Prof. Sanjay K. Srivastava

Texas Tech University Health Sciences Center, USA

Email: sanjay.srivastava@ttuhsc.edu

Qualifications

1991 Ph.D., ITRC/Kanpur University, India

1987 M.Sc., Lucknow University, India

1985 B.Sc., Lucknow University, India

Publications (selected)

1. P. K. Kandala and Sanjay K. Srivastava (2012). Diindolylmethane mediated Gli1 suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation in vivo. J. Biol. Chem. 287, Epub. July 6, 2012.
2. K.C. Pramanik and Sanjay K. Srivastava (2012). ASK1-Trx complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid. Redox Signal. Epub. June 11, 2012.
3. S.R. Boreddy and Sanjay K. Srivastava (2012). Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial to mesenchymal transition (EMT) in an orthotopic model. Oncogene (In Press). NIHMS396872.
4. P. K. Kandala and Sanjay K. Srivastava (2012). Diindolylmethane induces ER stress mediated autophagy in ovarian cancer cells. Oncotarget , 3(4), 435-449.
5. P. Kandala and Sanjay K. Srivastava (2012). Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting STAT-3. BMC-Medicine, 10(1):9, 1-18.
6. P. Kandala, S.W. Wright and Sanjay K. Srivastava (2012). Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J. Pharmacol. Exp. Therap., 341, 24-32.
7. S. Loganathan, P.K. Kandala, P. Gupta and Sanjay K. Srivastava (2012). Inhibition of EGFR-Akt axis results in the suppression of ovarian tumors in vitro and in a preclinical mouse model. PLoS ONE. (In Press).
8. P. Gupta and Sanjay K. Srivastava (2012). Anti-tumor activity of phenethyl isothiocyanate in HER2 positive breast cancer models BMC-Medicine 10:80, 1-18.
9. P. K. Kandala and Sanjay K. Srivastava (2012). Janus Activated Kinase 2 is a target of diindolylmethane in ovarian cancer in vitro and in vivo. Drug Discoveries and Therapeutics, 6(2), 94-101.
10. P. Gupta, C.A. Adkins, P.L. Lockman and Sanjay K. Srivastava (2012). Anti-metastatic effects of phenethyl isothiocyanate in a novel mouse model of breast tumor metastasis to brain. (Under Review).
11. K.C. Pramanik and Sanjay K. Srivastava (2012). FOXO-1 acetylation by capsaicin through SirT inhibits pancreatic tumor growth. (Under Review).
12. N.M. Fofaria and Sanjay K. Srivastava (2012). Activation of ATR/Chk1 by piperine causes cell cycle arrest and apoptosis in melanoma cells. (Under Review).
13. K.C. Pramanik, S.K. Kudugunti, M.Y. Moridani and Sanjay K. Srivastava (2012). Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. (Under Review).
14. S.R. Boreddy, K.C. Pramanik and Sanjay K. Srivastava (2011). Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/Akt/FOXO pathway. Clinical Cancer Research, 17, 1784-1795. (Work featured on the cover page of the journal).
15. K.C. Pramanik, S.R. Boreddy and Sanjay K. Srivastava (2011). Involvement of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress lead to apoptosis in pancreatic cancer cells. PLoS ONE. 6 (5), e20151, 1-16.
16. R. Sahu, S. Batra, P. Kandala, T.L. Brown and Sanjay K. Srivastava (2011). Mutation in the K-Ras gene is associated with resistance to TRAIL-induced apoptosis in pancreatic and lung cancer cells. Cancer Chemotherapy and Pharmacology, Published Online 17 September, 2010; 67, 481-487.
17. S.R. Boreddy, R.P. Sahu and Sanjay K. Srivastava (2011). Benzyl isothiocyanate suppress pancreatic tumor angiogenesis and invasion by inhibiting HIF-1α/VEGFR/Rho-GTPases. Pivotal role of STAT-3. PLoS ONE, 6 (10), e25799, 1-12.
18. Bai H, Li H, Zhang W, Matkowskyj, Liao J, Sanjay K. Srivastava, and Yang G-Y (2011). Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KRasG12D/Pdx-Cre mice. August 22, Advance Access. Carcinogenesis, 32, 1689-1696.
19. S.Q. Hussaini, S. Wang, T. Salihima, Sanjay K. Srivastava and X. Liu (2011). Nanoemulsions of cancer chemopreventive agent benzyl isothiocyanate display enhanced solubility, dissolution and permeability. J. Agri. Food Chem. 59, 12396-12404.
20. S. Batra, R. Sahu, P.K. Kandala and Sanjay K. Srivastava (2010). Benzyl isothiocyanate mediated histone deacetylase inhibition leads to turn-off of NF-kB in human pancreatic cancer cells. Molecular Cancer Therapeutics, 9, 1596-1608.
21. P. Kandala and Sanjay K. Srivastava (2010). Activation of Chk2 by DIM is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Molecular Pharmacology, 78, 297-309.
22. R.P. Sahu and Sanjay K. Srivastava (2009). The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. Journal of National Cancer Institute. 101, 176-193.
23. R. Sahu, R. Zhang, S. Batra, Y. Shi and Sanjay K. Srivastava (2009). Benzyl isothiocyanate mediated generation of ROS causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells. Carcinogenesis, 30, 1744-1753.
24. Sanjay K. Srivastava and R. Sahu (2009). Correspondence Re: The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J. Natl. Can. Inst. 101 (12), 893-894.
25. R.P. Sahu, S. Batra, and Sanjay K. Srivastava (2009). Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. British. J. Cancer 100, 1425-1433.
26. R.P. Sahu, Michael W. Epperly and Sanjay K. Srivastava (2009). Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation therapy. Frontiers in Bioscience E1, 568-576.
27. C.A. Wicker, R.P. Sahu, K. Kulkarni-Datar, Sanjay K. Srivastava, T.L. Brown (2009). BITC sensitizes pancreatic adenocarcinomas to TRAIL-induced apoptosis. Cancer Growth & Metastasis, 2, 45-55.
28. P.S. Rao, A. Satelli, S. Zhang, Sanjay K. Srivastava, K.S. Srivenugopal and U.S. Rao (2009). RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways. Proteomics 9, 2776-2787.
29. N.M. Vad, P.K. Kandala, Sanjay K. Srivastava, M.Y. Moridani (2009). Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: An enzyme directed prodrug approach. Chem Biol Interact. 183, 462-471.
30. R. Zhang, I. Humphreys, R. P. Sahu, Y. Shi, and Sanjay K. Srivastava (2008). In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis, 13, 1465-1478.
31. Y. Shi, R.P. Sahu and Sanjay K. Srivastava (2008). Triphala inhibits both in vitro and in vivo growth of pancreatic tumor cells by inducing apoptosis. BMC-Cancer, 8, 294.