Prof. Weizhen Zhang
Department of Physiology
Peking University, China
Email: weizhenz@umich.edu
Qualifications
1991-1994 Doctor in Medicine, Peking University Health
Science Center, Beijing, China
1987-1990 Master in Medicine, Capital Institute of Medicine,
Beijing, China
1981-1987 Bachelor in Medicine, Sun Yat-sen University of
Medical Sciences, Guangzhou, China
Publications (Selected)
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Zhang W*, Majumer A, Wu X, Mulholland MW. Regulation
of food intake and body weight by recombinant proghrelin. Am J
Physiol-Endocrinol Metab 2009;297:E1269-1275.
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Shi Y, Zhou YB, Cai Y, Teng X, Song JQ, Duan XH, Zhang
WZ, Qi YF. Effect of age on vascular calcification induced by vitamin D3 and
nicotine. Journal of Peking University (Health Sciences) 2010;42:131-6.
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Chai B, Li JY, Zhang W, Wu X, Zhang C, Mulholland MW. Melanocortin-4
receptor activation promotes insulin-stimulated mTOR signaling. Peptides 2010;
31(10):1888-93.
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Li J-Y, Chai B-X, Zhang W, Wang H, MW Mulholland.
Expression of ankyrin repeat and SOCS box containing protein 4 (Asb-4) in the
arcuate nucleus of mice produces a hyperphagic, lean phenotype. Endocrinology
2010; 151(1):134-42.
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Wang H, Wu X, Li J, Chai B, Wang J, Mulholland MW, Zhang
W. Functional protease-activated receptors in the dorsal motor nucleus of the
vagus. Neurogastroenterol Motil 2010;22:431-8,e105 (Editorial Viewpoint 2010;22:361-5).
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Deng FL, Zhang W, Zhang PF, Liu CH, Ling JQ. Improvement
in the morphology of micro-arc oxidized titanium surfaces: A new process to increase
osteoblast response. Mat Sci Eng C-Mater 2010; 30: 141-147.
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Xu G, An W, Li Y, Zhao J, Xiang X, Ding L, Li Z, Guan
Y, Wang X, Tang C, Mulholland MW, Zhang W. Regulation of gastric hormone
production by rapamycin. Peptides 2010;31: 2185-92. PMID: 20804797.
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An W, Li Y, Xu G, Zhao J, Xiang X, Ding L, Li J, Guan
Y, Wang X, Tang C, Mulholland MW, Zhang W. Modulation of ghrelin O
acyltransferase expression in pancreatic islets. Cell Physiol Biochem 2010;26:707-716.
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Xiang XX, Zhao J, Li Y, Zhang W. Directional
differentiation of adipose-derived stem cell. Prog Physiol Sci 2010;41(5):341-6.
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Wu X, Zhang W*, Peng J, Wang H, Li J-Y, Chai B-X,
Mulholland MW. Induction of apoptosis by thrombin in the dorsal motor nucleus
of the vagus. Neurogastroenterol Motil 2011;23:279-285, e123-4.
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Xiang X, Zhao J, Xu G, Li Y, Zhang W. mTOR and the
differentiation of mesenchymal stem cells. Acta Biochim Biophys Sin 2011;43:501-10.
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Li J-Y, Chai B, Zhang W, Wu X, Zhang C, Fritze D, Xia Z,
Patterson C and Mulholland MW. Ankyrin repeat and SOCS box containing protein 4
(Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the
hypothalamic neurons and mediates IRS4 degradation. BMC Neuroscience 2011;
12:95.
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Wang
Y, Zhao B, Zhang Y, Tang Z, Shen Q, Zhang Y, Zhang W, Du J, Chien S, Wang N.
Krüppel-like factor 4 is induced by rapamycin and mediates the
anti-proliferative effect of rapamycin in balloon-injured rat carotid arteries.
Br J Pharmacol 2011;165 (7):2378-2388.
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Xu
G, Li Y, Zhang W. Gastric mammalian target of rapamycin signaling, hormone production
and energy metabolism. World J Gastrointest Pathophysiol 2011;2:1-5. (editorial)
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Xu G, Wang Z, Li 1, Li Z, Tang H, Zhao J, Xiang X,
Ding L, Ma L, Yuan F, Fei J, Wang W, Wang N, Guan Y, Tang C, Mulholland M, Zhang
W. Ghrelin contributes to glucose intolerance induced by rapamycin in mice.
Diabetologia 2012;55:1813–1823.
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Li Z, Xu G, Li Y, Zhao J, Mulholland MW, Zhang W.
mTOR-dependent modulation of gastric nesfatin-1. Cell Physiol Biochem 2012;29(3-4):493-500.
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Xia
Z, Fritze DM, Li J, Chai B, Zhang C, Zhang W*, Mulholland MW*. Nesfatin-1
inhibits gastric acid secretion via a central vagal mechanism in rats. Am J
Physiol 2012; 303:G570-7. PMID:22723266
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Chai
B, Li J, Fritze D, Zhang W, Xia Z, Mulholland MW. A novel transcript is
up-regulated by fasting in the hypothalamus and enhances insulin signaling. J
Neuroendocrinol 2012;25(3):292-301.
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Amini
P, Wadden D, Cahill F, Randell E, Vasdev S, Chen X, Gulliver W, Zhang W, Zhang
H, Yi Y, Sun G. Serum Acylated Ghrelin is Negatively Correlated with the
Insulin Resistance in the CODING study. PLoS one 2012;7:e45657. doi:10.1371
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Wadden
D, Cahill F, Amini P, Randell E, Vasdev S, Yanqing Y, Zhang W, Sun G. Serum
ghrelin concentrations in response to short-term overfeeding in normal weight,
overweight, and obese men. PLoS one 2012;7:e45748
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Tang
H, Ma LX, Zhang W. Gastric hormones and glucose metabolism in skeletal muscle.
