Dr. X. Frank Yang
Department of Microbiology and Immunology
Indiana University School of Medicine, USA

Email: xfyang@iupui.edu

Qualifications
1997 Ph.D., The University of Texas at Dallas, USA
1994 M.S., The University of Texas at Dallas, USA

Publications

1. He M, Ouyang Z, Troxell B, Xu H, Moh A, Norgard M, Piesman J, Gomelsky, M, Yang XF*. 2011. c-di-GMP is essential for the enzootic cycle of Borrelia burgdorferi. PLoS Pathogens. 7(6): e1002133. doi: 10.1371/ journal.ppat. 1002133. (corresponding author)
2. Xu H, He M, Pang X, Xu ZC, Piesman J, Yang XF*. 2010. Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi. Infection and Immunity. 78(1):100-7.
3. Xu H, He, M, He, JJ, Yang XF*. 2010. The role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi. Infection and Immunity. 78:2910-18.(corresponding author)
4. Zou,W, Wang Z, LiuY, Fan Y, Zhou BY, Yang XF, He JJ. 2010. Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes. GLIA. Apr 6. [Epub ahead of print].
5. Xu H, Caimano M, Lin T, He M, Radolf J, Norris S, Gheradini F, Wolfe A, Yang XF*.2010. Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borreliaburgdorferi. PLoS Pathogens.6(9):e1001104. doi:10.1371/journal.ppat.1001104 (corresponding author)
6. Xue F, Dong H, Wu J, Wu Z, Zhao J, Hu W,Bu L, Sun A, Li L, Troxell B, Yang XF, Yan J. 2010. Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance and outer membrane. PLoS Neglected tropical diseases. 4(10): e857. doi:10.1371/journal.pntd.0000857.
7. Ouyang Z, He M, Oman, T, Yang XF, Norgard, MV. 2009. Anovel manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. Proceedings of the National Academy of Sciences, USA. 106:3449-54.
8. Blevins JS, Xu H, He M, Norgard MV, Reitzer L, Yang XF*. 2009. Rrp2, a σ54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. Journal of Bacteriology. 191:2902-05. (corresponding author)
9. Boardman BK, He M, Ouyang Z, Xu H, Pang X, Yang XF*. 2008. Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi. Infection and Immunity.76(9):3844-53 (*corresponding author)
10. He M, Oman T, Xu H, Blevins, JS, Norgard MV, Yang XF*. 2008. Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (SigmaN-SigmaS Cascade) in Borrelia burgdorferi. Molecular Microbiology. 70:1453-64. (*corresponding author)
11. Yang XF, Goldberg MS, He M, Xu H, Blevins JS, Norgard MV. 2008. Differential Expression of a Putative CarD-like Transcriptional Regulator, LtpA, in Borrelia burgdorferi. Infection and Immunity. 76(10):4439-44
12. Smith AH, Blevins JS, Bachlani GN, Yang XF, Norgard MV. 2007. Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN). Journal of Bacteriology. 189(5):2139-44.
13. He M, Boardman BK, Yan D, Yang XF*. 2007. Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi. Journal of Bacteriology. 189(22):8377-80 (*corresponding author)
14. Ranjit K. Deka, Brautigam CA, Yang XF, Blevins JS, Machius M, Tomchick DR, Norgard, MV. 2006. The PnrA (Tp0319; TmpC) lipoprotein represents a newfamilyof bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum. Journal of Biological Chemistry. 281(12):8072-81.
15. Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E. 2005. The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature. 436:573-7.
16. Yang XF, Lybecker MC, Pal U, Alani SM, Blevins JS, Revel AT, Samuels DS, Norgard MV. 2005. Analysis of the ospC regulatory element controlled by the RpoN-RpoSregulatory pathway in Borrelia burgdorferi.Journal of Bacteriology. 187(14):4822-9.