Prof. Binfeng Lu

Department of Immunology

University of Pittsburgh School of Medicine, USA

Email: binfeng@pitt.edu 

Qualifications

2009   Associate Professor, Immunology, University of Pittsburgh, USA
2003   Postdoctoral Training, Section of Immunobiology, Yale University, USA
1998   Ph.D., Degree, Columbia University New York, USA
  

Publications (Selected)

1. Yang Q, Li G, Zhu Y, Liu L, Chen E, Turnquist H, Zhang X, Finn OJ, Chen X, Lu B. IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8(+) T cells. Eur J Immunol. 2011 Sep 2. doi: 10.1002/eji.201141629. [Epub ahead of print] PMID: 21887788 
2. Jingting Jiang, Xiao Zheng, Xiao Xu, Qi Zhou, Haijiao Yan, Xueguang Zhang, Binfeng Lu, Changping Wu, and Jingfang Ju, Prognostic Significance of miR-181b and miR-21 in gastric cancer patients treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin PLoS ONE 6(8): e23271. doi:10.1371/journal.pone.0023271 
3. Kovacs J, Yang Q, Gonzalez-García I, Li C, Ju S, Gonzales-Garcia I, Chen X, Zhang X, and Lu B, Autophagy promotes T cell survival through degradation of proteins of the cell death machinery. Cell Death and Differentiation 2011 Jun 10. doi: 10.1038/cdd.2011.78. [Epub ahead of print] 
4. Lu-jun Chen, Jing Sun, Hong-ya Wu, Shu-ming Zhou, Yan Tan, Ming Tan, Bao-en Shan, Bin-feng Lu*, Xue-guang Zhang*. B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma. Cancer Immunol Immunother. 2011 Apr 26. [Epub ahead of print], *corresponding authors 
5. Jiang JT, Shen YP, Wu CP, Zhu YB, Wei WX, Chen LJ, Zheng X, Sun J, Lu BF, Zhang XG. Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients. World J Gastroenterol. 2010 Dec 28; 16(48):6155-62. PMID: 21182234 
6. Jiang J, Zhu Y, Wu C, Shen Y, Wei W, Chen L, Zheng X, Sun J, Lu B*, and Zhang X*, Tumor Expression of B7-H4 predicts poor Survival of Patients Suffering from Gastric Cancer. Cancer Immunology Immunotherapy 2010 Aug 20. [Epub ahead of print] PMID: 20725832. *corresponding author. 
7. Zhu Y, Ju S, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X, Lu B. T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune Responses. J Immunol. 2010 Aug 16. [Epub ahead of print] 
8. Ding WX, Li M, Chen X, Ni HM, Lin CW, Gao W, Lu B, Stolz DB, Clemens DL, Yin XM.  Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice. Gastroenterology. 2010 Jul 23. [Epub ahead of print]. 
9. Cao H, Yu S, Yao Z, Galson1 D, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu Y, Kurihara N, Patrene K, Roodman D, Xiao G, Activating Transcription Factor 4 Regulates Osteoclast Differentiation, Journal of Clinical Investigation 2010 Aug 2;120(8):2755-66. PMID: 20628199; PMCID: PMC2912190. 
10. Yamamoto Y, Moore R, Flavell RA, Lu B, Negishi M (2010) Nuclear Receptor CAR Represses TNFa-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B. PLoS ONE 5(4): e10121. doi:10.1371/journal.pone.0010121 
11. Sun J, Chen LJ, Zhang GB, Jiang JT, Zhu M, Tan Y, Wang HT, Lu BF, Zhang XG. Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma.
12. Cancer Immunol Immunother. 2010 Mar 24. [Epub ahead of print] PMID: 20333377 
13. Ju S, Ju S, Ge Y, Qiu H, Lu B, Qiu Y, Fu J, Liu G, Wang Q, Hu Y, Shu Y, Zhang X. A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverse signaling. Int Immunol. 2009 Aug 14. [Epub ahead of print] 
