Prof. Fausto Titti
National AIDS Center, Italy
Email: fausto.titti@iss.it
Qualifications
1977 Ph.D.,
University of Camerino, Italy
Publications (Selected)
-
Ferrantelli F, Maggiorella MT, Schiavoni I,
Sernicola L, Olivieri E, Farcomeni S, Pavone-Cossut MR, Moretti S, Belli R,
Collacchi B, Srivastava IK, Titti F, Cafaro A, Barnett SW, Ensoli B. A
combination HIV vaccine based on Tat and Env proteins was immunogenic and
protected macaques from mucosal SHIV challenge in a pilot study. Vaccine. 2011
Apr 5;29(16):2918-32. Epub 2011 Feb 21.
-
Cafaro A, Bellino S, Titti F, Maggiorella MT,
Sernicola L, Wiseman RW, Venzon D, Karl JA, O'Connor D, Monini P, Robert-Guroff
M, Ensoli B. Impact of viral dose and major histocompatibility complex class IB
haplotype on viral outcome in mauritian cynomolgus monkeys vaccinated with Tat
upon challenge with simian/human immunodeficiency virus SHIV89.6P. J Virol.
2010 Sep;84(17):8953-8. Epub 2010 Jun 16.
-
Ham C, Srinivasan P, Thorstensson R, Verschoor E,
Fagrouche Z, Sernicola L, Ramos A, Titti F, Almond N, Berry N. International
multicenter study to assess a panel of reference materials for quantification
of simian immunodeficiency virus RNA in plasma. J Clin Microbiol. 2010
Jul;48(7):2582-5. Epub 2010 Apr 28.
-
Lewis MG, Norelli S, Collins M, Barreca ML, Iraci
N, Chirullo B, Yalley-Ogunro J, Greenhouse J, Titti F, Garaci E, Savarino A.
Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis
for a new treatment for simian AIDS and an animal model for studying lentiviral
persistence during antiretroviral therapy. Retrovirology. 2010 Mar 16;7:21
-
Ridolfi B, Catone S, Sgarbanti M, Sernicola L,
Battistini A, Parolin C, Titti F, Borsetti A. Generation of a human
immunodeficiency virus type 1 chronicallyn infected monkey B cell line
expressing low levels of endogenous TRIM5alpha. J Cell Physiol. 2009
Dec;221(3):760-5.
-
Mee ET, Berry N, Ham C, Sauermann U, Maggiorella
MT, Martinon F, Verschoor EJ, Heeney JL, Le Grand R, Titti F, Almond N, Rose
NJ. Mhc haplotype H6 is associated with sustained control of SIVmac251
infection in Mauritian cynomolgus macaques. Immunogenetics. 2009
May;61(5):327-39. Epub 2009 Apr 1.
-
Borsetti A, Baroncelli S, Maggiorella MT, Moretti
S, Fanales-Belasio E, Sernicola L, Tripiciano A, Macchia I, Michelini Z, Belli
R, Farcomeni S, Pavone-Cossut MR, Negri D, Caputo A, Bellino S, Butto S, Titti
F, Cafaro A, Ensoli B. Containment of infection in tat vaccinated monkeys after
rechallenge with a higher dose of SHIV89.6P(cy243). Viral Immunol. 2009
Apr;22(2):117-24.
-
Fanales-Belasio E, Moretti S, Fiorelli V,
Tripiciano A, Pavone Cossut MR, Scoglio A, Collacchi B, Nappi F, Macchia I,
Bellino S, Francavilla V, Caputo A, Barillari G, Magnani M, Laguardia ME,
Cafaro A, Titti F, Monini P, Ensoli F, Ensoli B. HIV-1 Tat addresses dendritic
cells to induce a predominant Th1-type adaptive immune response that appears
prevalent in the asymptomatic stage of infection. J Immunol. 2009 Mar
1;182(5):2888-97.
-
Cafaro A, Macchia I, Maggiorella MT, Titti F,
Ensoli B. Innovative approaches to develop prophylactic and therapeutic
vaccines against HIV/AIDS. Adv Exp Med Biol. 2009;655:189-242.