Prog Physiol Sci 2013;44(1):63-66.(review)
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Tang
H, Zhang W.The diversity of ghrelin gene in its products and functions. Prog
Physiol Sci 2013;44(3):169-176.( invited review)
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Xiang
X, Yuan F, Zhao J, Li Z, Wang X, Guan Y, Tang C, Li Y, Zhang W. Deficiency in
pulmonary surfactant proteins in mice with FABP4-cre mediated knockout of TSC1
gene. Exp Physiol 2013;98:830-41.PMID:23143994
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Li
Z, Li Y, Zhang W. Ghrelin receptor in energy homeostasis and obesity
pathogenesis. Prog Mol Biol Transl. 2013; 114: 45-87 (invited review)
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Liang
WY, Li ZR, Li Y, Zhang W. Ghrelin and inflammation. Prog Physiol Sci 2013; 44(2):129-32.
(review)
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Zhang
XZ, Li ZR, Li Y, Zhang W. mTOR signaling as a fuel sensor and its role in the
regulation of energy homeostasis. Prog Physiol Sci 2013;44(5):390-4. (review)
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Li
Z, Mulholland M, Zhang W. Regulation of gastric nesfatin-1/NUCB2. Curr Pharm
Design 2013;19(39):6981-5. PMID:23537086 (invited review)
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Tong
Q, Duan L, Xu Z, Wang H, Wang X, Li Z, Zhang W, Zheng H. Improved insulin
secretion following intrapancreatic UCB transplantation in patients with T2DM. J
Clin Endocrinol Metab 2013; 98(9):E1501-4. PMID:23861460
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Li
Z, Gao L, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M, Zhang W.
Peripheral effects of nesfatin-1 on glucose homeostasis. PLoS one 2013;8(8):
e71513. doi:10.1371/journal.pone.0071513
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Zhang
W*, Zhang C, Fritze D, Chai B, Li J, Mulholland M. Modulation of food intake by
mTOR signaling in the dorsal motor nucleus of vagus in male rats: Focus on
ghrelin and nesfatin-1. Exp Physiol 2013;98(12):1696-704. PMID:23955309
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Xiang
X, An W, Jiang C, Zhao J, Wang X, Sun G, Li Y, Zhang W. Lipopolysaccharide
inhibits the expression of resistin in adipocytes. J Mol Endocrinol 2013;51(3):287-99.
PMID:23969982
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Li
JY, Chai B, Zhang W, Fritze DM, Zhang C, Mulholland MW. LGR4 and its ligands,
R-spondin 1 and 3, regulate food intake in the hypothalamus of male rats. Endocrinology.
2014;155(2):429-40. PMID:24280058
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Yin
Y, Li Y, Zhang W. The Growth Hormone Secretagogue Receptor: Its Intracellular
Signaling and Regulation. Int J Mol Sci 2014; 15: 4837-4855.
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Qin
Y, Li Z, Wang Z, Li Y, Zhao J, Mulholland M, Zhang W. Ghrelin contributes to
protection of hepatocellular injury induced by ischemia-reperfusion. Liver Int
2014; 34(4):567-75. doi: 10.1111/liv.12286
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Fritze
D, Zhang W, Li J-Y, Chai B, Mulholland M. Thrombin mediates vagal apoptosis and
dysfunction in inflammatory bowel disease. J Gastrointest Surg. 2014;18(8):1495-506.
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Fritze
D, Zhang W, Li J-Y, Chai B, Mulholland M. TNF causes thrombin-dependent vagal
neuron apoptosis in inflammatory bowel disease. J Gastrointest Surg. 2014;18(9):
1632-41. PMID:24961441
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Li
Z, Xu G, Qin Y, Zhang C, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M, Zhang
W. Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPAR signaling
pathway. Proc Natl Acad Sci USA 2014; 111(36):13163-8. doi/10.1073/pnas.1411571111
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Ding
L, Han L, Li Y, Zhao J, He P, Zhang W. Neurogenin 3 directed cre deletion of
Tsc1 gene causes pancreatic acinar carcinoma. Neoplasia 2014;16(11):909-17.
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Xiang
X, Lan H, Tang H, Yuan F, Xu Y, Zhao J, Li Y, Zhang W. TSC1-mTOR signaling
determines brown-to-white adipocyte phenotypic switch. Diabetes 2015;64(2):519-28.
PMID:25213336
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Xu
Y, Li Z, Yin Y, Lan H, Wang J, Zhao J, Feng J, Li Y, Zhang W. Ghrelin inhibits
the differentiation of T helper 17 cells through mTOR/STAT3 signaling pathway. PLoS
One 2015;10(2):e0117081. doi:10.1371/journal.pone.0117081. PMID:25658305
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Zhang W, Chang L, Zhang C, Zhang
R, Li Z, Chai B, Li J, Chen E, Mulholland M. Central and peripheral irisin
differentially regulate blood pressure. Cardiovasc Drugs Ther 2015;29(2):121-7.
PMID: 25820670
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Zhang W, Zhang C, Chang L, Zhang
R, Li Z, Chai B, Li J, Chen E, Mulholland MW. Irisin: a myokine with locomotor
activity. Neurosci Lett 2015;595:7-11. PMID:25841790
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Xu G, Li Z, Tang H, Guo S, Wang
H, Zhang W. Intestinal mTOR regulates GLP-1 production in L cells. Diabetologia
2015;58(8):1887-97. PMID:26037201
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Yin Y, Zhang W. The role of
ghrelin in senescence. Gerontology 2015. PMID:26160147