Lee, C., Wu, Y.C., Yu, L., Li, Z.J., Wong, C.C.M., Li, H.T., Zhang, L., Ren, S.X., Che, C.T., Yu, J. & Sung, J.J.Y. (2010). Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy, 6, 1-11.
24. Li, Z.J., Wu, W.K.K., Ng, S.S.M., Yu, L., Li, H.T., Wong C.C.M., Wu, Y. C., Zhang, L., Ren S.X., Sun, X.G., Chan, K.M. & Cho, C.H. (2010). A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. J.  Controlled Release 148, 292-302.
25. Yu, L., Chen, M.H., Li, Z.J., Wen J., Fu, S.G., Jiang Y., Wu S.G., Cho, C.H. & Liu S.W. (2011). Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation.  Mol. Pharmacol. 79, 608-617.
26. Ren S.X., Cheng, A.S.L., To, K.F., Tong, J. H.M., Li, M.S., Wong, C.C.M., Shen, J., Zhang, L.,  Chan, R.L.Y., Wang, X.J., Ng, S.S.M., Chiu, L.C.M., Marquez, V.E., Gallo, R.L., Chan, F.K.L., Yu, J., Sung, J.J.Y., Wu, W.K.K. & Cho, C.H. (2012). Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon colon cancer. Cancer Research 72, 6512-6523.
27. Zhang, L., Wu, W.K.K., Ling, T.K.W., Wong C.C.M., Li, Z.J., Chan, K.M., Ren, S.X., Shen J., Chan R.L.Y., Lee, C.C., Li, M.S.M., Cheng, A.S.L., To, K.F., Gallo, R.L. Yu, J. and Cho, C.H. (2013). Cathelicidinprotects againstHelicobacter pylori colonization and the associated gastritis  in mice. Gene Therapy 20, 751-760.
28. Shen, J., Xiao, Z.G.,, Wang, M.H.,To. K.F., Che, Y.C., Li, M.S., Tong, J.H., Kang W., Zhang  L.,  Wang , L., Lu, L., Chan, R.L.Y., Yu, J., Chan, F.K.L., Sung, J.J.Y., Cheng, A.S. & Cho, C.H. (2015).MiR-490-3p targeting SMARCD1, a member of the SWI/SNF chromatin remodeling family, was epigenetically silenced in H. pylori-induced gastric carcinogenesis. Cancer Res. 75, 754-765.
29. Lu, L., Li, Z.J., Li, L.F., Wu, W.K.K., Shen, J., Zhang, L., Chan, R.L.Y., Yu, L., Liu, Y.W., Ren, S.X., Chan, K.M. & Cho, C.H. (2015). Vascular-targeted TNFα enhances vascular function and benefitsantitumor immunotherapy in colorectal cancer. J. Controlled Release 210, 134-146.