-
Caputo A, Gavioli R, Bellino S, Longo O,
Tripiciano A, Francavilla V, Sgadari C, Paniccia G, Titti F, Cafaro A,
Ferrantelli F, Monini P, Ensoli F, Ensoli B. HIV-1 Tat-based vaccines: an
overview and perspectives in the field of HIV/AIDS vaccine development. Int Rev
Immunol. 2009;28(5):285-334. Review.
-
Florese RH, Wiseman RW, Venzon D, Karl JA,
Demberg T, Larsen K, Flanary L, Kalyanaraman VS, Pal R, Titti F, Patterson LJ,
Heath MJ, O'Connor DH, Cafaro A, Ensoli B, Robert-Guroff M. Comparative study
of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques:
influence of Mauritian MHC haplotypes on susceptibility/resistance to
SHIV(89.6P) infection. Vaccine. 2008 Jun 19;26(26):3312-21. Epub 2008 Apr 30
-
Ridolfi B, Genovese D, Argentini C, Maggiorella
MT, Sernicola L, Buttò S, Titti F, Borsetti A, Ensoli B. Tat protein
vaccination of cynomolgus macaques influences SHIV-89.6P cy243 epitope
variability. Virus Genes. 2008 Feb;36(1):105-15. Epub 2007 Nov 30.
-
Borsetti A, Baroncelli S, Maggiorella MT, Bellino
S, Moretti S, Sernicola L, Belli R, Ridolfi B, Farcomeni S, Negri DR, Cafaro A,
Ensoli B, Titti F. Viral outcome of simian-human immunodeficiency virus
SHIV-89.6P adapted to cynomolgus monkeys. Arch Virol. 2008;153(3):463-72. Epub
2007 Dec 15.
-
Maggiorella MT, Sernicola L, Crostarosa F, Belli
R, Pavone-Cossut MR, Macchia I, Farcomeni S, Tenner-Racz K, Racz P, Ensoli B,
Titti F. Multiprotein genetic vaccine in the SIV-Macaca animal model: a
promising approach to generate sterilizing immunity to HIV infection. J Med
Primatol. 2007 Aug;36(4-5):180-94.
-
Bona R, Macchia I, Baroncelli S, Negri DR, Leone
P, Pavone-Cossut MR, Catone S, Buffa V, Ciccozzi M, Heeney J, Fagrouch Z, Titti
F, Cara A. T cell receptor excision circles (TRECs) analysis during acute intrarectal
infection of cynomolgus monkeys with pathogenic chimeric simian human
immunodeficiency virus. Virus Res. 2007 Jun;126(1-2):86-95. Epub 2007 Mar 2.
-
Titti F, Cafaro A, Ferrantelli F, Tripiciano A,
Moretti S, Caputo A, Gavioli R, Ensoli F, Robert-Guroff M, Barnett S, Ensoli B.
Problems and emerging approaches in HIV/AIDS vaccine development. Expert Opin
Emerg Drugs. 2007 Mar;12(1):23-48. Review.
-
Ensoli B, Fiorelli V, Ensoli F, Cafaro A, Titti
F, Buttò S, Monini P, Magnani M, Caputo A, Garaci E. Candidate HIV-1 Tat
vaccine development: from basic science to clinical trials. AIDS. 2006 Nov
28;20(18):2245-61. Review.
-
Negri DR, Borghi M, Baroncelli S, Macchia I,
Buffa V, Sernicola L, Leone P, Titti F, Cara A. Identification of a cytotoxic
T-lymphocyte (CTL) epitope recognized by Gag-specific CTLs in cynomolgus
monkeys infected with simian/human immunodeficiency virus. J Gen Virol. 2006
Nov;87(Pt 11):3385-92.
-
Goletti D, Macchia I, Leone P, Pace M, Sernicola
L, Pavone-Cossut MR, Maggiorella MT, Cafaro A, Ensoli B, Titti F. Innate
anti-viral immunity is associated with the protection elicited by the simian
immunodeficiency virus (SIV) live attenuated virus vaccine in cynomolgus
monkeys. Med Sci Monit. 2006 Oct;12(10):BR330-40. Epub 2006 Sep 25.
