Dr. Marzenna Wiranowska

University of South Florida, USA 

Email: mwiranow@health.usf.edu

Qualifications

1980 Ph.D., Polish Academy of Sciences, Virology-Immunology

1974 M.Sc., Medical Academy of Warsaw, Microbiology-Immunology

1972 B.Sc., Warsaw University, Biology

Publications (Selected)

1. Szmigielski, S., Jeljaszewicz, J. and Wiranowska, M. (1974). "Acute staphylococcal infections in rabbits irradiated with 3GHz microwaves". Ann. New York Acad. Sci. 247:305-311.

2. Szmigielski, S., Luczak, M. and Wiranowska, M. (1975). "Effect of microwaves (3GHz) on cell function and virus replication in cell cultures irradiated in vitro". Ann. New York Acad. Sci., 247:263-274.

3. Szmigielski, S., Luczak, M. and Wiranowska, M. (1975). "Karyometric observations of WISH cell cultures irradiated with 3GHz microwaves". Folia Histochemica et Cytochemica, 13:151.

4. Stewart II, W.E., Wiranowska-Stewart, M., and LeGoff, S. (1977). "Characterization of the distinct molecular populations of Type I mouse interferons". J. Gen. Virol. 37:277-284.

5. Stewart II, W.E., Lin, L., Chudzio, T. and Wiranowska-Stewart, M. (1977). "Molecular alterations of interferons". Texas Reports on Biology & Medicine 35:193-197.

6. Wiranowska-Stewart, M., Chudzio, T., and Stewart II, W.E. (1977). "Repeated superinduction of interferon in human diploid fibroblast cultures". J. Gen. Virol. 37:221-223.

7. Wiranowska-Stewart, M. and Stewart II, W.E. (1977). "The role of chromosome 21 in sensitivity to human interferons". J. Gen. Virol. 37:629-633.

8. Stewart II, W.E., Lin, L.S., Wiranowska-Stewart, M., and Cantell, K. (1977). "Elimination of the size and charge heterogeneities of human leukocyte interferons by chemical cleavage". Proc. Natl. Acad. Sci. U.S.A. 74:4200-4204.

9. Lin, L.S., Wiranowska-Stewart, M., Chudzio, T., and Stewart II, W.E. (1977). "Characterization of the molecular heterogeneities of human interferons: Differences in the cross-species antiviral activities of various molecular populations in human leukocyte interferons". J. Gen. Virol. 39:259-264.

10. Lin, L.S., Wiranowska-Stewart, M., Chudzio, T., and Stewart II, W.E. (1978). "Characterization of the size and charge heterogeneities of human leukocyte interferon populations". Arch. Virol. 56:269-272.

11. Lin, L.S., Wiranowska-Stewart, M., Chudzio, T., and Stewart II, W.E. (1978). "Characterization of the heterogeneous molecules of human interferons: Differences in cross-species antiviral activities of various molecular populations in human leukocyte interferons". J. Gen. Virol. 39:125-130.

12. Stewart II, W.E., Chudzio, T., Lin, L.S., and Wiranowska-Stewart, M. (1978). "Interferoids: In Vitro and In Vivo conversion of interferons to lower molecular weight forms". Proc. Natl. Acad. Sci. U.S.A. 75:4814-4818.

13. Stewart II, W.E., Wiranowska-Stewart, M., Koistinen, V., and Cantell, K. (1979). "Effect of glycosylation inhibitors on the production and properties of human leukocyte interferon". Virology 97:473-478.

14. Hanley, D.P., Wiranowska-Stewart, M., and Stewart II, W.E. (1979). "Pharmacology of interferons. I. Pharmacologic distinctions between human leukocyte and fibroblast interferons". Int. J. Immunopharmacol. 1:219-226.

15. Wiranowska-Stewart, M., Lin, L.S., Braude, I.A., and Stewart II, W.E. (1980). "Production, partial purification and characterization of human and murine interferons-type II". Mol. Immunol. 17:625-633.

16. Wiranowska-Stewart, M. and Stewart II, W.E. (1980). "Determination of human leukocyte populations involved in production of interferons alpha and gamma". J. Interferon Res. 1:233-244.

17. Wiranowska-Stewart, M. (1981). "Heterogeneity of human gamma interferon preparations: Evidence for presence of alpha interferon". J. Interferon Res. 1:315-322.

18. Wussow, P., Platsoucas, C.D., Wiranowska-Stewart, M., and Stewart II, W.E. (1981). "Human interferon production by leukocytes induced with monoclonal antibodies recognizing T cells". J. Immunol. 127:1197-1200.

19. Wussow, P.V., Chen, Yu-Shiaw, Wiranowska-Stewart, M. and Stewart II, W.E. (1982). "Induction of human gamma interferon", J. Interferon Res. 2:11-20.

