Dr. Fang Yan
Department of Pediatrics, Division of
Gastroenterology
Vanderbilt University Medical Center, USA
E-mail: fang.yan@vanderbilt.edu
Qualifications
1997 PhD, Cell Biology. Department
of Anatomical Sciences and Neurobiology, University of Louisville,
Louisville, KY
1991 M.D., Medicine, Tianjin
Medical University, Eight-year Program, Tianjin, P. R. China
Publications (Selected)
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Yan, F., Lutz,
D., Shepherd, V.L., Boyle, D. and McLaughlin, B.J. (1995) Characterization of
rod outer segment plasma membrane proteins which bind to the mannose receptor. Curr.
Eye Res. 14: 465-471. PMID: 7671628.
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Yan, F.,
Cooper, N.G. and McLaughlin, B.J. (1998) Temperature-sensitive interactions
between RPE and rod outer segments surface proteins. Exp. Eye Res.
66:783-790. PMID: 9657911.
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Kaiser, G.C.,
Yan, F. and Polk, D.B. (1999) Mesalamine blocks tumor necrosis factor growth
inhibition and nuclear factor kB activation in mouse colonocytes.Gastroenterology. 116:
602-609. PMID: 10029619.
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Kaiser, G.C.,
Yan, F. and Polk, D.B. (1999) Conversion of TNFa antiproliferative to
proliferative ligand in mouse intestinal epithelial cells by regulating mitogen
activated protein kinase. Exp. Cell Res. 249: 349-358. PMID:
10366434.
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Yan, F. and
Polk, D.B. (1999) Aminosalicylic acid inhibits IkB
kinase a phosphorylation of IkBa in intestinal epithelial cells. J.
Biol. Chem. 274:36631-36636. PMID: 10593965.
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Yan, F. and
Polk, D.B. (2001) Kinase suppressor of Ras is necessary for
TNFa activation of ERK/MAP kinase in intestinal epithelial cells. Cancer
Res. 61: 963-969. PMID: 11221891.
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Gupta, G.A.,
Polk, D.B., Krishna,U., Israel, D.A., Yan, F., DuBois, R.N. and Peek, R.M.
(2001) Activation of peroxisomal proliferator-activated
receptor g suppresses NFkB-mediated apoptosis induced by Helicobacter
pylori in gastric epithelial cells. J. Biol. Chem. 276:
31059-31066. PMID: 11397815.
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Yan, F., John,
S.K. and Polk, D.B. (2001) Kinase suppressor of Ras determines survival of
intestinal epithelial cells exposed to tumor necrosis factor.Cancer Res. 61:
8668-8675. PMID: 11751383.
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Yan, F. and
Polk, D.B. (2002) Probiotic bacterium prevents cytokine-induced apoptosis in
intestinal epithelial cells. J. Biol. Chem. 277: 50959-50965. PMID:
12393915.
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Corredor, J.,
Yan, F., Shen, C., Tong, W., John, K.S., Whitehead, R., Wilson, G.
and Polk, D.B. (2003) Tumor necrosis factor regulates intestinal
epithelial cell migration by receptor-dependent mechanisms. Am. J.
Physiol., Cell Physiol. 284: C953-C961. PMID: 12466150.
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Yan, F., John,
K.S., Wilson, G., Jones, D.S., Washington, M.K. and Polk, D.B. (2004) Kinase
suppressor of Ras protects intestinal epithelium from cytokine-mediated
apoptosis during inflammation. J. Clin. Invest. 114:
1272-1280. PMID: 15520859.
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Yan, F. and Polk,
D.B. (2004) Commensal bacteria in the gut: learning who our friends are. Curr.
Opin. Gastroenterol. 20: 565-571. PMID: 15703684. (review)
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Edelblum,
K.L., Yan, F., Yamaoka, T. and Polk, D.B. (2006) Regulation of apoptosis during
homeostasis and disease in the intestinal epithelium. Inflamm. Bowel
Dis. 12: 413-424. PMID: 16670531. (review)
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Yan, F. and
Polk, D.B. (2006) Probiotics as functional food in the treatment of diarrhea. Curr.
Opin. Clin, Nutr. Metab, Care. 9: 717-271. PMID:
17053425. (review)
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Yan, F., Cao,
H., Cover, T. L., Whitehead, R., Washington, M, K. and Polk, D.B. (2007) Soluble proteins produced by
probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132:
562-575. PMID17258729.
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Seth, A., Yan,
F., Polk, D.B., and Rao, R.K. (2008) Probiotics ameliorate hydrogen
peroxide-induced epithelial barrier disruption by PKC and MAP kinase-dependent
mechanism. Am. J. Physiol. Gastrointest. Liver Physiol. 294:
G1060-1069. PMID: 18292183.
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McElroy, S.J.,
Frey, M.R., Yan, F., Edelblum, K.L., Goettel, J.A., John, S.K. and Polk, D.B.
(2008) Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation
through a TNF receptor 1-dependent mechanism. Am. J. Physiol.
