Dr. Joy Sinha
ANDalyze, Inc., USA
Research Fellow
Email: jsinh2@gmail.com
Qualifications
2006-2011 Postdoctoral Fellow, Department of Chemistry, Emory University
2001-2006 Doctoral Candidate, Department of Chemistry, University of Kentucky
Publications (selected)
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Sinha, J., Topp, S. & Gallivan, J.P. From SELEX to Cell: Dual Selections for Synthetic riboswitches. Methods Enzymol. 497, 207-220 (2011).
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Sinha, J., Reyes, S.J. & Gallivan, J.P. Reprogramming bacteria to seek and destroy an herbicide. Nat. Chem. Biol. 6, 464-470 (2010).
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This research has been listed among the key discoveries in chemical biology of the past decade by Nature Chemical Biology. Also mentioned in "Breakthrough of the Year" feature. Science magazine's
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Sinha, J., Dotson, P.P. & Testa, S.M. Kinetic characterization of the first step of the ribozyme-catalyzed trans excision-splicing reaction. FEBS J. 275, 3110-3122 (2008).
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Dotson, P.P., Sinha, J. & Testa, S.M. A Pneumocystis carinii group I intron-derived ribozyme utilizes an endogenous guanosine as the first reaction step nucleophile in the trans excision-splicing reaction. Biochemistry 47, 4780-4787 (2008).
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Johnson, A.K., Sinha, J. & Testa, S.M. Trans Insertion-Splicing: Ribozyme catalyzed insertion of targeted sequences into RNAs. Biochemistry 44, 10702-10710 (2005).
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Sinha, J., Baum, D.A. & Testa, S.M. Molecular recognition in a trans excision-splicing ribozyme: Non-Watson-Crick base pairs at the 5′-splice site andωG at the 3′-splice site can play a role in determining the binding register of reaction substrates. Biochemistry 44, 1067-1077 (2005). (Joint first author)
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Bell, M.A., Sinha, J., Johnson, A.K. & Testa, S.M. Enhancing the second step of the trans excision-splicing reaction of a group I ribozyme by exploiting P9.0 and P10 for intermolecular recognition. Biochemistry 43, 4323-4331 (2004).
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Sinha, J., Layek, S., Mandal, G.C. & Bhattacharjee, M. A green Hünsdiecker reaction: synthesis of β-bromostyrenes from the reaction of α, β-unsaturated aromatic carboxylic acids with KBr and H2O2 catalyzed by Na2MoO4. H2o in aqueous medium. Chem. Comm. 19, 1916-1917 (2001).
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