Dr. Munekazu Yamakuchi

Department of Medicine, School of Medicine and Dentistry
University of Rochester, USA

E-mail: myamakuchi@aol.com

Qualifications

1994-1998 Ph.D., Kagoshima University, Japan

1988-1994 M.D., Kagoshima University, Japan

Publications (Selected)

1. Liu Y, Wang Y, Yamakuchi M, Masuda S, Tokioka T, Yamaoka S, Maruyama I, Kitajima I. Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax. Oncogene. 2001 May 3;20(20):2514-26.
2. Wang Y, Liu Y, Ito Y, Hashiguchi T, Kitajima I, Yamakuchi M, Shimizu H, Matsuo S, Imaizumi H, Maruyama I. Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock. Anal Biochem. 2001 Jul 1;294(1):73-82.
3. Liu Y, Wang Y, Yamakuchi M, Isowaki S, Nagata E, Kanmura Y, Kitajima I, Maruyama I. Upregulation oftoll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-kappa b activation. Infect Immun. 2001 May;69(5):2788-96.
4. Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell. 2003 Oct 17;115(2):139-50.
5. Bhatia R, Matsushita K, Yamakuchi M, Morrell CN, Cao W, Lowenstein CJ. Ceramide triggers Weibel-Palade body exocytosis. Circ Res. 2004 Aug 6;95(3):319-24.
6. Matsushita K, Yamakuchi M, Morrell CN, Ozaki M, O'Rourke B, Irani K, Lowenstein CJ. Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis. Blood. 2005 Jan 1;105(1):207-14.
7. Morrell CN, Matsushita K, Chiles K, Scharpf RB, Yamakuchi M, Mason RJ, Bergmeier W, Mankowski JL, Baldwin WM 3rd, Faraday N, Lowenstein CJ. Regulation of platelet granule exocytosis by S-nitrosylation. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3782-7.
8. Yamakuchi M, Greer JJ, Cameron SJ, Matsushita K, Morrell CN, Talbot-Fox K, Baldwin WM 3rd, Lefer DJ, Lowenstein CJ. HMG-CoA Reductase Inhibitors Inhibit Endothelial Exocytosis and Decrease Myocardial Infarct Size. Circ Res. 2005 Jun 10;96(11):1185-92.
9. Yamakuchi M, Kirkiles-Smith N, Ferlito M, Cameron S, Bao C, Fox-Talbot K, WasowskaB, Baldwin, III W, Pober J. Lowenstein CJ. Antibody to Human Leukocyte Antigen Triggers Endothelial Exocytosis. Proc Natl Acad Sci U S A. 2007;104(4):1301-6
10. Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007 Jun 8;26(5):745-52.
11. Calvert JW, Gundewar S, Yamakuchi M, Park PC, Baldwin WM 3rd, Lefer DJ, Lowenstein CJ. Inhibition of N-ethylmaleimide--sensitive factor protects against myocardial ischemia/reperfusion injury. Circ Res. 2007 Dec 7;101(12):1247-54.
12. Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1516-21.
13. Yamakuchi M, Ferlito M, Lowenstein CJ. Epigallocatechin gallate inhibits endothelial exocytosis. Biol Chem. 2008 Jul 389(7):935-41.
14. YamakuchiM, Bao, C., Ferlito M, Lowenstein CJ. miR-34a repression of SIRT1 regulates apoptosis. 1. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13421-6.
15. Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. Aldosterone activates endothelial exocytosis. 1. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3782-7.