14. Ju S, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang X, Lu B. Gadd45b and Gadd45g are important for anti-tumor immune responses. Eur J Immunol. 2009 Nov;39 (11):3010-8. PMID: 19688743 
15. Zhang G, Xu Y, Lu X, Huang H, Zhou Y, Lu B, Zhang X. Diagnosis value of serum  B7-H3 expression in non-small cell lung cancer. Lung Cancer. 2009 Mar 6. [Epub ahead of print]  
16. Cheng Z, Zhou S, Wang X, Xie F, Wu H, Liu G, Wang Q, Chen Y, Hu Y, Lu B, Zhang X. Characterization and application of two novel monoclonal antibodies against human CXCR4: cell proliferation and migration regulation for glioma cell line in vitro by CXCR4/SDF-1alpha signal. Hybridoma (Larchmt). 2009 Feb;28(1):33-41. 
17. Ma DK, Jang M, Guo J, Kitabatake Y, Chang M, Pow-anpongkul N, Flavell RA, Lu B, Ming G, Song H. Neuronal Activity-induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis Science. 2009 Jan. 
18. Gonzalez G I, Zhao Y, Ju S, Gu Q, Liu L, Kolls J, Lu B. IL-17 signaling independent central nervous system autoimmunity is negatively . The Journal of Immunology 2009 Marbregulated by TGF 1;182(5):2665-71 
19. Zhang G, Hou J, Shi J, Yu G, Lu B, Zhang X.Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum. Immunology. 2008 Apr;123(4):538-46. Epub 2008 Jan 9. 
20. Zhang GB, Dong QM, Hou JQ, Ge Y, Ju SG, Lu BF, Zhang XG. Characterization and application of three novel monoclonal antibodies against human 4-1BB: distinct epitopes of human 4-1BB on lung tumor cells and immune cells. Tissue Antigens. 2007 Dec;70(6):470-9. 
21. Wang F, Zhu W, Liu T, Sun Z, Ju S, Ju S, Yu G, Xie W, Deng Z, Lu B, Zhang X. The expression analysis of ICOS-L on activated T cells and immature dendritic cells as well as malignant B cells and Grave's-disease-derived thyroid tissues by two novel mAbs against human ICOS-L. Tissue Antigens. 2007 Jan;69(1):62-72. 
22. Li C, Capan E, Zhao Y, Zhao J, Stolz D, Watkins S, Jin S, Lu B. Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. The Journal of Immunology 2006 Oct 15;177(8):5163-8. 
23. Liu L, Tran E, Zhao Y, Huang Y, Flavell R, Lu B. Gadd45b and Gadd45g are critical for regulating autoimmunity. J Exp Med. 2005 Nov 21; 202(10):1341-7. Epub 2005 Nov 14. 
24. Lee C, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. (2004) Egr-1-Mediated 1-Induced Pulmonary Fibrosis. J Exp Med.bApoptosis is a Prerequisite for TGF- 200(3):377-89. 
25. Chi H, Lu B, Takekawa M, Davis RJ, and Flavell RA. (2004) Gadd45b/Gadd45g and MEKK4 comprise a genetic pathway mediating STAT4-independent  production in CD4 T cells. EMBO J. 23(7):1576-86.gIFN 
26. Lu B, Ferrandino A, Flavell RA. (2004) Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells. Nat Immunol. 5(1):38-44. 
27. Lu B*, Zagouras P, Fischer EJ, Lu J, Li B, Flavell RA*. Genome wide analysis reveals key molecular circuitries that control T cell activation and Th1/Th2 differentiation. Proc Natl Acad Sci U S A. 101(9):3023-8. (*corresponding author). 
28. Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B. (2002) The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol. 22(4):1158-71. 
29. Lu* B, Sun* H, Li R, Flavell RA and Taneja R. (2001) Defective T-cell activation and autoimmune disorder in Stra13-deficient mice. (* These authors contribute equally) Nature Immunology. 2(11): 1040-7.
30. Lu B, Yu H, Chow C, Li B, Zheng W, Davis RJ, Flavell RA.( 2001) GADD45gamma Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector T(H)1 Cells. Immunity. 14(5):583-90.