20. Wiranowska-Stewart, M. and Hadden, J.W. (1986). "Effects of isoprinosine on interleukin II (IL-2) production". Int. J. Immunopharmacol. 8:63-69.

21. Wiranowska, M., Kaido, T., Caspritz, G., Cook, J. and Hadden, J.W. (1987). "Interleukin-2 and coculture with thymic epithelial cells synergistically induce prothymocyte differentiation and proliferation". Thymus 10:231-245.

22. Zheng, Q.Y., Wiranowska, M, Sadlik, J.R. and Hadden, J.W. (1987). "Purified podophyllotoxin (CPH-86) inhibits lymphocyte proliferation but augments macrophage proliferation". Int. J. Immunopharmacol., 9:539-549.

23. Wiranowska, M., Wilson, T.C., Bencze, K.S., Prockop, L.D. (1988). "A mouse model for the study of blood-brain barrier permeability". J. Neuroscience Meth. 26:105-109.

24. Wiranowska, M., Wilson, T., Thompson, K. and Prockop, L.D. (1989). "Cerebral Interferon entry in mice after osmotic alteration of blood-brain barrier". J. Interferon Res., 9:353-362.

25. Wiranowska, M., Gonzalvo, A.A., Saporta, S., Gonzalez, O.R. and Prockop, L.D. (1992). "Evaluation of blood-brain barrier permeability and the effect of interferon in mouse glioma model". J. Neuro-Oncol, 14:225-236.

26. Naidu, A.K., Wiranowska, M., Kori, S., Roetzheim, K. and Kulkarni, A.P. (1993). "Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma". J. Neuro-Oncol, 16:1-10.

27. Naidu, A.K., Wiranowska, M., Kori, S., Prockop, L.D. and Kulkarni, A.P. (1993). "Inhibition of human glioma cell proliferation and glutathione S-transferase by ascorbyl esters and interferon". Anticancer Res., 13:1469-1476.

28. Wiranowska, M. and Naidu, A.K. (1994). "Interferon effect on glycosaminoglycans in mouse glioma in vitro". J. Neuro-Oncol, 18:9-17.

29. Wiranowska, M., Prockop, L.D., Naidu, A.K., Saporta, S., Kori, S.H. and Kulkarni, A.P. (1994). "Interferon entry through the blood-brain barrier in glioma and its effect on lipoxygenase activity". Anticancer Res., 14:1121-1126.

30. Menzies, R., Phelps, C., Wiranowska, M., Oliver, Y., Chen, L., Horvath, E., Hall, N. (1996) The effect of interferon-" on the pituitary-adrenal-axis. J. Interferon and Cytokine Res. 16:619-629.

31. Naidu, A., Wiranowska, M., Phupanich, S., and Prockop, L. (1996) Modulation of glioma growth and 5-lipoxygenase expression by interferon. Anticancer Res. 16:3475-3482.

32. Wiranowska, M., Ranshohoff, J., Weingart, J.D., Phelps, C., Phuphanich, S., and Brem, H. (1998) Interferon-containing controlled-release polymers for localized cerebral immunotherapy. J. Interferon Cytokine Res. 18:377-385.

33. Wiranowska, M., Tresser, N., Saporta, S. (1998) The effect of interferon and anti-CD44 antibody on mouse glioma invasiveness in vitro. Anticancer Res. 18: 3331-3338.

34. Wiranowska, M., Rojiani, A.M., Gottschall, P., Moscinski, L., Johnson, J. and Saporta, S. (2000). CD44 expression and MMP-2 secretion by mouse glioma cells: effect of interferon and anti-CD44 antibody. Anticancer Res. 20:4301-4306.

35. Ma, X.C., Gottschall, P.E., Chen L.T., Wiranowska, M., Phelps, C.P. (2002). The role and mechanisms of interleukin-1 in modulation of neurotoxicity. Neuroimmunomodulation, 199-207.

36. Wiranowska, M., Ladd, S., Smith, R.S., and Gottschall, P.E. (2007).  CD44 adhesion molecule and neuro-glial proteoglycan NG2 as invasive markers of glioma. Brain Cell Biology, 35: 159-172.

37. Wiranowska, M, Ladd, S., Moscinski, L.C., Hill, B., Haller, E., Mikecz, K., Plass, A. (2009/2010).  Modulation of hyaluronan production by CD44 positive glioma cells. International Journal of Cancer 127:532-542 (Dec. 2009/2010 UICC).

38. Wiranowska, M., Colina, L.O., Johnson, J. Clathrin-mediated entry and cellular localization of chlorotoxin in human glioma. Cancer Cell International (submitted Feb 2011).