Dr. Cenci Giovanni

Sapienza University of Rome, Italy

Email:giovanni.cenci@uniroma1.it

Qualifications

2010 Associate Professor (Habilitation), University of L'Aquila

2000 Assistent Professor, University of Salento

1996 Ph.D., University of Bari

Publications(Seclected)

1. Cenci G, Bonaccorsi S, Pisano C, Verni F, and Gatti M (1994) Chromatin and microtubule organization during premeiotic, meiotic and early postmeiotic stages of Drosophila melanogaster spermatogenesis, J Cell Sci 107:3521-34.
2. Cenci G, Rawson RB, Belloni G, Castrillon DH, Tudor M, Petrucci R, Goldberg ML, Wasserman SA, and Gatti M (1997) UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior, Genes Dev 11:863-75.
3. Siriaco GM, Cenci G, Haoudi A, Champion LE, Zhou C, Gatti M, and Mason JM (2002), Telomere elongation (Tel), a new mutation in Drosophila melanogaster that produces long telomeres, Genetics 160:235-45.
4. Somma MP, Fasulo B, Cenci G, Cundari E, and Gatti M, (2002) Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells, Mol Biol Cell 13:2448-60.
5. Cenci G, Siriaco G, Raffa GD, Kellum R, and Gatti M (2003) The Drosophila HOAP protein is required for telomere capping, Nat Cell Biol 5: 82-4*.
6. Cenci G, Belloni G, and Dimitri P (2003) l(2)41Aa, a heterochromatic gene of Drosophila melanogaster, is required for mitotic and meiotic chromosome condensation. Genet. Res 81: 15-24.
7. Dimitri P, Corradini N, Rossi F, Vernì F, Cenci G, Belloni G, Zhimulev IF and Koryakov DE (2003). Vital genes in the heterochromatin of chromosomes 2 and 3 of Drosophila melanogaster. Genetica 177: 209-215
8. Cenci G, Siriaco G, and Gatti M (2003) The role of HeT-A and TART retrotransposons in Drosophila telomere capping. Genetica 117: 311-318
9. Somma, MP, Fasulo, B, Siriaco, G, and Cenci, G. 2003. Chromosome condensation defects in barren RNA-interfered Drosophila cells. Genetics. 165: 1607-1611
10. Ciapponi L, Cenci G, Ducau J, Flores C, Johnson-Schlitz D, Gorski MM, Engels WR, Gatti M (2004) The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr Biol. 10:1360-1366*.
11. Cenci G, Ciapponi L, Gatti M (2005). The mechanism of telomere protection: a comparison between Drosophila and humans. Chromosoma.114:135-45.
12. Raffa GD, Cenci G, Siriaco G, Goldberg ML, Gatti M (2005). The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Mol Cell. 20:821-31*
13. Ciapponi L, Cenci G, Gatti M (2006) The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Genetics. 173:1447-54.
14. Shaffer CD, Cenci G, Thompson B, Stephens GE, Slawson EE, Adu-Wusu K, Gatti M, Elgin SC (2006) The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure. Genetics 174: 1189-1204
15. Musarò M, Ciapponi L, Fasulo B, Gatti M, Cenci G (2008). Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint. Nat Genet. 40:362-6
16. Somma P, Ceprani F, Bucciarelli E, Naim V, De Arcangelis V, Piergentili R, Palena A, Ciapponi L, Giansanti MG, Pellacani C, Petrucci R, Cenci G, Vernì F, Fasulo B, Goldberg ML, Di Cunto F, Gatti M (2008). Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PLos Genetics, 4 Issue 7 | e1000126
17. Carrisi C, Madeo M, Morciano P, Dolce V, Cenci G, Cappello A, Mazzeo G, Iacopetta D, Capobianco L (2008) Identification of the Drosophila melanogaster mitochondrial citrate carrier: bacterial expression, reconstitution, functional characterization and developmental distribution. J Biochem 144:389-92
18. Ciapponi L, Cenci G (2008) Telomere capping and cellular checkpoints: clues from fruit flies. 2008. Cytogenet Genome Res.122:365-73.
19. Raffa GD, Siriaco G, Cugusi S, Ciapponi L, Cenci G, Wojcik E, Gatti M (2009). The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. Proc Natl Acad Sci USA.106:2271-6.
20. Cenci G (2009) Drosophila cell cycle under arrest: uncapped telomeres plead guilty. Cell Cycle 8:990-5
21. Morciano P, Carrisi C, Capobianco L, Mannini L, Burgio G, Cestra G, De Benedetto GE, Corona DF, Musio A, Cenci G (2009) A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity. Hum Mol Genet. 18:4180-8.
22. Raffa GD, Raimondo D, Sorino C, Cugusi S, Cenci G, Cacchione S, Gatti M, Ciapponi L (2010). Verrocchio, a Drosophila OB-fold containing protein, is a component of the terminin telomere-capping complex. Genes Dev, 24: 1596-1601
23. Mottier-Pavie V, Cenci G, Vernì F, Gatti M, Bonaccorsi S (2010) Phenotypic analysis fo misato function reveals roles of noncentrosomal microtubules in Drosophila spindle formation J Cell Sci, 124: 706-717.
24. Burgio G, Cipressa F, Ingrassia AM, Cenci G**, Corona D** (2011) The Histone De-acetylase Rpd3 Regulates Heterochromatin Structure of Drosophila Telomeres J Cell Sci, in press.