Dr. Maria Cristina Morganti-Kossmann

Department of Epidemiology and Preventive Medicine

Monash University, Melbourne, Australia

Email: cristina.morganti-kossmann@monash.edu

Qualifications

1984 Ph.D., University of Rome La Sapienza, Italy

Publications (Selected)

1. Otto V.I., Heinzel-Pleines U.E., Gloor S.M., Trentz O., Kossmann T., Morganti-Kossmann M.C. (2000) sICAM-1 and TNF-α induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells. J Neurosci Res 60: 733-742.

2. Stahel P.F., Kariya K., Shohami E., Barnum S.R., Eugster H.P., Trentz O., Kossmann T., Morganti-Kossmann M.C. (2000) Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-α following closed head injury in mice. J Neuroimmunol 109:164-172.

3. Csuka E., Hans V.H.J., Ammann E., Trentz O., Kossmann T., Morganti-Kossmann M.C. (2000) Cell activation and inflammatory response following traumatic axonal injury in the rat. Neuroreport 11: 2587-2590.

4. Emmerling M.R., Morganti-Kossmann M.C., Kossmann T., Stahel P.F., Watson M.D., Evans L.M., Mehta P.D., Spiegel K., Kuo Y.M., Roher A.E., Raby C.A. (2000) Traumatic brain injury elevates the Alzheimer’s amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury. Ann N Y Acad Sci 903: 118-122.

5. Pleines U.E., Morganti-Kossmann M.C., Rancan M., Joller H., Trentz O., Kossmann T. (2001) S-100b reflects the extent of injury and outcome, whereas NSE is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J Neurotrauma 18: 491-498.

6. Lenzlinger P.M., Morganti-Kossmann M.C., Hans V.H.J., Joller-Jemelka H.I., Trentz O., Kossmann T. (2001) Markers for cell-mediated immune response are elevated in cerebrospinal fluid and serum after severe traumatic brain injury in humans.J Neurotrauma 18: 479-489.

7. Rancan M., Hans V.H.J., Gerlach I., Jork R., Trentz O., Kossmann T., Morganti-Kossmann M.C. (2001) Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats. J Neurosci Res 63: 438-446.

8. Stahel P.F., Morganti-Kossmann M.C., Perez D., Redaelli C., Gloor B., M.D., Trentz O., Kossmann T. (2001) Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury. J Neurotrauma 18: 773-781.

9. Otto V.I., Stahel P.F., Rancan M., Kariya K., Shohami E., Yatsiv I., Eugster H.-P., Kossmann T., Trentz O., Morganti-Kossmann M.C. (2001) Regulation of chemokines and chemokine receptors after experimental closed head injury. Neuroreport 12: 2059-2063.

10. Lenzlinger P.M., Marx A., Kossmann T., Trentz O., Morganti-Kossmann M.C. (2002) Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. J Neuroimmunol 122: 161-168.

11. Otto V.I., Gloor S.M., Frentzel S., Gilli U., Ammann E., Hein A.E., Folkers G., Trentz O., Kossmann T., Morganti-Kossmann M.C. (2002) The production of macrophage inflammatory protein-2 induced by soluble ICAM-1 in mouse astrocytes is mediated by tyrosine kinases and p42/44 mitogen-activated protein kinase. J Neurochemistry 80: 824-834.

12. Yatsiv I., Morganti-Kossmann M.C., Perez D, Dinarello C.A., Novick D., Rubinstein M., Otto V.I., Rancan T., Kossmann T., Redaelli C.A., Trentz O., Shohami E., Stahel P.F. (2002) Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab 22: 971-978.

13. Rancan M., Morganti-Kossmann M.C., Barnum S.R., Saft S., Schmidt O.I., Ertel W., Stahel P.F. (2003) CNS-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice. J Cereb Blood Flow Metab 23:1070-1074.

14. Rancan M., Bye N., Otto V.I., Trentz O., Kossmann T., Frentzel S., Morganti-Kossmann M.C. (2004) The chemokine Fractalkine in patients with severe traumatic brain injury and a mouse model of closed head injury. J Cereb Blood Flow Metab 24:1110-1118.

15. Lenzlinger P.M., Shimizu S., Marklund N., Thompson H.J., Schwab M.,E., Saatman K.E., Hoover R.C., Bareyre F.M., Motta M., Luginbuhl A., Pape R., Clouse A.K., Morganti-Kossmann M.C., McIntosh T. (2005) Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats. Neuroscience 134: 1047-1056.

16. Sang Q., Kim M., Kumar S., Bye N., Morganti-Kossmann M.C., Gunnersen J., Fuller S., Howitt J., Hyde L., Beissbarth T., Scott H., Silke J., Tan S.S. (2006) Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury. J Neuroscience 26: 7234-44.

