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Biography

Prof. Upender Manne

University of Alabama at Birmingham, USA


Email: manne@uab.edu


Qualifications


1987 Ph.D., Osmania University, India

1983 M.Sc., Osmania University, India


Publications (selected)

  1. Doidge C., Gust I, Lee A, Buck F, Hazell S & Manne U:  Therapeutic immunization against Helicobacter infection. The Lancet, 343: 914-915, 1994.
  2. Manne U, Myers RB, Srivastava S, Grizzle WE.  Re:  Loss of tumor marker-immunostaining intensityon stored paraffin slides of breast cancer.  J Natl Cancer Inst 89(8):585-586, 1997.
  3. Manne U, Myers RB, Moron C, Poczantek RB, Stockard CR, Weiss H, Brown D, Srivastava S, Grizzle WE. Prognostic significance of Bcl-2 protein expression and p53 nuclear accumulation in colorectal adenocarcinoma.   Int J Cancer 74:346-358, 1997.
  4. Manne U, Weiss HL, Myers RB, Danner OK, Moron C, Srivastava S, Grizzle WE.  Nuclear accumulation of p53 in Colorectal Adenocarcinomas: Prognostic importance differs with race and location of the tumor.  Cancer 83:2456-2467, 1998.
  5. Manne U, Weiss H, Grizzle WE.  Bcl-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomas.  Int. J. Cancer (Pred. Oncol.): 89, 423-30, 2000
  6. Manne U, Weiss H, Grizzle WE. Racial differences in the prognostic usefulness of MUC1 and MUC2 in colorectal adenocarcinomas. Clin. Cancer Research 6, 4017-25, 2000.
  7. Manne U, Gary BD, Oelschlager DK, Frost AR, Weiss H, Grizzle W E: Altered sub-cellular localization of Suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas. Clinical Cancer Research 2001;7(11):3495-503.
  8. Chhieng DC, Benson E, Eltoum I, Eloubeidi M, Jhala N, Jhala D, Siegal GP, Grizzle, WE, and Manne U. MUC1 expression in diagnosing pancreatic ductal carcinoma obtained by fine needle aspiration. Cancer (Cytopathol.) 2003, 25; 99(6):365-371.
  9. Manne U, N. Jhala, J. Jones, H. L. Weiss, C. Chatla, Meleth, S. Suarez-Cuervo C., Grizzle W. E. Prognostic significance of p27kip-1 expression in colorectal adenocarcinomas is associated with tumor stage. Clinical Cancer Research 2004, 10: 1743-1752.
  10. Alexander D, Chatla C, Funkhouser E, Meleth S, Grizzle WE, Manne U. Post-surgical disparity in survival between African-Americans and Caucasians with colonic adenocarcinomas. Cancer 2004, 101:66-76.
  11. Alexander D, Nirag Jhala, Chatla C, Funkhouser E, Coffey C, Grizzle WE, Manne U. High grade tumor differentiation is a poor prognostic indicator of African Americans with colonic adenocarcinomas. Cancer 2005, 103:2163-2170.
  12. Manne U, Srivastava RG, Srivastava S. Keynote review: Recent advances in biomarker application in cancer diagnosis and treatment. Drug Discovery Today 2005, 10: 965-976.
  13. Grizzle WE, Semmes OJ, Bigbee W, Zhu L, Malik G, Oelschlager DK, Manne B, Manne U. The need for the review and understanding of SELDI-MALDI data prior to analysis. Cancer Informatics 2005, 1(1):86-97.
  14. Chatla C, Alexander D, Katkoori VR, Jhala NC, Katholi CR, Grizzle WE, Manne U. Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinomas. Cancer Biomarkers 2005, 1:241-250.
  15. Verma M, Manne, U. Genetic and epigenetic biomarkers in cancer diagnosis and identifying high risk populations. Reviews in Hematol and Oncol 2006, 60 (1): 9-18.
  16. Meleth S, Chatla C, Venkat Katkoori Anderson B, Hardin MJ, Al Bartolucci, Grizzle WE, Manne U. A comparison of proportional hazards regression to linear discriminant analysis. Cancer Informatics 2007, 2: 1-8.