Gastrointest. Liver Physiol. 295: G285-93. PMID: 18467504.
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Yamaoka, T., Yan, F., Cao, H., Hobbs, S.S., Dise,
R.S., Tong, W., and Polk, D.B. (2008) Transactivation of EGF receptor and ErbB2
protects intestinal epithelial cells from TNF-induced apoptosis. Proc.
Natl. Acad. Sci. USA.105: 11772-11777. PMID18701712.
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Edelblum,
K.L., Goettel, J.A., Koyama, T., McElroy, S.J., Yan, F., and Polk, D.B. (2008)
TNFR1 promotes TNF-mediated mouse colon epithelial cell survival through Raf
activation of NF-kB. J. Biol. Chem. 283: 29485-29494. PMID:
18713739.
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Vanderpool,
C., Yan, F. and Polk, D.B. (2008) Mechanisms of probiotic action-implications
for therapeutic applications in inflammatory bowel diseases.Inflamm. Bowel
Dis.14:1585-1596. PMID: 18623173. (review)
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Yan, F., Cao,
H., Chaturvedi, R, Krishna, U., Hobbs, S.S., Dempsey, P.J., Peek, R.M., Cover, T. L., Washington, M, K. Wilson, K.T., and
Polk, D.B. (2009) Epidermal growth factor receptor activation protects gastric
epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology 136:1297-1307.
PMID: 19250983.
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Nagy, T.A.,
Frey, M.R., Yan, F., Israel, D.A., Polk, D.B., and Peek, R.M. (2009) Helicobacter
pylori regulates cellular migration and apoptosis by activation of
phosphatidylinositol 3-kinase signaling. J. Infect. Dis. 199:
641-651. PMID: 19199544.
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Bäuerl, C., Pérez-Martínez, G., Yan, F., Polk, D.B., and Monedero, V.J. (2010) Functional Analysis of the p40 and p75 Proteins from
Lactobacillus casei BL23. Mol. Microbiol. Biotechnol. 17;
19:231-241. PMID: 21178363.
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Yan, F. and
Polk, D.B. (2010) Probiotics: progress toward novel therapies. Curr.
Opin. Gastroenterol. 26: 95-101. PMID: 19952741. (review)
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Yan, F. and
Polk, D.B. (2010) Disruption of NF-kB signaling by ancient microbial
molecules-novel therapies of the future? Gut 59:
421-426. PMID: 20332512. (review)
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Yan, F., Cao,
H., Cover, T. L.,
Washington, M.K. Shi, Y., Liu, L., Chaturvedi, R., Peek, R.M.,
Wilson, K.T., and Polk, D.B. (2011) Colon specific delivery of a
probiotic-derived soluble protein ameliorates intestinal inflammation in mice
through an EGF receptor-dependent mechanism. J. Clin. Invest. 121:2242-53.
PMID: 21606592
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Hobbs, S. S.,
Goettel, J.A., Liang, D., Yan, F., Edelblum, K.L., Frey, M.R., Mullane, M.T.,
and Polk, D.B. (2011) Transactivation of EGFR stimulates cytoprotective COX-2
expression in gastrointestinal epithelial cells. Am. J. Physiol.
Gastrointest. Liver Physiol. 301:G220-9. PMID: 21566012
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Chaturvedi,
R., Asim, M., Romero-Gallo, J., Barry, D.P., Hoge, S., de Sablet, Delgado,
A.G., Wroblewski, L.E., Piazuelo, M.B., Yan, F., Israel, D.A., Casero, R.A.,
Correa, P., Gobert, A.P., Polk, D.B., Peek, R.M., and Wilson, K.T.
(2011) Spermine oxidase mediates the gastric cancer risk associated with Helicobacter
pylori CagA. Gastroenterology141:1696-708. PMID: 21839041
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Yan, F. and
Polk, D.B. (2011) Probiotics and immune health. Curr. Opin.
Gastroenterol. 27: 496-501. PMID: 21897224 (review)
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Yan, F., Wang,
L., Shi, Y., Cao, H., Liu, L., Washington, M.K. Shi, Y., Chaturvedi,
R., Israel, D.A., Cao, H., Wang, B., Peek, R.M., Wilson, K.T., and Polk, D.B.
(2012) Berberine promotes recovery of colitis and inhibits inflammatory
responses in colonic macrophages and epithelial cells in DSS-treated mice.Am.
J. Physiol. Gastrointest. Liver Physiol.[Epub ahead of print]
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Zhang, Y.,
Dube, P., Washington, M.K., Yan, F., and Polk, D.B. (2012) ErbB2 and ErbB3
regulate recovery from dextran sulfate sodium-induced colitis by promoting
mouse colon epithelial cell survival. Lab Invest [Epub ahead
of print]
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Yan, F. and
Polk, D.B. (2012) Characterization of a probiotic-derived soluble protein
which reveals a mechanism of preventive and treatment effects of probiotics on
intestinal inflammatory diseases. Gut Microbes (In press)