17. Grosjean M.B., Lenzlinger P.M., Stahel P.F., Yatsiv I., Shohami E., Trentz O., Kossmann T., Morganti-Kossmann M.C. (2007) Immunohistochemical characterization of Fas (CD95) and Fas ligand (FasL/CD95L0 expression in the injured brain: correlation to neuronal cell death and inflammatory markers. Histology and Histopathology 22: 235-250.

18. Bye N., Habgood M.D., Callaway J.K., Malakooti N., Potter A., Kossmann T., Morganti-Kossmann M.C. (2007) Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration. Exp Neurol, 204: 220-233.

19. Habgood M.D., Bye N., Dziegielewska K.M., Ek C.J., Lane M.A., Potter A., Morganti-Kossmann M.C., Saunders N.R. (2007) Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice. Eur J Neurosci. 25: 231-238.

20. Gantois I., Fang K., Jiang L., Babovic D., Lawrence A.J., Ferreri V., Teper Y., Jupp B., Ziebell J., Morganti-Kossmann M.C., O'Brien T.J., Nally R., Schutz G., Waddington J., Egan G.F., Drago J. (2007) Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior. Proc Natl Acad Sci USA. 104:4182-4187.

21. Seifman M.A., Adamides A.A., Nguyen P., Vallance S.A. Cooper D.J., Kossmann T., Rosenfeld J.V., Morganti-Kossmann M.C. (2008) Endogenous melatonin increases in cerebrospinal fluid of patients following severe traumatic brain injury and correlates with oxidative stress and metabolic disarray. J Cereb Blood Flow Metab 28: 684-96.

22. Crack P.J., Gould J., Bye N., Ross S., Ali U., Habgood M.D., Morganti-Kossmann M.C., Saunders N.R., Hertzog P.J. (2009) The genomic profile of the cerebral cortex after closed head injury in mice: effects of minocycline. J Neural Transm 116:1-12.

23. Semple B.D., Bye N., Rancan M., Ziebell J.M., Morganti-Kossmann M.C. (2010) Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice. J Cereb Blood Flow Metab 30: 769-782.

24. Frugier T., Morganti-Kossmann M.C.*, O’Reilly D., McLean C.A. (2010) In situ detection of inflammatory mediators in post-mortem human brain tissue following traumatic injury. J Neurotrauma 27: 497-50. *1st and 2nd author contributed equally to the work.

25. Semple BD, Bye N, Ziebell JM Morganti-Kossmann MC. (2010) Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury. Neurobiol Disease 40: 394-403.

26. Hellewell S.C., Yan E.B., Agyapomaa D.A., Bye N., Morganti-Kossmann M.C. (2010) Post-traumatic hypoxia exacerbates brain tissue damage: Analysis of axonal injury and glial responses. J Neurotrauma 27:1997-2010.

27. Semple B.D., Frugier T., Morganti-Kossmann M.C. (2010) CCL2 modulates cytokine production in cultured mouse astrocytes. J Neuroinflamm 14; 7:67.

28. Bye N., Carron S., Han X., Agyapomaa D., Ng S.Y., Yan E., Rosenfeld J.V., Morganti-Kossmann M.C. (2011) Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats. J Neurosci Res 89:986–1000.

29. Ziebell J., Morganti-Kossmann M.C. (2010) Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics 7: 22-30.

30. Semple B.D., Kossmann T., Morganti-Kossmann M.C. (2010) Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. J Cereb Blood Flow Metab 30: 459-473.

31. Taylor, S.E, Morganti-Kossmann, M.C., Lifshitz, J., Ziebell, J.M. (2014) Rod Microglia: A morphological definition. PlosOne 15;9(5):e97096. doi: 10.1371/journal.pone.0097096.

32. Seifman, M.A., Gomes, K., Nguyen, P., Bailey, M., Rosenfeld, J.V., Cooper, D.J., Morganti-Kossmann, M.C. (2014) Measurement of serum melatonin in intensive care unit patients: changes in traumatic     brain injury, trauma and medical conditions. Frontiers in Neurol i2014 Nov 17;5:237. eCollection 2014).

33. Roberts, B.R., Hare, D.J., McLean, C., Conquest, A., Lind, M., Li, Q.X., Bushe A.I., Masters, C.L., Morganti-Kossmann, M.C., Frugier, T. (2014) Traumatic brain injury induces elevation of Co in the human     brain. Metallomics DOI: 10.1039/C4MT00258J.

34. Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A; CENTER-TBI Participants and Investigators (2015). Collaborative European NeuroTrauma Effectiveness     Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery 76: 67-80.

35. Yan, E., Frugier, T., Lim, C.K., Heng, B., Sundaram, G., Tan, M, Rosenfeld, J.V., Walker, D.W., Guillemin, G.J., Morganti-Kossmann, M.C. (2015) Activation of the kynurenine pathway and increased     production of the excitotoxin quinolinic acid following traumatic brain injury in humans. J Neuroinfl 12:110 doi:10.1186/s12974-015-0328-2.