  17. Manne, U. Understanding the racial disparity in colorectal cancer will aid in individualized medicine. Editorial. Future Medicine (Oncology Series) 2007 3(3):235-41.
  18. Alexander D, Waterbor J, Hughes T, Funkhouser E, Grizzle WE, Manne U. African-American and Caucasian disparities in colorectal cancer mortality and survival by data source: An epidemiologic review. Cancer Biomarkers 2007, 3:301-313.
  19. Chhieng D, Hardin M, Anderson B, Manne U. Predicting 5-year survival of colorectal carcinoma patients using data mining methods. Am Med Informatics 2007, 11:907-910.
  20. Katkoori VR, Chatla C, Jia X, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U. Clinical significance of a novel single nucleotide polymorphism in the 5’ untranslated region of the Rabphillin-3A-Like Gene in colorectal adenocarcinoma. Frontiers in Biosciences 2008, 13, 1050-1061.
  21. Katkoori VR, Jia X, Shanmugam CK, Wan W, Meleth S, Bumpers H, Grizzle WE, Manne U. Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma. Clinical Can Res 2009, 15(7):2406-2416.
  22. Hines R, Chatla C, Bumpers HL, Waterbor JW, McGwin G, Funkhouser E, Coffey CS., Posey J, Manne U. Predictive capacity of three comorbidity indices in estimating mortality following surgery for colon cancer. J Clinical Oncology 2009, 27(26):4339-4345.
  23. Hines R, Shanmugam C, Waterbor JW, McGwin G, Funkhouser E, Coffey CS, Posey J, Manne U. Effect of comorbidity and body mass index on colon cancer survival of African American and Caucasian patients. Cancer, 2009, 115(24):5798-5806.
  24. Anderson B, Hardin JM, Alexander D, Meleth S, Grizzle WE, Manne U. Comparison of the predictive qualities of three prognostic models built on a molecular biomarker dataset of colorectal cancer. Frontiers in Biosciences, 2010, E2; 849-56.
  25. Shanmugam C, Jhala NC, Katkoori VR, Wan W, Meleth S, Grizzle WE, Manne U. Prognostic value of MUC4 expression in colorectal adenocarcinomas. Cancer. 2010, 116(15):3577-86.
  26. Manne U, Shanmugam C, Katkoori VR, Bovell L, Bumpers HL, miRNAs as Biomarkers for Management of Patients with Colorectal Cancer. Biomarkers in Medicine (Future Medicine-Review) 2010, 4(5):22-31.
  27. Wang CW, Manne U, Reddy VB, Oelschlager DK, Katkoori VR, Grizzle WE, Kapoor R. Development of combination tapered fiber-optic biosensor dip-probe for quantitative estimation of interleukin-6 in serum samples. J Biological Sensors Journal of Biomedical Optics 2010, 15(6), 067005.
  28. Katkoori VR, Suerez-Curvo C, Shanmugam C, Bumpers, H, Posey J, Grizzle, WE, Manne U. Bax expression is a prognostic and predictive marker in colorectal cancer. J. Gastrointestial Oncol 2010, 1:76-89.
  29. Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B Bumpers HL, Posey J, Bumpers HL, Grizzle WE, Eltoum IE, Siegal GP, Manne U. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer. J. Hematol & Oncol 2011, 4:25-34.
  30. Kennedy RD, Davison T, Kerr P, Black JM, Bylesjo M, Kay E, Ahdesmaki M, Farztdinov V, Goffard N, Hey P, Holt R J, McDyer F, Mulligan K, Mussen J, O’Brien E, Oliver G, Proutski V, Walker SM, Wilson C, Winter A, O'Donoghue D, Mulcahy H, O'Sullivan J, Sheahan K, Hyland J, Dhir R, Bathe O, Winqvist O, Manne U, Shanmugam CK, Ramaswamy S, Smith W, McDermott U, Wilson R, Longley D, Marshall J, Cummins R, Sargent DJ, Johnston PG and Harkin PD. Development and independent validation of a prognostic assay for Stage II colon cancer using formalin fixed paraffin embedded tissue. J Clin Oncol (In Press).