-
Masella R, Varì R, D'Archivio M, Santangelo C,
Scazzocchio B, Maggiorella MT, Sernicola L, Titti F, Sanchez M, Di Mario U,
Leto G, Giovannini C. Oxidised LDL modulate adipogenesis in 3T3-L1
preadipocytes by affecting the balance between cell proliferation and
differentiation. FEBS Lett. 2006 May 1;580(10):2421-9.Epub 2006 Mar 30.
-
Ensoli B, Cafaro A, Caputo A, Fiorelli V, Ensoli
F, Gavioli R, Ferrantelli F, Cara A, Titti F, Magnani M. Vaccines based on the
native HIV Tat protein and on the combination of Tat and the structural HIV
protein variant DeltaV2 Env.Microbes Infect. 2005 Nov;7(14):1392-9. Epub 2005
Sep 15. PubMed PMID: 16243561.
-
Michelini Z, Negri DR, Baroncelli S, Catone S,
Comini A, Maggiorella MT, Sernicola L, Crostarosa F, Belli R, Mancini MG,
Farcomeni S, Fagrouch Z, Ciccozzi M, Rovetto C, Liljestrom P, Norley S, Heeney
J, Titti F. T-cell-mediated protective efficacy of a systemic vaccine approach
in cynomolgus monkeys after SIV mucosal challenge. J Med Primatol. 2004
Oct;33(5-6):251-61.
-
Ferrero E, Orciani M, Vacca P, Ortolan E,
Crovella S, Titti F, Saccucci F, Malavasi F. Characterization and phylogenetic
epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque. BMC Immunol.
2004 Sep 21;5:21.
-
Maggiorella MT, Baroncelli S, Michelini Z,
Fanales-Belasio E, Moretti S,Sernicola L, Cara A, Negri DR, Buttò S, Fiorelli
V, Tripiciano A, Scoglio A, Caputo A, Borsetti A, Ridolfi B, Bona R, ten Haaft
P, Macchia I, Leone P, Pavone-Cossut MR, Nappi F, Ciccozzi M, Heeney J, Titti
F, Cafaro A, Ensoli B.Long-term protection against SHIV89.6P replication in
HIV-1 Tat vaccinated cynomolgus monkeys. Vaccine. 2004 Sep 3;22(25-26):3258-69.
-
Ridolfi B, Titti F, Fulgenzi D, Maggiorella MT,
Tinari A, Superti F, Parolin C, Ensoli B, Borsetti A. Infection of a simian B
cell line by human and simian immunodeficiency viruses. AIDS Res Hum
Retroviruses. 2004 Jul;20(7):723-32.
-
Cara A, Maggiorella MT, Bona R, Sernicola L,
Baroncelli S, Negri DR, Leone P, Fagrouch Z, Heeney J, Titti F, Cafaro A,
Ensoli B. Circular viral DNA detection and junction sequence analysis from PBMC
of SHIV-infected cynomolgus monkeys with undetectable virus plasma RNA.
Virology. 2004 Jul 1;324(2):531-9.
-
Leuchte N, Berry N, Köhler B, Almond N, LeGrand
R, Thorstensson R, Titti F, Sauermann U. MhcDRB-sequences from cynomolgus
macaques (Macaca fascicularis) of different origin. Tissue Antigens. 2004
Jun;63(6):529-37.
-
Negri DR, Baroncelli S, Catone S, Comini A,
Michelini Z, Maggiorella MT, Sernicola L, Crostarosa F, Belli R, Mancini MG,
Farcomeni S, Fagrouch Z, Ciccozzi M, Boros S, Liljestrom P, Norley S, Heeney J,
Titti F. Protective efficacy of a multicomponent vector vaccine in cynomolgus
monkeys after intrarectal simian immunodeficiency virus challenge. J Gen Virol.
2004 May;85(Pt 5):1191-201.
-
Di Fabio S, Corrias F, Monardo F, Titti F. Flow
cytometry analysis of immune cell populations isolated from cervicovaginal
secretions of cynomolgus monkeys. J Immunol Methods. 2004 Jan;284(1-2):7-14.