Dr. Rujun Gong

Division of Kidney Disease and Hypertension, School of Medicine

Brown University, USA

Associate Professor

Email: Rujun_Gong@Brown.edu, RGong@Lifespan.org

Qualifications

2001 Ph.D., Nanjing University School of Medicine, China, Renal Physiology

1999 M.D., Nanjing University School of Medicine, China, Clinical Medicine

Publications

1. Andrew Brem, David Morris, Rujun Gong*. Aldosterone induced fibrosis in the kidney: Questions and controversies. American Journal of Kidney Disease 58(3):471-479, 2011.
2. Yan Ge, Jin Si, Li Tian, Shougang Zhuang, Lance Dworkin, Rujun Gong*. Conditional ablation of glycogen synthase kinase 3b in postnatal mouse kidney. Laboratory Investigation 91(1):85-96, 2011.
3. Murugavel Ponnusamy, Na Liu, Rujun Gong, Haidong Yan, Shougang Zhuang. ERK pathway mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed to necrotic renal epithelial cells. American Journal of Physiology Renal Physiology 301(3):F650-9, 2011.
4. Murugavel Ponnusamy, Li Ma, Rujun Gong, Pang M, Chin YE, Shougang Zhuang. P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk. American Journal of Physiology Renal Physiology 300(1):F62-70., 2011.
5. Junming Luo, Yingxin Li, Rujun Gong*. The mechanism of atopic march may be the social event of cells and molecules. [Review] Journal of International Molecular Medicine 26(12):779-785, 2010.
6. Maoyin Pang, Li Ma, Rujun Gong, Tolbert E, Mao H, Ponnusamy M, Chin YE, Haidong Yan, Lance Dworkin, Shougang Zhuang. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney International 78(3):257-268, 2010.
7. Andrew S. Brem, David J. Morris, Yan Ge, Lance Dworkin, Evelyn Tolbert, Rujun Gong*. Direct fibrogenic effects of aldosterone on -HSD activity.bnormotensive kidney: An effect modified by 11 American Journal of Physiology Renal Physiology 298(5): F1178-F1187, 2010.
8. Jin Si, Yan Ge, Shougang Zhuang, Rujun Gong*. Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal disease.  Laboratory Investigation 90(3): 448-458, 2010.
9. Featured article with commentary: Putting the brakes on inflammatory cell motility. Laboratory Investigation 90(3): 346-347, 2010.
10. Ponnusamy M, Maoyin Pang, Annamaraju PK, Zhu Zhang, Rujun Gong, Y. Eugene Chin, Shougang Zhuang. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and Akt signaling pathways. American Journal of Physiology Renal Physiology 297(5):F1361-70, 2009.
11. Zhu Zhang, Jingping Xing, Li Ma, Rujun Gong, Y. Eugene Chin, Shougang Zhuang. Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3.  Journal of Biological Chemistry 284(5):3345-3353, 2009.
12. Rujun Gong*. Multi-target anti-inflammatory action of hepatocyte growth factor. [Invited Review] Current Opinion in Investigational Drugs 9(11):1163-1170, 2008.
13. Rujun Gong, Syed Latif, David J. Morris, Andrew S. Brem. Co-localization of glucocorticoid metabolizing and prostaglandin synthesizing enzymes in rat kidney and liver. Life Sciences 83(21-22):725-731, 2008.
14. Shan Chen, Yan Ge, Jin Si, Abdalla Rifai, Lance D. Dworkin, Rujun Gong*. Candesartan suppresses chronic renal inflammation via a novel antioxidant action independent of AT1R blockade. Kidney International 74(9):1128-1138, 2008.
15. Rujun Gong*, Yan Ge, Shan Chen, Elizabeth Liang, Alfredo Esparza, Edmont Sabo, Agelito Yango, Regional Gohh, Abdalla Rifai, Lance D. Dworkin. Glycogen synthase kinase 3b: a novel marker and modulator of inflammatory injury in chronic renal allograft disease. American Journal of Transplantation 8(9):1852-1863, 2008.
16. Rujun Gong*, Abdalla Rifai, Yan Ge, Shan Chen, Lance D. Dworkin. Hepatocyte growth factor suppresses proinflammatory NF-kB activation through GSK3b inactivation in renal tubular epithelial cells. Journal of Biological Chemistry 283(12):7401-7410, 2008.
17. Rujun Gong, David J. Morris, Andrew A. Brem. Variable Expression of 11ß Hydroxysteroid Dehydrogenase (11b-HSD) Isoforms in Vascular Endothelial Cells. Steroids 73(11):1187-1196, 2008.
18. Rujun Gong, David J. Morris, Andrew S. Brem. Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2. Life Sciences 82(11-12):631-637, 2008.
19. Rujun Gong, Zhihong Liu, Leishi Li. Epistatic effect of plasminogen activator inhibitor 1 and b-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: Interaction with environmental/clinical factors. Arthritis and Rheumatism57(5):1608-1617, 2007.
20. Chen Yu, Rujun Gong, Abdalla Rifai, Evelyn M. Tolbert, Lance D. Dworkin. Long-term, high-dosage candesartan suppresses inflammation and injury in chronic kidney disease: nonhemodynamic renal protection. Journal of the American Society of Nephrology 18(3):750-759, 2007.

Profile Details

directly: http://www.Brown.edu/Research/Gong_Lab